Motif ID: NKX3-2.p2

Z-value: 1.220


Transcription factors associated with NKX3-2.p2:

Gene SymbolEntrez IDGene Name
NKX3-2 579 NK3 homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX3-2chr4_-_13155135-0.253.7e-01Click!


Activity profile for motif NKX3-2.p2.

activity profile for motif NKX3-2.p2


Sorted Z-values histogram for motif NKX3-2.p2

Sorted Z-values for motif NKX3-2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX3-2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_82163568 1.468 C10orf58
chromosome 10 open reading frame 58
chr2_+_228386800 0.918 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr10_-_123343761 0.861 NM_001144916
FGFR2
fibroblast growth factor receptor 2
chr8_-_122722674 0.805 NM_005328
HAS2
hyaluronan synthase 2
chr6_-_112001590 0.751 NM_001164282
TRAF3IP2
TRAF3 interacting protein 2
chr16_-_28130201 0.690 XPO6
exportin 6
chr10_-_5436781 0.683 NM_001171864
NM_024803
TUBAL3

tubulin, alpha-like 3

chr2_-_148495642 0.627 NM_181742
ORC4
origin recognition complex, subunit 4
chr3_+_69216747 0.619 NM_006407
ARL6IP5
ADP-ribosylation-like factor 6 interacting protein 5
chr1_+_46418786 0.604 TSPAN1
tetraspanin 1
chr17_+_71154240 0.581 NM_001162997
LOC100130933
hypothetical protein LOC100130933
chr12_-_122155998 0.581 PITPNM2
phosphatidylinositol transfer protein, membrane-associated 2
chr1_+_35507197 0.575 ZMYM4
zinc finger, MYM-type 4
chr2_+_64540843 0.574 HSPC159
galectin-related protein
chr1_-_24311212 0.571 NM_152372
MYOM3
myomesin family, member 3
chr9_-_33455191 0.550 NOL6
nucleolar protein family 6 (RNA-associated)
chr12_+_32578513 0.547 FGD4
FYVE, RhoGEF and PH domain containing 4
chr20_-_1420004 0.506 SIRPB2
signal-regulatory protein beta 2
chr14_-_22840249 0.503


chr20_+_19903778 0.498 RIN2
Ras and Rab interactor 2
chr5_+_118632403 0.497 TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chrX_-_107568211 0.495 NM_033641
COL4A6
collagen, type IV, alpha 6
chr18_-_26996742 0.494 NM_004948
NM_024421
DSC1

desmocollin 1

chr5_-_39460787 0.487 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr2_-_158439868 0.484 NM_001105
ACVR1
activin A receptor, type I
chr2_+_101981888 0.470 NM_173343
IL1R2
interleukin 1 receptor, type II
chr12_+_32546243 0.469 NM_139241
FGD4
FYVE, RhoGEF and PH domain containing 4
chrX_-_49852397 0.468 NM_003886
AKAP4
A kinase (PRKA) anchor protein 4
chr17_-_31337798 0.467 NM_032962
NM_032963
CCL14

chemokine (C-C motif) ligand 14

chr3_-_188936941 0.466 NM_001130845
BCL6
B-cell CLL/lymphoma 6
chr16_+_64958060 0.465 CDH5
cadherin 5, type 2 (vascular endothelium)
chr2_-_139254273 0.442 NM_007226
NXPH2
neurexophilin 2
chr5_+_118632316 0.440 NM_001077654
TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr13_+_25726238 0.430 CDK8
cyclin-dependent kinase 8
chr16_+_64958086 0.430 CDH5
cadherin 5, type 2 (vascular endothelium)
chr3_-_110155237 0.422 NM_005459
GUCA1C
guanylate cyclase activator 1C
chr5_-_39460687 0.407 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr20_-_1420168 0.405 NM_001122962
NM_001134836
SIRPB2

signal-regulatory protein beta 2

chr14_-_23878871 0.396 NM_006871
RIPK3
receptor-interacting serine-threonine kinase 3
chr18_+_40514772 0.391 NM_015559
SETBP1
SET binding protein 1
chrX_+_106050261 0.388 NM_020384
CLDN2
claudin 2
chr17_-_36418869 0.388 NM_031958
KRTAP3-1
keratin associated protein 3-1
chr3_-_132704339 0.384 NM_007208
MRPL3
mitochondrial ribosomal protein L3
chr15_+_28706170 0.378 NM_001039841
ARHGAP11B
Rho GTPase activating protein 11B
chr6_-_41823056 0.377 NM_001166424
NM_002630
PGC

progastricsin (pepsinogen C)

chr10_+_86174665 0.377 FAM190B
family with sequence similarity 190, member B
chr4_+_169789327 0.377 NM_001166109
PALLD
palladin, cytoskeletal associated protein
chr20_-_1420126 0.373 SIRPB2
signal-regulatory protein beta 2
chrX_+_70438352 0.371 NM_012278
ITGB1BP2
integrin beta 1 binding protein (melusin) 2
chr1_+_35507145 0.370 NM_005095
ZMYM4
zinc finger, MYM-type 4
chr6_-_138935359 0.369 NM_020464
NHSL1
NHS-like 1
chr1_+_78243181 0.366 NM_007034
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chrX_-_114703273 0.363


chr8_+_120289735 0.358 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr10_-_29963906 0.358 NM_021738
SVIL
supervillin
chr14_+_22305570 0.357 NM_005015
OXA1L
oxidase (cytochrome c) assembly 1-like
chr11_-_101906640 0.357 NM_002423
MMP7
matrix metallopeptidase 7 (matrilysin, uterine)
chrX_-_15530112 0.356 NM_021804
ACE2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr3_-_102194938 0.354 NM_015429
ABI3BP
ABI family, member 3 (NESH) binding protein
chr10_+_98582648 0.354 NM_032440
LCOR
ligand dependent nuclear receptor corepressor
chr20_-_16501911 0.351 NM_024704
KIF16B
kinesin family member 16B
chr11_-_119514058 0.348 NM_012101
TRIM29
tripartite motif containing 29
chr6_+_10629550 0.347 NM_145649
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr3_+_133798770 0.345 NM_016557
CCRL1
chemokine (C-C motif) receptor-like 1
chr5_+_131437383 0.344 NM_000758
CSF2
colony stimulating factor 2 (granulocyte-macrophage)
chr4_-_168392151 0.343 SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr4_-_168392266 0.340 SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr6_+_41712907 0.339 MDFI
MyoD family inhibitor
chr13_+_96726197 0.338 MBNL2
muscleblind-like 2 (Drosophila)
chr6_-_116706828 0.338 TSPYL1
TSPY-like 1
chr6_-_119297851 0.336 MCM9
minichromosome maintenance complex component 9
chr12_-_116283793 0.334 NM_000620
NOS1
nitric oxide synthase 1 (neuronal)
chr18_+_27152049 0.334 NM_001942
DSG1
desmoglein 1
chr22_-_35207582 0.332 NM_012473
TXN2
thioredoxin 2
chr2_+_218698980 0.328 NM_001557
CXCR2
chemokine (C-X-C motif) receptor 2
chr16_+_55963883 0.327 CX3CL1
chemokine (C-X3-C motif) ligand 1
chr5_-_39461054 0.326 NM_001343
DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr11_-_56846246 0.325 TNKS1BP1
tankyrase 1 binding protein 1, 182kDa
chr2_-_189752575 0.324 NM_000393
COL5A2
collagen, type V, alpha 2
chr12_+_67426225 0.322 SLC35E3
solute carrier family 35, member E3
chr4_-_54119102 0.321 LNX1
ligand of numb-protein X 1
chr20_-_3944035 0.319 NM_007219
NM_001134337
NM_001134338
RNF24


ring finger protein 24


chr16_+_55963899 0.319 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr5_-_22248630 0.317 CDH12
cadherin 12, type 2 (N-cadherin 2)
chr16_+_64958025 0.313 NM_001795
CDH5
cadherin 5, type 2 (vascular endothelium)
chr11_-_119513948 0.313 TRIM29
tripartite motif containing 29
chr3_-_192063158 0.313 NM_001146686
GEMC1
geminin coiled-coil domain-containing protein 1
chr17_+_7289086 0.312 NM_000747
CHRNB1
cholinergic receptor, nicotinic, beta 1 (muscle)
chr2_+_48395271 0.311 NM_002158
FOXN2
forkhead box N2
chr12_-_69317441 0.311 NM_001109754
PTPRB
protein tyrosine phosphatase, receptor type, B
chr9_+_111582317 0.308 NM_053016
NM_007203
NM_147150
PALM2
PALM2-AKAP2

paralemmin 2
PALM2-AKAP2 readthrough

chr12_-_6668085 0.306 NM_001039916
ZNF384
zinc finger protein 384
chr14_-_73296387 0.302 C14orf43
chromosome 14 open reading frame 43
chr20_-_17487480 0.302 NM_001161705
BFSP1
beaded filament structural protein 1, filensin
chr12_+_79995927 0.301 NM_024560
ACSS3
acyl-CoA synthetase short-chain family member 3
chr3_-_48446405 0.298 NM_001130082
PLXNB1
plexin B1
chr5_+_149960820 0.296 NM_001166208
SYNPO
synaptopodin
chr11_+_65023218 0.296


chr22_-_35914200 0.295 NM_031910
NM_182486
C1QTNF6

C1q and tumor necrosis factor related protein 6

chr11_+_66580861 0.293 NM_014578
RHOD
ras homolog gene family, member D
chr1_-_24342158 0.292 NM_021258
IL22RA1
interleukin 22 receptor, alpha 1
chr11_-_119499188 0.292 TRIM29
tripartite motif containing 29
chr6_-_116529101 0.291 LOC100287673
hypothetical LOC100287673
chr2_-_24123726 0.289 NM_001142319
NM_025203
C2orf44

chromosome 2 open reading frame 44

chr1_-_159257595 0.287 NM_016946
F11R
F11 receptor
chr3_-_123036526 0.286 IQCB1
IQ motif containing B1
chr1_-_23567084 0.286 NM_030634
ZNF436
zinc finger protein 436
chr6_+_131190237 0.286 NM_001195597
LOC285733
hypothetical LOC285733
chr14_-_20636909 0.285 NM_001101672
ZNF219
zinc finger protein 219
chr14_-_49848538 0.285 NM_024884
L2HGDH
L-2-hydroxyglutarate dehydrogenase
chr3_+_113180517 0.285 NM_018394
ABHD10
abhydrolase domain containing 10
chr12_-_121767272 0.284 NM_006018
GPR109B
G protein-coupled receptor 109B
chr14_-_64479198 0.282 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr10_+_102113410 0.281


chr4_-_54119123 0.280 LNX1
ligand of numb-protein X 1
chr17_+_42023353 0.280 NM_006178
NSF
N-ethylmaleimide-sensitive factor
chr11_-_119514011 0.280 TRIM29
tripartite motif containing 29
chr5_+_66160359 0.278 NM_015183
MAST4
microtubule associated serine/threonine kinase family member 4
chr14_+_20636935 0.278 NM_001146683
C14orf176
chromosome 14 open reading frame 176
chr4_+_141397889 0.274 NM_032547
SCOC
short coiled-coil protein
chr1_-_151630168 0.273 NM_002964
S100A8
S100 calcium binding protein A8
chr6_+_116956868 0.271 NM_153036
FAM26D
family with sequence similarity 26, member D
chr2_-_3360467 0.270 NM_003310
TSSC1
tumor suppressing subtransferable candidate 1
chr7_+_29200636 0.270 NM_004067
CHN2
chimerin (chimaerin) 2
chr10_-_123343320 0.270 NM_001144913
NM_001144914
FGFR2

fibroblast growth factor receptor 2

chr2_+_201099093 0.269 NM_001160033
NM_001160046
NM_152524
SGOL2


shugoshin-like 2 (S. pombe)


chr16_+_18903009 0.268 NM_001160364
TMC7
transmembrane channel-like 7
chr4_-_168392307 0.267 NM_001040159
NM_016950
SPOCK3

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3

chr9_-_101621964 0.267


chr17_-_6958282 0.264 NM_080914
ASGR2
asialoglycoprotein receptor 2
chr11_-_64484184 0.264 NM_001037225
C11orf85
chromosome 11 open reading frame 85
chr1_-_183392442 0.263 NM_030934
TRMT1L
TRM1 tRNA methyltransferase 1-like
chr14_-_22610610 0.263 NM_001164816
NM_001164817
ACIN1

apoptotic chromatin condensation inducer 1

chr15_+_62539831 0.262 ZNF609
zinc finger protein 609
chr2_-_68952006 0.262 NM_014482
BMP10
bone morphogenetic protein 10
chr1_-_20122638 0.261 NM_014589
PLA2G2E
phospholipase A2, group IIE
chr8_+_32905027 0.260


chrX_-_15198093 0.260 NM_001031739
NM_001168530
NM_024087
ASB9


ankyrin repeat and SOCS box containing 9


chr1_+_15955719 0.260 FBLIM1
filamin binding LIM protein 1
chr18_+_27425727 0.258 NM_000371
TTR
transthyretin
chr12_+_55018925 0.257 NM_016584
IL23A
interleukin 23, alpha subunit p19
chr7_+_134114701 0.257 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr20_+_35755865 0.257 CTNNBL1
catenin, beta like 1
chr7_-_43875597 0.256 NM_032014
MRPS24
mitochondrial ribosomal protein S24
chr1_+_198263352 0.256 NM_003822
NM_205860
NR5A2

nuclear receptor subfamily 5, group A, member 2

chr1_-_11029737 0.256 NM_006610
NM_139208
MASP2

mannan-binding lectin serine peptidase 2

chr9_-_27563444 0.256 NM_018325
C9orf72
chromosome 9 open reading frame 72
chr5_+_56507029 0.256 NM_001127235
GPBP1
GC-rich promoter binding protein 1
chr10_+_59942874 0.254 NM_001080512
BICC1
bicaudal C homolog 1 (Drosophila)
chr7_-_50596238 0.254 NM_000790
DDC
dopa decarboxylase (aromatic L-amino acid decarboxylase)
chr4_+_74497998 0.253 ALB
albumin
chr4_+_74498042 0.251 ALB
albumin
chr8_+_22266256 0.249 PIWIL2
piwi-like 2 (Drosophila)
chr16_-_31054563 0.249 NM_002773
PRSS8
protease, serine, 8
chr2_-_104834344 0.249 LOC100506421
hypothetical LOC100506421
chr10_+_96295511 0.248 NM_018063
HELLS
helicase, lymphoid-specific
chr5_+_118434966 0.247 NM_005509
DMXL1
Dmx-like 1
chr3_+_62279707 0.247 C3orf14
chromosome 3 open reading frame 14
chr1_+_86662356 0.247 NM_006536
CLCA2
chloride channel accessory 2
chr14_+_30564433 0.246 NM_001128126
NM_007077
AP4S1

adaptor-related protein complex 4, sigma 1 subunit

chr4_+_166348219 0.246 NM_007246
KLHL2
kelch-like 2, Mayven (Drosophila)
chr17_-_40843530 0.246 ARHGAP27
Rho GTPase activating protein 27
chr16_-_45562840 0.245 DNAJA2
DnaJ (Hsp40) homolog, subfamily A, member 2
chr14_-_22515725 0.244 JUB
jub, ajuba homolog (Xenopus laevis)
chr6_+_158358067 0.244 NM_001178088
SYNJ2
synaptojanin 2
chrX_+_48545230 0.243 HDAC6
histone deacetylase 6
chr2_-_178645718 0.241 NM_016953
PDE11A
phosphodiesterase 11A
chr3_-_79899748 0.241 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr3_-_123036597 0.240 NM_001023570
NM_001023571
IQCB1

IQ motif containing B1

chr12_+_49444509 0.239 ATF1
activating transcription factor 1
chr14_-_34414277 0.239 BAZ1A
bromodomain adjacent to zinc finger domain, 1A
chr2_+_27705018 0.238 NM_001145047
NM_001145048
NM_001145049
GPN1


GPN-loop GTPase 1


chr8_-_42515774 0.238 SLC20A2
solute carrier family 20 (phosphate transporter), member 2
chr11_-_116199145 0.237 NM_000482
APOA4
apolipoprotein A-IV
chr13_-_95503566 0.237 NM_020121
UGGT2
UDP-glucose glycoprotein glucosyltransferase 2
chr9_-_112010233 0.236 NM_001012993
C9orf152
chromosome 9 open reading frame 152
chr1_-_31542178 0.236 NM_004814
SNRNP40
small nuclear ribonucleoprotein 40kDa (U5)
chr3_-_58538110 0.234 FAM107A
family with sequence similarity 107, member A
chr22_+_36412277 0.233 NM_024313
NOL12
nucleolar protein 12
chr17_-_57023322 0.233 NM_199290
NACA2
nascent polypeptide-associated complex alpha subunit 2
chr4_-_54119159 0.232 NM_032622
LNX1
ligand of numb-protein X 1
chr17_-_40348378 0.232 NM_001131019
NM_002055
GFAP

glial fibrillary acidic protein

chr17_-_39651189 0.232 NM_014233
UBTF
upstream binding transcription factor, RNA polymerase I
chr4_+_35959638 0.231 NM_001136536
DTHD1
death domain containing 1
chr6_+_27464461 0.230 NM_001076781
ZNF391
zinc finger protein 391
chr8_+_42515873 0.230 NM_138436
NM_001135674
NM_001135675
C8orf40


chromosome 8 open reading frame 40


chr14_-_34943574 0.229 NM_020529
NFKBIA
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
chr3_-_81893308 0.229 GBE1
glucan (1,4-alpha-), branching enzyme 1
chr20_-_49852353 0.229 NM_020436
SALL4
sal-like 4 (Drosophila)
chr14_-_22610572 0.229 ACIN1
apoptotic chromatin condensation inducer 1
chr6_+_116528663 0.229 NM_152729
NT5DC1
5'-nucleotidase domain containing 1
chr20_-_581808 0.226 SRXN1
sulfiredoxin 1
chr6_+_139391511 0.226 NM_021243
C6orf115
chromosome 6 open reading frame 115
chr14_+_94097513 0.225 NM_006215
SERPINA4
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
chr10_+_5126613 0.224 AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr3_-_191522886 0.224 NM_021101
CLDN1
claudin 1
chr3_+_106568243 0.224 ALCAM
activated leukocyte cell adhesion molecule
chr6_+_160068135 0.223 NM_004906
NM_152858
WTAP

Wilms tumor 1 associated protein

chr1_-_153209625 0.223 NM_001130040
NM_183001
SHC1

SHC (Src homology 2 domain containing) transforming protein 1

chr20_+_51023159 0.222 TSHZ2
teashirt zinc finger homeobox 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.20 3.70e-08 GO:0044260 cellular macromolecule metabolic process
1.17 1.46e-06 GO:0043170 macromolecule metabolic process
1.08 4.53e-06 GO:0009987 cellular process
1.12 3.27e-05 GO:0008152 metabolic process
1.13 3.62e-05 GO:0044237 cellular metabolic process
1.23 1.65e-04 GO:0044267 cellular protein metabolic process
1.12 2.90e-04 GO:0044238 primary metabolic process
1.23 7.03e-03 GO:0043412 macromolecule modification
1.18 8.63e-03 GO:0019538 protein metabolic process
1.56 8.83e-03 GO:0016568 chromatin modification
1.23 1.66e-02 GO:0006464 protein modification process
1.47 1.83e-02 GO:0006325 chromatin organization
1.23 4.35e-02 GO:0006996 organelle organization
1.39 4.52e-02 GO:0051276 chromosome organization

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.09 1.29e-12 GO:0005622 intracellular
1.09 7.52e-12 GO:0044424 intracellular part
1.11 9.64e-10 GO:0043229 intracellular organelle
1.10 1.67e-09 GO:0043226 organelle
1.11 2.32e-08 GO:0043231 intracellular membrane-bounded organelle
1.11 3.60e-08 GO:0043227 membrane-bounded organelle
1.16 6.74e-08 GO:0044446 intracellular organelle part
1.11 9.65e-08 GO:0005737 cytoplasm
1.15 1.72e-07 GO:0044422 organelle part
1.13 3.84e-05 GO:0044444 cytoplasmic part
1.20 2.06e-04 GO:0043228 non-membrane-bounded organelle
1.20 2.06e-04 GO:0043232 intracellular non-membrane-bounded organelle
1.12 1.41e-03 GO:0005634 nucleus
1.20 2.05e-03 GO:0031974 membrane-enclosed lumen
1.19 4.51e-03 GO:0043233 organelle lumen
1.19 5.25e-03 GO:0070013 intracellular organelle lumen
2.40 6.50e-03 GO:0034708 methyltransferase complex
2.40 6.50e-03 GO:0035097 histone methyltransferase complex
1.14 1.97e-02 GO:0032991 macromolecular complex
1.19 3.91e-02 GO:0031981 nuclear lumen

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.14 8.82e-10 GO:0005515 protein binding
1.07 3.52e-06 GO:0005488 binding
1.31 4.28e-02 GO:0003723 RNA binding