Motif ID: TBX4,5.p2

Z-value: 1.564


Transcription factors associated with TBX4,5.p2:

Gene SymbolEntrez IDGene Name
TBX4 9496 T-box 4
TBX5 6910 T-box 5

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TBX4chr17_+_56884560-0.401.4e-01Click!
TBX5chr12_-_113330574-0.361.9e-01Click!


Activity profile for motif TBX4,5.p2.

activity profile for motif TBX4,5.p2


Sorted Z-values histogram for motif TBX4,5.p2

Sorted Z-values for motif TBX4,5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TBX4,5.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_-_76538859 2.298 NM_001007271
NM_001007272
NM_001007273
DUSP13


dual specificity phosphatase 13


chr1_+_149221122 1.985 NM_003568
ANXA9
annexin A9
chr15_-_41879426 1.846 NM_001033517
SERINC4
serine incorporator 4
chr12_+_130004404 1.829 NM_198827
GPR133
G protein-coupled receptor 133
chr19_+_7647934 1.723 NM_174918
C19orf59
chromosome 19 open reading frame 59
chr6_+_31731647 1.712 NM_019101
APOM
apolipoprotein M
chr7_+_139750311 1.536 NM_001008749
RAB19
RAB19, member RAS oncogene family
chr1_-_205161821 1.471 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr17_+_22823151 1.450 NM_014238
KSR1
kinase suppressor of ras 1
chr17_+_53769562 1.421 LOC100506779
hypothetical LOC100506779
chr6_-_3102690 1.379 NM_001069
TUBB2A
tubulin, beta 2A
chr22_+_18447732 1.253 NM_001190326
NM_022720
DGCR8

DiGeorge syndrome critical region gene 8

chr1_+_26609819 1.253 NM_024674
LIN28A
lin-28 homolog A (C. elegans)
chr11_-_65070625 1.243 LTBP3
latent transforming growth factor beta binding protein 3
chr2_-_96924582 1.230 NM_001172667
FAM178B
family with sequence similarity 178, member B
chr22_+_37823174 1.209 NM_001166002
NM_001166003
NM_001166004
NM_181773
APOBEC3H



apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H



chr6_+_31651319 1.186 NM_000594
TNF
tumor necrosis factor
chr20_-_30703219 1.148 NM_182584
C20orf203
chromosome 20 open reading frame 203
chr11_+_61279436 1.142 NM_013279
C11orf9
chromosome 11 open reading frame 9
chr6_+_31731667 1.140 APOM
apolipoprotein M
chr6_+_26476384 1.137 NM_001197246
BTN3A2
butyrophilin, subfamily 3, member A2
chr14_+_20580224 1.136 NM_032572
RNASE7
ribonuclease, RNase A family, 7
chr17_+_31455332 1.123 NM_002984
CCL4
chemokine (C-C motif) ligand 4
chr15_+_41879912 1.086 NM_016400
C15orf63
chromosome 15 open reading frame 63
chr14_-_20128721 1.080 NM_001024822
RNASE12
ribonuclease, RNase A family, 12 (non-active)
chr11_-_33870411 1.045 NM_005574
LMO2
LIM domain only 2 (rhombotin-like 1)
chr11_+_67532592 1.038 NM_001161473
ALDH3B1
aldehyde dehydrogenase 3 family, member B1
chr16_+_48865521 1.022 ADCY7
adenylate cyclase 7
chr1_+_9522107 0.999 NM_032315
SLC25A33
solute carrier family 25, member 33
chr11_-_118405288 0.990 NM_001164280
SLC37A4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr19_-_10074332 0.989 NM_031917
ANGPTL6
angiopoietin-like 6
chr22_+_33792125 0.984 NM_001008494
ISX
intestine-specific homeobox
chr20_+_58064360 0.975 NM_173644
C20orf197
chromosome 20 open reading frame 197
chr1_+_43661383 0.971 NM_015284
KIAA0467
KIAA0467
chr9_-_103237851 0.965 NM_000035
ALDOB
aldolase B, fructose-bisphosphate
chr1_+_46413335 0.950 NM_005727
TSPAN1
tetraspanin 1
chr17_-_3408038 0.934 NM_145068
TRPV3
transient receptor potential cation channel, subfamily V, member 3
chr2_+_220033777 0.908 NM_001173476
SPEG
SPEG complex locus
chr3_-_49701085 0.901 NM_020998
MST1
macrophage stimulating 1 (hepatocyte growth factor-like)
chr9_-_34387786 0.893 NM_032596
C9orf24
chromosome 9 open reading frame 24
chr1_+_157441133 0.886 NM_002036
DARC
Duffy blood group, chemokine receptor
chr19_-_60272708 0.878 NM_138412
RDH13
retinol dehydrogenase 13 (all-trans/9-cis)
chr4_+_661710 0.877 NM_002477
MYL5
myosin, light chain 5, regulatory
chr20_-_44612619 0.875 NM_080721
C20orf123
chromosome 20 open reading frame 123
chr1_+_26609893 0.868 LIN28A
lin-28 homolog A (C. elegans)
chr20_-_43177137 0.868 NM_145652
WFDC5
WAP four-disulfide core domain 5
chr17_-_6958282 0.863 NM_080914
ASGR2
asialoglycoprotein receptor 2
chr14_+_94148466 0.852 NM_001085
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr11_+_93394025 0.850 NM_001098672
HEPHL1
hephaestin-like 1
chr1_+_166516901 0.850 NM_005149
TBX19
T-box 19
chr19_-_43919428 0.822 CAPN12
calpain 12
chr1_+_17719405 0.797 ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr1_-_36721010 0.795 CSF3R
colony stimulating factor 3 receptor (granulocyte)
chr7_-_150960086 0.789 NM_024429
PRKAG2
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr17_+_4621924 0.785 NM_003963
TM4SF5
transmembrane 4 L six family member 5
chr1_-_36721501 0.784 NM_000760
NM_156039
NM_172313
CSF3R


colony stimulating factor 3 receptor (granulocyte)


chr6_+_31691745 0.783 NM_032955
AIF1
allograft inflammatory factor 1
chr5_-_39238818 0.773 FYB
FYN binding protein
chr20_+_61963009 0.760 NM_080622
ABHD16B
abhydrolase domain containing 16B
chr1_+_15935395 0.760 NM_207348
SLC25A34
solute carrier family 25, member 34
chr17_-_3407780 0.756 TRPV3
transient receptor potential cation channel, subfamily V, member 3
chr17_-_40858775 0.753 NM_199282
ARHGAP27
Rho GTPase activating protein 27
chr7_-_150604752 0.743 NM_001003802
SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr11_-_118055564 0.742 NM_007180
TREH
trehalase (brush-border membrane glycoprotein)
chrX_-_62564934 0.737 LOC92249
hypothetical LOC92249
chr12_+_6292077 0.734 NM_001144857
PLEKHG6
pleckstrin homology domain containing, family G (with RhoGef domain) member 6
chr7_-_135063461 0.732 NM_012450
SLC13A4
solute carrier family 13 (sodium/sulfate symporters), member 4
chr2_+_219453487 0.728 NM_025216
WNT10A
wingless-type MMTV integration site family, member 10A
chr16_+_73810383 0.728 NM_001906
CTRB1
CTRB2
chymotrypsinogen B1
chymotrypsinogen B2
chr11_-_16387001 0.728 NM_001145811
SOX6
SRY (sex determining region Y)-box 6
chr11_+_61204392 0.725 NM_006133
DAGLA
diacylglycerol lipase, alpha
chr17_-_59349867 0.721 NM_000515
NM_022559
NM_022560
NM_022561
NM_022562
GH1




growth hormone 1




chr7_+_142723340 0.721 NM_000083
CLCN1
chloride channel 1, skeletal muscle
chr8_+_21968375 0.720 EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr11_+_70926718 0.707 NM_021046
KRTAP5-8
keratin associated protein 5-8
chr19_-_4131778 0.706 SIRT6
sirtuin 6
chr5_+_132037271 0.704 NM_000589
NM_172348
IL4

interleukin 4

chr19_-_14748655 0.703 EMR2
egf-like module containing, mucin-like, hormone receptor-like 2
chr8_+_21968273 0.701 NM_001114136
NM_001114139
EPB49

erythrocyte membrane protein band 4.9 (dematin)

chr22_-_31732648 0.695 NM_003490
NM_133633
SYN3

synapsin III

chr1_-_20374273 0.693 NM_001105572
PLA2G2C
phospholipase A2, group IIC
chr1_-_30977931 0.691 LAPTM5
lysosomal protein transmembrane 5
chr14_+_20595820 0.684 NM_138331
RNASE8
ribonuclease, RNase A family, 8
chr8_-_38324809 0.668 WHSC1L1
Wolf-Hirschhorn syndrome candidate 1-like 1
chr6_-_167491305 0.660 NM_005299
GPR31
G protein-coupled receptor 31
chr6_-_130578110 0.660 NM_152552
SAMD3
sterile alpha motif domain containing 3
chr1_-_200395741 0.660 NM_080588
PTPN7
protein tyrosine phosphatase, non-receptor type 7
chr17_-_59304729 0.646 NM_020991
NM_022644
NM_022645
CSH2


chorionic somatomammotropin hormone 2


chr5_+_71438796 0.646 NM_005909
MAP1B
microtubule-associated protein 1B
chr4_-_186970366 0.645 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr11_+_67567022 0.645 NM_006053
TCIRG1
T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
chr2_+_218992053 0.643 NM_007127
VIL1
villin 1
chr19_-_14771947 0.637 NM_198944
OR7C1
olfactory receptor, family 7, subfamily C, member 1
chr17_+_31562577 0.635 NM_207007
NM_001001435
CCL4L2
CCL4L1
chemokine (C-C motif) ligand 4-like 2
chemokine (C-C motif) ligand 4-like 1
chr11_+_183079 0.633 NM_145651
SCGB1C1
secretoglobin, family 1C, member 1
chr14_+_22422270 0.631 NM_173527
REM2
RAS (RAD and GEM)-like GTP binding 2
chr8_-_144726064 0.629 NM_001100878
C8orf73
chromosome 8 open reading frame 73
chr7_-_150283794 0.622 NM_172057
KCNH2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr15_-_41346346 0.617 NM_004245
NM_201631
TGM5

transglutaminase 5

chr7_+_147667461 0.615 CNTNAP2
contactin associated protein-like 2
chr19_-_56567602 0.612 NM_005601
NKG7
natural killer cell group 7 sequence
chr11_+_70915960 0.609 NM_001012503
KRTAP5-7
keratin associated protein 5-7
chr10_+_82287637 0.607 NM_207372
SH2D4B
SH2 domain containing 4B
chr19_+_6415259 0.606 NM_139161
NM_174881
CRB3

crumbs homolog 3 (Drosophila)

chr1_+_200439486 0.603 NM_021636
LGR6
leucine-rich repeat containing G protein-coupled receptor 6
chr3_+_10832867 0.603 NM_014229
SLC6A11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr7_-_128330615 0.603 KCP
kielin/chordin-like protein
chr12_+_53241365 0.600 NM_001165975
PDE1B
phosphodiesterase 1B, calmodulin-dependent
chr6_-_41276901 0.598 NM_024807
TREML2
triggering receptor expressed on myeloid cells-like 2
chr6_-_41230003 0.591 NM_178174
TREML1
triggering receptor expressed on myeloid cells-like 1
chr10_-_99521701 0.583 NM_003015
SFRP5
secreted frizzled-related protein 5
chr1_-_43509187 0.576 EBNA1BP2
EBNA1 binding protein 2
chr1_+_204797079 0.572 NM_182665
RASSF5
Ras association (RalGDS/AF-6) domain family member 5
chr12_+_52665196 0.569 NM_017409
HOXC10
homeobox C10
chr13_-_99983945 0.565 NM_033110
A2LD1
AIG2-like domain 1
chr2_+_27046952 0.562 NM_012326
MAPRE3
microtubule-associated protein, RP/EB family, member 3
chr3_-_52235218 0.551 NM_017442
TLR9
toll-like receptor 9
chr11_+_118269310 0.543 NM_032966
CXCR5
chemokine (C-X-C motif) receptor 5
chr16_-_3082840 0.543 NM_032805
ZSCAN10
zinc finger and SCAN domain containing 10
chr17_-_59312892 0.542 NM_002059
NM_022556
NM_022557
NM_022558
GH2



growth hormone 2



chr1_-_27825633 0.540 NM_001042729
FGR
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
chr3_-_10307408 0.540 NM_001134941
NM_016362
GHRL

ghrelin/obestatin prepropeptide

chr17_+_42641712 0.537 NM_002476
MYL4
myosin, light chain 4, alkali; atrial, embryonic
chr6_+_167456230 0.537 NM_031409
CCR6
chemokine (C-C motif) receptor 6
chr3_+_139211639 0.534 NM_016369
CLDN18
claudin 18
chr8_+_145700272 0.533 NM_005309
GPT
glutamic-pyruvate transaminase (alanine aminotransferase)
chr1_-_172153087 0.532 NM_000488
SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr1_-_111848265 0.532 NM_000677
NM_020683
ADORA3

adenosine A3 receptor

chr12_+_56435042 0.526 NM_138396
MARCH9
membrane-associated ring finger (C3HC4) 9
chr6_+_97479216 0.526 NM_052904
KLHL32
kelch-like 32 (Drosophila)
chr8_-_81155564 0.526 NM_001025252
TPD52
tumor protein D52
chr1_-_46789473 0.525 NM_001097611
KNCN
kinocilin
chr1_-_151587645 0.525 NM_020393
PGLYRP4
peptidoglycan recognition protein 4
chr6_+_42991704 0.525 NM_138296
PTCRA
pre T-cell antigen receptor alpha
chr6_+_32090516 0.524 NM_007293
NM_001002029
C4A
C4B
complement component 4A (Rodgers blood group)
complement component 4B (Chido blood group)
chr16_-_4778317 0.523 NM_001154458
NM_144605
SEPT12

septin 12

chr22_+_23153529 0.523 NM_000675
ADORA2A
adenosine A2a receptor
chr7_+_50318801 0.519 IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr20_-_44713466 0.517 NM_001193339
NM_001193342
NM_022829
SLC13A3


solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3


chr7_-_155019299 0.515 NM_001103176
CNPY1
canopy 1 homolog (zebrafish)
chr1_-_20122638 0.512 NM_014589
PLA2G2E
phospholipase A2, group IIE
chr19_-_43800374 0.512 NM_001042600
NM_007181
MAP4K1

mitogen-activated protein kinase kinase kinase kinase 1

chr5_+_175597943 0.509 NM_198567
C5orf25
chromosome 5 open reading frame 25
chr9_-_122716670 0.506 NM_001190947
TRAF1
TNF receptor-associated factor 1
chr19_+_54530546 0.504 CD37
CD37 molecule
chr9_+_139241838 0.501 NM_001190228
LOC643596
hypothetical LOC643596
chr2_-_96873460 0.497 NM_144994
ANKRD23
ankyrin repeat domain 23
chr15_+_88120592 0.496 NM_001039958
MESP2
mesoderm posterior 2 homolog (mouse)
chrX_-_70248022 0.495 NM_000206
IL2RG
interleukin 2 receptor, gamma
chr10_+_44726635 0.495 NM_001123376
TMEM72
transmembrane protein 72
chr16_+_56134037 0.495 GPR114
G protein-coupled receptor 114
chr6_+_167445284 0.493 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr12_-_107551783 0.492 NM_003006
SELPLG
selectin P ligand
chr1_-_28375722 0.488 NM_001164723
PTAFR
platelet-activating factor receptor
chr1_+_204797120 0.487 RASSF5
Ras association (RalGDS/AF-6) domain family member 5
chr16_+_28785087 0.486 SH2B1
SH2B adaptor protein 1
chr19_+_15612706 0.485 NM_000896
CYP4F3
cytochrome P450, family 4, subfamily F, polypeptide 3
chr2_+_113389240 0.484 NM_173205
IL1F7
interleukin 1 family, member 7 (zeta)
chr3_+_48239865 0.483 NM_004345
CAMP
cathelicidin antimicrobial peptide
chr11_-_72057755 0.483 NM_001146209
PDE2A
phosphodiesterase 2A, cGMP-stimulated
chr5_+_140871107 0.483


chr1_-_28392966 0.483 NM_001164722
NM_001164721
PTAFR

platelet-activating factor receptor

chr1_+_204747486 0.482 NM_182663
NM_182664
RASSF5

Ras association (RalGDS/AF-6) domain family member 5

chr6_+_30958672 0.481 DDR1
discoidin domain receptor tyrosine kinase 1
chr19_-_14748623 0.479 EMR2
egf-like module containing, mucin-like, hormone receptor-like 2
chr1_-_181826086 0.477 NCF2
neutrophil cytosolic factor 2
chr16_+_68542126 0.474 NM_001136214
CLEC18A
C-type lectin domain family 18, member A
chr19_+_54530512 0.470 CD37
CD37 molecule
chr17_-_35327318 0.468 NM_018530
GSDMB
gasdermin B
chr12_-_116021473 0.466 NM_001168325
NM_017899
TESC

tescalcin

chr1_-_172153024 0.465 SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr20_-_52223918 0.465 NM_000782
NM_001128915
CYP24A1

cytochrome P450, family 24, subfamily A, polypeptide 1

chr5_-_177355848 0.463 NM_006261
PROP1
PROP paired-like homeobox 1
chr16_+_56211410 0.463 NM_001145770
NM_005682
GPR56

G protein-coupled receptor 56

chr6_-_41114905 0.462 NM_173561
UNC5CL
unc-5 homolog C (C. elegans)-like
chr9_-_138757175 0.460 NM_001001712
LCN10
lipocalin 10
chr19_+_55488632 0.458 MYH14
myosin, heavy chain 14, non-muscle
chr16_+_56134077 0.458 NM_153837
GPR114
G protein-coupled receptor 114
chr6_-_43586401 0.458 NM_001012974
C6orf154
chromosome 6 open reading frame 154
chr22_-_28992787 0.452 NM_020530
OSM
oncostatin M
chr12_-_51476047 0.450 NM_057088
KRT3
keratin 3
chr7_-_111633620 0.449 NM_014705
DOCK4
dedicator of cytokinesis 4
chr7_+_129807467 0.449 NM_001868
CPA1
carboxypeptidase A1 (pancreatic)
chr2_+_170298487 0.449


chr12_-_51173238 0.448 NM_005554
KRT6A
keratin 6A
chr1_-_200396328 0.447 PTPN7
protein tyrosine phosphatase, non-receptor type 7
chr1_-_10964680 0.446 NM_001170754
C1orf127
chromosome 1 open reading frame 127
chr11_+_70954256 0.444 NM_001012710
KRTAP5-10
keratin associated protein 5-10
chr14_+_23670514 0.442 NM_203402
FITM1
fat storage-inducing transmembrane protein 1
chr19_+_44478804 0.442 NM_172140
IL29
interleukin 29 (interferon, lambda 1)
chr19_+_54530458 0.441 CD37
CD37 molecule
chr1_-_27113018 0.441 NM_021969
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr1_+_144124547 0.441 NM_145277
NM_202004
NM_213652
NM_213653
HFE2



hemochromatosis type 2 (juvenile)



chr15_-_88095363 0.435 NM_018670
MESP1
mesoderm posterior 1 homolog (mouse)
chrX_+_122145776 0.435 NM_000828
NM_007325
GRIA3

glutamate receptor, ionotrophic, AMPA 3

chr22_+_27779877 0.435 ZNRF3
zinc and ring finger 3
chr1_-_20318578 0.432 NM_012400
PLA2G2D
phospholipase A2, group IID
chr17_+_35277942 0.431 NM_198844
NM_199321
ZPBP2

zona pellucida binding protein 2

chr2_+_238673689 0.430 NM_194312
ESPNL
espin-like
chr11_+_6216905 0.430 NM_001037329
CNGA4
cyclic nucleotide gated channel alpha 4

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.11 4.56e-03 GO:0065007 biological regulation
1.17 3.08e-02 GO:0023052 signaling
1.43 3.41e-02 GO:0007267 cell-cell signaling
1.37 3.54e-02 GO:0007154 cell communication

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.17 1.12e-03 GO:0005886 plasma membrane
1.17 1.36e-03 GO:0071944 cell periphery
1.24 2.94e-03 GO:0044459 plasma membrane part

Nothing significant found in function category.