Motif ID: LEF1_TCF7_TCF7L1,2.p2

Z-value: 1.908


Transcription factors associated with LEF1_TCF7_TCF7L1,2.p2:

Gene SymbolEntrez IDGene Name
LEF1 51176 lymphoid enhancer-binding factor 1
TCF7 6932 transcription factor 7 (T-cell specific, HMG-box)
TCF7L1 83439 transcription factor 7-like 1 (T-cell specific, HMG-box)
TCF7L2 6934 transcription factor 7-like 2 (T-cell specific, HMG-box)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TCF7L1chr2_+_852138840.371.8e-01Click!
TCF7L2chr10_+_1146999530.234.2e-01Click!
LEF1chr4_-_1093073250.175.5e-01Click!
TCF7chr5_+_1334791960.087.7e-01Click!


Activity profile for motif LEF1_TCF7_TCF7L1,2.p2.

activity profile for motif LEF1_TCF7_TCF7L1,2.p2


Sorted Z-values histogram for motif LEF1_TCF7_TCF7L1,2.p2

Sorted Z-values for motif LEF1_TCF7_TCF7L1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of LEF1_TCF7_TCF7L1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_11597530 3.654 NM_148903
GREB1
growth regulation by estrogen in breast cancer 1
chr6_+_167624792 2.858 NM_001143947
NM_018974
UNC93A

unc-93 homolog A (C. elegans)

chr2_+_233443237 2.577 NM_206895
C2orf82
chromosome 2 open reading frame 82
chr20_-_42457717 2.333


chr20_+_34937928 2.197 NM_080628
C20orf118
chromosome 20 open reading frame 118
chr14_+_20306425 1.998 NM_022360
EDDM3B
epididymal protein 3B
chr9_+_126460511 1.918


chr10_+_114144512 1.905 ACSL5
acyl-CoA synthetase long-chain family member 5
chr16_+_56259657 1.810 NM_170776
GPR97
G protein-coupled receptor 97
chr20_+_31334601 1.727 NM_033197
C20orf114
chromosome 20 open reading frame 114
chr17_-_36347197 1.701 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chr11_+_62813947 1.688 NM_001039752
SLC22A10
solute carrier family 22, member 10
chr10_+_102722275 1.632 NM_017893
SEMA4G
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr17_-_44226595 1.615 NM_173623
TTLL6
tubulin tyrosine ligase-like family, member 6
chr6_+_30212488 1.613 NM_138700
TRIM40
tripartite motif containing 40
chr2_+_97696462 1.613 NM_001079
ZAP70
zeta-chain (TCR) associated protein kinase 70kDa
chr17_-_43390108 1.605 NM_024320
PRR15L
proline rich 15-like
chr2_-_74606819 1.504 NM_133637
DQX1
DEAQ box RNA-dependent ATPase 1
chr2_+_38009405 1.469 NM_001170792
FAM82A1
family with sequence similarity 82, member A1
chr13_+_109936080 1.468 COL4A2
collagen, type IV, alpha 2
chr6_+_167456230 1.467 NM_031409
CCR6
chemokine (C-C motif) receptor 6
chr12_-_47868563 1.466 TUBA1A
tubulin, alpha 1a
chr14_-_20572783 1.465 NM_001012264
RNASE13
ribonuclease, RNase A family, 13 (non-active)
chr14_-_64479198 1.453 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr14_-_22521544 1.440 NM_032876
JUB
jub, ajuba homolog (Xenopus laevis)
chr11_+_74548472 1.435 NM_001145211
SLCO2B1
solute carrier organic anion transporter family, member 2B1
chr3_-_150422474 1.434 NM_000096
CP
ceruloplasmin (ferroxidase)
chr6_+_131190237 1.431 NM_001195597
LOC285733
hypothetical LOC285733
chr6_-_31789824 1.417


chr2_-_241484245 1.410 NM_001085437
C2orf54
chromosome 2 open reading frame 54
chr6_+_44076281 1.375 NM_001171992
NM_153246
C6orf223

chromosome 6 open reading frame 223

chr7_+_29486010 1.324 NM_001039936
CHN2
chimerin (chimaerin) 2
chr2_+_11600238 1.302 GREB1
growth regulation by estrogen in breast cancer 1
chr2_+_228386800 1.281 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr6_+_35812836 1.199 NM_145028
C6orf81
chromosome 6 open reading frame 81
chr2_+_11600287 1.190 NM_033090
GREB1
growth regulation by estrogen in breast cancer 1
chr6_-_29635456 1.189 UBD
ubiquitin D
chr12_+_117067214 1.162 PEBP1
phosphatidylethanolamine binding protein 1
chr1_+_16203317 1.153 NM_178840
C1orf64
chromosome 1 open reading frame 64
chr3_-_126136261 1.153 NM_033049
MUC13
mucin 13, cell surface associated
chr4_+_74566325 1.150 NM_001133
AFM
afamin
chr6_-_29635680 1.148 NM_006398
UBD
ubiquitin D
chr16_+_70646008 1.147 NM_001126102
NM_005143
HP

haptoglobin

chr11_+_22646229 1.139 NM_177553
GAS2
growth arrest-specific 2
chr14_-_20340830 1.130 NM_002933
NM_198234
NM_198235
RNASE1


ribonuclease, RNase A family, 1 (pancreatic)


chr5_-_138753443 1.121 NM_016459
MZB1
marginal zone B and B1 cell-specific protein
chr3_-_140677990 1.117 NM_004164
RBP2
retinol binding protein 2, cellular
chr14_-_22947320 1.100 NM_002471
MYH6
myosin, heavy chain 6, cardiac muscle, alpha
chr1_+_32251988 1.073 NM_006559
KHDRBS1
KH domain containing, RNA binding, signal transduction associated 1
chr2_-_160181206 1.066 NM_013450
BAZ2B
bromodomain adjacent to zinc finger domain, 2B
chr4_-_184480572 1.055 NM_001185149
CLDN24
claudin 24
chr10_-_123346148 1.035 NM_001144915
FGFR2
fibroblast growth factor receptor 2
chr6_-_52776558 1.035 NM_145740
GSTA1
glutathione S-transferase alpha 1
chr1_-_108032645 1.033 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr20_+_55399847 1.023 NM_017495
NM_183425
RBM38

RNA binding motif protein 38

chr6_-_26038817 1.019 NM_005835
SLC17A2
solute carrier family 17 (sodium phosphate), member 2
chr11_-_62753574 1.017 NM_199352
SLC22A25
solute carrier family 22, member 25
chrX_+_106050261 1.015 NM_020384
CLDN2
claudin 2
chr6_-_52736231 1.013 NM_000846
GSTA2
glutathione S-transferase alpha 2
chr12_+_121218218 1.008 NM_152759
LRRC43
leucine rich repeat containing 43
chr13_+_109932934 0.982 COL4A2
collagen, type IV, alpha 2
chr1_-_153537362 0.978 NM_181871
PKLR
pyruvate kinase, liver and RBC
chr18_+_3439972 0.970 NM_173209
NM_173208
NM_003244
TGIF1


TGFB-induced factor homeobox 1


chr20_+_42399039 0.966 NM_178491
R3HDML
R3H domain containing-like
chr8_-_145672525 0.959 NM_003923
FOXH1
forkhead box H1
chr20_-_1396336 0.957 NM_016143
NM_018839
NM_182483
NSFL1C


NSFL1 (p97) cofactor (p47)


chr19_-_17236522 0.954 NM_031941
USHBP1
Usher syndrome 1C binding protein 1
chr3_+_187866464 0.950 NM_000412
HRG
histidine-rich glycoprotein
chr1_-_11029737 0.926 NM_006610
NM_139208
MASP2

mannan-binding lectin serine peptidase 2

chr1_+_199259664 0.922


chr17_+_54997667 0.890 NM_001166301
NM_024612
DHX40

DEAH (Asp-Glu-Ala-His) box polypeptide 40

chr1_-_36721501 0.881 NM_000760
NM_156039
NM_172313
CSF3R


colony stimulating factor 3 receptor (granulocyte)


chr17_+_7900926 0.863


chr4_+_38740246 0.859 NM_015990
NM_199039
KLHL5

kelch-like 5 (Drosophila)

chr1_+_57093030 0.854 NM_000562
C8A
complement component 8, alpha polypeptide
chr20_+_32762976 0.853 TP53INP2
tumor protein p53 inducible nuclear protein 2
chr4_+_17125885 0.852 NM_001079827
CLRN2
clarin 2
chr8_-_42353719 0.849 NM_014420
DKK4
dickkopf homolog 4 (Xenopus laevis)
chr11_+_75106512 0.842 NM_025098
MOGAT2
monoacylglycerol O-acyltransferase 2
chr4_+_90252990 0.841 NM_145715
TIGD2
tigger transposable element derived 2
chr6_-_128883125 0.838 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr10_+_7785235 0.835 NM_002216
ITIH2
inter-alpha (globulin) inhibitor H2
chr6_-_88911708 0.830 NM_033181
CNR1
cannabinoid receptor 1 (brain)
chr20_-_32363268 0.827 NM_001161766
AHCY
adenosylhomocysteinase
chr1_+_2026014 0.827 NM_001033582
PRKCZ
protein kinase C, zeta
chr5_-_159759620 0.825 NM_022090
C5orf54
chromosome 5 open reading frame 54
chr12_+_19173669 0.825 NM_001143821
NM_001190860
NM_019012
PLEKHA5


pleckstrin homology domain containing, family A member 5


chr1_+_48460943 0.822 NM_001011547
NM_001135181
SLC5A9

solute carrier family 5 (sodium/glucose cotransporter), member 9

chr17_-_76985538 0.819


chr7_+_142850667 0.804 NM_177437
TAS2R60
taste receptor, type 2, member 60
chr14_-_34414277 0.800 BAZ1A
bromodomain adjacent to zinc finger domain, 1A
chrX_+_70359780 0.787 NM_000166
GJB1
gap junction protein, beta 1, 32kDa
chr22_+_19651446 0.775 NM_001146288
AIFM3
apoptosis-inducing factor, mitochondrion-associated, 3
chr7_+_100169184 0.773 NM_003386
NM_173059
ZAN

zonadhesin

chr19_-_6671585 0.766 NM_000064
C3
complement component 3
chr5_+_149526533 0.763 NM_001804
CDX1
caudal type homeobox 1
chr2_+_158666627 0.761 NM_173355
UPP2
uridine phosphorylase 2
chr3_+_123279439 0.754 NM_006889
CD86
CD86 molecule
chr6_-_24753934 0.750 NM_001168375
NM_001168376
NM_001168374
NM_001168377
NM_014809
KIAA0319




KIAA0319




chr1_+_151596953 0.747 NM_002965
S100A9
S100 calcium binding protein A9
chr17_-_60988226 0.743 AXIN2
axin 2
chr7_+_137411717 0.738 NM_001190906
NM_001190907
NM_005989
AKR1D1


aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)


chr9_+_90193807 0.736 SPIN1
spindlin 1
chr14_-_34414603 0.735 NM_013448
NM_182648
BAZ1A

bromodomain adjacent to zinc finger domain, 1A

chr1_+_62835759 0.725 NM_014495
ANGPTL3
angiopoietin-like 3
chr21_-_26294332 0.723 APP
amyloid beta (A4) precursor protein
chr20_+_18516541 0.722 NM_080820
DTD1
D-tyrosyl-tRNA deacylase 1 homolog (S. cerevisiae)
chr11_-_34491878 0.713 NM_001422
ELF5
E74-like factor 5 (ets domain transcription factor)
chr2_-_37047113 0.706 NM_003162
STRN
striatin, calmodulin binding protein
chr9_-_14858974 0.704 FREM1
FRAS1 related extracellular matrix 1
chr6_+_147568795 0.701 STXBP5
syntaxin binding protein 5 (tomosyn)
chr5_+_141326620 0.699 NM_183399
RNF14
ring finger protein 14
chr17_-_1359745 0.698 INPP5K
inositol polyphosphate-5-phosphatase K
chr12_-_28016182 0.682 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr6_+_64339869 0.677 NM_003463
PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr4_+_71330797 0.675 NM_001145006
MUC7
mucin 7, secreted
chr8_+_18072250 0.674 NM_001160179
NAT1
N-acetyltransferase 1 (arylamine N-acetyltransferase)
chr14_-_20642629 0.673 NM_001102454
ZNF219
zinc finger protein 219
chr7_+_94953148 0.672 NM_016116
NM_145872
ASB4

ankyrin repeat and SOCS box containing 4

chr20_+_39199263 0.671 PLCG1
phospholipase C, gamma 1
chr12_+_61645361 0.669 RPL14
ribosomal protein L14
chr17_-_36346240 0.662 KRT23
keratin 23 (histone deacetylase inducible)
chr1_-_180627934 0.657 NM_001033044
NM_002065
GLUL

glutamate-ammonia ligase

chr7_+_142692165 0.657 NM_153345
TMEM139
transmembrane protein 139
chr1_+_40635058 0.650 NM_001198980
SMAP2
small ArfGAP2
chr20_-_45410033 0.649 ZMYND8
zinc finger, MYND-type containing 8
chr10_+_7785347 0.648 ITIH2
inter-alpha (globulin) inhibitor H2
chr11_+_66034652 0.645 NM_024649
BBS1
Bardet-Biedl syndrome 1
chr14_-_34414201 0.644 BAZ1A
bromodomain adjacent to zinc finger domain, 1A
chr17_+_7474177 0.642 NM_001040
NM_001146279
NM_001146280
NM_001146281
SHBG



sex hormone-binding globulin



chr9_+_114671635 0.642 SNX30
sorting nexin family member 30
chr12_-_7709734 0.636 NM_001644
APOBEC1
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
chr3_-_169295752 0.635 GOLIM4
golgi integral membrane protein 4
chr14_-_34414241 0.632 BAZ1A
bromodomain adjacent to zinc finger domain, 1A
chr14_+_20283938 0.632 NM_006683
EDDM3A
epididymal protein 3A
chr16_-_11274952 0.629 NM_021247
PRM3
protamine 3
chr1_-_211087570 0.627 NM_001024601
C1orf227
chromosome 1 open reading frame 227
chr9_-_101621964 0.626


chr9_+_115246831 0.626 NM_144488
RGS3
regulator of G-protein signaling 3
chr17_-_53849888 0.624 RNF43
ring finger protein 43
chr17_+_69939806 0.623 GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr3_+_39346200 0.622 NM_005201
CCR8
chemokine (C-C motif) receptor 8
chr14_-_20340377 0.609 NM_198232
RNASE1
ribonuclease, RNase A family, 1 (pancreatic)
chr10_+_115302767 0.606 NM_004132
HABP2
hyaluronan binding protein 2
chrX_+_49718954 0.600 NM_000084
CLCN5
chloride channel 5
chrX_-_105169370 0.600 NM_000354
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr16_-_45422540 0.597 NM_001001436
C16orf87
chromosome 16 open reading frame 87
chr2_-_9687817 0.597 YWHAQ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
chr2_+_9900933 0.593 NM_005680
TAF1B
TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa
chr2_+_187163232 0.587 ITGAV
integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
chr2_-_165133239 0.583 GRB14
growth factor receptor-bound protein 14
chr1_-_176329357 0.574 LOC100302401
hypothetical LOC100302401
chr10_-_98935369 0.573 SLIT1
slit homolog 1 (Drosophila)
chr20_+_52258023 0.570 PFDN4
prefoldin subunit 4
chr15_+_38082041 0.567 EIF2AK4
eukaryotic translation initiation factor 2 alpha kinase 4
chr2_+_185171537 0.566 ZNF804A
zinc finger protein 804A
chr2_+_185171682 0.564 ZNF804A
zinc finger protein 804A
chr3_+_52788976 0.559 NM_001166435
NM_001166436
ITIH1

inter-alpha (globulin) inhibitor H1

chr17_-_35273947 0.558 NM_012481
NM_183228
NM_183229
NM_183230
NM_183231
NM_183232
IKZF3





IKAROS family zinc finger 3 (Aiolos)





chr1_-_9008990 0.556 NM_207420
SLC2A7
solute carrier family 2 (facilitated glucose transporter), member 7
chr13_+_75108450 0.552 LMO7
LIM domain 7
chr9_-_103187082 0.550 NM_001701
BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr6_+_88111289 0.547 NM_001010868
C6orf163
chromosome 6 open reading frame 163
chr10_+_7785290 0.545 ITIH2
inter-alpha (globulin) inhibitor H2
chr4_-_158111504 0.545 PDGFC
platelet derived growth factor C
chr10_+_7785331 0.543 ITIH2
inter-alpha (globulin) inhibitor H2
chr20_+_18742369 0.543 NM_178483
C20orf79
chromosome 20 open reading frame 79
chr7_+_139750311 0.542 NM_001008749
RAB19
RAB19, member RAS oncogene family
chr13_-_98708549 0.538 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chr17_-_53849929 0.533 NM_017763
RNF43
ring finger protein 43
chr7_+_20336849 0.533 ITGB8
integrin, beta 8
chr15_-_87565813 0.529 NM_000326
RLBP1
retinaldehyde binding protein 1
chr4_+_170817787 0.528 CLCN3
chloride channel 3
chr6_-_2696152 0.526 NM_001012418
MYLK4
myosin light chain kinase family, member 4
chr3_+_187813405 0.526 AHSG
alpha-2-HS-glycoprotein
chr2_+_169634330 0.520 DHRS9
dehydrogenase/reductase (SDR family) member 9
chr14_+_38720085 0.519 PNN
pinin, desmosome associated protein
chr19_-_6453224 0.515 NM_006087
TUBB4
tubulin, beta 4
chr8_+_121892719 0.513


chr13_+_109935250 0.511 COL4A2
collagen, type IV, alpha 2
chr13_-_71339313 0.509 NM_004392
NM_080759
NM_080760
DACH1


dachshund homolog 1 (Drosophila)


chr6_-_28294642 0.508 LOC222699
transducer of ERBB2, 2 pseudogene
chr12_+_107797985 0.506 NM_001917
DAO
D-amino-acid oxidase
chr3_-_115960807 0.506 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr19_+_47073029 0.505 NM_001783
NM_021601
CD79A

CD79a molecule, immunoglobulin-associated alpha

chr2_+_169631777 0.503 NM_199204
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr10_+_114699953 0.502 NM_001146274
NM_001146283
NM_001146284
NM_001146285
NM_001146286
NM_001198525
NM_001198526
NM_001198527
NM_001198528
NM_001198529
NM_001198530
NM_001198531
NM_030756
TCF7L2












transcription factor 7-like 2 (T-cell specific, HMG-box)












chr12_-_53065758 0.499 ZNF385A
zinc finger protein 385A
chr10_-_101831579 0.497 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chrX_-_55037235 0.497 NM_002625
PFKFB1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr17_+_55269974 0.496


chr11_+_62893836 0.495 NM_080866
SLC22A9
solute carrier family 22 (organic anion transporter), member 9
chr2_-_135498716 0.495 NM_001018046
NM_025052
YSK4

YSK4 Sps1/Ste20-related kinase homolog (S. cerevisiae)

chr12_+_8958397 0.487 NM_004426
PHC1
polyhomeotic homolog 1 (Drosophila)
chr15_+_41672543 0.487 NM_020990
CKMT1B
CKMT1A
creatine kinase, mitochondrial 1B
creatine kinase, mitochondrial 1A
chrX_+_48505097 0.487 NM_001080489
GLOD5
glyoxalase domain containing 5
chr6_-_27548438 0.479 NM_007149
ZNF184
zinc finger protein 184
chr10_+_114033403 0.478 NM_058222
TECTB
tectorin beta
chr5_-_39460687 0.478 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr4_-_120462705 0.477 NM_000134
FABP2
fatty acid binding protein 2, intestinal

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.