Motif ID: EWSR1-FLI1.p2

Z-value: 1.203


Transcription factors associated with EWSR1-FLI1.p2:

fusion protein between EWSR1 and FLI1 in an oncogenic event

Gene SymbolEntrez IDGene Name
EWSR1 2130 Ewing sarcoma breakpoint region 1
FLI1 2313 Friend leukemia virus integration 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FLI1chr11_+_128068982-0.401.4e-01Click!
EWSR1chr22_+_27993997-0.058.7e-01Click!


Activity profile for motif EWSR1-FLI1.p2.

activity profile for motif EWSR1-FLI1.p2


Sorted Z-values histogram for motif EWSR1-FLI1.p2

Sorted Z-values for motif EWSR1-FLI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EWSR1-FLI1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_93030538 5.359 NM_005665
EVI5
ecotropic viral integration site 5
chr1_+_221955876 3.208 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr5_-_148422799 2.171 NM_024577
SH3TC2
SH3 domain and tetratricopeptide repeats 2
chr19_-_9098625 1.498 NM_001001958
OR7G3
olfactory receptor, family 7, subfamily G, member 3
chr19_-_55763091 1.378 NM_001080457
LRRC4B
leucine rich repeat containing 4B
chr11_+_73034870 1.341 NM_001130033
NM_021200
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr10_+_23424383 1.293 NM_012228
MSRB2
methionine sulfoxide reductase B2
chr1_-_155281785 1.149 NM_014784
NM_198236
ARHGEF11

Rho guanine nucleotide exchange factor (GEF) 11

chrX_-_148394570 1.148 NM_000202
NM_001166550
NM_006123
IDS


iduronate 2-sulfatase


chr20_-_48741481 1.132


chr1_+_12627152 1.120 NM_001013630
AADACL4
arylacetamide deacetylase-like 4
chr9_+_35528890 1.091 RUSC2
RUN and SH3 domain containing 2
chr7_+_143043871 1.000 NM_001130026
FAM115C
family with sequence similarity 115, member C
chr11_-_62213946 0.998 NM_203422
LRRN4CL
LRRN4 C-terminal like
chr1_-_68071635 0.991 NM_018841
GNG12
guanine nucleotide binding protein (G protein), gamma 12
chr6_-_143307976 0.991 NM_006734
HIVEP2
human immunodeficiency virus type I enhancer binding protein 2
chr12_-_115660017 0.928 NM_024738
C12orf49
chromosome 12 open reading frame 49
chr12_+_88627601 0.878 LOC338758
hypothetical LOC338758
chr8_-_93176819 0.864 RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chrX_-_49851743 0.841 NM_139289
AKAP4
A kinase (PRKA) anchor protein 4
chr4_+_120029426 0.836 NM_001128933
NM_001128934
NM_133477
SYNPO2


synaptopodin 2


chr2_+_113532685 0.804 NM_173170
IL1F5
interleukin 1 family, member 5 (delta)
chr8_-_93177057 0.793 NM_001198625
NM_001198626
NM_001198627
NM_001198631
NM_001198634
NM_001198679
RUNX1T1





runt-related transcription factor 1; translocated to, 1 (cyclin D-related)





chr3_-_15875932 0.785 NM_015199
ANKRD28
ankyrin repeat domain 28
chr6_+_31698447 0.746


chr16_-_48960186 0.709 NM_001173984
NM_013263
BRD7

bromodomain containing 7

chr2_-_26395420 0.703 NM_001145168
NM_001145169
GPR113

G protein-coupled receptor 113

chr10_+_83627422 0.701 NM_001165973
NRG3
neuregulin 3
chr1_-_224564038 0.685 LIN9
lin-9 homolog (C. elegans)
chr2_+_113533155 0.661 NM_012275
IL1F5
interleukin 1 family, member 5 (delta)
chr8_-_95556460 0.646 NM_012415
RAD54B
RAD54 homolog B (S. cerevisiae)
chr9_+_35528628 0.628 NM_001135999
RUSC2
RUN and SH3 domain containing 2
chr2_+_79593567 0.600 NM_001164883
NM_004389
CTNNA2

catenin (cadherin-associated protein), alpha 2

chr2_-_55349851 0.570 NM_002453
MTIF2
mitochondrial translational initiation factor 2
chr6_-_24827265 0.568 NM_030939
C6orf62
chromosome 6 open reading frame 62
chr16_-_73198416 0.562 GLG1
golgi glycoprotein 1
chr7_+_21434818 0.540


chr5_-_38631263 0.539 NM_002310
LIFR
leukemia inhibitory factor receptor alpha
chr2_+_179053512 0.529 PLEKHA3
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3
chrX_-_109447970 0.525 NM_001025580
NM_015365
AMMECR1

Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1

chr3_-_42282665 0.519 NM_000729
CCK
cholecystokinin
chr19_+_12996830 0.518 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr5_-_141981083 0.517 NM_001144892
FGF1
fibroblast growth factor 1 (acidic)
chrX_+_107569671 0.517 NM_000495
NM_033380
COL4A5

collagen, type IV, alpha 5

chr1_-_109957195 0.512 NM_005272
GNAT2
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
chrX_+_48529905 0.508 NM_002049
GATA1
GATA binding protein 1 (globin transcription factor 1)
chr15_-_56829225 0.493 NM_001110
ADAM10
ADAM metallopeptidase domain 10
chr10_+_88708267 0.490 NM_003087
SNCG
synuclein, gamma (breast cancer-specific protein 1)
chr7_-_106991941 0.479 NM_001161520
NM_006348
NM_181733
COG5


component of oligomeric golgi complex 5


chrX_-_109448083 0.478 AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr5_-_64100239 0.477 NM_173829
SREK1IP1
SREK1-interacting protein 1
chr8_-_38127489 0.473 NM_000349
STAR
steroidogenic acute regulatory protein
chr7_+_128142661 0.472 NM_032599
FAM71F1
family with sequence similarity 71, member F1
chrX_-_109447954 0.458 AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr8_-_145671947 0.446 FOXH1
forkhead box H1
chr1_+_246087104 0.443 NM_015431
TRIM58
tripartite motif containing 58
chr12_+_10222823 0.441 NM_153022
C12orf59
chromosome 12 open reading frame 59
chr7_-_75256999 0.436 NM_006072
CCL26
chemokine (C-C motif) ligand 26
chr11_-_117628211 0.428 NM_198275
MPZL3
myelin protein zero-like 3
chr1_-_31003181 0.420 LAPTM5
lysosomal protein transmembrane 5
chr2_+_149118791 0.416 EPC2
enhancer of polycomb homolog 2 (Drosophila)
chr2_-_99284070 0.415 NM_174898
LYG1
lysozyme G-like 1
chr12_-_47464143 0.414 NM_015270
ADCY6
adenylate cyclase 6
chr5_-_71838875 0.411 NM_152625
ZNF366
zinc finger protein 366
chr16_-_73198498 0.407 GLG1
golgi glycoprotein 1
chr1_-_21478571 0.406 NM_001113347
ECE1
endothelin converting enzyme 1
chr2_-_218551786 0.403 TNS1
tensin 1
chrX_-_102870207 0.400 NM_001024452
NM_001172285
GLRA4

glycine receptor, alpha 4

chr1_-_202730135 0.399 PIK3C2B
phosphoinositide-3-kinase, class 2, beta polypeptide
chr7_+_16759845 0.398 NM_014399
TSPAN13
tetraspanin 13
chr16_-_73198515 0.398 NM_001145666
NM_001145667
NM_012201
GLG1


golgi glycoprotein 1


chr16_-_79811475 0.394 NM_001076780
NM_052892
PKD1L2

polycystic kidney disease 1-like 2

chr1_+_246087230 0.393 TRIM58
tripartite motif containing 58
chr11_+_71605466 0.392 NM_000803
NM_001113534
NM_001113535
NM_001113536
FOLR2



folate receptor 2 (fetal)



chr9_-_106705867 0.390 ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr2_+_182464910 0.389 SSFA2
sperm specific antigen 2
chr3_-_158704056 0.385 NM_001167915
NM_001167916
VEPH1

ventricular zone expressed PH domain homolog 1 (zebrafish)

chr4_-_86106567 0.381 NM_014991
WDFY3
WD repeat and FYVE domain containing 3
chr1_-_231498081 0.381 NM_014801
PCNXL2
pecanex-like 2 (Drosophila)
chr12_+_84198015 0.381 NM_006982
ALX1
ALX homeobox 1
chr17_-_70901303 0.379 GRB2
growth factor receptor-bound protein 2
chr3_+_77171938 0.375 NM_002942
ROBO2
roundabout, axon guidance receptor, homolog 2 (Drosophila)
chr14_-_63079299 0.372 PPP2R5E
protein phosphatase 2, regulatory subunit B', epsilon isoform
chr5_-_64100176 0.371 SREK1IP1
SREK1-interacting protein 1
chr19_-_18220009 0.370 NM_000923
PDE4C
phosphodiesterase 4C, cAMP-specific
chr10_-_13429397 0.363 SEPHS1
selenophosphate synthetase 1
chr8_-_22982435 0.363 NM_003842
NM_147187
TNFRSF10B

tumor necrosis factor receptor superfamily, member 10b

chr6_+_26491302 0.361 NM_001197238
NM_001197239
NM_001197240
NM_006995
NM_181531
NM_001197237
BTN2A2





butyrophilin, subfamily 2, member A2





chr1_-_184684478 0.358 NM_022576
PDC
phosducin
chr8_-_145672525 0.358 NM_003923
FOXH1
forkhead box H1
chr19_+_12996745 0.354 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr12_-_120503241 0.351 NM_032590
KDM2B
lysine (K)-specific demethylase 2B
chr1_+_26895108 0.350 NM_006015
NM_139135
ARID1A

AT rich interactive domain 1A (SWI-like)

chr1_-_224563820 0.344 NM_173083
LIN9
lin-9 homolog (C. elegans)
chr2_-_55349818 0.344 NM_001005369
MTIF2
mitochondrial translational initiation factor 2
chr3_-_56477404 0.342 NM_015576
ERC2
ELKS/RAB6-interacting/CAST family member 2
chrX_+_56606686 0.338 NM_013444
UBQLN2
ubiquilin 2
chr1_+_93317374 0.337 NM_001164391
NM_001164392
NM_001164393
NM_007358
MTF2



metal response element binding transcription factor 2



chr19_-_14447122 0.334 PTGER1
prostaglandin E receptor 1 (subtype EP1), 42kDa
chr2_+_182464713 0.329 NM_001130445
NM_006751
SSFA2

sperm specific antigen 2

chr1_+_44185005 0.326 NM_014652
IPO13
importin 13
chr11_-_62213577 0.322 LRRN4CL
LRRN4 C-terminal like
chr1_-_224563461 0.320 LIN9
lin-9 homolog (C. elegans)
chrX_+_67635348 0.316 NM_001195214
NM_173834
YIPF6

Yip1 domain family, member 6

chr1_+_168898898 0.309 PRRX1
paired related homeobox 1
chr15_+_39310757 0.306 CHP
calcium binding protein P22
chr8_-_93176618 0.296 NM_001198629
NM_001198630
NM_001198632
NM_175635
RUNX1T1



runt-related transcription factor 1; translocated to, 1 (cyclin D-related)



chr10_-_14412813 0.296 NM_018027
FRMD4A
FERM domain containing 4A
chr15_-_56829069 0.290 ADAM10
ADAM metallopeptidase domain 10
chr4_-_16509354 0.279 LDB2
LIM domain binding 2
chr1_+_28935719 0.278 NM_001173128
NM_016258
YTHDF2

YTH domain family, member 2

chr5_+_150020595 0.278 NM_001122853
NM_133371
MYOZ3

myozenin 3

chr9_-_106705780 0.275 ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr9_+_33807168 0.273 NM_017811
UBE2R2
ubiquitin-conjugating enzyme E2R 2
chrX_-_107569256 0.271 NM_001847
COL4A6
collagen, type IV, alpha 6
chr7_-_99365178 0.269 NM_181538
GJC3
gap junction protein, gamma 3, 30.2kDa
chr21_+_44544392 0.268 PFKL
phosphofructokinase, liver
chr11_+_2279932 0.263 TSPAN32
tetraspanin 32
chr3_-_188936941 0.263 NM_001130845
BCL6
B-cell CLL/lymphoma 6
chr19_+_54621499 0.261 NM_001195256
LOC645971
hypothetical protein LOC645971
chr20_+_41621079 0.260 NM_170693
SGK2
serum/glucocorticoid regulated kinase 2
chr10_-_103864651 0.260 NM_003893
LDB1
LIM domain binding 1
chr15_-_66285427 0.255 NM_001031733
NM_033429
CALML4

calmodulin-like 4

chr4_-_16509446 0.254 NM_001130834
NM_001290
LDB2

LIM domain binding 2

chr10_+_104211134 0.253 TMEM180
transmembrane protein 180
chr11_-_74119833 0.251 NM_015424
CHRDL2
chordin-like 2
chr19_-_8581559 0.249 NM_030957
ADAMTS10
ADAM metallopeptidase with thrombospondin type 1 motif, 10
chr11_+_58668827 0.246 NM_022074
NM_198847
FAM111A

family with sequence similarity 111, member A

chr9_-_129679760 0.245 NM_000476
AK1
adenylate kinase 1
chr15_+_81907176 0.243 SH3GL3
SH3-domain GRB2-like 3
chr15_+_81906983 0.242 NM_003027
SH3GL3
SH3-domain GRB2-like 3
chr10_+_70553862 0.237 NM_001035260
NM_004896
VPS26A

vacuolar protein sorting 26 homolog A (S. pombe)

chr1_+_28936030 0.237 NM_001172828
YTHDF2
YTH domain family, member 2
chr19_-_242168 0.236 NM_177543
PPAP2C
phosphatidic acid phosphatase type 2C
chr7_-_94123308 0.235 SGCE
sarcoglycan, epsilon
chr11_+_10434056 0.233 NM_001025390
AMPD3
adenosine monophosphate deaminase 3
chr2_-_128155829 0.233 NM_001161404
LIMS2
LIM and senescent cell antigen-like domains 2
chr18_+_54682261 0.230 ZNF532
zinc finger protein 532
chr16_-_69277194 0.226 MTSS1L
metastasis suppressor 1-like
chr5_+_35892747 0.223 NM_002185
IL7R
interleukin 7 receptor
chr18_+_75388522 0.218 NFATC1
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
chr9_+_134843918 0.218 NM_001135031
NM_004188
GFI1B

growth factor independent 1B transcription repressor

chr7_+_36395913 0.217 NM_018685
ANLN
anillin, actin binding protein
chr9_-_125732005 0.214 NM_020946
NM_024820
DENND1A

DENN/MADD domain containing 1A

chr10_+_104211148 0.214 NM_024789
TMEM180
transmembrane protein 180
chr19_-_44518465 0.213 GMFG
glia maturation factor, gamma
chr15_+_89248423 0.213 NM_006122
MAN2A2
mannosidase, alpha, class 2A, member 2
chr15_+_72861767 0.211 CSK
c-src tyrosine kinase
chr11_-_74120077 0.210 CHRDL2
chordin-like 2
chr12_+_54947293 0.206 NM_001099337
COQ10A
coenzyme Q10 homolog A (S. cerevisiae)
chr21_+_44544381 0.206 PFKL
phosphofructokinase, liver
chrX_-_131918905 0.205 HS6ST2
heparan sulfate 6-O-sulfotransferase 2
chr10_+_75211810 0.204 NM_203298
CHCHD1
coiled-coil-helix-coiled-coil-helix domain containing 1
chr11_-_76800525 0.201 PAK1
p21 protein (Cdc42/Rac)-activated kinase 1
chr1_-_31003260 0.199 NM_006762
LAPTM5
lysosomal protein transmembrane 5
chrX_+_24077649 0.197 NM_001178086
NM_001178095
NM_001178084
NM_001178085
NM_003410
ZFX




zinc finger protein, X-linked




chrX_+_152252738 0.196 NM_001080485
ZNF275
zinc finger protein 275
chr10_-_35143900 0.196 NM_001184785
NM_001184786
NM_001184787
NM_001184788
NM_001184789
NM_001184790
NM_001184791
NM_001184792
NM_001184793
NM_001184794
NM_019619
PARD3










par-3 partitioning defective 3 homolog (C. elegans)










chr3_+_143925904 0.195 NM_003304
TRPC1
transient receptor potential cation channel, subfamily C, member 1
chr11_-_65244486 0.195 RNASEH2C
ribonuclease H2, subunit C
chr4_-_16509126 0.193 LDB2
LIM domain binding 2
chr19_-_55914837 0.192


chr7_+_8440109 0.191 NM_152745
NXPH1
neurexophilin 1
chr13_+_28131279 0.188 POMP
proteasome maturation protein
chrX_-_85189194 0.183 NM_000390
NM_001145414
CHM

choroideremia (Rab escort protein 1)

chr3_-_120878910 0.182 NM_005694
COX17
COX17 cytochrome c oxidase assembly homolog (S. cerevisiae)
chr3_+_188131209 0.180 ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr17_-_8004671 0.179 VAMP2
vesicle-associated membrane protein 2 (synaptobrevin 2)
chr19_-_14447163 0.178 NM_000955
PTGER1
prostaglandin E receptor 1 (subtype EP1), 42kDa
chr11_+_68614059 0.177


chrX_-_133757901 0.176 NM_001170756
NM_145284
FAM122B

family with sequence similarity 122B

chr13_+_28131140 0.169 NM_015932
POMP
proteasome maturation protein
chr19_+_54883732 0.167 NM_001101340
C19orf76
chromosome 19 open reading frame 76
chr16_-_45565068 0.165 NM_005880
DNAJA2
DnaJ (Hsp40) homolog, subfamily A, member 2
chr11_+_2279812 0.165 NM_139022
TSPAN32
tetraspanin 32
chr15_+_39310693 0.165 NM_007236
CHP
calcium binding protein P22
chr3_+_171558215 0.164 SKIL
SKI-like oncogene
chr6_-_32251877 0.164 NM_006411
AGPAT1
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
chr21_+_44544349 0.160 NM_002626
PFKL
phosphofructokinase, liver
chr16_-_67723511 0.160 NM_001040146
CHTF8
CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)
chr12_+_92295738 0.156 NM_019094
NM_199040
NUDT4

NUDT4P1
nudix (nucleoside diphosphate linked moiety X)-type motif 4

nudix (nucleoside diphosphate linked moiety X)-type motif 4 pseudogene 1
chr12_+_44409762 0.155 NM_152641
ARID2
AT rich interactive domain 2 (ARID, RFX-like)
chr2_-_104834344 0.154 LOC100506421
hypothetical LOC100506421
chr3_+_33130563 0.152 CRTAP
cartilage associated protein
chr12_+_54947180 0.152 COQ10A
coenzyme Q10 homolog A (S. cerevisiae)
chr2_+_79593679 0.151 CTNNA2
catenin (cadherin-associated protein), alpha 2
chr10_+_70553936 0.149 VPS26A
vacuolar protein sorting 26 homolog A (S. pombe)
chrX_+_133758108 0.149 NM_001170780
FAM122C
family with sequence similarity 122C
chr3_+_188130967 0.148 NM_173216
NM_173217
ST6GAL1

ST6 beta-galactosamide alpha-2,6-sialyltranferase 1

chr11_+_10433241 0.148 NM_001025389
AMPD3
adenosine monophosphate deaminase 3
chr6_-_130578110 0.148 NM_152552
SAMD3
sterile alpha motif domain containing 3
chr20_+_41621119 0.147 SGK2
serum/glucocorticoid regulated kinase 2
chr3_+_33130451 0.147 NM_006371
CRTAP
cartilage associated protein
chr14_-_99016833 0.147 SETD3
SET domain containing 3
chr20_+_10147455 0.146 NM_003081
NM_130811
SNAP25

synaptosomal-associated protein, 25kDa

chr10_-_103864579 0.145 LDB1
LIM domain binding 1
chr12_+_44409743 0.144 ARID2
AT rich interactive domain 2 (ARID, RFX-like)
chr5_+_137701601 0.141 NM_016605
FAM53C
family with sequence similarity 53, member C
chr12_-_91346054 0.141 NM_001025232
CLLU1OS
chronic lymphocytic leukemia up-regulated 1 opposite strand
chr19_+_60487345 0.140 NM_032430
BRSK1
BR serine/threonine kinase 1

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.