Motif ID: SP1.p2

Z-value: 2.564


Transcription factors associated with SP1.p2:

Gene SymbolEntrez IDGene Name
SP1 6667 Sp1 transcription factor

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SP1chr12_+_520601910.371.7e-01Click!


Activity profile for motif SP1.p2.

activity profile for motif SP1.p2


Sorted Z-values histogram for motif SP1.p2

Sorted Z-values for motif SP1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SP1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_659766 3.004 NM_001040134
NM_002579
 PALM

paralemmin

chr7_-_158073121 2.224 NM_002847
NM_130842
NM_130843
 PTPRN2


protein tyrosine phosphatase, receptor type, N polypeptide 2


chr9_-_122679387 2.113 NM_001009936
NM_015651
 PHF19

PHD finger protein 19

chr17_-_76622967 2.083 FLJ90757
hypothetical LOC440465
chr20_-_62151216 1.957 NM_018419
 SOX18
SRY (sex determining region Y)-box 18
chr19_-_55524445 1.894 NM_004977
 KCNC3
potassium voltage-gated channel, Shaw-related subfamily, member 3
chr22_+_18081968 1.855 NM_002688
 SEPT5
septin 5
chr1_+_16247870 1.767 NM_001165945
 CLCNKB
chloride channel Kb
chr9_+_132961723 1.716 AIF1L
allograft inflammatory factor 1-like
chr3_+_37878647 1.712 NM_001008392
NM_005808
 CTDSPL

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like

chr16_-_960982 1.663 NM_022773
 LMF1
lipase maturation factor 1
chr9_+_131974506 1.618 NM_014286
 NCS1
neuronal calcium sensor 1
chr2_+_42128521 1.597 NM_138370
 PKDCC
protein kinase domain containing, cytoplasmic homolog (mouse)
chr19_+_57492236 1.595 NM_144684
 ZNF480
zinc finger protein 480
chr6_+_44295219 1.570 NM_001078174
NM_004955
 SLC29A1

solute carrier family 29 (nucleoside transporters), member 1

chr2_+_238265791 1.566 LRRFIP1
leucine rich repeat (in FLII) interacting protein 1
chr22_+_48951286 1.516 NM_001160300
NM_052839
 PANX2

pannexin 2

chr19_+_59064795 1.504 MYADM
myeloid-associated differentiation marker
chr5_-_140875591 1.483 DIAPH1
diaphanous homolog 1 (Drosophila)
chr22_-_21231421 1.475 NM_206955
NM_206956
NM_006115
NM_206953
NM_206954
 PRAME




preferentially expressed antigen in melanoma





Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 174 entries
enrichment   p-value GO term description
1.76 2.42e-02 GO:0017148 negative regulation of translation
1.62 1.33e-02 GO:0034138 toll-like receptor 3 signaling pathway
1.61 4.59e-03 GO:0007173 epidermal growth factor receptor signaling pathway
1.57 2.45e-02 GO:0006473 protein acetylation
1.54 1.57e-02 GO:0043543 protein acylation
1.53 4.69e-05 GO:0008286 insulin receptor signaling pathway
1.51 4.56e-02 GO:0018205 peptidyl-lysine modification
1.46 8.15e-07 GO:0048011 nerve growth factor receptor signaling pathway
1.45 1.05e-04 GO:0032869 cellular response to insulin stimulus
1.42 3.48e-05 GO:0032868 response to insulin stimulus
1.42 5.32e-04 GO:0016569 covalent chromatin modification
1.42 6.80e-04 GO:0016570 histone modification
1.41 6.35e-05 GO:0071375 cellular response to peptide hormone stimulus
1.40 8.42e-03 GO:0006417 regulation of translation
1.36 9.06e-05 GO:0051270 regulation of cellular component movement
1.36 1.87e-04 GO:0010608 posttranscriptional regulation of gene expression
1.35 1.19e-04 GO:0032870 cellular response to hormone stimulus
1.34 9.67e-04 GO:0040012 regulation of locomotion
1.34 2.29e-03 GO:0016567 protein ubiquitination
1.34 2.45e-03 GO:2000145 regulation of cell motility

Gene overrepresentation in compartment category:

Showing 1 to 20 of 43 entries
enrichment   p-value GO term description
2.02 1.14e-02 GO:0031519 PcG protein complex
1.66 3.24e-03 GO:0034708 methyltransferase complex
1.66 3.24e-03 GO:0035097 histone methyltransferase complex
1.56 1.37e-02 GO:0000123 histone acetyltransferase complex
1.51 1.00e-02 GO:0000790 nuclear chromatin
1.48 1.11e-02 GO:0042470 melanosome
1.48 1.11e-02 GO:0048770 pigment granule
1.36 4.38e-03 GO:0031252 cell leading edge
1.27 2.16e-08 GO:0044451 nucleoplasm part
1.27 1.86e-03 GO:0048471 perinuclear region of cytoplasm
1.25 4.75e-14 GO:0005654 nucleoplasm
1.25 1.60e-06 GO:0015630 microtubule cytoskeleton
1.25 3.69e-02 GO:0015629 actin cytoskeleton
1.23 1.88e-03 GO:0000139 Golgi membrane
1.22 1.35e-18 GO:0005829 cytosol
1.22 2.14e-16 GO:0031981 nuclear lumen
1.22 5.17e-04 GO:0044431 Golgi apparatus part
1.20 1.05e-15 GO:0044428 nuclear part
1.20 2.07e-06 GO:0005794 Golgi apparatus
1.19 2.17e-15 GO:0070013 intracellular organelle lumen

Gene overrepresentation in function category:

Showing 1 to 20 of 50 entries
enrichment   p-value GO term description
1.69 1.78e-02 GO:0004722 protein serine/threonine phosphatase activity
1.45 1.39e-04 GO:0004721 phosphoprotein phosphatase activity
1.35 1.46e-05 GO:0016564 transcription repressor activity
1.35 3.22e-04 GO:0016791 phosphatase activity
1.34 9.63e-04 GO:0019900 kinase binding
1.33 2.05e-04 GO:0008134 transcription factor binding
1.31 3.90e-05 GO:0000988 protein binding transcription factor activity
1.31 3.90e-05 GO:0000989 transcription factor binding transcription factor activity
1.31 1.58e-02 GO:0019787 small conjugating protein ligase activity
1.31 2.84e-02 GO:0004842 ubiquitin-protein ligase activity
1.31 4.41e-02 GO:0019901 protein kinase binding
1.30 5.14e-05 GO:0003712 transcription cofactor activity
1.29 1.04e-03 GO:0042578 phosphoric ester hydrolase activity
1.29 4.44e-03 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.28 1.57e-09 GO:0019899 enzyme binding
1.28 4.87e-03 GO:0016563 transcription activator activity
1.28 1.78e-02 GO:0016881 acid-amino acid ligase activity
1.28 3.99e-02 GO:0003702 RNA polymerase II transcription factor activity
1.27 4.16e-04 GO:0004674 protein serine/threonine kinase activity
1.27 9.26e-03 GO:0003779 actin binding