Motif ID: TLX2.p2

Z-value: 1.376


Transcription factors associated with TLX2.p2:

Gene SymbolEntrez IDGene Name
TLX2 3196 T-cell leukemia homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TLX2chr2_+_745940930.244.0e-01Click!


Activity profile for motif TLX2.p2.

activity profile for motif TLX2.p2


Sorted Z-values histogram for motif TLX2.p2

Sorted Z-values for motif TLX2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TLX2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_73810383 1.408 NM_001906
 CTRB1
CTRB2
chymotrypsinogen B1
chymotrypsinogen B2
chr12_+_55018925 1.386 NM_016584
 IL23A
interleukin 23, alpha subunit p19
chr11_-_83071084 1.205 NM_001142702
 DLG2
discs, large homolog 2 (Drosophila)
chr7_+_31693155 1.203 NM_001145123
NM_006658
 C7orf16

chromosome 7 open reading frame 16

chr9_+_94766379 1.165 FGD3
FYVE, RhoGEF and PH domain containing 3
chr1_-_155834357 1.082 NM_031282
 FCRL4
Fc receptor-like 4
chr6_-_41114905 1.068 NM_173561
 UNC5CL
unc-5 homolog C (C. elegans)-like
chr19_-_6671585 1.048 NM_000064
 C3
complement component 3
chr1_-_26553168 1.041 NM_001039775
 AIM1L
absent in melanoma 1-like
chr2_+_97696462 0.980 NM_001079
 ZAP70
zeta-chain (TCR) associated protein kinase 70kDa
chr16_-_70763524 0.979 NM_031293
 PMFBP1
polyamine modulated factor 1 binding protein 1
chr1_-_25164061 0.953 NM_001031680
 RUNX3
runt-related transcription factor 3
chr6_+_167445284 0.938 NM_004367
 CCR6
chemokine (C-C motif) receptor 6
chr11_-_60880799 0.925 NM_001161452
 CYBASC3
cytochrome b, ascorbate dependent 3
chr10_-_97190885 0.895 NM_001034954
NM_001034955
NM_001034956
NM_001034957
NM_006434
 SORBS1




sorbin and SH3 domain containing 1




chr20_-_34707971 0.891 NM_032214
NM_175077
 SLA2

Src-like-adaptor 2

chr19_-_56612653 0.886 NM_001171156
NM_001171157
NM_001171158
NM_001171159
NM_001171160
NM_001171161
NM_033130
 SIGLEC10






sialic acid binding Ig-like lectin 10






chr1_+_159032551 0.877 NM_001033667
NM_002348
 LY9

lymphocyte antigen 9

chr7_-_99411573 0.864 NM_001185
 AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr8_-_27997306 0.833 NM_001010906
 C8orf80
chromosome 8 open reading frame 80

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 14 of 14 entries
enrichment   p-value GO term description
2.73 2.62e-02 GO:0050852 T cell receptor signaling pathway
2.49 1.83e-02 GO:0002429 immune response-activating cell surface receptor signaling pathway
2.39 4.00e-02 GO:0002768 immune response-regulating cell surface receptor signaling pathway
2.12 1.35e-02 GO:0002757 immune response-activating signal transduction
2.07 2.43e-02 GO:0002764 immune response-regulating signaling pathway
2.05 4.01e-03 GO:0002253 activation of immune response
1.69 1.25e-02 GO:0050776 regulation of immune response
1.62 1.90e-04 GO:0006955 immune response
1.59 2.48e-03 GO:0002682 regulation of immune system process
1.51 3.77e-02 GO:0006915 apoptosis
1.50 4.29e-05 GO:0002376 immune system process
1.50 4.43e-02 GO:0012501 programmed cell death
1.39 1.93e-02 GO:0009893 positive regulation of metabolic process
1.27 2.48e-03 GO:0048518 positive regulation of biological process

Gene overrepresentation in compartment category:

Showing 1 to 5 of 5 entries
enrichment   p-value GO term description
5.32 1.33e-02 GO:0042613 MHC class II protein complex
2.62 4.44e-02 GO:0016459 myosin complex
1.69 4.98e-02 GO:0015629 actin cytoskeleton
1.27 3.91e-03 GO:0044459 plasma membrane part
1.25 2.13e-02 GO:0005829 cytosol

Gene overrepresentation in function category:

Showing 1 to 1 of 1 entries
enrichment   p-value GO term description
1.12 8.64e-03 GO:0005515 protein binding