Motif ID: CDC5L.p2

Z-value: 0.980


Transcription factors associated with CDC5L.p2:

Gene SymbolEntrez IDGene Name
CDC5L 988 CDC5 cell division cycle 5-like (S. pombe)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
CDC5Lchr6_+_44463418-0.371.7e-01Click!


Activity profile for motif CDC5L.p2.

activity profile for motif CDC5L.p2


Sorted Z-values histogram for motif CDC5L.p2

Sorted Z-values for motif CDC5L.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of CDC5L.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr18_+_59593591 2.164 NM_003784
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr3_-_110155237 2.129 NM_005459
GUCA1C
guanylate cyclase activator 1C
chr2_-_162808123 1.736 NM_004460
FAP
fibroblast activation protein, alpha
chr6_-_112001590 1.672 NM_001164282
TRAF3IP2
TRAF3 interacting protein 2
chr5_+_147423727 1.611 NM_001127698
NM_001127699
NM_006846
SPINK5


serine peptidase inhibitor, Kazal type 5


chr17_-_7434113 1.554 NM_006942
SOX15
SRY (sex determining region Y)-box 15
chr12_-_15706340 1.435 EPS8
epidermal growth factor receptor pathway substrate 8
chr13_-_109600709 1.379 COL4A1
collagen, type IV, alpha 1
chr12_-_51114372 1.240 NM_004693
KRT75
keratin 75
chr3_-_95230143 1.232 NM_001001850
STX19
syntaxin 19
chr13_-_37070862 1.208 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr2_+_228386800 1.193 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr1_-_20682541 1.185


chr3_-_139315011 1.171 NM_001170538
DZIP1L
DAZ interacting protein 1-like
chr1_+_84382575 1.120 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr11_+_27019084 1.089 NM_003986
BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr4_-_68432293 1.080 NM_004262
TMPRSS11D
transmembrane protease, serine 11D
chr1_+_84382562 1.053 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr4_-_152368492 1.048 SH3D19
SH3 domain containing 19
chr3_+_191588354 1.045 NM_006580
CLDN16
claudin 16
chrX_-_15593074 1.017 NM_020665
TMEM27
transmembrane protein 27
chr6_+_12825818 1.010 NM_030948
PHACTR1
phosphatase and actin regulator 1
chr1_+_84382529 1.004 NM_182948
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr16_+_14201687 0.971 MKL2
MKL/myocardin-like 2
chr8_+_75899326 0.969 NM_015886
PI15
peptidase inhibitor 15
chr13_-_85271329 0.960 NM_032229
SLITRK6
SLIT and NTRK-like family, member 6
chr4_+_69465107 0.879 NM_014058
TMPRSS11E
transmembrane protease, serine 11E
chr5_-_138238877 0.841 LRRTM2
leucine rich repeat transmembrane neuronal 2
chr10_-_90601655 0.834 NM_144590
ANKRD22
ankyrin repeat domain 22
chr7_+_80145461 0.789 CD36
CD36 molecule (thrombospondin receptor)
chr2_+_165804157 0.773 NM_001040142
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr2_-_133895795 0.742 NCKAP5
NCK-associated protein 5
chr12_-_13139848 0.741 NM_031289
NM_153823
GSG1

germ cell associated 1

chr12_-_90097384 0.741 NM_133503
DCN
decorin
chr4_+_41309482 0.721 LIMCH1
LIM and calponin homology domains 1
chr6_-_116973465 0.718 NM_001139444
BET3L
BET3 like (S. cerevisiae)
chr21_-_30774502 0.716 NM_181607
KRTAP19-1
keratin associated protein 19-1
chr20_-_1420168 0.673 NM_001122962
NM_001134836
SIRPB2

signal-regulatory protein beta 2

chr4_-_77176163 0.670 NM_005409
CXCL11
chemokine (C-X-C motif) ligand 11
chr1_+_194887630 0.657 NM_000186
NM_001014975
CFH

complement factor H

chr4_+_41309690 0.654 LIMCH1
LIM and calponin homology domains 1
chr4_+_41309668 0.652 NM_001112719
NM_001112720
LIMCH1

LIM and calponin homology domains 1

chr4_-_68678181 0.652 NM_207407
TMPRSS11F
transmembrane protease, serine 11F
chr1_+_151270301 0.650 NM_003125
SPRR1B
small proline-rich protein 1B
chr21_+_42492867 0.649 NM_207627
NM_207628
ABCG1

ATP-binding cassette, sub-family G (WHITE), member 1

chr10_-_116434102 0.635 ABLIM1
actin binding LIM protein 1
chr8_+_1940282 0.628 KBTBD11
kelch repeat and BTB (POZ) domain containing 11
chr5_-_138238891 0.627 CTNNA1
LRRTM2
catenin (cadherin-associated protein), alpha 1, 102kDa
leucine rich repeat transmembrane neuronal 2
chrX_-_19598912 0.620 NM_001184960
SH3KBP1
SH3-domain kinase binding protein 1
chr20_-_1420126 0.607 SIRPB2
signal-regulatory protein beta 2
chr5_-_125956996 0.602 ALDH7A1
aldehyde dehydrogenase 7 family, member A1
chr10_-_116434364 0.602 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chr14_-_80934523 0.600 NM_033104
STON2
stonin 2
chr1_-_85816520 0.592 NM_001134445
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr13_-_40454360 0.574 NM_001145353
ELF1
E74-like factor 1 (ets domain transcription factor)
chr12_+_13240983 0.568 EMP1
epithelial membrane protein 1
chr16_+_27248806 0.567 IL4R
interleukin 4 receptor
chr4_-_15549047 0.567 NM_005130
FGFBP1
fibroblast growth factor binding protein 1
chr21_+_29439768 0.565 C21orf7
chromosome 21 open reading frame 7
chr5_+_149867866 0.543 NM_001543
NDST1
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
chr18_-_49944986 0.537 MBD2
methyl-CpG binding domain protein 2
chr18_+_59705918 0.525 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr4_+_109033868 0.523 NM_001136257
NM_152621
SGMS2

sphingomyelin synthase 2

chr2_+_101981888 0.518 NM_173343
IL1R2
interleukin 1 receptor, type II
chr4_-_186537145 0.517 NM_018409
LRP2BP
LRP2 binding protein
chr14_-_60818263 0.511 NM_001017970
TMEM30B
transmembrane protein 30B
chr12_+_13240987 0.509 EMP1
epithelial membrane protein 1
chr4_+_91375204 0.504 NM_207491
FAM190A
family with sequence similarity 190, member A
chr21_-_31012965 0.503 NM_001164435
KRTAP21-3
keratin associated protein 21-3
chr18_-_29882555 0.503 NM_001198549
NOL4
nucleolar protein 4
chr4_-_23500706 0.502 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr5_-_138238953 0.495 NM_015564
LRRTM2
leucine rich repeat transmembrane neuronal 2
chr12_+_10222823 0.494 NM_153022
C12orf59
chromosome 12 open reading frame 59
chr3_+_187840842 0.492 NM_014375
FETUB
fetuin B
chr2_-_215711313 0.488 NM_173076
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12
chr4_+_106851415 0.486 NM_001031720
GSTCD
glutathione S-transferase, C-terminal domain containing
chr15_+_60146467 0.486 NM_207322
C2CD4A
C2 calcium-dependent domain containing 4A
chr6_+_55147029 0.481 NM_001526
HCRTR2
hypocretin (orexin) receptor 2
chr7_+_18502342 0.476 NM_058176
NM_178425
HDAC9

histone deacetylase 9

chr1_-_150328153 0.474 NM_001008536
TCHHL1
trichohyalin-like 1
chr19_-_10558906 0.469 NM_005498
AP1M2
adaptor-related protein complex 1, mu 2 subunit
chr14_-_49543987 0.465 NM_001012706
C14orf182
chromosome 14 open reading frame 182
chr10_-_116276560 0.464 ABLIM1
actin binding LIM protein 1
chr18_-_35634247 0.463 LOC647946
hypothetical LOC647946
chr12_+_18305740 0.460 NM_004570
PIK3C2G
phosphoinositide-3-kinase, class 2, gamma polypeptide
chr3_-_156876798 0.459 NM_001130960
NM_001130961
PLCH1

phospholipase C, eta 1

chr5_+_147775652 0.456 FBXO38
F-box protein 38
chr1_-_149004852 0.455 CTSS
cathepsin S
chr2_+_162189090 0.453 NM_001178015
NM_001178016
NM_022058
SLC4A10


solute carrier family 4, sodium bicarbonate transporter, member 10


chr1_+_78888064 0.447 NM_006417
IFI44
interferon-induced protein 44
chr3_+_137224266 0.445 NM_181897
PPP2R3A
protein phosphatase 2, regulatory subunit B'', alpha
chr5_+_147562531 0.441 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chr4_-_70760381 0.439 NM_005420
SULT1E1
sulfotransferase family 1E, estrogen-preferring, member 1
chr6_+_125346208 0.438 NM_152553
RNF217
ring finger protein 217
chr6_-_32447626 0.437 NM_006781
C6orf10
chromosome 6 open reading frame 10
chr4_-_24590867 0.435 NM_173463
CCDC149
coiled-coil domain containing 149
chr9_+_74956494 0.432 NM_000700
ANXA1
annexin A1
chr14_-_79748273 0.431 NM_000793
NM_013989
DIO2

deiodinase, iodothyronine, type II

chr9_+_674193 0.431


chr4_+_120029426 0.430 NM_001128933
NM_001128934
NM_133477
SYNPO2


synaptopodin 2


chr13_-_98428244 0.429 NM_001130048
NM_001130050
DOCK9

dedicator of cytokinesis 9

chr4_-_177427252 0.428 NM_080874
ASB5
ankyrin repeat and SOCS box containing 5
chr22_-_37598176 0.418 NM_014292
CBX6
chromobox homolog 6
chr4_+_128773529 0.413 NM_015693
INTU
inturned planar cell polarity effector homolog (Drosophila)
chr4_+_95595419 0.403 PDLIM5
PDZ and LIM domain 5
chr22_-_34564611 0.403 RPL41P5
ribosomal protein L41 pseudogene 5
chr1_+_89602023 0.401 NM_198460
GBP6
guanylate binding protein family, member 6
chr10_-_105835609 0.399 NM_000494
COL17A1
collagen, type XVII, alpha 1
chrX_-_131089552 0.396 NM_194277
FRMD7
FERM domain containing 7
chrX_+_105823723 0.396 NM_024539
RNF128
ring finger protein 128
chr9_+_74956601 0.394 ANXA1
annexin A1
chr20_+_43691797 0.394 NM_080753
WFDC10A
WAP four-disulfide core domain 10A
chr12_+_8866416 0.392 NM_144670
A2ML1
alpha-2-macroglobulin-like 1
chr21_-_30460841 0.391 NM_012131
CLDN17
claudin 17
chrX_-_114703273 0.389


chrX_+_106057984 0.387 CLDN2
claudin 2
chr2_-_160764819 0.380 NM_000888
ITGB6
integrin, beta 6
chr9_+_74956614 0.380 ANXA1
annexin A1
chr15_-_53996597 0.377 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr17_-_19592178 0.377 NM_000691
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr18_+_59405513 0.375 NM_012397
SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chr1_-_149004879 0.374 CTSS
cathepsin S
chr15_-_97607108 0.373 NM_001040655
NM_001040656
NM_001040657
NM_001040658
NM_001040659
NM_001040660
NM_022905
TTC23






tetratricopeptide repeat domain 23






chr9_-_92444886 0.372 NM_017594
DIRAS2
DIRAS family, GTP-binding RAS-like 2
chr2_-_75650355 0.371 NM_032181
FAM176A
family with sequence similarity 176, member A
chr2_+_44356100 0.366 NM_000341
SLC3A1
solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1
chr11_-_102156531 0.365 NM_002425
MMP10
matrix metallopeptidase 10 (stromelysin 2)
chr1_-_120112989 0.362 NM_001166107
NM_005518
HMGCS2

3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)

chr6_-_32892705 0.362 NM_002120
HLA-DOB
major histocompatibility complex, class II, DO beta
chr11_-_85107569 0.360 NM_206929
SYTL2
synaptotagmin-like 2
chr2_-_160765008 0.355 ITGB6
integrin, beta 6
chr2_+_69055208 0.353 NM_019617
GKN1
gastrokine 1
chr7_-_16888121 0.352 NM_176813
AGR3
anterior gradient homolog 3 (Xenopus laevis)
chr1_-_42549347 0.349


chr10_-_94247450 0.348 NM_001165946
IDE
insulin-degrading enzyme
chr4_-_159313167 0.347 NM_016613
FAM198B
family with sequence similarity 198, member B
chr12_-_66905802 0.347 NM_018402
IL26
interleukin 26
chr4_+_155703581 0.347 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr6_+_121798443 0.344 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr20_-_9767406 0.340 NM_020341
NM_177990
PAK7

p21 protein (Cdc42/Rac)-activated kinase 7

chr15_+_52092392 0.338 NM_001080534
UNC13C
unc-13 homolog C (C. elegans)
chr4_-_87989291 0.338 NM_197965
SLC10A6
solute carrier family 10 (sodium/bile acid cotransporter family), member 6
chr17_-_34377150 0.337 NM_001008777
FBXO47
F-box protein 47
chr19_+_16691786 0.335 NM_001007525
NWD1
NACHT and WD repeat domain containing 1
chr1_+_176577228 0.333 NM_004841
RASAL2
RAS protein activator like 2
chr14_-_94677807 0.328 NM_030621
DICER1
dicer 1, ribonuclease type III
chr22_-_43987010 0.324 NM_015264
KIAA0930
KIAA0930
chr9_-_4656665 0.323 NM_001039395
C9orf68
chromosome 9 open reading frame 68
chr6_-_165643064 0.315 NM_144980
C6orf118
chromosome 6 open reading frame 118
chr15_-_68781662 0.314 NM_001008224
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr2_+_166034402 0.310 NM_001172173
CSRNP3
cysteine-serine-rich nuclear protein 3
chr5_-_98290117 0.309 NM_001270
CHD1
chromodomain helicase DNA binding protein 1
chr12_+_28301399 0.309 NM_018318
CCDC91
coiled-coil domain containing 91
chr10_+_49279647 0.308 NM_002750
NM_139046
NM_139047
NM_139049
MAPK8



mitogen-activated protein kinase 8



chr10_-_23673777 0.305 NM_153714
C10orf67
chromosome 10 open reading frame 67
chr5_+_145296313 0.305 NM_152550
SH3RF2
SH3 domain containing ring finger 2
chr8_-_122722674 0.305 NM_005328
HAS2
hyaluronan synthase 2
chr4_+_119174947 0.302 NM_004784
NDST3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr14_+_38772870 0.302 NM_054024
MIA2
melanoma inhibitory activity 2
chr4_-_87247829 0.301 NM_138981
MAPK10
mitogen-activated protein kinase 10
chr10_-_98021144 0.299 NM_001114094
NM_013314
BLNK

B-cell linker

chr12_-_55990512 0.294 NM_014925
R3HDM2
R3H domain containing 2
chr15_-_70838703 0.291


chr8_-_102029997 0.289 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr3_-_64647325 0.288 ADAMTS9
ADAM metallopeptidase with thrombospondin type 1 motif, 9
chr12_-_52939636 0.286 NM_001127321
CBX5
chromobox homolog 5
chr12_-_52939584 0.286 NM_001127322
CBX5
chromobox homolog 5
chr12_+_53534565 0.285 NM_058173
MUCL1
mucin-like 1
chr3_+_50281582 0.285 SEMA3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr12_-_109842736 0.284 NM_000432
MYL2
myosin, light chain 2, regulatory, cardiac, slow
chr11_-_5766621 0.284 NM_001001913
OR52N1
olfactory receptor, family 52, subfamily N, member 1
chr16_+_4485859 0.283 NM_001127205
HMOX2
heme oxygenase (decycling) 2
chr21_+_38550533 0.282 NM_002243
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr6_-_139654807 0.282 NM_153235
TXLNB
taxilin beta
chr21_-_35174742 0.276 RUNX1
runt-related transcription factor 1
chr6_-_25679197 0.275


chr12_-_51887266 0.271 NM_000889
ITGB7
integrin, beta 7
chr14_+_51397059 0.271 GNG2
guanine nucleotide binding protein (G protein), gamma 2
chr2_+_64540843 0.266 HSPC159
galectin-related protein
chr3_+_113241154 0.264 NM_001042575
TMPRSS7
transmembrane protease, serine 7
chr20_+_10363949 0.263 NM_001009608
C20orf94
chromosome 20 open reading frame 94
chr2_+_66516196 0.263 MEIS1
Meis homeobox 1
chr12_-_90100679 0.259 DCN
decorin
chr3_+_108578877 0.258 NM_032600
CCDC54
coiled-coil domain containing 54
chr17_-_19231049 0.258 NM_001198695
NM_002404
MFAP4

microfibrillar-associated protein 4

chr3_-_116272911 0.257 NM_001164343
ZBTB20
zinc finger and BTB domain containing 20
chr7_+_28418668 0.257 NM_182898
CREB5
cAMP responsive element binding protein 5
chr12_-_10433852 0.256 NM_007360
KLRK1
killer cell lectin-like receptor subfamily K, member 1
chr4_+_141484046 0.256 NM_001153446
NM_001153635
NM_001153585
NM_001153690
SCOC



short coiled-coil protein



chr1_+_239762179 0.256 NM_003679
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr10_-_116276651 0.255 NM_006720
ABLIM1
actin binding LIM protein 1
chr17_-_26672757 0.254 NM_001003927
NM_014210
EVI2A

ecotropic viral integration site 2A

chr12_+_54080480 0.254 NM_001005518
OR6C65
olfactory receptor, family 6, subfamily C, member 65
chr4_-_38534802 0.254 NM_006068
TLR6
toll-like receptor 6
chr6_+_127006298 0.253 LOC728666
PRELI domain containing 1 pseudogene
chrX_+_114734074 0.253 NM_001136025
NM_001172335
PLS3

plastin 3

chr1_-_93172119 0.250


chr9_+_22436783 0.248 NM_022160
DMRTA1
DMRT-like family A1
chr14_+_51397113 0.247 GNG2
guanine nucleotide binding protein (G protein), gamma 2
chr8_+_104380234 0.247 NM_001164616
NM_003506
FZD6

frizzled homolog 6 (Drosophila)


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
9.04 4.46e-04 GO:0018149 peptide cross-linking

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.54 3.23e-04 GO:0005576 extracellular region
1.30 4.43e-03 GO:0071944 cell periphery
1.71 4.47e-03 GO:0044421 extracellular region part
1.29 8.45e-03 GO:0005886 plasma membrane
2.31 1.32e-02 GO:0005578 proteinaceous extracellular matrix

Gene overrepresentation in function category:

enrichment   p-value GO term description
4.16 2.33e-03 GO:0004867 serine-type endopeptidase inhibitor activity
1.92 7.10e-03 GO:0005509 calcium ion binding
3.03 1.08e-02 GO:0030414 peptidase inhibitor activity
3.02 1.89e-02 GO:0004866 endopeptidase inhibitor activity
2.90 3.13e-02 GO:0061135 endopeptidase regulator activity