Motif ID: ESR1.p2

Z-value: 2.504


Transcription factors associated with ESR1.p2:

Gene SymbolEntrez IDGene Name
ESR1 2099 estrogen receptor 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ESR1chr6_+_1521703780.371.8e-01Click!


Activity profile for motif ESR1.p2.

activity profile for motif ESR1.p2


Sorted Z-values histogram for motif ESR1.p2

Sorted Z-values for motif ESR1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ESR1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_+_29734785 2.385 C16orf53
chromosome 16 open reading frame 53
chr17_-_34635446 2.117 NM_198993
STAC2
SH3 and cysteine rich domain 2
chr21_-_45786709 1.940 NM_194255
SLC19A1
solute carrier family 19 (folate transporter), member 1
chr17_-_7238546 1.881 NM_020360
PLSCR3
phospholipid scramblase 3
chr13_+_75108450 1.872 LMO7
LIM domain 7
chrX_-_71442488 1.688 NM_001144885
NM_001144887
CITED1

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1

chr14_+_99273751 1.594 EML1
echinoderm microtubule associated protein like 1
chr1_+_178466064 1.436 NM_033343
LHX4
LIM homeobox 4
chr3_+_52504391 1.413 NM_015136
STAB1
stabilin 1
chr20_-_36322587 1.392 NM_001029864
KIAA1755
KIAA1755
chr11_-_69228286 1.379 NM_005117
FGF19
fibroblast growth factor 19
chr8_-_145090892 1.374 NM_201381
PLEC
plectin
chr3_-_135852514 1.339 NM_178554
KY
kyphoscoliosis peptidase
chr12_-_123568781 1.332


chr7_+_1543644 1.284 MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr2_+_238200922 1.263 NM_001137550
LRRFIP1
leucine rich repeat (in FLII) interacting protein 1
chr22_+_36632242 1.256 NM_033386
MICALL1
MICAL-like 1
chr9_+_139202874 1.256 NM_003731
SSNA1
Sjogren syndrome nuclear autoantigen 1
chr11_-_72530605 1.246 NM_014824
FCHSD2
FCH and double SH3 domains 2
chr19_-_10091534 1.222 NM_003755
EIF3G
eukaryotic translation initiation factor 3, subunit G
chr11_-_1549719 1.199 NM_004420
DUSP8
dual specificity phosphatase 8
chr7_+_6622051 1.186 NM_017560
ZNF853
zinc finger protein 853
chr9_-_109290107 1.182 KLF4
Kruppel-like factor 4 (gut)
chr16_+_550394 1.179 NM_145270
C16orf11
chromosome 16 open reading frame 11
chr3_-_135231417 1.165 SLCO2A1
solute carrier organic anion transporter family, member 2A1
chr16_+_29734990 1.161 NM_024516
C16orf53
chromosome 16 open reading frame 53
chr10_-_133971136 1.114 NM_173575
STK32C
serine/threonine kinase 32C
chr1_+_179148935 1.108 NM_020950
KIAA1614
KIAA1614
chr9_-_133141726 1.100 NM_033387
FAM78A
family with sequence similarity 78, member A
chr9_-_85342868 1.092 NM_174938
FRMD3
FERM domain containing 3
chr7_+_45894480 1.090 NM_000596
IGFBP1
insulin-like growth factor binding protein 1
chr19_+_3536541 1.083 NM_133261
GIPC3
GIPC PDZ domain containing family, member 3
chr12_-_119291276 1.076 NM_002442
MSI1
musashi homolog 1 (Drosophila)
chr11_-_118716244 1.074 MFRP
membrane frizzled-related protein
chr9_-_129557373 1.063 NM_001142534
NM_001142533
SH2D3C

SH2 domain containing 3C

chr20_-_24986501 1.057 ACSS1
acyl-CoA synthetase short-chain family member 1
chr7_-_28964186 1.050


chr20_+_54637714 1.014 NM_003222
TFAP2C
transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
chr14_+_105063975 1.001 NM_025268
TMEM121
transmembrane protein 121
chr11_-_72031083 0.995 NM_001143839
PDE2A
phosphodiesterase 2A, cGMP-stimulated
chr10_+_129595289 0.985 NM_006504
PTPRE
protein tyrosine phosphatase, receptor type, E
chr5_-_172594691 0.969 NM_001166175
NM_001166176
NM_004387
NKX2-5


NK2 transcription factor related, locus 5 (Drosophila)


chr14_+_78815406 0.961 NM_001105250
NM_138970
NRXN3

neurexin 3

chr16_-_265868 0.957 NM_003834
NM_183337
RGS11

regulator of G-protein signaling 11

chr17_+_59429442 0.940 NM_001164257
NM_001191029
NM_001191030
NM_001191031
C17orf72



chromosome 17 open reading frame 72



chr16_+_66244314 0.936 RLTPR
RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
chr3_-_135231518 0.934 NM_005630
SLCO2A1
solute carrier organic anion transporter family, member 2A1
chr9_-_139202804 0.928 ANAPC2
anaphase promoting complex subunit 2
chr16_+_54072969 0.918 NM_001127891
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr1_-_29322993 0.916 NM_001003682
TMEM200B
transmembrane protein 200B
chr4_-_41579325 0.913


chr10_-_62882930 0.912 TMEM26
transmembrane protein 26
chr4_+_1842947 0.909 WHSC1
Wolf-Hirschhorn syndrome candidate 1
chr3_-_46710137 0.898 NM_001190707
NM_147129
ALS2CL

ALS2 C-terminal like

chr8_+_21980315 0.894 EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr16_+_29819647 0.891 NM_181718
ASPHD1
aspartate beta-hydroxylase domain containing 1
chr18_-_72973698 0.884 MBP
myelin basic protein
chr6_+_158877455 0.876 NM_020823
TMEM181
transmembrane protein 181
chr3_+_52504410 0.867 STAB1
stabilin 1
chr2_-_233501069 0.859 NM_001114090
NGEF
neuronal guanine nucleotide exchange factor
chr8_-_61356436 0.854 NM_004056
CA8
carbonic anhydrase VIII
chr1_+_148089251 0.852 NM_001040874
NM_003516
HIST2H2AA4
HIST2H2AA3
histone cluster 2, H2aa4
histone cluster 2, H2aa3
chr16_+_84204424 0.835 NM_014615
KIAA0182
KIAA0182
chr11_-_75599433 0.829 WNT11
wingless-type MMTV integration site family, member 11
chr14_+_89597860 0.826 NM_022054
KCNK13
potassium channel, subfamily K, member 13
chr6_-_117193505 0.822 NM_001085480
FAM162B
family with sequence similarity 162, member B
chr11_+_126378507 0.820 NCRNA00288
non-protein coding RNA 288
chr18_-_72973750 0.819 NM_001025100
NM_001025101
MBP

myelin basic protein

chr6_+_72949092 0.814 RIMS1
regulating synaptic membrane exocytosis 1
chr18_+_75825563 0.813 NM_001136180
HSBP1L1
heat shock factor binding protein 1-like 1
chr17_+_19853200 0.812 SPECC1
sperm antigen with calponin homology and coiled-coil domains 1
chr11_-_605920 0.811 IRF7
interferon regulatory factor 7
chr10_+_118990573 0.802 NM_003054
SLC18A2
solute carrier family 18 (vesicular monoamine), member 2
chr4_+_94969064 0.798 NM_005172
ATOH1
atonal homolog 1 (Drosophila)
chr11_-_605649 0.797 NM_004031
IRF7
interferon regulatory factor 7
chr9_-_139202831 0.792 ANAPC2
anaphase promoting complex subunit 2
chr11_-_605998 0.790 NM_001572
NM_004029
IRF7

interferon regulatory factor 7

chr19_-_1463997 0.785 ADAMTSL5
ADAMTS-like 5
chr13_+_102249399 0.784 NM_001159596
NM_017693
BIVM

basic, immunoglobulin-like variable motif containing

chr10_-_62883213 0.780 NM_178505
TMEM26
transmembrane protein 26
chr9_+_136673464 0.779 NM_000093
COL5A1
collagen, type V, alpha 1
chr11_+_1846478 0.773 NM_001013253
LSP1
lymphocyte-specific protein 1
chr12_+_130979729 0.771 NM_001002019
NM_025215
PUS1

pseudouridylate synthase 1

chr16_+_29735208 0.770 C16orf53
chromosome 16 open reading frame 53
chr20_+_61842880 0.770 SLC2A4RG
SLC2A4 regulator
chr17_-_45619038 0.755 COL1A1
collagen, type I, alpha 1
chr16_+_1974017 0.753 NM_005262
GFER
growth factor, augmenter of liver regeneration
chr11_-_117528744 0.750 NM_001142348
NM_174934
SCN4B

sodium channel, voltage-gated, type IV, beta

chr15_-_50375143 0.744 NM_018728
MYO5C
myosin VC
chr15_+_66695932 0.742 NM_001190456
CORO2B
coronin, actin binding protein, 2B
chr19_+_1442000 0.737 NM_138393
REEP6
receptor accessory protein 6
chr16_+_88512769 0.733 MC1R
melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
chr7_-_72676750 0.729 NM_032951
NM_032952
NM_032953
NM_032954
MLXIPL



MLX interacting protein-like



chr14_+_104244998 0.728 INF2
inverted formin, FH2 and WH2 domain containing
chr20_-_3696344 0.725 NM_001039140
C20orf27
chromosome 20 open reading frame 27
chr17_-_8006979 0.724 NM_014232
VAMP2
vesicle-associated membrane protein 2 (synaptobrevin 2)
chr1_-_19473021 0.724 NM_001145289
NM_201252
AKR7L

aldo-keto reductase family 7-like

chr19_+_47521600 0.723 NM_001410
MEGF8
multiple EGF-like-domains 8
chr3_-_186353321 0.722 C3orf70
chromosome 3 open reading frame 70
chr12_+_130979696 0.717 NM_001002020
PUS1
pseudouridylate synthase 1
chr2_+_100802923 0.711 NM_002518
NPAS2
neuronal PAS domain protein 2
chr19_+_41177882 0.708 NM_001042631
SDHAF1
succinate dehydrogenase complex assembly factor 1
chr1_-_19487790 0.704 NM_012067
AKR7A3
aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
chr8_+_16929116 0.704 NM_181723
EFHA2
EF-hand domain family, member A2
chr10_+_122206455 0.700 NM_001030059
PPAPDC1A
phosphatidic acid phosphatase type 2 domain containing 1A
chr9_-_139202855 0.695 NM_013366
ANAPC2
anaphase promoting complex subunit 2
chr3_-_129690056 0.693 NM_001145661
GATA2
GATA binding protein 2
chr5_-_1165106 0.691 NM_006598
SLC12A7
solute carrier family 12 (potassium/chloride transporters), member 7
chr1_+_3360880 0.691 NM_014448
ARHGEF16
Rho guanine nucleotide exchange factor (GEF) 16
chr10_+_81882409 0.691 PLAC9
placenta-specific 9
chr2_+_236067424 0.689 NM_001037131
NM_014914
AGAP1

ArfGAP with GTPase domain, ankyrin repeat and PH domain 1

chr22_+_44925162 0.687 NM_001001928
NM_005036
PPARA

peroxisome proliferator-activated receptor alpha

chr21_+_32167175 0.687 NM_014586
HUNK
hormonally up-regulated Neu-associated kinase
chr11_+_128266460 0.684 NM_000890
KCNJ5
potassium inwardly-rectifying channel, subfamily J, member 5
chr14_-_22904681 0.679 NM_005864
NM_032459
EFS

embryonal Fyn-associated substrate

chr10_-_131799051 0.677 LOC387723
hypothetical LOC387723
chr9_+_89302574 0.676 NM_004938
DAPK1
death-associated protein kinase 1
chr10_+_94823221 0.675 NM_057157
CYP26A1
cytochrome P450, family 26, subfamily A, polypeptide 1
chr6_+_30082331 0.674 HLA-J
major histocompatibility complex, class I, J (pseudogene)
chr20_-_61600834 0.667 NM_001958
EEF1A2
eukaryotic translation elongation factor 1 alpha 2
chr2_+_127130148 0.663 NM_002101
NM_016815
GYPC

glycophorin C (Gerbich blood group)

chr5_+_1061900 0.659 NM_033120
NKD2
naked cuticle homolog 2 (Drosophila)
chr5_+_167889123 0.659


chr22_-_45024820 0.659 NM_207327
C22orf40
chromosome 22 open reading frame 40
chr14_+_105024576 0.658 CRIP1
cysteine-rich protein 1 (intestinal)
chr19_-_44503328 0.656


chr5_-_178983241 0.652 HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr15_+_72695248 0.649 CLK3
CDC-like kinase 3
chr19_-_15172773 0.649 NM_000435
NOTCH3
notch 3
chr2_+_127130209 0.639 GYPC
glycophorin C (Gerbich blood group)
chr3_+_8750485 0.634 NM_033337
NM_001234
CAV3

caveolin 3

chr20_-_61933012 0.631 ZBTB46
zinc finger and BTB domain containing 46
chr9_+_71848555 0.623 MAMDC2
MAM domain containing 2
chr4_+_37569093 0.619 NM_015173
TBC1D1
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
chr5_+_133889584 0.616 NM_015288
PHF15
PHD finger protein 15
chr20_-_29896981 0.616 NM_004118
FOXS1
forkhead box S1
chr4_+_1842833 0.613 NM_001042424
WHSC1
Wolf-Hirschhorn syndrome candidate 1
chr6_+_158877640 0.609 TMEM181
transmembrane protein 181
chr10_-_30388439 0.606 NM_020848
KIAA1462
KIAA1462
chr12_+_63504618 0.603 NM_015279
TBC1D30
TBC1 domain family, member 30
chr16_-_3014226 0.602 NM_001002017
NM_001002018
NM_017885
HCFC1R1


host cell factor C1 regulator 1 (XPO1 dependent)


chr9_+_45331898 0.601 LOC100132167
hypothetical LOC100132167
chr11_+_822965 0.600 CD151
CD151 molecule (Raph blood group)
chr10_+_129595349 0.596 PTPRE
protein tyrosine phosphatase, receptor type, E
chr1_-_181188625 0.595 SHCBP1L
SHC SH2-domain binding protein 1-like
chr17_-_45622064 0.593


chr16_-_674357 0.591 NM_001005920
JMJD8
jumonji domain containing 8
chr3_-_173648896 0.589 NM_004122
NM_198407
GHSR

growth hormone secretagogue receptor

chr3_-_186353421 0.588 NM_001025266
C3orf70
chromosome 3 open reading frame 70
chr10_-_43224604 0.584 NM_004966
NM_001098204
HNRNPF

heterogeneous nuclear ribonucleoprotein F

chr15_+_30797466 0.584 NM_001191322
NM_001191323
NM_013372
GREM1


gremlin 1


chr12_-_48583842 0.583 NM_012306
FAIM2
Fas apoptotic inhibitory molecule 2
chr16_+_4361775 0.581 NM_138440
VASN
vasorin
chr22_-_36245155 0.579 NM_014550
CARD10
caspase recruitment domain family, member 10
chr16_-_65984836 0.575 NM_015964
NM_016140
TPPP3

tubulin polymerization-promoting protein family member 3

chr19_-_19245022 0.575 NM_001001524
TM6SF2
transmembrane 6 superfamily member 2
chr18_+_32131628 0.574 NM_025135
FHOD3
formin homology 2 domain containing 3
chr11_+_63883192 0.571 NM_001006944
NM_003942
RPS6KA4

ribosomal protein S6 kinase, 90kDa, polypeptide 4

chr15_-_76890626 0.570 NM_014272
ADAMTS7
ADAM metallopeptidase with thrombospondin type 1 motif, 7
chr10_-_43224312 0.569 NM_001098205
HNRNPF
heterogeneous nuclear ribonucleoprotein F
chr10_+_81882477 0.568 PLAC9
placenta-specific 9
chr5_-_81082614 0.567 SSBP2
single-stranded DNA binding protein 2
chr17_-_6400470 0.563 NM_001165966
NM_031220
PITPNM3

PITPNM family member 3

chr8_+_63324053 0.562 NM_173688
NKAIN3
Na+/K+ transporting ATPase interacting 3
chr17_-_45562112 0.559 NM_174920
SAMD14
sterile alpha motif domain containing 14
chr4_-_101330629 0.557 NM_145244
DDIT4L
DNA-damage-inducible transcript 4-like
chr5_-_178983281 0.551 NM_005520
HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr19_+_58750305 0.546 NM_001079907
ZNF331
zinc finger protein 331
chr12_+_63504708 0.545 TBC1D30
TBC1 domain family, member 30
chr7_+_44110470 0.545 NM_001129
AEBP1
AE binding protein 1
chr12_-_55920741 0.543 NM_020142
NDUFA4L2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
chr6_+_45498354 0.539 RUNX2
runt-related transcription factor 2
chr20_-_61649259 0.535 NM_080823
SRMS
src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites
chr1_+_155157047 0.533 NM_144702
LRRC71
leucine rich repeat containing 71
chr16_+_559970 0.533 NM_004204
NM_148920
PIGQ

phosphatidylinositol glycan anchor biosynthesis, class Q

chr19_-_11234117 0.532 NM_020812
DOCK6
dedicator of cytokinesis 6
chr16_+_67017 0.532 NM_001015054
MPG
N-methylpurine-DNA glycosylase
chr19_-_1464187 0.530 NM_213604
ADAMTSL5
ADAMTS-like 5
chr16_+_711139 0.530 NM_023933
FAM173A
family with sequence similarity 173, member A
chr1_+_77520874 0.529 NM_012093
AK5
adenylate kinase 5
chr7_-_47588266 0.528 TNS3
tensin 3
chr22_+_45071301 0.526 NM_016426
GTSE1
G-2 and S-phase expressed 1
chr1_+_213323182 0.525 NM_001017425
NM_014217
KCNK2

potassium channel, subfamily K, member 2

chr19_-_14447122 0.520 PTGER1
prostaglandin E receptor 1 (subtype EP1), 42kDa
chr19_-_41191423 0.519 NM_001039876
C19orf46
chromosome 19 open reading frame 46
chr2_+_10969513 0.518 NM_002236
KCNF1
potassium voltage-gated channel, subfamily F, member 1
chr7_-_47588160 0.518 TNS3
tensin 3
chr21_+_46367216 0.517 COL6A2
collagen, type VI, alpha 2
chr19_+_42517337 0.517 NM_181786
HKR1
HKR1, GLI-Kruppel zinc finger family member
chr21_-_42303517 0.517 NM_001098402
NM_001098403
NM_020727
ZNF295


zinc finger protein 295


chr19_-_14447163 0.515 NM_000955
PTGER1
prostaglandin E receptor 1 (subtype EP1), 42kDa
chr16_+_57106883 0.514 NM_001160305
NM_024860
SETD6

SET domain containing 6

chr13_-_25523164 0.513 NM_001007538
SHISA2
shisa homolog 2 (Xenopus laevis)
chr7_+_30927439 0.509 NM_001185060
NM_001185061
NM_001185062
AQP1


aquaporin 1 (Colton blood group)


chr10_-_120345148 0.504 NM_004248
PRLHR
prolactin releasing hormone receptor
chr16_+_30867914 0.504 ORAI3
ORAI calcium release-activated calcium modulator 3
chr10_+_94342789 0.504 NM_004523
KIF11
kinesin family member 11
chr3_+_127743868 0.503 CHST13
carbohydrate (chondroitin 4) sulfotransferase 13
chr6_+_31976754 0.502 NM_001178063
C2
complement component 2
chr20_-_60415729 0.502 NM_031215
CABLES2
Cdk5 and Abl enzyme substrate 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.09 4.04e-04 GO:0009987 cellular process
1.14 3.50e-03 GO:0050794 regulation of cellular process
1.22 3.98e-03 GO:0032502 developmental process
1.12 1.72e-02 GO:0065007 biological regulation
1.37 1.89e-02 GO:0035556 intracellular signal transduction
2.76 2.10e-02 GO:0009123 nucleoside monophosphate metabolic process
1.12 2.10e-02 GO:0050789 regulation of biological process
1.21 3.63e-02 GO:0007275 multicellular organismal development

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.13 1.10e-03 GO:0005515 protein binding
1.07 2.62e-03 GO:0005488 binding