Motif ID: ZEB1.p2

Z-value: 1.803


Transcription factors associated with ZEB1.p2:

Gene SymbolEntrez IDGene Name
ZEB1 6935 zinc finger E-box binding homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ZEB1chr10_+_31647425-0.431.1e-01Click!


Activity profile for motif ZEB1.p2.

activity profile for motif ZEB1.p2


Sorted Z-values histogram for motif ZEB1.p2

Sorted Z-values for motif ZEB1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ZEB1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_6415259 2.540 NM_139161
NM_174881
CRB3

crumbs homolog 3 (Drosophila)

chr19_-_14177980 2.042 NM_001008701
NM_014921
LPHN1

latrophilin 1

chr14_+_71468902 1.830 RGS6
regulator of G-protein signaling 6
chr5_-_138753443 1.737 NM_016459
MZB1
marginal zone B and B1 cell-specific protein
chr8_+_145158432 1.719 NM_001134374
NM_198572
SPATC1

spermatogenesis and centriole associated 1

chr17_-_60208083 1.622 LOC146880
hypothetical LOC146880
chr2_-_97016027 1.582 NM_001122646
FAM178B
family with sequence similarity 178, member B
chr9_-_139183675 1.579


chr17_-_7106497 1.524 CLDN7
claudin 7
chr9_-_96441409 1.447 FBP1
fructose-1,6-bisphosphatase 1
chr9_-_139184247 1.397 NM_001013653
LRRC26
leucine rich repeat containing 26
chr9_-_96441567 1.340 FBP1
fructose-1,6-bisphosphatase 1
chr17_-_6887965 1.322 NM_153357
SLC16A11
solute carrier family 16, member 11 (monocarboxylic acid transporter 11)
chr14_+_30413393 1.200 NM_001135058
NM_004086
COCH

coagulation factor C homolog, cochlin (Limulus polyphemus)

chr5_-_157011665 1.161


chr3_-_184316553 1.159 MCCC1
methylcrotonoyl-CoA carboxylase 1 (alpha)
chr22_-_41419800 1.152 A4GALT
alpha 1,4-galactosyltransferase
chr9_-_96441654 1.137 NM_000507
FBP1
fructose-1,6-bisphosphatase 1
chr6_+_36206239 1.116 NM_002754
MAPK13
mitogen-activated protein kinase 13
chr5_+_68746694 1.102 NM_001038603
MARVELD2
MARVEL domain containing 2
chr17_+_38064787 1.072 NM_016437
TUBG2
tubulin, gamma 2
chr15_-_42274760 1.041 FRMD5
FERM domain containing 5
chr1_+_1062137 1.002 LOC254099
hypothetical protein LOC254099
chr1_+_112852892 0.999 NM_024494
WNT2B
wingless-type MMTV integration site family, member 2B
chr17_-_7106987 0.986 NM_001185023
NM_001307
CLDN7

claudin 7

chr3_-_123223658 0.983 NM_175924
ILDR1
immunoglobulin-like domain containing receptor 1
chr8_+_120289735 0.977 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr21_+_42807052 0.974 SLC37A1
solute carrier family 37 (glycerol-3-phosphate transporter), member 1
chr22_+_38720881 0.974 NM_138435
FAM83F
family with sequence similarity 83, member F
chr1_-_3517918 0.969 NM_001409
MEGF6
multiple EGF-like-domains 6
chr7_-_927035 0.968 ADAP1
ArfGAP with dual PH domains 1
chr19_+_17499064 0.953 FAM129C
family with sequence similarity 129, member C
chr11_+_70926718 0.945 NM_021046
KRTAP5-8
keratin associated protein 5-8
chr22_-_37858871 0.930 CBX7
chromobox homolog 7
chr8_-_145609737 0.922 SLC39A4
solute carrier family 39 (zinc transporter), member 4
chr19_-_6150536 0.913


chr2_+_120820140 0.912 NM_002193
INHBB
inhibin, beta B
chr2_-_241270982 0.906 NM_001102467
AQP12A
AQP12B
aquaporin 12A
aquaporin 12B
chr3_+_98016114 0.902 NM_001080448
EPHA6
EPH receptor A6
chr1_+_60053050 0.900 NM_015888
HOOK1
hook homolog 1 (Drosophila)
chr19_+_7608020 0.898 STXBP2
syntaxin binding protein 2
chr17_-_70480385 0.892 NM_030630
C17orf28
chromosome 17 open reading frame 28
chr19_+_7608015 0.874 STXBP2
syntaxin binding protein 2
chr16_+_87232501 0.858 NM_013278
IL17C
interleukin 17C
chr19_+_7607976 0.852 NM_001127396
NM_006949
STXBP2

syntaxin binding protein 2

chr11_+_75157414 0.851 NM_032564
DGAT2
diacylglycerol O-acyltransferase 2
chr19_-_17217022 0.849 NM_005234
NR2F6
nuclear receptor subfamily 2, group F, member 6
chr19_+_10392128 0.841 NM_001111307
PDE4A
phosphodiesterase 4A, cAMP-specific
chr9_-_125070675 0.836 NM_001171137
STRBP
spermatid perinuclear RNA binding protein
chr11_+_75157450 0.821 DGAT2
diacylglycerol O-acyltransferase 2
chr4_-_35922288 0.815 NM_015230
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr19_-_7607852 0.815


chr14_-_105392671 0.801


chr2_+_74595073 0.787 NM_016170
TLX2
T-cell leukemia homeobox 2
chr6_-_63053811 0.786 NM_152688
KHDRBS2
KH domain containing, RNA binding, signal transduction associated 2
chr16_-_66827449 0.777 NM_024939
ESRP2
epithelial splicing regulatory protein 2
chr7_+_26298136 0.777 SNX10
sorting nexin 10
chr2_+_111594921 0.775 NM_006538
NM_138621
NM_207002
BCL2L11


BCL2-like 11 (apoptosis facilitator)


chr19_+_7608010 0.775 STXBP2
syntaxin binding protein 2
chr13_-_100039008 0.773 NM_001195087
A2LD1
AIG2-like domain 1
chr12_+_6290127 0.771 PLEKHG6
pleckstrin homology domain containing, family G (with RhoGef domain) member 6
chr4_-_41848874 0.758 BEND4
BEN domain containing 4
chr2_-_100125402 0.753 NM_002285
AFF3
AF4/FMR2 family, member 3
chr7_+_26298018 0.753 NM_013322
SNX10
sorting nexin 10
chr2_-_73350103 0.744 NM_001080410
FBXO41
F-box protein 41
chr14_-_77034853 0.744 NM_182509
NM_199296
ISM2

isthmin 2 homolog (zebrafish)

chr9_-_91302707 0.739 SEMA4D
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
chr6_-_3172775 0.725 NM_178012
TUBB2B
tubulin, beta 2B
chr13_+_32488477 0.723 NM_004795
KL
klotho
chr6_+_31648071 0.720 NM_000595
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr18_-_70110089 0.710 NM_001190807
NM_001914
NM_148923
CYB5A


cytochrome b5 type A (microsomal)


chr3_-_52235218 0.703 NM_017442
TLR9
toll-like receptor 9
chr11_-_6298284 0.701 NM_145040
PRKCDBP
protein kinase C, delta binding protein
chr1_+_152644471 0.701 IL6R
interleukin 6 receptor
chr11_+_20342262 0.701 NM_001098523
HTATIP2
HIV-1 Tat interactive protein 2, 30kDa
chr17_+_71033339 0.696 NM_001015002
NM_001031803
NM_004524
LLGL2


lethal giant larvae homolog 2 (Drosophila)


chr5_+_132111034 0.695 NM_001039780
CCNI2
cyclin I family, member 2
chr17_-_70480345 0.692


chr12_+_6290359 0.690 NM_001144856
PLEKHG6
pleckstrin homology domain containing, family G (with RhoGef domain) member 6
chr15_-_42274529 0.689 NM_032892
FRMD5
FERM domain containing 5
chr1_+_67545634 0.685 NM_001559
IL12RB2
interleukin 12 receptor, beta 2
chr22_-_35232979 0.683 FOXRED2
FAD-dependent oxidoreductase domain containing 2
chr14_+_104338423 0.675 ZBTB42
zinc finger and BTB domain containing 42
chr11_+_712282 0.674 EPS8L2
EPS8-like 2
chr1_-_74912009 0.667 NM_001002912
C1orf173
chromosome 1 open reading frame 173
chr19_-_19142053 0.664 MEF2B
myocyte enhancer factor 2B
chr2_-_166359016 0.660 NM_004482
GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chr12_+_7174230 0.659 NM_014718
CLSTN3
calsyntenin 3
chr4_-_2390050 0.658 NM_001172656
NM_001172657
NM_001172658
NM_020972
ZFYVE28



zinc finger, FYVE domain containing 28



chr5_+_156625629 0.656 NM_001037333
NM_001037332
CYFIP2

cytoplasmic FMR1 interacting protein 2

chr19_-_19142090 0.655 NM_001145785
MEF2B
myocyte enhancer factor 2B
chr10_+_70881322 0.648


chr14_+_73073570 0.646 NM_001037161
ACOT1
acyl-CoA thioesterase 1
chr7_-_156125876 0.634 C7orf13
chromosome 7 open reading frame 13
chr7_+_50314801 0.632 NM_006060
IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr14_-_105851580 0.632 IGHA1
IGHA2
IGHD
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 1 (G1m marker)
chr18_-_45975163 0.630 NM_001080467
MYO5B
myosin VB
chr11_+_66381451 0.630 NM_024036
LRFN4
leucine rich repeat and fibronectin type III domain containing 4
chr20_+_42463279 0.628 NM_000457
NM_178849
NM_178850
HNF4A


hepatocyte nuclear factor 4, alpha


chr19_-_10900086 0.626 NM_024029
YIPF2
Yip1 domain family, member 2
chr10_+_70881221 0.625 NM_012339
TSPAN15
tetraspanin 15
chr3_-_120236118 0.619 IGSF11
immunoglobulin superfamily, member 11
chr19_+_868285 0.619 NM_032551
KISS1R
KISS1 receptor
chr19_-_18409788 0.611 NM_001170939
ISYNA1
inositol-3-phosphate synthase 1
chr17_-_58877276 0.610 NM_001017916
NM_001915
CYB561

cytochrome b-561

chr2_+_10779191 0.608 NM_001039362
NM_144583
ATP6V1C2

ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2

chr19_+_40431122 0.606 LSR
lipolysis stimulated lipoprotein receptor
chr17_-_8643163 0.605 NM_152599
MFSD6L
major facilitator superfamily domain containing 6-like
chr1_+_152644292 0.602 NM_000565
NM_181359
IL6R

interleukin 6 receptor

chr12_+_53229625 0.601 PDE1B
phosphodiesterase 1B, calmodulin-dependent
chr2_-_166358951 0.597 GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chr2_+_222997456 0.594 SGPP2
sphingosine-1-phosphate phosphatase 2
chr3_-_120236355 0.594 NM_001015887
IGSF11
immunoglobulin superfamily, member 11
chr17_+_26839143 0.593 RAB11FIP4
RAB11 family interacting protein 4 (class II)
chr1_-_27834210 0.593 NM_005248
FGR
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
chr12_-_7793335 0.588 NM_130441
NM_203503
CLEC4C

C-type lectin domain family 4, member C

chr11_+_1287553 0.588 LOC255512
hypothetical LOC255512
chr1_+_67546143 0.583 IL12RB2
interleukin 12 receptor, beta 2
chr1_+_205736095 0.582 NM_000573
NM_000651
CR1

complement component (3b/4b) receptor 1 (Knops blood group)

chr9_-_125070613 0.579 NM_018387
STRBP
spermatid perinuclear RNA binding protein
chr12_+_6926014 0.579 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr18_-_5620629 0.577 EPB41L3
erythrocyte membrane protein band 4.1-like 3
chr19_+_590878 0.577 NM_020637
FGF22
fibroblast growth factor 22
chrX_+_69591639 0.576 NM_001166278
DLG3
discs, large homolog 3 (Drosophila)
chr1_+_12046020 0.572 NM_001243
TNFRSF8
tumor necrosis factor receptor superfamily, member 8
chr19_+_18391423 0.567


chr11_-_684842 0.567 DEAF1
deformed epidermal autoregulatory factor 1 (Drosophila)
chr7_-_37454933 0.562 NM_014800
ELMO1
engulfment and cell motility 1
chr5_+_176492629 0.561 NSD1
nuclear receptor binding SET domain protein 1
chr17_+_68672705 0.560 NM_001050
SSTR2
somatostatin receptor 2
chr16_+_1524162 0.560 NM_024600
TMEM204
transmembrane protein 204
chr17_+_71229191 0.558 ITGB4
integrin, beta 4
chr19_+_17843753 0.554 NM_000453
SLC5A5
solute carrier family 5 (sodium iodide symporter), member 5
chr10_-_105208634 0.551 NM_001001412
CALHM1
calcium homeostasis modulator 1
chr1_+_109458093 0.549 NM_020775
KIAA1324
KIAA1324
chr11_+_45900731 0.549 GYLTL1B
glycosyltransferase-like 1B
chr1_-_1840564 0.549 NM_178545
TMEM52
transmembrane protein 52
chr12_+_119562737 0.547 NM_001033677
CABP1
calcium binding protein 1
chr19_+_18391211 0.547 NM_001009998
NM_032627
SSBP4

single stranded DNA binding protein 4

chr2_-_96145614 0.545 NM_000682
ADRA2B
adrenergic, alpha-2B-, receptor
chr12_-_92489652 0.544 LOC144481
hypothetical protein LOC144481
chr15_+_81567327 0.538 NM_001144903
NM_023003
TM6SF1

transmembrane 6 superfamily member 1

chr5_-_1647617 0.535 SDHAP3
succinate dehydrogenase complex, subunit A, flavoprotein pseudogene 3
chr21_+_33364316 0.533 NM_138983
OLIG1
oligodendrocyte transcription factor 1
chr7_-_72822471 0.528 NM_001306
CLDN3
claudin 3
chr1_-_159257486 0.525 F11R
F11 receptor
chr2_-_25390266 0.524 DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr15_+_72315719 0.521 NM_025055
CCDC33
coiled-coil domain containing 33
chr11_-_1287256 0.518 TOLLIP
toll interacting protein
chr17_+_71229151 0.518 ITGB4
integrin, beta 4
chr20_+_42007949 0.515 NM_001098798
TOX2
TOX high mobility group box family member 2
chr5_-_132976094 0.514 FSTL4
follistatin-like 4
chr1_+_63561632 0.512 FOXD3
forkhead box D3
chr1_-_159257567 0.512 F11R
F11 receptor
chr11_-_72057755 0.511 NM_001146209
PDE2A
phosphodiesterase 2A, cGMP-stimulated
chr5_-_132976121 0.506 NM_015082
FSTL4
follistatin-like 4
chr11_-_1287384 0.505 TOLLIP
toll interacting protein
chr16_+_29374479 0.505 NM_001017389
NM_003166
SULT1A4
SULT1A3
SLX1B
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)
chr9_-_139047112 0.504 NM_004479
FUT7
fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
chr3_+_47004457 0.504 NBEAL2
neurobeachin-like 2
chr1_-_58815415 0.504 TACSTD2
tumor-associated calcium signal transducer 2
chr19_+_45811647 0.504 LTBP4
latent transforming growth factor beta binding protein 4
chr18_+_58143499 0.501 NM_003839
TNFRSF11A
tumor necrosis factor receptor superfamily, member 11a, NFKB activator
chr22_-_30071565 0.501 PATZ1
POZ (BTB) and AT hook containing zinc finger 1
chr20_+_60744231 0.499 NM_016354
SLCO4A1
solute carrier organic anion transporter family, member 4A1
chr15_-_50375143 0.499 NM_018728
MYO5C
myosin VC
chr1_+_52871603 0.498 NM_001042693
FAM159A
family with sequence similarity 159, member A
chr1_+_109458299 0.498 KIAA1324
KIAA1324
chr20_-_10602139 0.497 JAG1
jagged 1
chr12_+_131797455 0.494 NM_001170543
NM_001170544
NM_138575
PGAM5


phosphoglycerate mutase family member 5


chr18_-_42815965 0.493 NM_016427
TCEB3B
transcription elongation factor B polypeptide 3B (elongin A2)
chr6_+_44295219 0.493 NM_001078174
NM_004955
SLC29A1

solute carrier family 29 (nucleoside transporters), member 1

chr2_+_109112428 0.491 NM_001099289
SH3RF3
SH3 domain containing ring finger 3
chr20_+_42463350 0.489 HNF4A
hepatocyte nuclear factor 4, alpha
chr11_-_34491878 0.489 NM_001422
ELF5
E74-like factor 5 (ets domain transcription factor)
chr16_-_626293 0.487 NM_001040160
NM_001040161
NM_001040162
NM_001040165
NM_032366
C16orf13




chromosome 16 open reading frame 13




chr11_-_1287416 0.484 TOLLIP
toll interacting protein
chr2_+_46378405 0.484 EPAS1
endothelial PAS domain protein 1
chr17_-_34084682 0.483 NM_001130677
C17orf96
chromosome 17 open reading frame 96
chr1_-_109458001 0.482 NM_001122961
C1orf194
chromosome 1 open reading frame 194
chr11_-_1287467 0.479 NM_019009
TOLLIP
toll interacting protein
chr8_+_95722448 0.478 ESRP1
epithelial splicing regulatory protein 1
chr17_+_32368611 0.477 NM_005568
LHX1
LIM homeobox 1
chr1_+_27433593 0.476 NM_015023
WDTC1
WD and tetratricopeptide repeats 1
chr8_-_141537035 0.475 NM_001160372
TRAPPC9
trafficking protein particle complex 9
chr5_-_1348103 0.474 NM_001193376
NM_198253
TERT

telomerase reverse transcriptase

chr5_+_140997171 0.473 RELL2
RELT-like 2
chr11_-_407324 0.472 NM_001135053
NM_021805
SIGIRR

single immunoglobulin and toll-interleukin 1 receptor (TIR) domain

chr22_-_22426551 0.471 NM_013378
VPREB3
pre-B lymphocyte 3
chr10_-_97040661 0.468 NM_020992
PDLIM1
PDZ and LIM domain 1
chr2_-_25245062 0.468 NM_000939
NM_001035256
POMC

proopiomelanocortin

chr17_+_71229110 0.467 NM_000213
NM_001005731
ITGB4

integrin, beta 4

chr14_-_105549177 0.466 IGHV4-31
IGHD
IGHG3
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
chr3_-_56810869 0.466 NM_019555
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr20_-_3097070 0.461 NM_014731
ProSAPiP1
ProSAPiP1 protein
chr7_-_22363036 0.461 NM_012294
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr2_-_6923215 0.458 NM_207315
CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr2_-_230287442 0.456 NM_139072
DNER
delta/notch-like EGF repeat containing
chr17_-_34015631 0.455 NM_025248
SRCIN1
SRC kinase signaling inhibitor 1
chr11_+_66643311 0.455 NM_012308
KDM2A
lysine (K)-specific demethylase 2A

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.44 1.03e-03 GO:0045595 regulation of cell differentiation
1.20 1.18e-03 GO:0048518 positive regulation of biological process
1.36 2.35e-03 GO:0050793 regulation of developmental process
1.09 4.13e-03 GO:0065007 biological regulation
1.71 4.75e-03 GO:0030168 platelet activation
1.20 5.37e-03 GO:0048522 positive regulation of cellular process
1.38 6.09e-03 GO:0051173 positive regulation of nitrogen compound metabolic process
1.38 6.97e-03 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.35 1.03e-02 GO:0009891 positive regulation of biosynthetic process
1.35 1.08e-02 GO:0031328 positive regulation of cellular biosynthetic process
1.46 1.13e-02 GO:0001775 cell activation
1.10 1.13e-02 GO:0050794 regulation of cellular process
1.49 1.18e-02 GO:0051094 positive regulation of developmental process
1.26 1.54e-02 GO:0007399 nervous system development
1.32 1.77e-02 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.22 2.05e-02 GO:0048583 regulation of response to stimulus
1.09 2.35e-02 GO:0050789 regulation of biological process
1.38 2.51e-02 GO:0051254 positive regulation of RNA metabolic process
1.15 2.78e-02 GO:0023052 signaling
1.38 2.92e-02 GO:0010628 positive regulation of gene expression
1.36 3.10e-02 GO:2000026 regulation of multicellular organismal development
1.83 3.30e-02 GO:0034330 cell junction organization
1.51 3.85e-02 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.12 1.02e-08 GO:0005737 cytoplasm
1.07 1.31e-05 GO:0005622 intracellular
1.07 2.69e-05 GO:0044424 intracellular part
1.09 2.63e-02 GO:0044444 cytoplasmic part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.12 4.46e-06 GO:0005515 protein binding
1.35 2.13e-02 GO:0043565 sequence-specific DNA binding
1.05 2.65e-02 GO:0005488 binding