Motif ID: HIC1.p2

Z-value: 4.999


Transcription factors associated with HIC1.p2:

Gene SymbolEntrez IDGene Name
HIC1 3090 hypermethylated in cancer 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HIC1chr17_+_19062620.803.9e-04Click!


Activity profile for motif HIC1.p2.

activity profile for motif HIC1.p2


Sorted Z-values histogram for motif HIC1.p2

Sorted Z-values for motif HIC1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HIC1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_48235148 5.983 NM_001194986
LOC388630
UPF0632 protein A
chr9_+_17568952 4.851 NM_003026
SH3GL2
SH3-domain GRB2-like 2
chr22_-_39964001 4.585 CHADL
chondroadherin-like
chr2_+_9532087 4.501 NM_001039613
IAH1
isoamyl acetate-hydrolyzing esterase 1 homolog (S. cerevisiae)
chr15_-_49174107 4.246 TNFAIP8L3
tumor necrosis factor, alpha-induced protein 8-like 3
chr16_+_2510323 4.228 NM_001145815
NM_015944
AMDHD2

amidohydrolase domain containing 2

chr3_+_53504070 4.194 NM_000720
NM_001128839
NM_001128840
CACNA1D


calcium channel, voltage-dependent, L type, alpha 1D subunit


chr7_+_154943466 3.934 NM_001427
EN2
engrailed homeobox 2
chr2_+_238200922 3.763 NM_001137550
LRRFIP1
leucine rich repeat (in FLII) interacting protein 1
chr6_+_137285071 3.712 NM_001008783
SLC35D3
solute carrier family 35, member D3
chr9_+_123501186 3.598 DAB2IP
DAB2 interacting protein
chr3_-_199291938 3.521 LOC348840
hypothetical LOC348840
chr13_+_95541093 3.421 NM_153456
HS6ST3
heparan sulfate 6-O-sulfotransferase 3
chr13_-_94162249 3.373 NM_007084
SOX21
SRY (sex determining region Y)-box 21
chr2_+_238060602 3.351 NM_001042467
NM_024101
MLPH

melanophilin

chr1_-_62557559 3.325 KANK4
KN motif and ankyrin repeat domains 4
chr2_-_233501069 3.287 NM_001114090
NGEF
neuronal guanine nucleotide exchange factor
chr18_-_68361742 3.256 CBLN2
cerebellin 2 precursor
chr13_-_20193739 3.148


chr5_+_76542461 3.139 NM_001029851
NM_001029852
NM_001029853
NM_001029854
NM_003719
PDE8B




phosphodiesterase 8B




chr2_+_120820140 3.062 NM_002193
INHBB
inhibin, beta B
chr15_+_99237527 3.058 NM_000693
ALDH1A3
aldehyde dehydrogenase 1 family, member A3
chr13_-_43259032 3.053 NM_017993
ENOX1
ecto-NOX disulfide-thiol exchanger 1
chr3_-_126414252 2.989 NM_024628
SLC12A8
solute carrier family 12 (potassium/chloride transporters), member 8
chr14_+_89597860 2.967 NM_022054
KCNK13
potassium channel, subfamily K, member 13
chr14_+_104226769 2.919 NM_001031714
NM_022489
NM_032714
INF2


inverted formin, FH2 and WH2 domain containing


chr2_-_112907577 2.899 NM_001164463
RGPD8
RGPD5
RANBP2-like and GRIP domain containing 8
RANBP2-like and GRIP domain containing 5
chr2_+_241586927 2.889 NM_001080437
SNED1
sushi, nidogen and EGF-like domains 1
chr1_-_62557655 2.848 NM_181712
KANK4
KN motif and ankyrin repeat domains 4
chr1_-_6162669 2.838 NM_015557
CHD5
chromodomain helicase DNA binding protein 5
chr20_-_17459973 2.821 NM_001195
BFSP1
beaded filament structural protein 1, filensin
chr20_-_61933012 2.821 ZBTB46
zinc finger and BTB domain containing 46
chr21_-_43671355 2.820 NM_173354
SIK1
salt-inducible kinase 1
chr11_-_45643711 2.795 NM_003654
CHST1
carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
chr8_+_145461356 2.746 NM_001008271
NM_001080514
SCXA
SCXB
scleraxis homolog A (mouse)
scleraxis homolog B (mouse)
chr22_+_47263919 2.693 NM_001082967
FAM19A5
family with sequence similarity 19 (chemokine (C-C motif)-like), member A5
chr10_+_116843108 2.676 NM_207303
ATRNL1
attractin-like 1
chr8_-_145090892 2.667 NM_201381
PLEC
plectin
chr7_-_131911808 2.634 NM_001105543
NM_020911
PLXNA4

plexin A4

chr18_+_29412538 2.605 NM_030632
ASXL3
additional sex combs like 3 (Drosophila)
chr20_-_24986501 2.597 ACSS1
acyl-CoA synthetase short-chain family member 1
chr16_+_705080 2.583 NM_024042
METRN
meteorin, glial cell differentiation regulator
chr11_-_110088097 2.575 ARHGAP20
Rho GTPase activating protein 20
chr15_-_27650218 2.569 NM_015307
FAM189A1
family with sequence similarity 189, member A1
chr4_+_19864332 2.566 NM_004787
SLIT2
slit homolog 2 (Drosophila)
chr20_+_60810610 2.549 NM_002531
NTSR1
neurotensin receptor 1 (high affinity)
chr4_-_1692776 2.529 NM_001127266
NM_138385
TMEM129

transmembrane protein 129

chr17_+_8865547 2.522 NM_004822
NTN1
netrin 1
chr3_+_53503626 2.494 CACNA1D
calcium channel, voltage-dependent, L type, alpha 1D subunit
chr12_+_20413445 2.479 NM_000921
PDE3A
phosphodiesterase 3A, cGMP-inhibited
chr11_-_110088330 2.476 NM_020809
ARHGAP20
Rho GTPase activating protein 20
chr17_-_10042579 2.469 NM_201433
GAS7
growth arrest-specific 7
chr15_-_81744469 2.453 NM_001717
BNC1
basonuclin 1
chr14_+_92049396 2.428 NM_024832
RIN3
Ras and Rab interactor 3
chrX_+_147389825 2.396 NM_001169122
NM_001169123
NM_001169124
NM_001169125
NM_002025
AFF2




AF4/FMR2 family, member 2




chr18_-_42590989 2.394 NM_013305
ST8SIA5
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
chr8_+_145705253 2.380 NM_138431
MFSD3
major facilitator superfamily domain containing 3
chr7_-_27136876 2.351 NM_002141
HOXA4
homeobox A4
chr18_+_65219114 2.338 NM_152721
DOK6
docking protein 6
chr9_+_128128913 2.330 NM_001011703
NM_033446
FAM125B

family with sequence similarity 125, member B

chr10_+_112394094 2.305 NM_001134363
RBM20
RNA binding motif protein 20
chr1_+_226261374 2.290 NM_033131
WNT3A
wingless-type MMTV integration site family, member 3A
chr13_+_32488477 2.275 NM_004795
KL
klotho
chr2_+_28887203 2.275 NM_001142634
NM_182756
SPDYA

speedy homolog A (Xenopus laevis)

chr20_-_4177519 2.259 NM_000678
ADRA1D
adrenergic, alpha-1D-, receptor
chr10_-_118022707 2.252 NM_001145453
GFRA1
GDNF family receptor alpha 1
chr17_-_74432671 2.247 TIMP2
TIMP metallopeptidase inhibitor 2
chr15_-_91433165 2.241 NM_020211
RGMA
RGM domain family, member A
chr10_-_128066935 2.236 ADAM12
ADAM metallopeptidase domain 12
chr10_-_103525646 2.218 NM_006119
NM_033163
NM_033164
NM_033165
FGF8



fibroblast growth factor 8 (androgen-induced)



chr11_-_112851051 2.206 NM_000795
NM_016574
DRD2

dopamine receptor D2

chr9_+_94987032 2.189 NM_006648
WNK2
WNK lysine deficient protein kinase 2
chr3_+_71885890 2.179 NM_018971
GPR27
G protein-coupled receptor 27
chr8_-_143856179 2.172 LYNX1
Ly6/neurotoxin 1
chr22_+_45071301 2.165 NM_016426
GTSE1
G-2 and S-phase expressed 1
chr3_+_198214173 2.163 LOC100507057
MFI2
hypothetical LOC100507057
antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5
chr15_+_66658626 2.156 NM_006091
CORO2B
coronin, actin binding protein, 2B
chr2_+_109112428 2.152 NM_001099289
SH3RF3
SH3 domain containing ring finger 3
chr6_+_160689355 2.150 NM_021977
SLC22A3
solute carrier family 22 (extraneuronal monoamine transporter), member 3
chr17_-_72045218 2.122 NM_134268
CYGB
cytoglobin
chr18_-_5620629 2.119 EPB41L3
erythrocyte membrane protein band 4.1-like 3
chr4_-_1692574 2.116 TMEM129
transmembrane protein 129
chr7_+_3307445 2.116 NM_152744
SDK1
sidekick homolog 1, cell adhesion molecule (chicken)
chr7_-_81910956 2.110 NM_000722
CACNA2D1
calcium channel, voltage-dependent, alpha 2/delta subunit 1
chr14_+_105012106 2.108 NM_001312
CRIP2
cysteine-rich protein 2
chr1_+_17738863 2.108 NM_018125
ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr10_-_128067001 2.104 ADAM12
ADAM metallopeptidase domain 12
chr7_-_32077504 2.099 NM_001191059
NM_005020
PDE1C

phosphodiesterase 1C, calmodulin-dependent 70kDa

chr6_+_159510416 2.085 NM_032532
FNDC1
fibronectin type III domain containing 1
chr10_+_71908535 2.076 NM_014431
KIAA1274
KIAA1274
chr3_+_141136691 2.070 NM_022131
CLSTN2
calsyntenin 2
chr11_+_126378507 2.056 NCRNA00288
non-protein coding RNA 288
chr2_-_232499202 2.040 NM_024409
NPPC
natriuretic peptide C
chr13_-_100866839 2.029 NALCN
sodium leak channel, non-selective
chr15_+_82113813 2.023 NM_207517
ADAMTSL3
ADAMTS-like 3
chr14_+_72773957 2.022 NM_173462
NDRG2
PAPLN
NDRG family member 2
papilin, proteoglycan-like sulfated glycoprotein
chr16_+_84204424 2.022 NM_014615
KIAA0182
KIAA0182
chr2_+_235525355 2.018 NM_014521
SH3BP4
SH3-domain binding protein 4
chr11_-_9069668 2.008 NM_001170690
NM_020974
SCUBE2

signal peptide, CUB domain, EGF-like 2

chr10_+_80672842 2.002 ZMIZ1
zinc finger, MIZ-type containing 1
chr2_+_95376494 2.002 NM_001034914
KCNIP3
Kv channel interacting protein 3, calsenilin
chr6_-_166641860 1.999 NM_175922
PRR18
proline rich 18
chr12_-_131415854 1.998 NM_001122636
GALNT9
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9 (GalNAc-T9)
chr9_-_71476917 1.970 NM_001163
APBA1
amyloid beta (A4) precursor protein-binding, family A, member 1
chr11_+_1367665 1.962 NM_003957
BRSK2
BR serine/threonine kinase 2
chr15_+_99237555 1.959 ALDH1A3
aldehyde dehydrogenase 1 family, member A3
chr7_+_48041632 1.956 NM_001100159
C7orf57
chromosome 7 open reading frame 57
chr8_+_22492586 1.946 PDLIM2
PDZ and LIM domain 2 (mystique)
chr7_-_44331544 1.944 NM_001220
NM_172078
NM_172079
NM_172080
NM_172081
NM_172082
NM_172083
NM_172084
CAMK2B







calcium/calmodulin-dependent protein kinase II beta







chr10_+_42892506 1.941 NM_020630
NM_020975
RET

ret proto-oncogene

chr4_-_24523605 1.935 NM_001130726
CCDC149
coiled-coil domain containing 149
chr11_+_66547391 1.935 NM_177963
SYT12
synaptotagmin XII
chr1_+_199108705 1.934 NM_005298
GPR25
G protein-coupled receptor 25
chr4_-_110443247 1.931 NM_032518
NM_198721
COL25A1

collagen, type XXV, alpha 1

chr12_+_3056781 1.925 NM_001168320
NM_006675
TSPAN9

tetraspanin 9

chr6_-_18230829 1.919 NM_198586
NHLRC1
NHL repeat containing 1
chr6_+_1335067 1.918 NM_001452
FOXF2
forkhead box F2
chr2_-_160972606 1.915 RBMS1
RNA binding motif, single stranded interacting protein 1
chr15_-_38362078 1.912 NM_001190479
LOC100131244
hypothetical protein LOC100131244
chr5_+_129268352 1.911 NM_175856
CHSY3
chondroitin sulfate synthase 3
chr18_-_55091596 1.907 NM_013435
RAX
retina and anterior neural fold homeobox
chr2_-_96174502 1.903 DUSP2
dual specificity phosphatase 2
chr18_-_29412148 1.895


chr17_-_6400470 1.891 NM_001165966
NM_031220
PITPNM3

PITPNM family member 3

chr2_-_98919109 1.885 NM_207362
C2orf55
chromosome 2 open reading frame 55
chr2_-_235070431 1.883 NM_005737
ARL4C
ADP-ribosylation factor-like 4C
chr15_+_31390454 1.881 NM_001036
RYR3
ryanodine receptor 3
chr19_+_540849 1.880 NM_001194
HCN2
hyperpolarization activated cyclic nucleotide-gated potassium channel 2
chr2_-_10137626 1.874 CYS1
cystin 1
chr20_+_56701224 1.871 NM_024663
NPEPL1
aminopeptidase-like 1
chr14_-_100104014 1.859 NM_001159531
BEGAIN
brain-enriched guanylate kinase-associated homolog (rat)
chr14_-_76807302 1.855 NM_021257
NGB
neuroglobin
chr18_+_74841262 1.851 NM_171999
SALL3
sal-like 3 (Drosophila)
chr8_+_144420939 1.849 NM_138465
GLI4
GLI family zinc finger 4
chr15_-_64333048 1.840 NM_032445
MEGF11
multiple EGF-like-domains 11
chr11_+_63815348 1.833 NM_033310
KCNK4
potassium channel, subfamily K, member 4
chr16_-_17472238 1.833 NM_022166
XYLT1
xylosyltransferase I
chr14_+_99181232 1.832 NM_001127258
NM_032425
HHIPL1

HHIP-like 1

chr16_-_71639670 1.823 NM_006885
ZFHX3
zinc finger homeobox 3
chr8_-_41286088 1.819 NM_003012
SFRP1
secreted frizzled-related protein 1
chr2_+_26924466 1.818 NM_020134
DPYSL5
dihydropyrimidinase-like 5
chr10_+_122206455 1.817 NM_001030059
PPAPDC1A
phosphatidic acid phosphatase type 2 domain containing 1A
chr3_+_12304332 1.816 NM_005037
NM_138712
PPARG

peroxisome proliferator-activated receptor gamma

chr14_-_77034853 1.815 NM_182509
NM_199296
ISM2

isthmin 2 homolog (zebrafish)

chr16_-_2186465 1.813 NM_020764
CASKIN1
CASK interacting protein 1
chr17_-_42411587 1.809 NM_203400
RPRML
reprimo-like
chr18_-_24011349 1.808 NM_001792
CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr20_+_20296744 1.806 NM_002196
INSM1
insulinoma-associated 1
chr1_+_237616457 1.806 CHRM3
cholinergic receptor, muscarinic 3
chr8_-_41873401 1.785 NM_001142446
ANK1
ankyrin 1, erythrocytic
chr5_+_7449030 1.781 NM_020546
ADCY2
adenylate cyclase 2 (brain)
chr3_+_11171213 1.781 NM_001098212
HRH1
histamine receptor H1
chr17_-_1874927 1.773 NM_178568
RTN4RL1
reticulon 4 receptor-like 1
chr15_-_63457378 1.766 NM_004884
IGDCC3
immunoglobulin superfamily, DCC subclass, member 3
chr22_-_49315341 1.765 NM_001113755
NM_001953
TYMP

thymidine phosphorylase

chr20_+_8997660 1.751 NM_001172646
PLCB4
phospholipase C, beta 4
chr14_+_51804180 1.748 NM_000953
PTGDR
prostaglandin D2 receptor (DP)
chr13_+_109757593 1.748 NM_001846
COL4A2
collagen, type IV, alpha 2
chr11_-_1549719 1.746 NM_004420
DUSP8
dual specificity phosphatase 8
chr14_+_103621768 1.741 NM_001080464
ASPG
asparaginase homolog (S. cerevisiae)
chr7_-_27162688 1.740 NM_006896
HOXA7
homeobox A7
chr5_-_58370693 1.740 NM_001197221
NM_001197222
PDE4D

phosphodiesterase 4D, cAMP-specific

chr1_+_226937732 1.740 RHOU
ras homolog gene family, member U
chr14_-_87859284 1.737 NM_138317
KCNK10
potassium channel, subfamily K, member 10
chr22_-_43784444 1.730 NM_001135862
PHF21B
PHD finger protein 21B
chr12_-_94708477 1.726 NTN4
netrin 4
chr11_-_60475558 1.718 NM_016582
SLC15A3
solute carrier family 15, member 3
chr16_+_631828 1.714 NM_138418
FAM195A
family with sequence similarity 195, member A
chr17_+_19853200 1.712 SPECC1
sperm antigen with calponin homology and coiled-coil domains 1
chr5_+_78568094 1.712


chr20_+_32610161 1.707 NM_032514
MAP1LC3A
microtubule-associated protein 1 light chain 3 alpha
chr14_+_95575319 1.704 C14orf132
chromosome 14 open reading frame 132
chr12_-_43731148 1.702 NM_001004329
DBX2
developing brain homeobox 2
chr16_+_88169612 1.700 NM_014427
NM_153636
CPNE7

copine VII

chr8_+_142207866 1.699 NM_014957
DENND3
DENN/MADD domain containing 3
chr8_-_144583718 1.697 NM_201589
MAFA
v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)
chr4_+_15388985 1.697 NM_001775
CD38
CD38 molecule
chr10_-_128067052 1.689 ADAM12
ADAM metallopeptidase domain 12
chr2_-_106869488 1.682


chr16_-_4105703 1.681 ADCY9
adenylate cyclase 9
chr10_+_133850325 1.675 NM_006426
DPYSL4
dihydropyrimidinase-like 4
chr22_-_37180958 1.675 NM_152868
KCNJ4
potassium inwardly-rectifying channel, subfamily J, member 4
chr12_+_4788602 1.671 NM_002235
KCNA6
potassium voltage-gated channel, shaker-related subfamily, member 6
chr18_+_19523402 1.670 LAMA3
laminin, alpha 3
chr9_-_15297148 1.670 TTC39B
tetratricopeptide repeat domain 39B
chr15_+_78483624 1.669 NM_014862
ARNT2
aryl-hydrocarbon receptor nuclear translocator 2
chr6_+_1257674 1.668 NM_033260
FOXQ1
forkhead box Q1
chr7_-_107089387 1.659 LOC286002
hypothetical LOC286002
chr17_+_43127628 1.653 NM_014726
TBKBP1
TBK1 binding protein 1
chr17_-_29930431 1.652 NM_207454
C17orf102
chromosome 17 open reading frame 102
chr11_-_74818858 1.652 KLHL35
kelch-like 35 (Drosophila)
chr13_-_100866706 1.651 NM_052867
NALCN
sodium leak channel, non-selective
chr16_-_1908231 1.650 NM_001009606
HS3ST6
heparan sulfate (glucosamine) 3-O-sulfotransferase 6
chr3_-_191522886 1.643 NM_021101
CLDN1
claudin 1
chr14_+_58174489 1.641 NM_001079520
NM_016651
DACT1

dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)

chr1_-_234294997 1.638 NID1
nidogen 1
chr11_-_117528744 1.637 NM_001142348
NM_174934
SCN4B

sodium channel, voltage-gated, type IV, beta

chr10_+_128583984 1.637 NM_001380
DOCK1
dedicator of cytokinesis 1
chr15_+_77511912 1.626 NM_015206
KIAA1024
KIAA1024
chr15_-_50869379 1.623 NM_004498
ONECUT1
one cut homeobox 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.54 8.28e-29 GO:0007399 nervous system development
1.30 9.48e-28 GO:0032502 developmental process
1.32 1.84e-26 GO:0007275 multicellular organismal development
1.42 1.36e-25 GO:0030154 cell differentiation
1.41 5.75e-25 GO:0048869 cellular developmental process
1.64 5.29e-24 GO:0022008 neurogenesis
1.48 3.28e-23 GO:0009653 anatomical structure morphogenesis
1.64 2.30e-22 GO:0048699 generation of neurons
1.33 2.56e-22 GO:0048731 system development
1.30 7.52e-22 GO:0048856 anatomical structure development
1.59 3.09e-20 GO:0048468 cell development
1.80 3.65e-19 GO:0000904 cell morphogenesis involved in differentiation
1.66 7.90e-19 GO:0030182 neuron differentiation
1.71 1.38e-17 GO:0048666 neuron development
1.81 4.84e-17 GO:0048667 cell morphogenesis involved in neuron differentiation
1.82 1.07e-16 GO:0007409 axonogenesis
1.68 1.15e-16 GO:0000902 cell morphogenesis
1.79 2.22e-16 GO:0048812 neuron projection morphogenesis
1.65 4.11e-16 GO:0032989 cellular component morphogenesis
1.74 7.31e-16 GO:0031175 neuron projection development
1.72 1.33e-15 GO:0032990 cell part morphogenesis
1.72 2.19e-15 GO:0048858 cell projection morphogenesis
1.09 3.66e-15 GO:0009987 cellular process
1.62 8.20e-15 GO:0030030 cell projection organization
1.14 4.95e-14 GO:0050794 regulation of cellular process
1.36 1.95e-13 GO:0023051 regulation of signaling
1.13 2.76e-13 GO:0065007 biological regulation
1.13 4.23e-12 GO:0050789 regulation of biological process
1.79 4.98e-12 GO:0007411 axon guidance
1.58 1.11e-11 GO:0009887 organ morphogenesis
1.63 1.58e-11 GO:0007417 central nervous system development
1.30 6.58e-11 GO:0048513 organ development
1.75 3.60e-10 GO:0001501 skeletal system development
1.39 1.32e-09 GO:0010646 regulation of cell communication
1.73 1.56e-09 GO:0060284 regulation of cell development
1.33 4.20e-09 GO:0009966 regulation of signal transduction
1.67 4.71e-09 GO:0007420 brain development
1.48 5.05e-09 GO:0045595 regulation of cell differentiation
1.48 5.98e-09 GO:0009790 embryo development
1.39 9.99e-09 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.73 1.11e-08 GO:0048729 tissue morphogenesis
1.75 1.23e-08 GO:0035295 tube development
1.65 1.53e-08 GO:0048598 embryonic morphogenesis
1.18 2.32e-08 GO:0023052 signaling
1.78 4.44e-08 GO:0050767 regulation of neurogenesis
1.72 7.31e-08 GO:0051960 regulation of nervous system development
1.39 9.12e-08 GO:0050793 regulation of developmental process
1.43 1.55e-07 GO:2000026 regulation of multicellular organismal development
1.14 2.56e-07 GO:0032501 multicellular organismal process
1.32 2.87e-07 GO:0051239 regulation of multicellular organismal process
2.32 3.94e-07 GO:0021953 central nervous system neuron differentiation
1.46 4.10e-07 GO:0045893 positive regulation of transcription, DNA-dependent
1.23 5.84e-07 GO:0048523 negative regulation of cellular process
1.52 6.34e-07 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.22 6.76e-07 GO:0048519 negative regulation of biological process
1.76 8.06e-07 GO:0002009 morphogenesis of an epithelium
1.53 9.74e-07 GO:0048646 anatomical structure formation involved in morphogenesis
1.84 9.91e-07 GO:0035239 tube morphogenesis
1.43 1.48e-06 GO:0010628 positive regulation of gene expression
1.91 2.40e-06 GO:0045165 cell fate commitment
1.78 2.46e-06 GO:0045664 regulation of neuron differentiation
1.59 4.08e-06 GO:0007389 pattern specification process
1.42 4.60e-06 GO:0051254 positive regulation of RNA metabolic process
1.51 6.82e-06 GO:0023057 negative regulation of signaling
1.36 7.16e-06 GO:0009888 tissue development
1.24 7.53e-06 GO:0007166 cell surface receptor linked signaling pathway
1.51 8.44e-06 GO:0010648 negative regulation of cell communication
2.19 1.06e-05 GO:0060485 mesenchyme development
1.16 1.23e-05 GO:0007165 signal transduction
1.48 1.24e-05 GO:0072358 cardiovascular system development
1.48 1.24e-05 GO:0072359 circulatory system development
1.52 1.60e-05 GO:0009968 negative regulation of signal transduction
1.92 1.75e-05 GO:0030111 regulation of Wnt receptor signaling pathway
1.36 2.61e-05 GO:0051173 positive regulation of nitrogen compound metabolic process
1.85 2.86e-05 GO:0060562 epithelial tube morphogenesis
1.46 4.80e-05 GO:0019226 transmission of nerve impulse
1.46 4.80e-05 GO:0035637 multicellular organismal signaling
1.31 5.43e-05 GO:0007154 cell communication
1.19 6.57e-05 GO:0048522 positive regulation of cellular process
1.99 7.20e-05 GO:0010720 positive regulation of cell development
1.39 8.50e-05 GO:0007167 enzyme linked receptor protein signaling pathway
1.33 9.56e-05 GO:0040011 locomotion
1.47 1.53e-04 GO:0007268 synaptic transmission
1.26 1.84e-04 GO:0035556 intracellular signal transduction
1.35 2.09e-04 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.18 2.13e-04 GO:0071842 cellular component organization at cellular level
1.17 2.27e-04 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.77 2.46e-04 GO:0048562 embryonic organ morphogenesis
1.19 2.48e-04 GO:0051252 regulation of RNA metabolic process
1.76 2.70e-04 GO:0006813 potassium ion transport
1.85 2.70e-04 GO:0048705 skeletal system morphogenesis
1.14 2.97e-04 GO:0031323 regulation of cellular metabolic process
2.04 3.17e-04 GO:0060828 regulation of canonical Wnt receptor signaling pathway
1.62 3.18e-04 GO:0048568 embryonic organ development
1.47 4.57e-04 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.49 4.84e-04 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.17 4.91e-04 GO:0048518 positive regulation of biological process
1.48 5.91e-04 GO:0043009 chordate embryonic development
1.40 6.18e-04 GO:0045892 negative regulation of transcription, DNA-dependent
1.16 6.46e-04 GO:0051171 regulation of nitrogen compound metabolic process
1.48 7.18e-04 GO:0009792 embryo development ending in birth or egg hatching
1.19 7.44e-04 GO:0006355 regulation of transcription, DNA-dependent
1.13 8.38e-04 GO:0051716 cellular response to stimulus
1.41 8.83e-04 GO:0048585 negative regulation of response to stimulus
1.33 9.12e-04 GO:0010557 positive regulation of macromolecule biosynthetic process
1.40 9.81e-04 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
2.06 1.06e-03 GO:0016331 morphogenesis of embryonic epithelium
2.02 1.06e-03 GO:0048706 embryonic skeletal system development
1.39 1.14e-03 GO:0051253 negative regulation of RNA metabolic process
1.50 1.15e-03 GO:0045597 positive regulation of cell differentiation
1.75 1.19e-03 GO:0001655 urogenital system development
1.69 1.19e-03 GO:0030900 forebrain development
1.20 1.25e-03 GO:0048583 regulation of response to stimulus
1.14 1.34e-03 GO:0080090 regulation of primary metabolic process
2.07 1.71e-03 GO:0048762 mesenchymal cell differentiation
2.37 1.85e-03 GO:0001704 formation of primary germ layer
1.84 1.99e-03 GO:0043583 ear development
1.30 2.07e-03 GO:0031328 positive regulation of cellular biosynthetic process
1.14 2.57e-03 GO:0016043 cellular component organization
1.50 2.71e-03 GO:0022603 regulation of anatomical structure morphogenesis
1.38 3.21e-03 GO:0006935 chemotaxis
1.38 3.21e-03 GO:0042330 taxis
1.45 3.44e-03 GO:0060429 epithelium development
1.76 3.74e-03 GO:0001503 ossification
1.16 3.76e-03 GO:0010468 regulation of gene expression
1.28 4.02e-03 GO:0006811 ion transport
1.62 4.42e-03 GO:0048732 gland development
1.29 4.57e-03 GO:0009891 positive regulation of biosynthetic process
1.48 4.93e-03 GO:0051093 negative regulation of developmental process
1.35 5.04e-03 GO:0010629 negative regulation of gene expression
1.44 5.12e-03 GO:0051056 regulation of small GTPase mediated signal transduction
1.12 5.50e-03 GO:0019222 regulation of metabolic process
2.06 5.80e-03 GO:0014031 mesenchymal cell development
1.40 5.94e-03 GO:0051094 positive regulation of developmental process
1.15 6.03e-03 GO:0031326 regulation of cellular biosynthetic process
1.50 6.37e-03 GO:0001944 vasculature development
1.88 6.84e-03 GO:0051216 cartilage development
1.96 6.86e-03 GO:0050769 positive regulation of neurogenesis
1.15 7.15e-03 GO:0009889 regulation of biosynthetic process
1.61 7.49e-03 GO:0032582 negative regulation of gene-specific transcription
1.52 7.87e-03 GO:0045596 negative regulation of cell differentiation
1.40 9.01e-03 GO:0032583 regulation of gene-specific transcription
1.15 9.04e-03 GO:0071841 cellular component organization or biogenesis at cellular level
2.07 9.40e-03 GO:0043279 response to alkaloid
1.54 9.40e-03 GO:0003002 regionalization
1.30 9.82e-03 GO:0007267 cell-cell signaling
1.59 1.02e-02 GO:0007548 sex differentiation
1.78 1.08e-02 GO:0060541 respiratory system development
1.74 1.09e-02 GO:0001763 morphogenesis of a branching structure
1.26 1.14e-02 GO:0042127 regulation of cell proliferation
1.79 1.26e-02 GO:0072001 renal system development
2.22 1.27e-02 GO:0001649 osteoblast differentiation
2.57 1.38e-02 GO:0061035 regulation of cartilage development
1.49 1.47e-02 GO:0007423 sensory organ development
1.27 1.48e-02 GO:0006351 transcription, DNA-dependent
1.82 1.67e-02 GO:0030323 respiratory tube development
2.05 1.97e-02 GO:0072175 epithelial tube formation
1.91 2.06e-02 GO:0030178 negative regulation of Wnt receptor signaling pathway
1.79 2.07e-02 GO:0001822 kidney development
1.25 3.05e-02 GO:0009605 response to external stimulus
2.12 3.10e-02 GO:0090090 negative regulation of canonical Wnt receptor signaling pathway
1.32 3.18e-02 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.71 3.34e-02 GO:0010975 regulation of neuron projection development
1.82 3.55e-02 GO:0021537 telencephalon development
2.52 3.56e-02 GO:0021954 central nervous system neuron development
1.77 3.75e-02 GO:0035107 appendage morphogenesis
1.77 3.75e-02 GO:0035108 limb morphogenesis
1.80 3.96e-02 GO:0030324 lung development
2.02 4.07e-02 GO:0001838 embryonic epithelial tube formation
1.61 4.27e-02 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter
1.50 4.36e-02 GO:0007507 heart development
1.86 4.59e-02 GO:0021915 neural tube development
1.32 4.79e-02 GO:0006812 cation transport
1.29 4.86e-02 GO:0009890 negative regulation of biosynthetic process
1.29 4.91e-02 GO:0031327 negative regulation of cellular biosynthetic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.58 1.80e-08 GO:0045202 synapse
1.22 1.09e-07 GO:0044459 plasma membrane part
1.57 9.96e-06 GO:0044456 synapse part
1.39 1.28e-05 GO:0030054 cell junction
1.48 3.27e-05 GO:0031012 extracellular matrix
1.70 7.51e-05 GO:0043025 neuronal cell body
1.67 1.43e-04 GO:0044297 cell body
1.43 2.57e-04 GO:0043005 neuron projection
1.21 2.81e-03 GO:0031226 intrinsic to plasma membrane
1.56 4.31e-03 GO:0030425 dendrite
1.43 5.24e-03 GO:0005578 proteinaceous extracellular matrix
1.48 6.80e-03 GO:0005667 transcription factor complex
1.21 8.04e-03 GO:0005887 integral to plasma membrane
1.23 2.45e-02 GO:0042995 cell projection
1.04 2.48e-02 GO:0044424 intracellular part
1.60 2.68e-02 GO:0034703 cation channel complex
1.75 2.80e-02 GO:0008076 voltage-gated potassium channel complex
1.75 2.80e-02 GO:0034705 potassium channel complex
1.06 4.22e-02 GO:0016020 membrane
1.55 4.69e-02 GO:0005912 adherens junction
1.04 4.76e-02 GO:0005622 intracellular

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.43 2.63e-12 GO:0001071 nucleic acid binding transcription factor activity
1.43 2.63e-12 GO:0003700 sequence-specific DNA binding transcription factor activity
1.52 5.07e-12 GO:0043565 sequence-specific DNA binding
1.42 1.24e-11 GO:0030528 transcription regulator activity
1.58 2.19e-06 GO:0016563 transcription activator activity
1.05 4.53e-06 GO:0005488 binding
1.29 1.27e-04 GO:0022857 transmembrane transporter activity
1.64 1.50e-04 GO:0000975 regulatory region DNA binding
1.64 1.50e-04 GO:0001067 regulatory region nucleic acid binding
1.64 1.50e-04 GO:0044212 transcription regulatory region DNA binding
1.65 1.75e-04 GO:0010843 promoter binding
1.30 1.99e-04 GO:0022891 substrate-specific transmembrane transporter activity
1.80 2.81e-04 GO:0005267 potassium channel activity
1.12 7.07e-04 GO:0046872 metal ion binding
1.12 1.08e-03 GO:0043167 ion binding
1.12 1.19e-03 GO:0043169 cation binding
1.61 1.27e-03 GO:0005244 voltage-gated ion channel activity
1.61 1.27e-03 GO:0022832 voltage-gated channel activity
1.24 4.11e-03 GO:0022892 substrate-specific transporter activity
1.33 5.54e-03 GO:0008324 cation transmembrane transporter activity
1.28 6.07e-03 GO:0015075 ion transmembrane transporter activity
1.65 7.65e-03 GO:0022843 voltage-gated cation channel activity
1.36 8.94e-03 GO:0019904 protein domain specific binding
1.78 9.22e-03 GO:0005249 voltage-gated potassium channel activity
1.43 9.22e-03 GO:0022836 gated channel activity
1.40 1.32e-02 GO:0042578 phosphoric ester hydrolase activity
1.45 1.60e-02 GO:0005261 cation channel activity
1.82 2.04e-02 GO:0003705 sequence-specific enhancer binding RNA polymerase II transcription factor activity
1.76 2.74e-02 GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
1.35 3.29e-02 GO:0022803 passive transmembrane transporter activity
1.14 3.66e-02 GO:0003677 DNA binding
1.34 4.51e-02 GO:0015267 channel activity