Motif ID: ALX1.p2

Z-value: 0.726


Transcription factors associated with ALX1.p2:

Gene SymbolEntrez IDGene Name
ALX1 8092 ALX homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ALX1chr12_+_84198015-0.794.2e-04Click!


Activity profile for motif ALX1.p2.

activity profile for motif ALX1.p2


Sorted Z-values histogram for motif ALX1.p2

Sorted Z-values for motif ALX1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ALX1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_5212168 3.257 NM_000519
HBD
hemoglobin, delta
chr7_-_107667728 2.061 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr1_+_166516901 2.056 NM_005149
TBX19
T-box 19
chr12_+_130004404 1.660 NM_198827
GPR133
G protein-coupled receptor 133
chr8_-_86477585 1.526 NM_001128829
NM_001128830
NM_001128831
NM_001738
CA1



carbonic anhydrase I



chr1_-_41399632 1.449 NM_001031694
SCMH1
sex comb on midleg homolog 1 (Drosophila)
chr11_+_59580630 1.438 NM_001031666
NM_001031809
NM_006138
MS4A3


membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)


chr17_+_19917420 1.399 SPECC1
sperm antigen with calponin homology and coiled-coil domains 1
chr7_-_44547382 1.137 NM_001101648
NM_013389
NPC1L1

NPC1 (Niemann-Pick disease, type C1, gene)-like 1

chr19_-_14030970 1.121 NM_001145028
PALM3
paralemmin 3
chr4_+_43185 1.107 NM_182524
ZNF595
ZNF718
zinc finger protein 595
zinc finger protein 718
chr19_-_53444733 1.028 NM_001184901
NM_001184903
NM_014959
CARD8


caspase recruitment domain family, member 8


chr6_-_2696152 0.999 NM_001012418
MYLK4
myosin light chain kinase family, member 4
chr1_+_181028016 0.995 NM_030769
NPL
N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
chr7_+_77307382 0.946 NM_001127357
NM_001127359
NM_020432
PHTF2


putative homeodomain transcription factor 2


chr5_-_138746840 0.865 SLC23A1
solute carrier family 23 (nucleobase transporters), member 1
chr10_+_5976354 0.848 NM_032807
FBXO18
F-box protein, helicase, 18
chr1_+_154120170 0.833 SYT11
synaptotagmin XI
chr6_+_53043729 0.826 NM_012347
FBXO9
F-box protein 9
chr3_-_197726587 0.819 NM_001077657
C3orf43
chromosome 3 open reading frame 43
chr11_-_59707074 0.818 NM_022349
NM_152851
NM_152852
MS4A6A


membrane-spanning 4-domains, subfamily A, member 6A


chr7_+_73826244 0.811 NM_000265
NCF1
NCF1B
NCF1C
neutrophil cytosolic factor 1
neutrophil cytosolic factor 1B pseudogene
neutrophil cytosolic factor 1C pseudogene
chr11_-_123695302 0.795 NM_001002918
OR8D2
olfactory receptor, family 8, subfamily D, member 2
chr2_-_224974954 0.782 NM_001122779
NM_024785
FAM124B

family with sequence similarity 124B

chr7_-_25234582 0.780 NM_022150
NPVF
neuropeptide VF precursor
chr1_+_559618 0.776


chr17_-_16038607 0.775 NM_001190438
NM_001190440
NCOR1

nuclear receptor corepressor 1

chr11_+_123600553 0.759 NM_001007249
OR8G2
olfactory receptor, family 8, subfamily G, member 2
chr17_-_44006808 0.753 NM_002146
HOXB3
homeobox B3
chr14_+_20306425 0.742 NM_022360
EDDM3B
epididymal protein 3B
chr1_+_150005754 0.738 NM_016178
OAZ3
ornithine decarboxylase antizyme 3
chr7_-_158304062 0.711 ESYT2
extended synaptotagmin-like protein 2
chr6_+_31791063 0.699 NM_021246
LY6G6D
lymphocyte antigen 6 complex, locus G6D
chr19_+_7468444 0.686 NM_198534
C19orf45
chromosome 19 open reading frame 45
chr11_+_123625632 0.659 NM_001002905
OR8G1
olfactory receptor, family 8, subfamily G, member 1
chr5_+_137701122 0.644 NM_001135647
FAM53C
family with sequence similarity 53, member C
chr14_-_74400288 0.644 NM_001080408
PROX2
prospero homeobox 2
chr4_-_123761615 0.637 NM_021803
IL21
interleukin 21
chr7_-_86433139 0.629 NM_152748
KIAA1324L
KIAA1324-like
chr11_+_5610060 0.621 NM_130390
TRIM34
tripartite motif containing 34
chr1_+_559129 0.621


chr5_-_39306465 0.618 FYB
FYN binding protein
chr19_-_60528480 0.607 NM_001085488
TMEM150B
transmembrane protein 150B
chrX_-_48976714 0.601 NM_005183
CACNA1F
calcium channel, voltage-dependent, L type, alpha 1F subunit
chr8_+_107807415 0.598 NM_001198534
NM_001198535
OXR1

oxidation resistance 1

chr1_-_7923464 0.595 NM_001561
TNFRSF9
tumor necrosis factor receptor superfamily, member 9
chr3_-_15357878 0.589 NM_001018009
SH3BP5
SH3-domain binding protein 5 (BTK-associated)
chr14_+_100365390 0.576 MEG3
maternally expressed 3 (non-protein coding)
chr6_-_76259976 0.570 NM_015687
FILIP1
filamin A interacting protein 1
chr16_+_31178828 0.566 ITGAM
integrin, alpha M (complement component 3 receptor 3 subunit)
chr19_+_44478804 0.559 NM_172140
IL29
interleukin 29 (interferon, lambda 1)
chr19_+_60962318 0.544 NM_001145014
RFPL4A
ret finger protein-like 4A
chr21_-_44899003 0.529 NM_198698
KRTAP12-4
keratin associated protein 12-4
chr7_+_143043871 0.520 NM_001130026
FAM115C
family with sequence similarity 115, member C
chr10_-_42183441 0.517 LOC283027
hypothetical protein LOC283027
chr11_+_93940121 0.514 NM_152431
PIWIL4
piwi-like 4 (Drosophila)
chr16_+_31178778 0.509 NM_000632
NM_001145808
ITGAM

integrin, alpha M (complement component 3 receptor 3 subunit)

chr21_+_37377116 0.508 NM_003316
TTC3
tetratricopeptide repeat domain 3
chr19_-_4486202 0.508 NM_001013706
PLIN5
perilipin 5
chr1_+_54132447 0.504 NM_000792
NM_001039715
NM_001039716
NM_213593
DIO1



deiodinase, iodothyronine, type I



chr16_+_31178812 0.502 ITGAM
integrin, alpha M (complement component 3 receptor 3 subunit)
chr4_-_160175782 0.499 NM_152543
C4orf45
chromosome 4 open reading frame 45
chr3_-_9895633 0.494 NM_022094
CIDEC
cell death-inducing DFFA-like effector c
chr20_+_31717964 0.486 NM_001024675
C20orf134
chromosome 20 open reading frame 134
chr2_-_74235860 0.486


chr5_+_61910318 0.480 NM_181506
LRRC70
leucine rich repeat containing 70
chr1_-_156923111 0.480 NM_003126
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr22_-_20667131 0.479 NM_003935
TOP3B
topoisomerase (DNA) III beta
chr2_-_178681311 0.479 NM_001077197
PDE11A
phosphodiesterase 11A
chr3_-_139960874 0.478 NM_006219
PIK3CB
phosphoinositide-3-kinase, catalytic, beta polypeptide
chr2_-_25320299 0.474 DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr19_-_23661779 0.473 NM_138330
ZNF675
zinc finger protein 675
chr11_+_59564323 0.467 NM_173801
PLAC1L
placenta-specific 1-like
chr19_-_61431470 0.463 NM_024303
ZSCAN5A
zinc finger and SCAN domain containing 5A
chr7_+_99263571 0.461 NM_022820
NM_057095
NM_057096
CYP3A43


cytochrome P450, family 3, subfamily A, polypeptide 43


chr8_-_110730183 0.459 NM_001099747
NM_001099748
NM_001099749
NM_001099750
NM_017786
SYBU




syntabulin (syntaxin-interacting)




chr2_-_127817143 0.455 NM_006609
MAP3K2
mitogen-activated protein kinase kinase kinase 2
chr10_+_35524060 0.446 NM_182717
NM_182718
NM_182719
NM_182720
CREM



cAMP responsive element modulator



chr1_+_67404756 0.445 NM_144701
IL23R
interleukin 23 receptor
chr1_-_201044168 0.444 NM_006618
KDM5B
lysine (K)-specific demethylase 5B
chr19_-_56564068 0.443 NM_152353
CLDND2
claudin domain containing 2
chr3_-_25658829 0.440 TOP2B
topoisomerase (DNA) II beta 180kDa
chrX_-_11194015 0.438 NM_013423
ARHGAP6
Rho GTPase activating protein 6
chr9_+_89687560 0.431 NM_178828
C9orf79
chromosome 9 open reading frame 79
chr19_+_21116666 0.429 NM_133473
ZNF431
zinc finger protein 431
chr1_-_51757490 0.429 EPS15
epidermal growth factor receptor pathway substrate 15
chr5_-_37220702 0.427 C5orf42
chromosome 5 open reading frame 42
chr9_+_99807257 0.427


chr7_+_101810018 0.425


chr5_+_76470829 0.419


chr6_-_25982418 0.419 NM_001098486
NM_006632
SLC17A3

solute carrier family 17 (sodium phosphate), member 3

chr1_-_201044137 0.417 KDM5B
lysine (K)-specific demethylase 5B
chr1_+_156991133 0.414 NM_001005184
OR6K6
olfactory receptor, family 6, subfamily K, member 6
chrX_-_153716130 0.407 NM_001162936
LOC100132963
hypothetical protein LOC100132963
chr6_+_27215039 0.403 NM_003495
HIST1H4I
histone cluster 1, H4i
chr12_+_53177806 0.395 NCKAP1L
NCK-associated protein 1-like
chr12_+_53177789 0.393 NCKAP1L
NCK-associated protein 1-like
chr1_-_180908639 0.392 NM_001102450
NM_033345
RGS8

regulator of G-protein signaling 8

chr12_+_9033403 0.390 NM_005810
KLRG1
killer cell lectin-like receptor subfamily G, member 1
chr11_+_120478584 0.382 NM_005422
TECTA
tectorin alpha
chr12_+_53177758 0.378 NM_005337
NCKAP1L
NCK-associated protein 1-like
chr17_+_59875623 0.378 NM_001085423
C17orf60
chromosome 17 open reading frame 60
chr19_+_21480229 0.372 NM_001001415
ZNF429
zinc finger protein 429
chr14_-_105542441 0.371 IGLJ3
IGHA1
IGHG1
IGHM
immunoglobulin lambda joining 3
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr1_+_200584421 0.368 NM_001167857
NM_001167858
NM_002481
PPP1R12B


protein phosphatase 1, regulatory (inhibitor) subunit 12B


chr1_+_234624266 0.356 NM_145861
EDARADD
EDAR-associated death domain
chr1_-_67039518 0.343 NM_005478
INSL5
insulin-like 5
chr3_+_123817151 0.340 NM_152615
PARP15
poly (ADP-ribose) polymerase family, member 15
chr19_+_53450743 0.338


chr19_+_60053709 0.336 NM_006737
KIR3DL2
killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2
chr1_+_242582559 0.335 NM_001012970
C1orf100
chromosome 1 open reading frame 100
chr1_+_190394214 0.322 NM_130782
RGS18
regulator of G-protein signaling 18
chr7_+_37689903 0.321


chr9_-_122852356 0.320 NM_001735
C5
complement component 5
chr1_-_89414310 0.317 NM_207398
GBP7
guanylate binding protein 7
chr1_+_117345894 0.317 NM_004258
CD101
CD101 molecule
chr2_+_169637255 0.316 NM_001142270
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr18_+_8708448 0.315


chr3_-_87408301 0.313 NM_000306
NM_001122757
POU1F1

POU class 1 homeobox 1

chr2_-_162717159 0.311 NM_002054
GCG
glucagon
chr11_+_46255737 0.310 NM_052854
CREB3L1
cAMP responsive element binding protein 3-like 1
chr22_-_22252376 0.307 NM_020070
NM_152855
IGLL1

immunoglobulin lambda-like polypeptide 1

chr7_+_63305015 0.302 NM_001159524
ZNF735
zinc finger protein 735
chr18_-_50134940 0.300 NM_139171
STARD6
StAR-related lipid transfer (START) domain containing 6
chr4_-_164754106 0.299 NM_017923
MARCH1
membrane-associated ring finger (C3HC4) 1
chr14_+_19735334 0.299 NM_001005503
OR11G2
olfactory receptor, family 11, subfamily G, member 2
chr7_-_107930170 0.293 PNPLA8
patatin-like phospholipase domain containing 8
chr20_+_56912146 0.287 GNAS
GNAS complex locus
chr4_+_68107039 0.286 NM_012108
STAP1
signal transducing adaptor family member 1
chr3_+_122769467 0.286 NM_001012659
ARGFX
arginine-fifty homeobox
chr2_-_68952006 0.286 NM_014482
BMP10
bone morphogenetic protein 10
chr12_+_9925354 0.282 NM_001190765
KLRF2
killer cell lectin-like receptor subfamily F, member 2
chr2_-_88946767 0.282


chr17_+_69781980 0.278 NM_001172810
NM_023036
DNAI2

dynein, axonemal, intermediate chain 2

chrX_-_151370325 0.274 NM_000808
GABRA3
gamma-aminobutyric acid (GABA) A receptor, alpha 3
chr19_+_59941785 0.273 NM_015868
KIR2DS2
KIR2DL3
killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2
killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
chr20_+_51235228 0.272 NM_001193421
TSHZ2
teashirt zinc finger homeobox 2
chr11_-_16387001 0.269 NM_001145811
SOX6
SRY (sex determining region Y)-box 6
chr11_+_113351006 0.267 NM_000869
NM_213621
HTR3A

5-hydroxytryptamine (serotonin) receptor 3A

chr7_-_44834702 0.265 H2AFV
H2A histone family, member V
chr5_-_176258920 0.263 NM_002115
HK3
hexokinase 3 (white cell)
chr11_-_64459910 0.260 NM_130769
GPHA2
glycoprotein hormone alpha 2
chr1_-_157014048 0.258 NM_001005278
OR6N2
olfactory receptor, family 6, subfamily N, member 2
chr14_-_22574193 0.258 NM_001144932
NM_002797
NM_001130725
PSMB5


proteasome (prosome, macropain) subunit, beta type, 5


chr11_-_10546654 0.257 NM_006691
LYVE1
lymphatic vessel endothelial hyaluronan receptor 1
chr13_-_98757634 0.257 NM_004951
GPR183
G protein-coupled receptor 183
chr19_+_40824486 0.252 NM_014209
ETV2
ets variant 2
chr21_+_37714470 0.250 NM_130438
NM_001396
DYRK1A

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

chr11_+_123639909 0.249 NM_001005198
OR8G5
olfactory receptor, family 8, subfamily G, member 5
chr19_+_61039755 0.249 NM_134444
NLRP4
NLR family, pyrin domain containing 4
chr8_-_37876129 0.247 NM_001002814
NM_025151
RAB11FIP1

RAB11 family interacting protein 1 (class I)

chr9_-_27287106 0.247 NM_001161585
NM_020641
C9orf11

chromosome 9 open reading frame 11

chr19_+_7410573 0.245 NM_001130955
ARHGEF18
Rho/Rac guanine nucleotide exchange factor (GEF) 18
chr5_-_132228375 0.243 NM_005260
GDF9
growth differentiation factor 9
chr4_-_72868598 0.241 NM_000583
GC
group-specific component (vitamin D binding protein)
chr3_-_69120188 0.241 C3orf64
chromosome 3 open reading frame 64
chr10_-_50066386 0.240 NM_001010863
C10orf128
chromosome 10 open reading frame 128
chr16_-_79811475 0.240 NM_001076780
NM_052892
PKD1L2

polycystic kidney disease 1-like 2

chr1_-_20014180 0.240 NM_019062
RNF186
ring finger protein 186
chrX_+_108665665 0.236 NM_018698
NXT2
nuclear transport factor 2-like export factor 2
chr19_-_21438525 0.235


chr7_+_142590633 0.235 NM_176881
TAS2R39
taste receptor, type 2, member 39
chr4_+_55956520 0.235


chr7_+_115650240 0.234 NM_152829
TES
testis derived transcript (3 LIM domains)
chr2_-_63518589 0.234 NM_001042692
WDPCP
WD repeat containing planar cell polarity effector
chr22_-_20667165 0.233 TOP3B
topoisomerase (DNA) III beta
chr12_-_69434598 0.233 NM_130846
PTPRR
protein tyrosine phosphatase, receptor type, R
chr19_-_44518516 0.232 NM_004877
GMFG
glia maturation factor, gamma
chr20_+_31713750 0.231 NM_080825
C20orf144
chromosome 20 open reading frame 144
chr10_+_43187095 0.231 NM_001184963
NM_173160
FXYD4

FXYD domain containing ion transport regulator 4

chrX_+_41433169 0.231 NM_001097579
NM_005300
GPR34

G protein-coupled receptor 34

chr14_-_19867372 0.230 NM_182852
NM_182851
CCNB1IP1

cyclin B1 interacting protein 1, E3 ubiquitin protein ligase

chr2_-_178495768 0.228 NM_001077358
PDE11A
phosphodiesterase 11A
chr7_-_92615593 0.227 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr19_+_12064077 0.227 ZNF788
zinc finger family member 788
chr19_-_4509471 0.226 NM_032108
SEMA6B
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
chr16_+_87687734 0.225 NM_001127214
NM_174917
ACSF3

acyl-CoA synthetase family member 3

chr1_+_51340487 0.225 NM_001136508
C1orf185
chromosome 1 open reading frame 185
chr1_+_235025162 0.223 NM_000254
MTR
5-methyltetrahydrofolate-homocysteine methyltransferase
chr13_+_48923688 0.223 NM_001160308
SETDB2
SET domain, bifurcated 2
chr11_+_59920062 0.223 NM_001079692
NM_032597
MS4A14

membrane-spanning 4-domains, subfamily A, member 14

chr14_-_20098929 0.223 NM_001001673
NM_001110356
NM_001110357
NM_001110358
NM_001110359
NM_001110360
NM_001110361
RNASE9






ribonuclease, RNase A family, 9 (non-active)






chr10_-_21226536 0.223 NM_006393
NEBL
nebulette
chr3_-_127810087 0.222 NM_001039783
TXNRD3IT1
thioredoxin reductase 3 intronic transcript 1
chr6_+_132000134 0.220 NM_005021
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr19_+_21056792 0.220 NM_182515
ZNF714
zinc finger protein 714
chr2_-_190635566 0.220 NM_005259
MSTN
myostatin
chr6_+_26195426 0.220 NM_000410
NM_139003
NM_139004
NM_139006
NM_139007
NM_139008
NM_139009
NM_139010
NM_139011
HFE








hemochromatosis








chr1_+_235025313 0.219 MTR
5-methyltetrahydrofolate-homocysteine methyltransferase
chr1_-_44593522 0.217 NM_024066
ERI3
ERI1 exoribonuclease family member 3
chr10_+_13668964 0.217 PRPF18
PRP18 pre-mRNA processing factor 18 homolog (S. cerevisiae)
chr2_+_48698440 0.215 NM_001193487
NM_006872
GTF2A1L

general transcription factor IIA, 1-like

chr14_-_105997732 0.212 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr7_+_91762227 0.212


chr1_+_171871283 0.211 NM_001195190
LOC730159
hypothetical protein LOC730159
chr8_+_7821268 0.210 NM_001193630
LOC100132396
zinc finger protein 705D-like
chr19_+_15699833 0.208 NM_013939
OR10H2
olfactory receptor, family 10, subfamily H, member 2
chr1_-_39119845 0.208 NM_030772
GJA9-MYCBP
GJA9
GJA9-MYCBP read-through transcript
gap junction protein, alpha 9, 59kDa
chrX_+_47999740 0.207 NM_005635
SSX1
synovial sarcoma, X breakpoint 1
chr4_-_38534802 0.207 NM_006068
TLR6
toll-like receptor 6

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.72 1.23e-06 GO:0007606 sensory perception of chemical stimulus
2.15 1.46e-05 GO:0007600 sensory perception
2.64 3.65e-05 GO:0007608 sensory perception of smell
1.65 1.22e-02 GO:0050877 neurological system process
1.54 3.31e-02 GO:0003008 system process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.35 2.59e-04 GO:0071944 cell periphery
1.28 4.80e-04 GO:0016021 integral to membrane
1.28 4.90e-04 GO:0031224 intrinsic to membrane
1.34 5.20e-04 GO:0005886 plasma membrane
1.20 3.23e-02 GO:0044425 membrane part
1.56 3.57e-02 GO:0005887 integral to plasma membrane
1.55 3.66e-02 GO:0031226 intrinsic to plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.83 7.56e-08 GO:0004872 receptor activity
1.71 2.41e-07 GO:0004871 signal transducer activity
1.71 2.41e-07 GO:0060089 molecular transducer activity
2.77 2.36e-06 GO:0004984 olfactory receptor activity
1.84 1.08e-05 GO:0004888 transmembrane receptor activity
2.07 1.40e-05 GO:0004930 G-protein coupled receptor activity