Motif ID: SPI1.p2

Z-value: 3.251


Transcription factors associated with SPI1.p2:

Gene SymbolEntrez IDGene Name
SPI1 6688 spleen focus forming virus (SFFV) proviral integration oncogene spi1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SPI1chr11_-_473566500.543.7e-02Click!


Activity profile for motif SPI1.p2.

activity profile for motif SPI1.p2


Sorted Z-values histogram for motif SPI1.p2

Sorted Z-values for motif SPI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SPI1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr22_+_35586950 5.684 NM_000631
NM_013416
 NCF4

neutrophil cytosolic factor 4, 40kDa

chrX_-_47374187 4.842 NM_001145252
 CFP
complement factor properdin
chr1_+_159899528 4.539 NM_001002273
NM_001002274
NM_001002275
NM_001190828
NM_004001
 FCGR2B




FCGR2C
Fc fragment of IgG, low affinity IIb, receptor (CD32)




Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr12_+_48443232 4.203 TMBIM6
transmembrane BAX inhibitor motif containing 6
chr16_-_87570716 3.690 NM_005187
 CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chrX_-_47374647 3.319 NM_002621
 CFP
complement factor properdin
chr1_+_159817752 3.119 NM_201563
 FCGR2C
Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr10_+_49562866 3.005 WDFY4
WDFY family member 4
chr6_+_31690957 2.999 NM_004847
NM_001623
 AIF1

allograft inflammatory factor 1

chr11_+_65164767 2.956 SIPA1
signal-induced proliferation-associated 1
chr6_+_31661934 2.927 NM_205838
NM_205839
 LST1

leukocyte specific transcript 1

chr6_+_31662454 2.809 NM_205837
 LST1
leukocyte specific transcript 1
chr2_+_108604111 2.778 NM_001193484
 LIMS1
LIM and senescent cell antigen-like domains 1
chr19_-_10311262 2.636 NM_002162
 ICAM3
intercellular adhesion molecule 3
chr17_+_53625084 2.591 NM_000502
 EPX
eosinophil peroxidase
chr11_+_63864263 2.547 NM_032251
 CCDC88B
coiled-coil domain containing 88B
chr14_+_20319049 2.536 NM_005615
 RNASE6
ribonuclease, RNase A family, k6
chr19_-_46504831 2.520


chr7_+_106292932 2.495 PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr16_+_28413421 2.424 NM_018690
 APOBR
apolipoprotein B receptor

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 107 entries
enrichment   p-value GO term description
2.24 2.39e-02 GO:0002285 lymphocyte activation involved in immune response
2.14 1.10e-03 GO:0002263 cell activation involved in immune response
2.14 1.10e-03 GO:0002366 leukocyte activation involved in immune response
2.10 2.44e-02 GO:0045727 positive regulation of translation
1.93 2.94e-02 GO:0060326 cell chemotaxis
1.88 3.58e-03 GO:0007173 epidermal growth factor receptor signaling pathway
1.80 1.03e-03 GO:0030098 lymphocyte differentiation
1.66 4.12e-03 GO:0032318 regulation of Ras GTPase activity
1.64 4.66e-07 GO:0045321 leukocyte activation
1.63 1.26e-03 GO:0050900 leukocyte migration
1.60 2.25e-04 GO:0046649 lymphocyte activation
1.58 1.26e-02 GO:0043087 regulation of GTPase activity
1.57 1.74e-02 GO:0033124 regulation of GTP catabolic process
1.52 4.53e-04 GO:0030097 hemopoiesis
1.46 2.10e-07 GO:0001775 cell activation
1.46 1.36e-03 GO:0002520 immune system development
1.46 2.90e-03 GO:0048534 hemopoietic or lymphoid organ development
1.46 1.08e-02 GO:0002694 regulation of leukocyte activation
1.46 3.42e-02 GO:0051249 regulation of lymphocyte activation
1.45 1.50e-02 GO:0050865 regulation of cell activation

Gene overrepresentation in compartment category:

Showing 1 to 20 of 24 entries
enrichment   p-value GO term description
1.34 1.35e-02 GO:0048471 perinuclear region of cytoplasm
1.29 1.01e-04 GO:0044451 nucleoplasm part
1.24 4.09e-06 GO:0005654 nucleoplasm
1.20 1.86e-07 GO:0005829 cytosol
1.19 4.15e-07 GO:0044428 nuclear part
1.19 7.79e-06 GO:0031981 nuclear lumen
1.14 1.31e-03 GO:0043233 organelle lumen
1.14 2.57e-03 GO:0031974 membrane-enclosed lumen
1.14 4.88e-03 GO:0070013 intracellular organelle lumen
1.13 1.13e-11 GO:0005634 nucleus
1.13 3.05e-04 GO:0043234 protein complex
1.11 2.49e-03 GO:0032991 macromolecular complex
1.10 6.41e-06 GO:0044422 organelle part
1.10 8.28e-06 GO:0044446 intracellular organelle part
1.09 6.79e-11 GO:0043227 membrane-bounded organelle
1.09 1.14e-10 GO:0043231 intracellular membrane-bounded organelle
1.09 7.27e-05 GO:0044444 cytoplasmic part
1.08 4.53e-11 GO:0043226 organelle
1.08 5.67e-11 GO:0043229 intracellular organelle
1.08 8.87e-09 GO:0005737 cytoplasm

Gene overrepresentation in function category:

Showing 1 to 20 of 22 entries
enrichment   p-value GO term description
1.76 3.87e-03 GO:0035257 nuclear hormone receptor binding
1.75 1.14e-03 GO:0005099 Ras GTPase activator activity
1.67 1.19e-02 GO:0051427 hormone receptor binding
1.59 6.28e-07 GO:0005096 GTPase activator activity
1.49 3.82e-02 GO:0004721 phosphoprotein phosphatase activity
1.44 3.81e-07 GO:0060589 nucleoside-triphosphatase regulator activity
1.43 8.74e-07 GO:0030695 GTPase regulator activity
1.43 2.10e-02 GO:0003713 transcription coactivator activity
1.42 3.09e-05 GO:0008047 enzyme activator activity
1.41 1.53e-03 GO:0016564 transcription repressor activity
1.41 3.16e-03 GO:0005083 small GTPase regulator activity
1.40 3.33e-02 GO:0019900 kinase binding
1.39 2.78e-02 GO:0032403 protein complex binding
1.36 7.39e-04 GO:0019904 protein domain specific binding
1.35 7.74e-03 GO:0003712 transcription cofactor activity
1.34 9.32e-03 GO:0000988 protein binding transcription factor activity
1.34 9.32e-03 GO:0000989 transcription factor binding transcription factor activity
1.27 1.18e-03 GO:0019899 enzyme binding
1.25 1.06e-04 GO:0030528 transcription regulator activity
1.23 1.32e-03 GO:0030234 enzyme regulator activity