Motif ID: TP53.p2

Z-value: 0.956


Transcription factors associated with TP53.p2:

Gene SymbolEntrez IDGene Name
TP53 7157 tumor protein p53

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TP53chr17_-_7531456-0.342.1e-01Click!


Activity profile for motif TP53.p2.

activity profile for motif TP53.p2


Sorted Z-values histogram for motif TP53.p2

Sorted Z-values for motif TP53.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TP53.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_5556923 2.093 NM_005185
CALML3
calmodulin-like 3
chr1_+_3597092 1.862 NM_001126240
NM_001126241
NM_001126242
TP73


tumor protein p73


chr19_+_17766907 0.900 NM_014256
B3GNT3
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
chr20_-_60435983 0.892 NM_080833
C20orf151
chromosome 20 open reading frame 151
chr19_+_17766935 0.800 B3GNT3
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
chr8_-_145671947 0.782 FOXH1
forkhead box H1
chr2_+_113546365 0.687 NM_032556
IL1F10
interleukin 1 family, member 10 (theta)
chr16_-_66555449 0.684 NM_001145963
SLC12A4
solute carrier family 12 (potassium/chloride transporters), member 4
chr7_+_72206961 0.677 GTF2IP1
general transcription factor IIi, pseudogene 1
chr9_-_114814286 0.662 NM_001101338
ZNF883
zinc finger protein 883
chr1_-_25619863 0.658 NM_020485
NM_138616
NM_138617
NM_138618
RHCE



RHD
Rh blood group, CcEe antigens



Rh blood group, D antigen
chr19_+_44379440 0.627 NM_001001414
NCCRP1
non-specific cytotoxic cell receptor protein 1 homolog (zebrafish)
chr4_+_48683021 0.593 NM_025087
CWH43
cell wall biogenesis 43 C-terminal homolog (S. cerevisiae)
chr19_+_15644885 0.589 NM_023944
CYP4F12
cytochrome P450, family 4, subfamily F, polypeptide 12
chr7_-_74291367 0.585 GTF2IP1
general transcription factor IIi, pseudogene 1
chr2_+_74610666 0.583 HTRA2
HtrA serine peptidase 2
chr4_-_40211324 0.569 RBM47
RNA binding motif protein 47
chr20_-_62151216 0.566 NM_018419
SOX18
SRY (sex determining region Y)-box 18
chr16_+_56211410 0.549 NM_001145770
NM_005682
GPR56

G protein-coupled receptor 56

chr16_-_14695930 0.548 NM_003561
PLA2G10
phospholipase A2, group X
chr19_+_17766609 0.532 B3GNT3
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
chr22_-_29231597 0.512 NM_001161368
NM_174977
SEC14L4

SEC14-like 4 (S. cerevisiae)

chr1_+_25471470 0.500 NM_001127691
NM_016124
RHD

Rh blood group, D antigen

chr9_-_137992967 0.485 NM_016172
UBAC1
UBA domain containing 1
chr1_+_149851112 0.460


chr16_+_56211150 0.449 GPR56
G protein-coupled receptor 56
chr21_+_45649429 0.447 NM_130445
COL18A1
collagen, type XVIII, alpha 1
chr19_-_12807221 0.430 NM_031429
RTBDN
retbindin
chr2_+_74610751 0.421 HTRA2
HtrA serine peptidase 2
chr20_+_4077409 0.419 NM_175839
NM_175840
NM_175841
NM_175842
SMOX



spermine oxidase



chr1_-_52936611 0.416 NM_023077
C1orf163
chromosome 1 open reading frame 163
chr4_+_41631862 0.407 NM_018126
TMEM33
transmembrane protein 33
chr1_-_52936573 0.406 C1orf163
chromosome 1 open reading frame 163
chr2_+_74610635 0.404 HTRA2
HtrA serine peptidase 2
chr1_-_52936602 0.401 C1orf163
chromosome 1 open reading frame 163
chr2_+_74610624 0.396 HTRA2
HtrA serine peptidase 2
chr3_-_44494160 0.394 NM_181489
ZNF445
zinc finger protein 445
chrX_+_152565849 0.388 DUSP9
dual specificity phosphatase 9
chr15_+_38319326 0.381 NM_020168
PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr1_-_54256390 0.380 NM_001010978
LDLRAD1
low density lipoprotein receptor class A domain containing 1
chr22_-_18687511 0.371 NM_033257
DGCR6L
DiGeorge syndrome critical region gene 6-like
chr19_+_48772791 0.370 NM_001193621
LOC390940
hypothetical protein LOC390940
chr19_-_60382529 0.367 SYT5
synaptotagmin V
chr11_-_47356479 0.365 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr2_-_26058941 0.363 NM_002254
KIF3C
kinesin family member 3C
chr1_+_11718764 0.363 AGTRAP
angiotensin II receptor-associated protein
chr1_+_32417909 0.362 NM_175852
TXLNA
taxilin alpha
chr3_-_42892195 0.359 CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr11_-_47356672 0.354 NM_001080547
NM_003120
SPI1

spleen focus forming virus (SFFV) proviral integration oncogene spi1

chr1_+_149851287 0.352 SNX27
sorting nexin family member 27
chr15_-_40173949 0.351 NM_178034
PLA2G4D
phospholipase A2, group IVD (cytosolic)
chr11_-_128567302 0.345 NM_001142685
ARHGAP32
Rho GTPase activating protein 32
chr3_-_150993299 0.345 NM_001144960
C3orf16
chromosome 3 open reading frame 16
chr10_+_11824361 0.345 NM_024693
ECHDC3
enoyl CoA hydratase domain containing 3
chr7_-_72380020 0.344 NM_178125
TRIM50
tripartite motif containing 50
chr11_-_47356642 0.343 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr8_-_22982435 0.342 NM_003842
NM_147187
TNFRSF10B

tumor necrosis factor receptor superfamily, member 10b

chr7_-_72077805 0.342 NM_198853
TRIM73
TRIM74
tripartite motif containing 73
tripartite motif containing 74
chr11_+_118544625 0.341 NM_024618
NM_170722
NLRX1

NLR family member X1

chr1_+_41217555 0.340 NM_001905
CTPS
CTP synthase
chr1_+_11718798 0.340 AGTRAP
angiotensin II receptor-associated protein
chr22_+_23753940 0.334 NM_001145206
KIAA1671
KIAA1671
chr1_+_149851138 0.331 NM_030918
SNX27
sorting nexin family member 27
chr5_-_141041982 0.329 NM_022481
ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr12_+_67489063 0.329 MDM2
Mdm2 p53 binding protein homolog (mouse)
chr20_+_36643251 0.327 NM_001018082
ADIG
adipogenin
chr1_+_45578464 0.326 TOE1
target of EGR1, member 1 (nuclear)
chr3_+_184898234 0.323 NM_018023
YEATS2
YEATS domain containing 2
chr20_+_4077466 0.321 SMOX
spermine oxidase
chr11_-_47356650 0.319 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr3_-_44494108 0.319 ZNF445
zinc finger protein 445
chr19_+_49866563 0.318 NM_001127893
NM_020219
CEACAM19

carcinoembryonic antigen-related cell adhesion molecule 19

chr6_+_24511123 0.318 NM_020662
MRS2
MRS2 magnesium homeostasis factor homolog (S. cerevisiae)
chr2_-_242096673 0.315 NM_006374
STK25
serine/threonine kinase 25
chr13_-_99422163 0.312 NM_033132
ZIC5
Zic family member 5 (odd-paired homolog, Drosophila)
chr11_-_47356562 0.309 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr22_+_21852551 0.308 NM_004327
NM_021574
BCR

breakpoint cluster region

chr7_-_100091912 0.306 ACTL6B
actin-like 6B
chr19_-_5741913 0.297 DUS3L
dihydrouridine synthase 3-like (S. cerevisiae)
chrX_-_153716130 0.294 NM_001162936
LOC100132963
hypothetical protein LOC100132963
chr3_+_44354594 0.294 NM_001029840
C3orf23
chromosome 3 open reading frame 23
chr21_-_42172476 0.289 NM_001040424
NM_022115
PRDM15

PR domain containing 15

chr20_-_52223918 0.287 NM_000782
NM_001128915
CYP24A1

cytochrome P450, family 24, subfamily A, polypeptide 1

chr2_-_26058831 0.286 KIF3C
kinesin family member 3C
chr19_+_7859380 0.285 NM_025061
LRRC8E
leucine rich repeat containing 8 family, member E
chr8_-_145672525 0.285 NM_003923
FOXH1
forkhead box H1
chrX_+_134306337 0.283 NM_152695
ZNF449
zinc finger protein 449
chr8_+_145692916 0.281 NM_032902
PPP1R16A
protein phosphatase 1, regulatory (inhibitor) subunit 16A
chr14_-_22693333 0.281 NM_182728
SLC7A8
solute carrier family 7 (amino acid transporter, L-type), member 8
chr22_-_16637194 0.281 BID
BH3 interacting domain death agonist
chr22_-_16637221 0.280 BID
BH3 interacting domain death agonist
chr20_+_34667566 0.280 NM_018840
NM_199483
C20orf24

chromosome 20 open reading frame 24

chr11_+_93917214 0.280 FUT4
fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
chr5_+_176446425 0.280 NM_002011
NM_213647
FGFR4

fibroblast growth factor receptor 4

chr19_-_47438384 0.277 GSK3A
glycogen synthase kinase 3 alpha
chr19_+_54149963 0.275 BAX
BCL2-associated X protein
chr3_-_186454509 0.274 NM_001166415
NM_001966
EHHADH

enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase

chr14_-_76807302 0.272 NM_021257
NGB
neuroglobin
chr20_-_47238310 0.272 NM_001037328
NM_004602
NM_017452
NM_017453
NM_017454
STAU1




staufen, RNA binding protein, homolog 1 (Drosophila)




chr20_+_34667590 0.272 C20orf24
chromosome 20 open reading frame 24
chr16_-_56389176 0.272 NM_001130099
KIFC3
kinesin family member C3
chr19_-_6542012 0.270 CD70
CD70 molecule
chr2_-_120697382 0.270 TMEM185B
transmembrane protein 185B (pseudogene)
chr10_+_72102563 0.270 NM_080722
NM_139155
ADAMTS14

ADAM metallopeptidase with thrombospondin type 1 motif, 14

chr12_-_14612057 0.270 NM_024829
PLBD1
phospholipase B domain containing 1
chr22_-_16637160 0.269 BID
BH3 interacting domain death agonist
chr22_-_21231421 0.268 NM_206955
NM_206956
NM_006115
NM_206953
NM_206954
PRAME




preferentially expressed antigen in melanoma




chr19_-_8670054 0.266 NM_178525
ACTL9
actin-like 9
chr13_-_113192986 0.266 NM_001014283
DCUN1D2
DCN1, defective in cullin neddylation 1, domain containing 2 (S. cerevisiae)
chr5_-_141041933 0.263 ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chrX_+_38548316 0.258 MID1IP1
MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))
chr2_+_74610494 0.257 HTRA2
HtrA serine peptidase 2
chr2_-_241484245 0.256 NM_001085437
C2orf54
chromosome 2 open reading frame 54
chr1_-_10455100 0.254 DFFA
DNA fragmentation factor, 45kDa, alpha polypeptide
chr7_-_100092003 0.253 NM_016188
ACTL6B
actin-like 6B
chr19_-_1062972 0.253 SBNO2
strawberry notch homolog 2 (Drosophila)
chr10_+_47216925 0.252 NM_001630
ANXA8L2
ANXA8
annexin A8-like 2
annexin A8
chr1_+_232107170 0.247 NM_173508
SLC35F3
solute carrier family 35, member F3
chr19_+_54149843 0.244 NM_004324
NM_138761
NM_138763
NM_138764
BAX



BCL2-associated X protein



chr1_-_43055631 0.242 NM_199342
CCDC23
coiled-coil domain containing 23
chr4_+_6835354 0.240 NM_001100590
NM_014743
KIAA0232

KIAA0232

chr7_-_74705276 0.240 NM_001145064
GATSL2
GATS protein-like 2
chr16_-_31054321 0.240 PRSS8
protease, serine, 8
chr10_-_46593923 0.239 NM_001040084
NM_001098845
ANXA8L2
LOC653110
ANXA8
ANXA8L1
annexin A8-like 2
hypothetical LOC653110
annexin A8
annexin A8-like 1
chr19_-_15869870 0.239 NM_001082
CYP4F2
cytochrome P450, family 4, subfamily F, polypeptide 2
chr9_-_111300350 0.235 NM_001145368
NM_002829
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr1_+_27925054 0.235 NM_001143912
NM_001143913
NM_001143914
NM_001143915
NM_152660
FAM76A




family with sequence similarity 76, member A




chr1_+_114249549 0.235 DCLRE1B
DNA cross-link repair 1B
chr17_-_4879423 0.231 NM_001104577
NM_017986
GPR172B

G protein-coupled receptor 172B

chr18_+_27152049 0.231 NM_001942
DSG1
desmoglein 1
chrX_+_38548373 0.231 MID1IP1
MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))
chr15_+_76952356 0.228 MORF4L1
mortality factor 4 like 1
chr2_+_47021816 0.223 NM_020458
TTC7A
tetratricopeptide repeat domain 7A
chr1_+_11718715 0.220 NM_001040194
NM_001040195
NM_001040196
NM_001040197
NM_020350
AGTRAP




angiotensin II receptor-associated protein




chr4_-_9727384 0.218


chr7_+_72380090 0.218 NM_001135211
NM_003602
FKBP6

FK506 binding protein 6, 36kDa

chr1_+_149851289 0.217 SNX27
sorting nexin family member 27
chr7_+_43589163 0.217 NM_004760
STK17A
serine/threonine kinase 17a
chr9_+_118489394 0.216 NM_001099679
NM_012210
TRIM32

tripartite motif containing 32

chr22_+_27498628 0.214 NM_173510
CCDC117
coiled-coil domain containing 117
chr9_+_103200939 0.212 NM_003452
NM_197977
ZNF189

zinc finger protein 189

chr4_+_41632125 0.211 TMEM33
transmembrane protein 33
chr10_+_82163568 0.211 C10orf58
chromosome 10 open reading frame 58
chr20_+_4614796 0.206 NM_000311
NM_001080121
NM_001080122
NM_183079
NM_001080123
PRNP




prion protein




chr19_-_43406621 0.202 NM_001135155
NM_004647
DPF1

D4, zinc and double PHD fingers family 1

chr5_-_95323180 0.201 ELL2
elongation factor, RNA polymerase II, 2
chr14_+_96333434 0.201 NM_003384
VRK1
vaccinia related kinase 1
chr1_-_45578193 0.198 NM_001048174
NM_001048172
NM_001048173
NM_001048171
NM_001128425
NM_012222
MUTYH





mutY homolog (E. coli)





chr9_+_131974506 0.196 NM_014286
NCS1
neuronal calcium sensor 1
chr1_-_26070330 0.194 NM_178422
PAQR7
progestin and adipoQ receptor family member VII
chr10_+_50557689 0.193 NM_001042427
NM_182554
C10orf53

chromosome 10 open reading frame 53

chr1_+_13782838 0.191 NM_006474
NM_198389
PDPN

podoplanin

chr1_+_32417846 0.191 TXLNA
taxilin alpha
chr10_+_120853616 0.190 FAM45A
FAM45B
family with sequence similarity 45, member A
family with sequence similarity 45, member A pseudogene
chr17_+_73721871 0.189 NM_001012270
NM_001012271
NM_001168
BIRC5


baculoviral IAP repeat containing 5


chr3_+_185375263 0.188 NM_001025205
NM_004068
AP2M1

adaptor-related protein complex 2, mu 1 subunit

chr3_+_9919511 0.188 NM_001193380
NM_153480
IL17RE

interleukin 17 receptor E

chr19_-_6542082 0.186 CD70
CD70 molecule
chr17_-_59304729 0.186 NM_020991
NM_022644
NM_022645
CSH2


chorionic somatomammotropin hormone 2


chr4_+_6835363 0.185 KIAA0232
KIAA0232
chr1_+_32418234 0.185 TXLNA
taxilin alpha
chr22_+_18085990 0.185 SEPT5-GP1BB
SEPT5
SEPT5-GP1BB read-through transcript
septin 5
chr17_-_47590975 0.185 CA10
carbonic anhydrase X
chr17_-_4410565 0.185 NM_001122890
NM_153338
GGT6

gamma-glutamyltransferase 6

chr4_+_6835388 0.183 KIAA0232
KIAA0232
chr20_+_34667624 0.182 C20orf24
chromosome 20 open reading frame 24
chr1_+_45578370 0.180 TOE1
target of EGR1, member 1 (nuclear)
chr12_-_14887648 0.179 NM_021071
ART4
ADP-ribosyltransferase 4 (Dombrock blood group)
chr5_-_95323353 0.179 NM_012081
ELL2
elongation factor, RNA polymerase II, 2
chr16_-_10943803 0.179 DEXI
Dexi homolog (mouse)
chr17_+_28279283 0.178 TMEM98
transmembrane protein 98
chr12_+_22090399 0.175 NM_018686
CMAS
cytidine monophosphate N-acetylneuraminic acid synthetase
chr1_+_159760659 0.175 NM_002155
HSPA6
heat shock 70kDa protein 6 (HSP70B')
chr12_-_52980914 0.175 NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr22_-_37569962 0.173 NM_014293
NPTXR
neuronal pentraxin receptor
chr3_+_197951121 0.172 NM_002577
PAK2
p21 protein (Cdc42/Rac)-activated kinase 2
chr19_+_45811647 0.170 LTBP4
latent transforming growth factor beta binding protein 4
chr17_-_73640082 0.170 NM_007267
TMC6
transmembrane channel-like 6
chr3_+_44355217 0.168 C3orf23
chromosome 3 open reading frame 23
chr19_-_14089560 0.168 PRKACA
protein kinase, cAMP-dependent, catalytic, alpha
chr10_+_120853548 0.167 FAM45A
family with sequence similarity 45, member A
chr20_-_44713466 0.167 NM_001193339
NM_001193342
NM_022829
SLC13A3


solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3


chr12_-_14611820 0.166 PLBD1
phospholipase B domain containing 1
chr19_+_1358664 0.166 DAZAP1
DAZ associated protein 1
chr19_+_54149941 0.165 BAX
BCL2-associated X protein
chr16_-_56789142 0.164 NM_001896
CSNK2A2
casein kinase 2, alpha prime polypeptide
chr1_+_32418395 0.163 TXLNA
taxilin alpha
chrX_-_15593074 0.163 NM_020665
TMEM27
transmembrane protein 27
chr1_+_154318954 0.162 LMNA
lamin A/C
chr4_+_103641585 0.161 NFKB1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr1_-_1233109 0.161 NM_030649
ACAP3
ArfGAP with coiled-coil, ankyrin repeat and PH domains 3
chr1_+_43084846 0.161 NM_015911
ZNF691
zinc finger protein 691
chr15_+_76952250 0.160 MORF4L1
mortality factor 4 like 1
chr5_-_10361167 0.160 NM_138809
CMBL
carboxymethylenebutenolidase homolog (Pseudomonas)
chr21_-_43671355 0.159 NM_173354
SIK1
salt-inducible kinase 1
chr15_-_62242352 0.157 NM_000942
PPIB
peptidylprolyl isomerase B (cyclophilin B)
chr17_+_12633504 0.156 NM_014859
ARHGAP44
Rho GTPase activating protein 44
chr11_+_45783216 0.155 NM_018389
SLC35C1
solute carrier family 35, member C1
chr7_+_100792841 0.152 NM_133457
EMID2
EMI domain containing 2
chr1_-_151775119 0.151 S100A6
S100 calcium binding protein A6

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.32 1.86e-06 GO:0044444 cytoplasmic part
1.70 3.36e-05 GO:0012505 endomembrane system
1.21 4.26e-05 GO:0005737 cytoplasm
1.51 8.89e-04 GO:0031090 organelle membrane
1.84 3.05e-03 GO:0031982 vesicle
1.84 5.06e-03 GO:0031410 cytoplasmic vesicle

Nothing significant found in function category.