Motif ID: ZBTB16.p2

Z-value: 1.964


Transcription factors associated with ZBTB16.p2:

Gene SymbolEntrez IDGene Name
ZBTB16 7704 zinc finger and BTB domain containing 16

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ZBTB16chr11_+_113435506-0.611.6e-02Click!


Activity profile for motif ZBTB16.p2.

activity profile for motif ZBTB16.p2


Sorted Z-values histogram for motif ZBTB16.p2

Sorted Z-values for motif ZBTB16.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ZBTB16.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_+_188197029 3.695


chr9_-_70780574 3.588


chr12_+_121218218 3.522 NM_152759
LRRC43
leucine rich repeat containing 43
chr11_-_73397929 3.503 NM_003356
NM_022803
UCP3

uncoupling protein 3 (mitochondrial, proton carrier)

chr19_-_53444733 3.236 NM_001184901
NM_001184903
NM_014959
CARD8


caspase recruitment domain family, member 8


chr1_+_173111306 2.761 NM_001035230
RABGAP1L
RAB GTPase activating protein 1-like
chr6_+_10629550 2.474 NM_145649
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr3_+_32968069 2.415 NM_005508
CCR4
chemokine (C-C motif) receptor 4
chr13_-_98708549 2.341 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chr11_+_70926718 2.181 NM_021046
KRTAP5-8
keratin associated protein 5-8
chr19_+_14554895 2.179 NM_207390
CLEC17A
C-type lectin domain family 17, member A
chr12_-_78831821 2.039 NM_001143886
PPP1R12A
protein phosphatase 1, regulatory (inhibitor) subunit 12A
chr7_+_99263571 1.992 NM_022820
NM_057095
NM_057096
CYP3A43


cytochrome P450, family 3, subfamily A, polypeptide 43


chr8_-_81155564 1.942 NM_001025252
TPD52
tumor protein D52
chr8_+_39890484 1.869 NM_002164
IDO1
indoleamine 2,3-dioxygenase 1
chr5_+_141326620 1.848 NM_183399
RNF14
ring finger protein 14
chr21_+_42697058 1.840 NM_001001895
NM_018961
UBASH3A

ubiquitin associated and SH3 domain containing A

chr1_-_180822686 1.819 NM_021133
RNASEL
ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
chr11_+_59920062 1.794 NM_001079692
NM_032597
MS4A14

membrane-spanning 4-domains, subfamily A, member 14

chr12_-_10453409 1.793 NM_013431
KLRC4-KLRK1
KLRC4
KLRC4-KLRK1 read-through transcript
killer cell lectin-like receptor subfamily C, member 4
chr2_-_135498716 1.785 NM_001018046
NM_025052
YSK4

YSK4 Sps1/Ste20-related kinase homolog (S. cerevisiae)

chr19_+_4104593 1.782 NM_032607
CREB3L3
cAMP responsive element binding protein 3-like 3
chr14_+_19761708 1.767 NM_001004480
OR11H6
olfactory receptor, family 11, subfamily H, member 6
chr7_+_106293112 1.766 NM_002649
PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr9_+_263025 1.763 NM_001190458
NM_001193536
DOCK8

dedicator of cytokinesis 8

chr19_-_56612653 1.757 NM_001171156
NM_001171157
NM_001171158
NM_001171159
NM_001171160
NM_001171161
NM_033130
SIGLEC10






sialic acid binding Ig-like lectin 10






chr6_-_44341296 1.757 NM_004556
NFKBIE
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
chr19_-_45141473 1.751 LOC440525
PRR13
proline rich 13 pseudogene
proline rich 13
chr10_+_35466715 1.745 NM_183011
NM_183012
CREM

cAMP responsive element modulator

chrX_-_153903963 1.739 NM_000132
F8
coagulation factor VIII, procoagulant component
chr3_-_15357878 1.736 NM_001018009
SH3BP5
SH3-domain binding protein 5 (BTK-associated)
chr1_+_165565006 1.671 POU2F1
POU class 2 homeobox 1
chr8_+_86287161 1.650 NM_001083589
E2F5
E2F transcription factor 5, p130-binding
chr3_-_9895633 1.612 NM_022094
CIDEC
cell death-inducing DFFA-like effector c
chr9_+_107464558 1.610 NM_005421
TAL2
T-cell acute lymphocytic leukemia 2
chr6_+_28032997 1.591 NM_012367
OR2B6
olfactory receptor, family 2, subfamily B, member 6
chr17_+_71975224 1.591 NM_001088
AANAT
aralkylamine N-acetyltransferase
chr4_-_47709717 1.585 NM_000087
CNGA1
cyclic nucleotide gated channel alpha 1
chr2_+_24660849 1.578 NM_003743
NM_147223
NM_147233
NCOA1


nuclear receptor coactivator 1


chr12_-_9777126 1.559 NM_172004
CLECL1
C-type lectin-like 1
chr3_+_153074118 1.549 NM_033050
SUCNR1
succinate receptor 1
chr12_-_10173947 1.545 NM_022570
NM_197947
NM_197948
NM_197949
NM_197950
NM_197954
CLEC7A





C-type lectin domain family 7, member A





chr11_-_5110383 1.539 NM_001005160
OR52A5
olfactory receptor, family 52, subfamily A, member 5
chr8_-_37916803 1.513 NM_152413
GOT1L1
glutamic-oxaloacetic transaminase 1-like 1
chr2_+_201833467 1.508 NM_033356
CASP8
caspase 8, apoptosis-related cysteine peptidase
chr9_-_116196505 1.505 NM_030767
AKNA
AT-hook transcription factor
chr1_+_170894780 1.488 NM_000639
FASLG
Fas ligand (TNF superfamily, member 6)
chr21_+_29374743 1.473 NM_020152
C21orf7
chromosome 21 open reading frame 7
chr11_-_5212168 1.420 NM_000519
HBD
hemoglobin, delta
chr6_-_49820030 1.398 NM_001190986
NM_006061
CRISP3

cysteine-rich secretory protein 3

chr19_-_46504831 1.378


chr1_-_32054164 1.331 NM_144569
SPOCD1
SPOC domain containing 1
chr12_-_10953427 1.329 NM_023920
TAS2R13
taste receptor, type 2, member 13
chr16_+_20682812 1.319 NM_005622
NM_202000
ACSM3

acyl-CoA synthetase medium-chain family member 3

chr6_+_167445284 1.316 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr1_+_245779018 1.314 NM_145278
C1orf150
chromosome 1 open reading frame 150
chr1_-_205186330 1.310 NM_002644
PIGR
polymeric immunoglobulin receptor
chr2_-_207291364 1.305 NM_001093730
DYTN
dystrotelin
chr22_+_20880112 1.304


chr5_-_135259403 1.293 NM_000590
IL9
interleukin 9
chr1_+_196874759 1.289 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr21_+_36458708 1.254 NM_005128
DOPEY2
dopey family member 2
chr22_+_20880159 1.248 IGLV6-57
immunoglobulin lambda variable 6-57
chr4_-_77176163 1.246 NM_005409
CXCL11
chemokine (C-X-C motif) ligand 11
chr17_+_19917420 1.242 SPECC1
sperm antigen with calponin homology and coiled-coil domains 1
chr3_+_38238080 1.240 OXSR1
oxidative-stress responsive 1
chr6_-_88095714 1.234 NM_198568
GJB7
gap junction protein, beta 7, 25kDa
chr14_-_105549177 1.233 IGHV4-31
IGHD
IGHG3
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
chr1_-_204455269 1.220 NM_001007544
C1orf186
chromosome 1 open reading frame 186
chr12_+_53178834 1.214 NM_001184976
NCKAP1L
NCK-associated protein 1-like
chr15_-_48192804 1.204 ATP8B4
ATPase, class I, type 8B, member 4
chr3_+_46370228 1.196 NM_001123041
NM_001123396
CCR2

chemokine (C-C motif) receptor 2

chrX_+_12795111 1.195 NM_016562
TLR7
toll-like receptor 7
chr2_-_242205556 1.184 NM_001164356
THAP4
THAP domain containing 4
chr14_+_69306019 1.184 SRSF5
serine/arginine-rich splicing factor 5
chr19_-_60528480 1.177 NM_001085488
TMEM150B
transmembrane protein 150B
chr1_-_143708467 1.173 NM_001195260
PDE4DIP
phosphodiesterase 4D interacting protein
chr7_-_142369534 1.171 NM_000420
KEL
Kell blood group, metallo-endopeptidase
chr5_-_88155360 1.154 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr8_-_27997306 1.152 NM_001010906
C8orf80
chromosome 8 open reading frame 80
chr11_-_117600918 1.149 NM_001098526
AMICA1
adhesion molecule, interacts with CXADR antigen 1
chr1_+_196874839 1.147 PTPRC
protein tyrosine phosphatase, receptor type, C
chr19_+_50137334 1.145 NM_001646
APOC4-APOC2
APOC4
APOC4-APOC2 read-through transcript
apolipoprotein C-IV
chr7_-_142369519 1.136 KEL
Kell blood group, metallo-endopeptidase
chr10_-_64698831 1.135 NM_004241
JMJD1C
jumonji domain containing 1C
chr1_-_20318578 1.122 NM_012400
PLA2G2D
phospholipase A2, group IID
chr13_+_47948586 1.107 RB1
retinoblastoma 1
chr3_-_184756101 1.094 NM_130446
KLHL6
kelch-like 6 (Drosophila)
chr7_-_92693716 1.093 NM_001039372
HEPACAM2
HEPACAM family member 2
chr11_-_34491878 1.092 NM_001422
ELF5
E74-like factor 5 (ets domain transcription factor)
chr5_+_148711419 1.076 GRPEL2
GrpE-like 2, mitochondrial (E. coli)
chr3_+_46258875 1.071 NM_001164680
NM_001837
NM_178328
NM_178329
CCR3



chemokine (C-C motif) receptor 3



chr1_-_180624494 1.069 GLUL
glutamate-ammonia ligase
chr20_-_3592045 1.063 NM_022139
NM_145762
GFRA4

GDNF family receptor alpha 4

chr17_-_16038607 1.062 NM_001190438
NM_001190440
NCOR1

nuclear receptor corepressor 1

chr2_+_170370290 1.053 SSB
Sjogren syndrome antigen B (autoantigen La)
chr14_+_87541220 1.039 NM_003608
GPR65
G protein-coupled receptor 65
chr15_-_56093477 1.035 NM_170697
ALDH1A2
aldehyde dehydrogenase 1 family, member A2
chr10_-_69267774 1.026 NM_021800
NM_201262
DNAJC12

DnaJ (Hsp40) homolog, subfamily C, member 12

chr4_-_145159889 1.024 NM_002100
GYPB
glycophorin B (MNS blood group)
chr21_-_14840506 1.017 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr10_+_21924265 1.017 MLLT10
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
chr9_+_134843918 1.011 NM_001135031
NM_004188
GFI1B

growth factor independent 1B transcription repressor

chr11_+_123600553 0.995 NM_001007249
OR8G2
olfactory receptor, family 8, subfamily G, member 2
chr4_+_123311207 0.995 NM_015312
KIAA1109
KIAA1109
chr7_-_36730525 0.985 NM_001177506
NM_001177507
NM_001637
AOAH


acyloxyacyl hydrolase (neutrophil)


chr1_-_20374273 0.981 NM_001105572
PLA2G2C
phospholipase A2, group IIC
chr11_+_63030099 0.972 NM_001142535
NM_001142536
NM_033101
LGALS12


lectin, galactoside-binding, soluble, 12


chrX_-_23955223 0.968 NM_030624
KLHL15
kelch-like 15 (Drosophila)
chr11_+_59902598 0.967 MS4A7
membrane-spanning 4-domains, subfamily A, member 7
chr2_-_157890400 0.967 NM_020711
ERMN
ermin, ERM-like protein
chr19_+_56990222 0.959 NM_002030
FPR3
formyl peptide receptor 3
chr9_-_21375258 0.952 NM_000605
IFNA2
interferon, alpha 2
chr11_+_63030131 0.951 LGALS12
lectin, galactoside-binding, soluble, 12
chr7_+_37689903 0.948


chr2_+_161701711 0.943 NM_004180
NM_133484
TANK

TRAF family member-associated NFKB activator

chr5_-_75044001 0.936 NM_152408
POC5
POC5 centriolar protein homolog (Chlamydomonas)
chr8_-_59575249 0.934 NM_000780
CYP7A1
cytochrome P450, family 7, subfamily A, polypeptide 1
chr10_-_69125932 0.925 NM_013266
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr2_+_38746555 0.924 NM_138801
GALM
galactose mutarotase (aldose 1-epimerase)
chr3_+_39346200 0.921 NM_005201
CCR8
chemokine (C-C motif) receptor 8
chr1_+_67404756 0.915 NM_144701
IL23R
interleukin 23 receptor
chr4_-_80548378 0.908 NM_033214
GK2
glycerol kinase 2
chr5_+_67622242 0.907 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr3_-_171070314 0.904 NM_024727
LRRC31
leucine rich repeat containing 31
chr2_+_68726457 0.890 NM_138964
PROKR1
prokineticin receptor 1
chr9_-_21358005 0.888 NM_006900
IFNA1
IFNA13
interferon, alpha 1
interferon, alpha 13
chr7_+_106292932 0.885 PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr2_+_228064531 0.884 AGFG1
ArfGAP with FG repeats 1
chr12_+_12829807 0.883 NM_030817
APOLD1
apolipoprotein L domain containing 1
chr11_+_59027624 0.877 NM_001004706
OR4D11
olfactory receptor, family 4, subfamily D, member 11
chr4_-_17415918 0.877 DCAF16
DDB1 and CUL4 associated factor 16
chr19_-_14646626 0.876 NM_032571
EMR3
egf-like module containing, mucin-like, hormone receptor-like 3
chr10_+_35524060 0.875 NM_182717
NM_182718
NM_182719
NM_182720
CREM



cAMP responsive element modulator



chr6_+_4835224 0.873 NM_001143971
CDYL
chromodomain protein, Y-like
chr1_-_166149867 0.868 NM_001167749
NM_018417
ADCY10

adenylate cyclase 10 (soluble)

chr1_+_58899 0.868 NM_001005484
OR4F4
OR4F5
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 5
chr5_+_61910318 0.866 NM_181506
LRRC70
leucine rich repeat containing 70
chr19_+_61624 0.860 NM_001005240
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr4_-_110942783 0.857 NM_000204
CFI
complement factor I
chr1_+_100099353 0.854 NM_000645
AGL
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
chr14_-_105804211 0.851 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr8_-_66863841 0.840 NM_002603
PDE7A
phosphodiesterase 7A
chr1_+_51340487 0.828 NM_001136508
C1orf185
chromosome 1 open reading frame 185
chr7_+_132588359 0.826 NM_001037126
NM_021807
EXOC4

exocyst complex component 4

chr6_+_64289585 0.824 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr11_-_5487728 0.821 NM_017481
UBQLN3
ubiquilin 3
chr2_-_197383120 0.820 NM_213608
C2orf66
chromosome 2 open reading frame 66
chrX_-_153698930 0.817 HMGN1P37
high-mobility group nucleosome binding domain 1 pseudogene 37
chr12_+_14429499 0.817 ATF7IP
activating transcription factor 7 interacting protein
chr8_+_26569709 0.808 DPYSL2
dihydropyrimidinase-like 2
chr5_+_171553780 0.806 NM_001171183
EFCAB9
EF-hand calcium binding domain 9
chr3_-_152585226 0.797 NM_022788
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr10_+_97505398 0.795 NM_001164178
NM_001164181
NM_001164179
NM_001164182
NM_001164183
NM_001776
ENTPD1





ectonucleoside triphosphate diphosphohydrolase 1





chr1_+_20227480 0.794 PLA2G5
phospholipase A2, group V
chr2_-_73860609 0.787 NM_003584
DUSP11
dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
chr6_+_26476384 0.780 NM_001197246
BTN3A2
butyrophilin, subfamily 3, member A2
chr20_+_1132097 0.778 NM_001009612
C20orf202
chromosome 20 open reading frame 202
chr1_-_41398126 0.771 NM_001172222
SCMH1
sex comb on midleg homolog 1 (Drosophila)
chr1_-_51660328 0.769 NM_001159969
EPS15
epidermal growth factor receptor pathway substrate 15
chr8_-_95298706 0.758 NM_001144663
CDH17
cadherin 17, LI cadherin (liver-intestine)
chr10_-_49152918 0.755 NM_001018071
FRMPD2
FERM and PDZ domain containing 2
chr12_+_94200306 0.754 VEZT
vezatin, adherens junctions transmembrane protein
chr11_+_5667392 0.751 TRIM22
tripartite motif containing 22
chr3_-_46043982 0.750 NM_001024644
NM_005283
XCR1

chemokine (C motif) receptor 1

chr11_-_59707074 0.750 NM_022349
NM_152851
NM_152852
MS4A6A


membrane-spanning 4-domains, subfamily A, member 6A


chr2_+_170363573 0.742 NM_003142
SSB
Sjogren syndrome antigen B (autoantigen La)
chr4_-_160175782 0.740 NM_152543
C4orf45
chromosome 4 open reading frame 45
chr6_-_31668476 0.740 NM_001145466
NM_001145467
NM_147130
NCR3


natural cytotoxicity triggering receptor 3


chr11_+_4965996 0.739 NM_021801
MMP26
matrix metallopeptidase 26
chr21_+_37377116 0.736 NM_003316
TTC3
tetratricopeptide repeat domain 3
chr1_-_167969802 0.734 NM_000450
SELE
selectin E
chr7_-_86433139 0.733 NM_152748
KIAA1324L
KIAA1324-like
chr6_-_44341222 0.730 NFKBIE
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
chr8_+_24207524 0.729 NM_014265
NM_021777
ADAM28

ADAM metallopeptidase domain 28

chr11_-_5756472 0.727 NM_001001922
OR52N5
olfactory receptor, family 52, subfamily N, member 5
chr7_+_77307382 0.726 NM_001127357
NM_001127359
NM_020432
PHTF2


putative homeodomain transcription factor 2


chr19_-_14750347 0.725 NM_013447
NM_152916
NM_152917
NM_152918
NM_152919
NM_152920
NM_152921
EMR2






egf-like module containing, mucin-like, hormone receptor-like 2






chr13_+_108079570 0.724 NM_001198950
MYO16
myosin XVI
chr4_+_43185 0.724 NM_182524
ZNF595
ZNF718
zinc finger protein 595
zinc finger protein 718
chr6_-_108252200 0.722 NM_198081
SCML4
sex comb on midleg-like 4 (Drosophila)
chr4_-_110942576 0.721 CFI
complement factor I
chr4_+_74520796 0.721 NM_001134
AFP
alpha-fetoprotein
chr1_-_159543847 0.718 MPZ
myelin protein zero
chr1_+_154120170 0.716 SYT11
synaptotagmin XI
chr14_-_19867372 0.711 NM_182852
NM_182851
CCNB1IP1

cyclin B1 interacting protein 1, E3 ubiquitin protein ligase

chr11_-_16387001 0.711 NM_001145811
SOX6
SRY (sex determining region Y)-box 6
chr15_+_89248423 0.710 NM_006122
MAN2A2
mannosidase, alpha, class 2A, member 2
chr8_-_102029997 0.708 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr3_+_184836049 0.706 NM_017644
KLHL24
kelch-like 24 (Drosophila)
chr12_+_68028397 0.705 NM_000239
LYZ
lysozyme
chrX_+_79562601 0.704 NM_152630
FAM46D
family with sequence similarity 46, member D
chr8_-_102005697 0.704 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr3_+_99733432 0.704 NM_005290
GPR15
G protein-coupled receptor 15
chr1_+_178232379 0.704 CEP350
centrosomal protein 350kDa
chr10_-_11614279 0.700 NM_001080491
USP6NL
USP6 N-terminal like
chr3_-_9895471 0.699 CIDEC
cell death-inducing DFFA-like effector c
chr19_+_21056792 0.696 NM_182515
ZNF714
zinc finger protein 714
chr17_+_37247568 0.696 NM_152467
KLHL10
kelch-like 10 (Drosophila)
chr1_-_20014180 0.695 NM_019062
RNF186
ring finger protein 186

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.99 5.90e-09 GO:0006955 immune response
1.69 1.37e-07 GO:0002376 immune system process
1.88 1.37e-07 GO:0006952 defense response
2.24 3.70e-07 GO:0007608 sensory perception of smell
2.06 8.33e-06 GO:0007606 sensory perception of chemical stimulus
2.88 2.03e-05 GO:0009615 response to virus
2.07 7.08e-05 GO:0051707 response to other organism
1.93 6.80e-04 GO:0050776 regulation of immune response
1.86 1.06e-03 GO:0009607 response to biotic stimulus
1.70 1.83e-03 GO:0002682 regulation of immune system process
1.98 2.34e-03 GO:0045087 innate immune response
1.17 7.25e-03 GO:0050896 response to stimulus
1.55 2.83e-02 GO:0007600 sensory perception
1.77 3.90e-02 GO:0002684 positive regulation of immune system process

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.28 7.46e-08 GO:0004984 olfactory receptor activity
1.66 1.02e-04 GO:0004930 G-protein coupled receptor activity
1.39 1.56e-03 GO:0004872 receptor activity
1.44 4.82e-03 GO:0004888 transmembrane receptor activity
1.30 2.13e-02 GO:0004871 signal transducer activity
1.30 2.13e-02 GO:0060089 molecular transducer activity