Motif ID: EP300.p2

Z-value: 1.787


Transcription factors associated with EP300.p2:

Gene SymbolEntrez IDGene Name
EP300 2033 E1A binding protein p300

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
EP300chr22_+_398185530.175.6e-01Click!


Activity profile for motif EP300.p2.

activity profile for motif EP300.p2


Sorted Z-values histogram for motif EP300.p2

Sorted Z-values for motif EP300.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EP300.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr21_+_44941514 1.335 NM_198699
KRTAP10-12
keratin associated protein 10-12
chr4_-_122213018 1.196 NM_024574
C4orf31
chromosome 4 open reading frame 31
chr17_-_72045218 1.188 NM_134268
CYGB
cytoglobin
chr15_-_66511488 1.143 NM_001004439
ITGA11
integrin, alpha 11
chr3_-_51971915 1.089 NM_033010
PCBP4
poly(rC) binding protein 4
chr10_-_21502993 0.963 NEBL
nebulette
chr20_+_60810610 0.926 NM_002531
NTSR1
neurotensin receptor 1 (high affinity)
chr13_-_43259032 0.926 NM_017993
ENOX1
ecto-NOX disulfide-thiol exchanger 1
chr9_+_35782405 0.900 NM_003995
NPR2
natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
chr22_-_43040063 0.887 NM_001099294
KIAA1644
KIAA1644
chr13_+_36146048 0.868 NM_203451
C13orf36
chromosome 13 open reading frame 36
chr12_-_6313219 0.839 TNFRSF1A
tumor necrosis factor receptor superfamily, member 1A
chr14_-_104515738 0.823 NM_138420
AHNAK2
AHNAK nucleoprotein 2
chr17_-_4792971 0.821 PFN1
profilin 1
chr19_+_10900502 0.819 C19orf52
chromosome 19 open reading frame 52
chr3_+_48482625 0.817 TREX1
three prime repair exonuclease 1
chr2_-_230287442 0.814 NM_139072
DNER
delta/notch-like EGF repeat containing
chr9_+_111442888 0.805 NM_001037293
PALM2
paralemmin 2
chr17_-_975809 0.793 ABR
active BCR-related gene
chr9_-_116920232 0.788 NM_002160
TNC
tenascin C
chr16_+_84204424 0.780 NM_014615
KIAA0182
KIAA0182
chr16_+_639278 0.763 NM_145294
WDR90
WD repeat domain 90
chr18_-_45630154 0.755 MYO5B
myosin VB
chr3_-_38046034 0.743 NM_006225
PLCD1
phospholipase C, delta 1
chr14_+_20580224 0.711 NM_032572
RNASE7
ribonuclease, RNase A family, 7
chr22_+_39404940 0.711 NM_005297
MCHR1
melanin-concentrating hormone receptor 1
chr2_-_26554413 0.698 NM_004802
NM_194322
NM_194323
OTOF


otoferlin


chr15_+_90738108 0.680 NM_006011
ST8SIA2
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr22_-_49025499 0.669 NM_020461
TUBGCP6
tubulin, gamma complex associated protein 6
chr1_-_245342150 0.668 NM_207401
C1orf229
chromosome 1 open reading frame 229
chr4_+_61749540 0.667 LPHN3
latrophilin 3
chr12_-_6354650 0.663 NM_001159576
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr13_-_37341859 0.661 NM_001135955
NM_001135956
NM_001135957
NM_001135958
NM_003306
NM_016179
TRPC4





transient receptor potential cation channel, subfamily C, member 4





chr16_-_85099941 0.658 LOC400550
hypothetical LOC400550
chr6_-_33822659 0.656 NM_001142883
NM_054111
IP6K3

inositol hexakisphosphate kinase 3

chr19_-_1352474 0.650 NM_000156
NM_138924
GAMT

guanidinoacetate N-methyltransferase

chr20_-_4177519 0.648 NM_000678
ADRA1D
adrenergic, alpha-1D-, receptor
chr3_+_50281582 0.646 SEMA3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr22_-_43987010 0.642 NM_015264
KIAA0930
KIAA0930
chr16_+_2023279 0.641 SLC9A3R2
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
chr1_+_213323182 0.640 NM_001017425
NM_014217
KCNK2

potassium channel, subfamily K, member 2

chr15_+_72695248 0.640 CLK3
CDC-like kinase 3
chr11_-_128279670 0.638 C11orf45
chromosome 11 open reading frame 45
chr19_-_60573552 0.635 NM_000641
IL11
interleukin 11
chr3_+_180348818 0.635 NM_006218
PIK3CA
phosphoinositide-3-kinase, catalytic, alpha polypeptide
chr2_-_219826854 0.630 NM_006000
TUBA4A
tubulin, alpha 4a
chr5_+_174084137 0.630 NM_002449
MSX2
msh homeobox 2
chr12_-_122684150 0.629 NM_001414
EIF2B1
eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa
chr11_+_92342436 0.629 NM_005959
MTNR1B
melatonin receptor 1B
chr16_+_66129481 0.629 FAM65A
family with sequence similarity 65, member A
chr10_+_46413551 0.628 NM_014696
GPRIN2
G protein regulated inducer of neurite outgrowth 2
chr1_+_179148935 0.628 NM_020950
KIAA1614
KIAA1614
chr1_-_159275357 0.627 NM_001113205
NM_001113206
NM_001113207
TSTD1


F11R
thiosulfate sulfurtransferase (rhodanese)-like domain containing 1


F11 receptor
chr2_-_97016027 0.625 NM_001122646
FAM178B
family with sequence similarity 178, member B
chr5_-_92982927 0.621


chr13_-_113151453 0.609 NM_199162
ADPRHL1
ADP-ribosylhydrolase like 1
chr19_-_40938046 0.606 HSPB6
heat shock protein, alpha-crystallin-related, B6
chr22_-_43986896 0.604 KIAA0930
KIAA0930
chr2_+_20729904 0.594 NM_182828
GDF7
growth differentiation factor 7
chr3_+_50281309 0.593 SEMA3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr1_-_99242765 0.591 NM_001010861
NM_001037317
LPPR5

lipid phosphate phosphatase-related protein type 5

chr8_-_122722674 0.588 NM_005328
HAS2
hyaluronan synthase 2
chr6_-_40663089 0.583 NM_020737
LRFN2
leucine rich repeat and fibronectin type III domain containing 2
chr12_-_6354818 0.582 SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr9_+_71848555 0.581 MAMDC2
MAM domain containing 2
chr17_+_63799228 0.575 ARSG
arylsulfatase G
chr15_-_63457378 0.575 NM_004884
IGDCC3
immunoglobulin superfamily, DCC subclass, member 3
chr10_-_126839546 0.572 NM_001083914
CTBP2
C-terminal binding protein 2
chr8_+_31616809 0.572 NM_013962
NRG1
neuregulin 1
chr5_-_139992621 0.569 NM_000591
CD14
CD14 molecule
chr19_+_951295 0.560 NM_138690
GRIN3B
glutamate receptor, ionotropic, N-methyl-D-aspartate 3B
chr18_+_53253775 0.560 NM_004852
ONECUT2
one cut homeobox 2
chr12_+_6179736 0.553 NM_001769
CD9
CD9 molecule
chr11_+_2378559 0.551 TSSC4
tumor suppressing subtransferable candidate 4
chr11_-_72111027 0.549 NM_001135190
NM_015242
ARAP1

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

chr20_-_26137755 0.548 LOC284801
hypothetical protein LOC284801
chr18_-_33399997 0.548 NM_001025087
NM_001025088
NM_001025089
NM_020180
CELF4



CUGBP, Elav-like family member 4



chr10_-_134449467 0.543 NM_177400
NKX6-2
NK6 homeobox 2
chr16_-_49742008 0.539 NM_001127892
SALL1
sal-like 1 (Drosophila)
chr7_-_45927263 0.538 NM_000598
NM_001013398
IGFBP3

insulin-like growth factor binding protein 3

chr12_-_118725672 0.533 CIT
citron (rho-interacting, serine/threonine kinase 21)
chr16_+_2226468 0.531 NM_001374
DNASE1L2
deoxyribonuclease I-like 2
chr19_+_52451642 0.531 CCDC9
coiled-coil domain containing 9
chr19_-_63565890 0.529 NM_198458
ZNF497
zinc finger protein 497
chr10_-_21503025 0.519 NM_001173484
NM_213569
NEBL

nebulette

chr11_-_63014986 0.519 NM_001146728
NM_001146729
NM_054108
HRASLS5


HRAS-like suppressor family, member 5


chr1_+_199519202 0.518 NM_000299
NM_001005337
PKP1

plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)

chr12_-_46438447 0.517 NM_001098532
NM_006105
RAPGEF3

Rap guanine nucleotide exchange factor (GEF) 3

chr7_+_54577512 0.516 NM_182546
VSTM2A
V-set and transmembrane domain containing 2A
chr14_+_105028614 0.514 NM_001134875
NM_001134876
C14orf80

chromosome 14 open reading frame 80

chr1_+_151917674 0.511 NM_000906
NPR1
natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)
chr16_-_30992574 0.510 ZNF668
zinc finger protein 668
chr4_+_183302105 0.510 ODZ3
odz, odd Oz/ten-m homolog 3 (Drosophila)
chr4_+_107036076 0.508 NPNT
nephronectin
chr16_-_30993004 0.508 NM_024706
ZNF668
zinc finger protein 668
chr14_-_37134191 0.508 NM_004496
FOXA1
forkhead box A1
chr22_-_49063088 0.507 PLXNB2
plexin B2
chr15_-_86600658 0.506 NM_001007156
NM_001012338
NM_002530
NTRK3


neurotrophic tyrosine kinase, receptor, type 3


chr10_+_52504239 0.503 NM_006258
PRKG1
protein kinase, cGMP-dependent, type I
chr10_-_30388439 0.501 NM_020848
KIAA1462
KIAA1462
chr11_+_1925162 0.500 MRPL23
mitochondrial ribosomal protein L23
chr2_+_109112428 0.499 NM_001099289
SH3RF3
SH3 domain containing ring finger 3
chr1_+_153241665 0.499 NM_015872
ZBTB7B
zinc finger and BTB domain containing 7B
chr11_-_64641700 0.498 NM_014205
ZNHIT2
zinc finger, HIT-type containing 2
chr19_-_40938251 0.498 HSPB6
heat shock protein, alpha-crystallin-related, B6
chr11_+_566482 0.498 NM_020901
PHRF1
PHD and ring finger domains 1
chr3_-_10003512 0.497 NM_018447
TMEM111
transmembrane protein 111
chr8_+_106400322 0.497 NM_012082
ZFPM2
zinc finger protein, multitype 2
chr2_-_238861830 0.495 NM_022817
PER2
period homolog 2 (Drosophila)
chr1_+_156229934 0.493 KIRREL
kin of IRRE like (Drosophila)
chr9_-_128924706 0.489 ANGPTL2
angiopoietin-like 2
chr11_+_131286513 0.489 NTM
neurotrimin
chr7_-_117300763 0.488 NM_033427
CTTNBP2
cortactin binding protein 2
chr5_-_111782637 0.486 NM_022140
EPB41L4A
erythrocyte membrane protein band 4.1 like 4A
chr17_-_39757725 0.485 NM_001143780
NM_016016
SLC25A39

solute carrier family 25, member 39

chr15_+_66658626 0.485 NM_006091
CORO2B
coronin, actin binding protein, 2B
chr3_+_160964574 0.485 SCHIP1
schwannomin interacting protein 1
chr2_-_160627181 0.485 PLA2R1
phospholipase A2 receptor 1, 180kDa
chr7_-_35192177 0.484 DPY19L2P1
dpy-19-like 2 pseudogene 1 (C. elegans)
chr19_+_4229597 0.483 NM_020209
SHD
Src homology 2 domain containing transforming protein D
chr5_-_131854325 0.481 NM_002198
IRF1
interferon regulatory factor 1
chr22_-_42619139 0.481 NM_001177675
NM_138814
PNPLA5

patatin-like phospholipase domain containing 5

chr19_+_52451570 0.480 NM_015603
CCDC9
coiled-coil domain containing 9
chr9_-_128924782 0.479 ANGPTL2
angiopoietin-like 2
chr11_+_129823667 0.479 NM_139055
ADAMTS15
ADAM metallopeptidase with thrombospondin type 1 motif, 15
chr4_-_142273881 0.479 NM_020724
RNF150
ring finger protein 150
chr19_+_10900419 0.476 NM_138358
C19orf52
chromosome 19 open reading frame 52
chr14_+_78815406 0.473 NM_001105250
NM_138970
NRXN3

neurexin 3

chr12_-_47468985 0.472 NM_020983
ADCY6
adenylate cyclase 6
chr2_-_160627366 0.472 NM_001007267
NM_001195641
NM_007366
PLA2R1


phospholipase A2 receptor 1, 180kDa


chr10_+_88720477 0.470 NM_133447
AGAP11
ankyrin repeat and GTPase domain Arf GTPase activating protein 11
chr19_+_54786723 0.469 NM_020719
PRR12
proline rich 12
chr4_-_5761194 0.468 NM_147127
EVC2
Ellis van Creveld syndrome 2
chr17_+_1580504 0.466 WDR81
WD repeat domain 81
chr11_+_66547391 0.465 NM_177963
SYT12
synaptotagmin XII
chr11_+_1925075 0.463 NM_021134
MRPL23
mitochondrial ribosomal protein L23
chr3_-_127558747 0.463 NM_014079
KLF15
Kruppel-like factor 15
chr10_-_121292139 0.463 NM_001005339
RGS10
regulator of G-protein signaling 10
chr22_+_23753940 0.462 NM_001145206
KIAA1671
KIAA1671
chr1_+_156229686 0.461 NM_018240
KIRREL
kin of IRRE like (Drosophila)
chr2_-_56266408 0.461 LOC100129434
hypothetical LOC100129434
chr1_+_56883333 0.460 NM_006252
PRKAA2
protein kinase, AMP-activated, alpha 2 catalytic subunit
chr12_+_106236281 0.454 NM_001018072
BTBD11
BTB (POZ) domain containing 11
chr11_+_696607 0.453 EPS8L2
EPS8-like 2
chr22_-_39362630 0.453 NM_020831
MKL1
megakaryoblastic leukemia (translocation) 1
chr11_+_12355600 0.452 NM_018222
PARVA
parvin, alpha
chr1_+_203064397 0.450 NM_001005388
NM_001005389
NM_001160332
NM_001160333
NM_015090
NFASC




neurofascin




chr3_+_71885890 0.449 NM_018971
GPR27
G protein-coupled receptor 27
chrX_+_152684150 0.448 PLXNB3
plexin B3
chr4_+_156900053 0.446 GUCY1B3
guanylate cyclase 1, soluble, beta 3
chr11_-_27700180 0.445 NM_170731
BDNF
brain-derived neurotrophic factor
chr16_-_342399 0.445 NM_003502
NM_181050
AXIN1

axin 1

chr14_+_103674812 0.445 NM_015656
KIF26A
kinesin family member 26A
chr2_-_229844198 0.444 NM_001100818
NM_017933
PID1

phosphotyrosine interaction domain containing 1

chr7_-_32077504 0.443 NM_001191059
NM_005020
PDE1C

phosphodiesterase 1C, calmodulin-dependent 70kDa

chr5_+_139155569 0.441 NM_032289
PSD2
pleckstrin and Sec7 domain containing 2
chr19_-_4054200 0.440 MAP2K2
mitogen-activated protein kinase kinase 2
chr22_-_30356783 0.440 NM_014338
PISD
phosphatidylserine decarboxylase
chr10_+_81882409 0.440 PLAC9
placenta-specific 9
chr17_-_76985538 0.438


chr11_+_124539814 0.438 PKNOX2
PBX/knotted 1 homeobox 2
chrX_-_99551926 0.436 NM_001105243
NM_001184880
NM_020766
PCDH19


protocadherin 19


chr22_-_36907638 0.432 NM_001004426
NM_003560
PLA2G6

phospholipase A2, group VI (cytosolic, calcium-independent)

chr12_-_43731148 0.431 NM_001004329
DBX2
developing brain homeobox 2
chr19_-_51010272 0.427 NM_030785
RSPH6A
radial spoke head 6 homolog A (Chlamydomonas)
chr20_+_10147455 0.424 NM_003081
NM_130811
SNAP25

synaptosomal-associated protein, 25kDa

chr14_+_103675194 0.422 KIF26A
kinesin family member 26A
chr1_-_40009513 0.420 NM_022120
OXCT2
3-oxoacid CoA transferase 2
chr1_+_154878344 0.419 NM_021948
NM_198427
BCAN

brevican

chr8_-_145090045 0.419 NM_201382
PLEC
plectin
chr11_+_104986009 0.417 NM_000829
NM_001077243
NM_001077244
GRIA4


glutamate receptor, ionotrophic, AMPA 4


chr11_+_15051683 0.416 NM_000728
CALCB
calcitonin-related polypeptide beta
chr14_+_55654900 0.416 PELI2
pellino homolog 2 (Drosophila)
chr16_-_73859451 0.415 NM_001170715
BCAR1
breast cancer anti-estrogen resistance 1
chr11_+_8059267 0.414 NM_177972
TUB
tubby homolog (mouse)
chr6_+_30082331 0.413 HLA-J
major histocompatibility complex, class I, J (pseudogene)
chr20_-_22512893 0.410 FOXA2
forkhead box A2
chr19_+_39664706 0.409 NM_001080436
WTIP
Wilms tumor 1 interacting protein
chr3_-_131948202 0.408 NM_014602
PIK3R4
phosphoinositide-3-kinase, regulatory subunit 4
chr9_-_20612433 0.408 MLLT3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr10_-_95350949 0.408 NM_006744
RBP4
retinol binding protein 4, plasma
chr1_+_196148241 0.408 NM_001014434
LHX9
LIM homeobox 9
chr1_-_20685314 0.407 NM_018584
CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr20_+_9236446 0.406 NM_000933
PLCB4
phospholipase C, beta 4
chr14_-_37134050 0.405 FOXA1
forkhead box A1
chr1_+_219026661 0.405 NM_022746
MOSC1
MOCO sulphurase C-terminal domain containing 1
chr1_+_6008956 0.404 NM_003636
NM_172130
KCNAB2

potassium voltage-gated channel, shaker-related subfamily, beta member 2

chr20_+_61798512 0.404 TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chr12_-_47651812 0.402 NM_003394
WNT10B
wingless-type MMTV integration site family, member 10B
chr16_+_65818511 0.402 NM_014187
TMEM208
transmembrane protein 208
chr11_-_122571198 0.401 NM_024769
CLMP
CXADR-like membrane protein
chr14_+_66044958 0.400 GPHN
gephyrin
chr10_+_81882477 0.398 PLAC9
placenta-specific 9
chr11_+_63750296 0.396 NM_001128612
NM_001128613
NM_032344
NUDT22


nudix (nucleoside diphosphate linked moiety X)-type motif 22


chr7_+_28305464 0.394 NM_182899
CREB5
cAMP responsive element binding protein 5
chr12_+_122684265 0.393 NM_001516
GTF2H3
general transcription factor IIH, polypeptide 3, 34kDa
chrX_-_3274680 0.391 NM_015419
MXRA5
matrix-remodelling associated 5
chr1_-_12599934 0.390 NM_004753
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr9_+_88953378 0.388 NM_001001709
C9orf170
chromosome 9 open reading frame 170
chr17_+_76988134 0.387 NM_001080519
BAHCC1
BAH domain and coiled-coil containing 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.22 8.87e-05 GO:0048731 system development
1.31 2.61e-04 GO:0007399 nervous system development
1.19 6.65e-04 GO:0048856 anatomical structure development
1.23 3.70e-03 GO:0030154 cell differentiation
1.06 4.25e-03 GO:0009987 cellular process
1.23 4.53e-03 GO:0048869 cellular developmental process
1.16 7.92e-03 GO:0032502 developmental process
1.16 1.02e-02 GO:0007275 multicellular organismal development
3.01 1.04e-02 GO:0002088 lens development in camera-type eye
1.10 2.42e-02 GO:0050794 regulation of cellular process

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.11 3.78e-05 GO:0005515 protein binding
1.06 1.09e-03 GO:0005488 binding
1.29 2.37e-02 GO:0001071 nucleic acid binding transcription factor activity
1.29 2.37e-02 GO:0003700 sequence-specific DNA binding transcription factor activity
1.34 4.38e-02 GO:0043565 sequence-specific DNA binding