Motif ID: FOX{C1,C2}.p2

Z-value: 1.246


Transcription factors associated with FOX{C1,C2}.p2:

Gene SymbolEntrez IDGene Name
FOXC1 2296 forkhead box C1
FOXC2 2303 forkhead box C2 (MFH-1, mesenchyme forkhead 1)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOXC1chr6_+_1556543-0.381.6e-01Click!
FOXC2chr16_+_851583570.361.9e-01Click!


Activity profile for motif FOX{C1,C2}.p2.

activity profile for motif FOX{C1,C2}.p2


Sorted Z-values histogram for motif FOX{C1,C2}.p2

Sorted Z-values for motif FOX{C1,C2}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOX{C1,C2}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_169392771 2.774


chr17_-_78391178 2.481 NM_024702
ZNF750
zinc finger protein 750
chr22_+_19239221 2.052 MED15
mediator complex subunit 15
chr20_-_60435983 1.804 NM_080833
C20orf151
chromosome 20 open reading frame 151
chr18_+_41558141 1.637 SLC14A1
solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
chr8_+_55691179 1.547 NM_006269
RP1
retinitis pigmentosa 1 (autosomal dominant)
chr2_+_73973600 1.491 NM_001615
ACTG2
actin, gamma 2, smooth muscle, enteric
chr6_+_47732181 1.454 NM_153839
GPR111
G protein-coupled receptor 111
chr7_-_98643024 1.439 NM_001145715
KPNA7
karyopherin alpha 7 (importin alpha 8)
chr7_-_99115454 1.433 NM_000777
NM_001190484
CYP3A5

cytochrome P450, family 3, subfamily A, polypeptide 5

chr2_+_73973640 1.419 ACTG2
actin, gamma 2, smooth muscle, enteric
chr11_+_111288686 1.231 HSPB2-C11ORF52
HSPB2
HSPB2-C11orf52 read-through transcript
heat shock 27kDa protein 2
chr3_+_137224266 1.226 NM_181897
PPP2R3A
protein phosphatase 2, regulatory subunit B'', alpha
chr15_-_56093477 1.150 NM_170697
ALDH1A2
aldehyde dehydrogenase 1 family, member A2
chr1_-_26553168 1.110 NM_001039775
AIM1L
absent in melanoma 1-like
chr2_-_233349469 1.104 NM_001172416
NM_001172417
NM_002242
KCNJ13


potassium inwardly-rectifying channel, subfamily J, member 13


chr1_+_150958621 1.101 NM_001024679
C1orf68
chromosome 1 open reading frame 68
chr11_+_111288669 1.058 NM_001541
HSPB2-C11ORF52
HSPB2
HSPB2-C11orf52 read-through transcript
heat shock 27kDa protein 2
chr17_-_39191658 1.040 NM_025237
SOST
sclerostin
chr1_-_110735158 1.022 NM_004696
SLC16A4
solute carrier family 16, member 4 (monocarboxylic acid transporter 5)
chr11_+_110890719 0.988 NM_001100388
NM_207430
C11orf88

chromosome 11 open reading frame 88

chr9_+_123088217 0.957 GSN
gelsolin
chr11_-_8789457 0.939 NM_139157
ST5
suppression of tumorigenicity 5
chr9_+_139265533 0.923 NM_001004353
C9orf173
chromosome 9 open reading frame 173
chr7_-_92686773 0.913 NM_198151
HEPACAM2
HEPACAM family member 2
chr20_-_43601542 0.905 NM_080827
WFDC6
WAP four-disulfide core domain 6
chr3_-_52688768 0.898 NM_018165
NM_181042
PBRM1

polybromo 1

chr16_+_68516401 0.886 NM_199424
WWP2
WW domain containing E3 ubiquitin protein ligase 2
chr15_+_60838053 0.886 TLN2
talin 2
chr1_+_158352143 0.849 NM_000702
ATP1A2
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr17_-_45620313 0.822


chr17_-_36347197 0.818 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chr4_+_186368277 0.787 NM_031953
SNX25
sorting nexin 25
chr11_-_62445308 0.773 CHRM1
cholinergic receptor, muscarinic 1
chr12_-_25597444 0.765 NM_152590
NM_001145728
NM_001145729
IFLTD1


intermediate filament tail domain containing 1


chr12_+_45896511 0.757 FAM113B
family with sequence similarity 113, member B
chr4_-_68678181 0.750 NM_207407
TMPRSS11F
transmembrane protease, serine 11F
chr8_-_11742668 0.719


chr12_+_25096755 0.713 LRMP
lymphoid-restricted membrane protein
chr2_-_160765008 0.712 ITGB6
integrin, beta 6
chr10_-_60792225 0.710 NM_001001971
NM_001166698
NM_198215
FAM13C


family with sequence similarity 13, member C


chr17_+_46176105 0.702 LUC7L3
LUC7-like 3 (S. cerevisiae)
chr5_+_38481392 0.700 NM_182801
EGFLAM
EGF-like, fibronectin type III and laminin G domains
chr1_-_166965034 0.696 NM_001937
DPT
dermatopontin
chr14_+_99309688 0.679 EML1
echinoderm microtubule associated protein like 1
chr11_-_3759886 0.679 NUP98
nucleoporin 98kDa
chr1_-_56750235 0.675 PPAP2B
phosphatidic acid phosphatase type 2B
chr5_+_150000394 0.652 NM_001109974
NM_007286
SYNPO

synaptopodin

chr9_+_111442888 0.649 NM_001037293
PALM2
paralemmin 2
chr11_+_93940121 0.639 NM_152431
PIWIL4
piwi-like 4 (Drosophila)
chr1_+_64442077 0.637 NM_152489
UBE2U
ubiquitin-conjugating enzyme E2U (putative)
chr16_-_31054321 0.636 PRSS8
protease, serine, 8
chr3_+_134978615 0.631 TF
transferrin
chr3_-_195571748 0.627 NM_001135057
NM_130830
LRRC15

leucine rich repeat containing 15

chr3_+_153014550 0.626 NM_001086
AADAC
arylacetamide deacetylase (esterase)
chr20_+_9146036 0.611 NM_182797
PLCB4
phospholipase C, beta 4
chr21_-_42689192 0.611 NM_024022
NM_032405
TMPRSS3

transmembrane protease, serine 3

chr20_-_60360789 0.610 LAMA5
laminin, alpha 5
chr4_+_17125885 0.607 NM_001079827
CLRN2
clarin 2
chr7_-_7724762 0.599 NM_002947
RPA3
replication protein A3, 14kDa
chr7_+_99263571 0.588 NM_022820
NM_057095
NM_057096
CYP3A43


cytochrome P450, family 3, subfamily A, polypeptide 43


chr11_+_113672407 0.588 NNMT
nicotinamide N-methyltransferase
chr16_+_54158084 0.584 NM_032330
CAPNS2
calpain, small subunit 2
chr3_-_158700036 0.580 NM_024621
VEPH1
ventricular zone expressed PH domain homolog 1 (zebrafish)
chr12_+_99391681 0.577 NM_005123
NR1H4
nuclear receptor subfamily 1, group H, member 4
chr8_-_13018123 0.573 NM_001164271
DLC1
deleted in liver cancer 1
chr1_+_111573855 0.570 NM_001025199
CHI3L2
chitinase 3-like 2
chr5_+_127012611 0.559 NM_001048252
CTXN3
cortexin 3
chr3_-_150578103 0.558 TM4SF1
transmembrane 4 L six family member 1
chr6_-_117256890 0.557 NM_148963
GPRC6A
G protein-coupled receptor, family C, group 6, member A
chr1_+_151867483 0.550 NM_006271
S100A1
S100 calcium binding protein A1
chr5_+_140454382 0.544 NM_018936
PCDHB2
protocadherin beta 2
chr1_-_36721010 0.540 CSF3R
colony stimulating factor 3 receptor (granulocyte)
chr2_+_121271336 0.537 NM_005270
GLI2
GLI family zinc finger 2
chr17_+_74542066 0.537 NM_198593
C1QTNF1
C1q and tumor necrosis factor related protein 1
chr11_-_5212168 0.530 NM_000519
HBD
hemoglobin, delta
chr3_-_117647053 0.529 NM_002338
LSAMP
limbic system-associated membrane protein
chr11_-_59390518 0.523 NM_001062
TCN1
transcobalamin I (vitamin B12 binding protein, R binder family)
chr11_+_111294868 0.521 C11orf52
chromosome 11 open reading frame 52
chr5_+_140690387 0.521 NM_018912
NM_031993
PCDHGA1

protocadherin gamma subfamily A, 1

chr8_-_86477585 0.520 NM_001128829
NM_001128830
NM_001128831
NM_001738
CA1



carbonic anhydrase I



chr22_+_16423147 0.519 NM_031481
SLC25A18
solute carrier family 25 (mitochondrial carrier), member 18
chr12_-_54522881 0.519 NM_002429
MMP19
matrix metallopeptidase 19
chr1_+_40508336 0.514 ZMPSTE24
zinc metallopeptidase (STE24 homolog, S. cerevisiae)
chr11_+_114054409 0.502 NM_182495
FAM55B
family with sequence similarity 55, member B
chr11_+_113672378 0.500 NNMT
nicotinamide N-methyltransferase
chr2_+_69055208 0.494 NM_019617
GKN1
gastrokine 1
chr19_-_9087438 0.491 NM_001005192
OR7G1
olfactory receptor, family 7, subfamily G, member 1
chr3_-_150578148 0.483 TM4SF1
transmembrane 4 L six family member 1
chr7_+_143263191 0.481 NM_001004685
OR2F2
olfactory receptor, family 2, subfamily F, member 2
chr20_-_5982617 0.481 NM_152611
LRRN4
leucine rich repeat neuronal 4
chr5_+_140848905 0.480 NM_018929
NM_032407
PCDHGC5

protocadherin gamma subfamily C, 5

chr3_+_120375053 0.476 NM_006952
UPK1B
uroplakin 1B
chr3_+_115099007 0.473 NM_001172105
GRAMD1C
GRAM domain containing 1C
chr7_-_56128098 0.472 NM_006213
PHKG1
phosphorylase kinase, gamma 1 (muscle)
chr17_+_19917420 0.468 SPECC1
sperm antigen with calponin homology and coiled-coil domains 1
chr8_-_125785611 0.465 MTSS1
metastasis suppressor 1
chr3_-_150578023 0.463 TM4SF1
transmembrane 4 L six family member 1
chr4_+_14985272 0.458 NM_001135171
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr18_+_41558089 0.452 NM_001128588
NM_001146036
NM_015865
SLC14A1


solute carrier family 14 (urea transporter), member 1 (Kidd blood group)


chr9_+_115958051 0.449 NM_032888
COL27A1
collagen, type XXVII, alpha 1
chr11_-_57728228 0.448 NM_001004459
OR1S2
olfactory receptor, family 1, subfamily S, member 2
chr15_+_100163424 0.448 NM_001005326
OR4F6
olfactory receptor, family 4, subfamily F, member 6
chr4_-_3503881 0.446 LRPAP1
low density lipoprotein receptor-related protein associated protein 1
chr1_-_160648429 0.439 NM_053282
SH2D1B
SH2 domain containing 1B
chr9_-_35860316 0.437 NM_001004487
OR13J1
olfactory receptor, family 13, subfamily J, member 1
chr5_-_58918031 0.434 NM_006203
PDE4D
phosphodiesterase 4D, cAMP-specific
chr12_+_99391870 0.434 NR1H4
nuclear receptor subfamily 1, group H, member 4
chr2_+_178893216 0.432 NM_145739
OSBPL6
oxysterol binding protein-like 6
chr11_+_111294810 0.430 NM_080659
C11orf52
chromosome 11 open reading frame 52
chr2_+_33213111 0.424 NM_000627
NM_001166264
NM_001166265
NM_001166266
LTBP1



latent transforming growth factor beta binding protein 1



chr6_+_12824873 0.423 PHACTR1
phosphatase and actin regulator 1
chr11_+_59580630 0.418 NM_001031666
NM_001031809
NM_006138
MS4A3


membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)


chr19_-_14771947 0.400 NM_198944
OR7C1
olfactory receptor, family 7, subfamily C, member 1
chr12_+_70618892 0.395 NM_173353
TPH2
tryptophan hydroxylase 2
chr1_-_53972464 0.393 NM_147193
GLIS1
GLIS family zinc finger 1
chr8_-_23619866 0.392 NM_001136271
NKX2-6
NK2 transcription factor related, locus 6 (Drosophila)
chr4_+_120276386 0.391 NM_016599
MYOZ2
myozenin 2
chr17_+_23875085 0.389 NM_003593
FOXN1
forkhead box N1
chr16_+_85158357 0.376 NM_005251
FOXC2
forkhead box C2 (MFH-1, mesenchyme forkhead 1)
chr6_+_42896771 0.374 NM_015349
KIAA0240
KIAA0240
chr8_-_110689396 0.371 SYBU
syntabulin (syntaxin-interacting)
chr19_+_7859380 0.368 NM_025061
LRRC8E
leucine rich repeat containing 8 family, member E
chr6_+_12825022 0.366 PHACTR1
phosphatase and actin regulator 1
chr6_-_41230003 0.363 NM_178174
TREML1
triggering receptor expressed on myeloid cells-like 1
chr1_+_179269766 0.356 MR1
major histocompatibility complex, class I-related
chr12_-_53064565 0.354 ZNF385A
zinc finger protein 385A
chr6_+_12825818 0.353 NM_030948
PHACTR1
phosphatase and actin regulator 1
chr4_-_84254912 0.352 PLAC8
placenta-specific 8
chr2_-_167058829 0.351 SCN7A
sodium channel, voltage-gated, type VII, alpha
chr17_-_3740785 0.349 NM_172206
CAMKK1
calcium/calmodulin-dependent protein kinase kinase 1, alpha
chr6_+_72982865 0.349 NM_001168409
RIMS1
regulating synaptic membrane exocytosis 1
chr11_-_85107569 0.347 NM_206929
SYTL2
synaptotagmin-like 2
chr6_+_31016755 0.347 NM_080870
DPCR1
diffuse panbronchiolitis critical region 1
chr7_-_87694218 0.342 NM_198901
SRI
sorcin
chr8_-_107023 0.339 NM_001005504
OR4F21
olfactory receptor, family 4, subfamily F, member 21
chr2_+_238432925 0.338 NM_005855
RAMP1
receptor (G protein-coupled) activity modifying protein 1
chr7_+_141265085 0.338 NM_001001656
OR9A4
olfactory receptor, family 9, subfamily A, member 4
chr3_-_9266251 0.337 NM_001033117
NM_014850
SRGAP3

SLIT-ROBO Rho GTPase activating protein 3

chr13_-_109600709 0.337 COL4A1
collagen, type IV, alpha 1
chr22_+_49272078 0.336 NM_017584
MIOX
myo-inositol oxygenase
chr1_-_68688219 0.327 NM_000329
RPE65
retinal pigment epithelium-specific protein 65kDa
chrX_+_123307812 0.327 NM_001114937
NM_002351
SH2D1A

SH2 domain containing 1A

chrX_-_135783496 0.325


chr1_+_35020425 0.325 NM_001005752
GJB3
gap junction protein, beta 3, 31kDa
chr20_+_17628592 0.319 NM_001014977
NM_178477
BANF2

barrier to autointegration factor 2

chr11_-_6418705 0.316 NM_000613
HPX
hemopexin
chr1_-_226670928 0.314 TRIM17
tripartite motif containing 17
chr4_-_3503951 0.311 NM_002337
LRPAP1
low density lipoprotein receptor-related protein associated protein 1
chr15_+_76171981 0.309 NM_001101404
SH2D7
SH2 domain containing 7
chr17_+_31195760 0.309 TAF15
TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
chr11_+_56224436 0.307 NM_001005213
NM_001013358
OR9G1
OR9G9
olfactory receptor, family 9, subfamily G, member 1
olfactory receptor, family 9, subfamily G, member 9
chr4_-_84254932 0.305 NM_001130715
NM_016619
PLAC8

placenta-specific 8

chr11_+_48194937 0.303 NM_001005470
OR4B1
olfactory receptor, family 4, subfamily B, member 1
chr4_-_84254873 0.302 PLAC8
placenta-specific 8
chr14_+_28306633 0.302 FOXG1
forkhead box G1
chr9_+_123088690 0.294 GSN
gelsolin
chr7_-_50596238 0.290 NM_000790
DDC
dopa decarboxylase (aromatic L-amino acid decarboxylase)
chr16_-_31054563 0.288 NM_002773
PRSS8
protease, serine, 8
chr7_+_104468614 0.287 MLL5
myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
chr7_-_14847479 0.285 NM_004080
NM_145695
DGKB

diacylglycerol kinase, beta 90kDa

chr16_+_22011362 0.285 NM_173615
VWA3A
von Willebrand factor A domain containing 3A
chr2_-_190635566 0.284 NM_005259
MSTN
myostatin
chr5_-_59819642 0.284 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr8_-_11739592 0.280 CTSB
cathepsin B
chr1_+_179269761 0.277 MR1
major histocompatibility complex, class I-related
chr1_+_46745254 0.277 NM_147192
NM_172225
DMBX1

diencephalon/mesencephalon homeobox 1

chr1_-_46853380 0.274 NM_145279
MOBKL2C
MOB1, Mps One Binder kinase activator-like 2C (yeast)
chr19_+_53770804 0.272 NM_004605
SULT2B1
sulfotransferase family, cytosolic, 2B, member 1
chr9_+_130684189 0.270 NM_001127245
NM_019594
LRRC8A

leucine rich repeat containing 8 family, member A

chr7_+_147667461 0.268 CNTNAP2
contactin associated protein-like 2
chr16_-_31068329 0.266 PRSS36
protease, serine, 36
chr1_-_149415049 0.264 NM_013353
TMOD4
tropomodulin 4 (muscle)
chrX_-_44087778 0.264 NM_025184
EFHC2
EF-hand domain (C-terminal) containing 2
chr11_-_4902144 0.264 NM_001005237
OR51G1
olfactory receptor, family 51, subfamily G, member 1
chr1_+_27591738 0.263 NM_005281
GPR3
G protein-coupled receptor 3
chr11_-_5232480 0.261 NM_000184
HBG1
HBG2
hemoglobin, gamma A
hemoglobin, gamma G
chr2_+_48649662 0.260 NM_172311
STON1-GTF2A1L
STON1-GTF2A1L readthrough
chr14_+_94117511 0.258 SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr1_+_151081953 0.257 NM_001128600
LCE6A
late cornified envelope 6A
chr11_-_5946299 0.251 NM_001146033
OR56A5
olfactory receptor, family 56, subfamily A, member 5
chr19_+_43502360 0.249 KCNK6
potassium channel, subfamily K, member 6
chr17_-_51155073 0.246 NM_018286
TMEM100
transmembrane protein 100
chr6_+_132915522 0.244 NM_053278
TAAR8
trace amine associated receptor 8
chr21_-_35174742 0.243 RUNX1
runt-related transcription factor 1
chr2_-_119322228 0.242 NM_001426
EN1
engrailed homeobox 1
chrX_+_125781427 0.242 NM_001122716
CXorf64
chromosome X open reading frame 64
chr2_+_172530120 0.242 HAT1
histone acetyltransferase 1
chr9_-_34387786 0.239 NM_032596
C9orf24
chromosome 9 open reading frame 24
chr2_+_189547377 0.236 COL3A1
collagen, type III, alpha 1
chr8_+_104900591 0.234 NM_014677
RIMS2
regulating synaptic membrane exocytosis 2
chr6_-_49820030 0.228 NM_001190986
NM_006061
CRISP3

cysteine-rich secretory protein 3

chr3_+_129117007 0.227 KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr7_+_91762227 0.226


chr14_-_80934523 0.226 NM_033104
STON2
stonin 2
chr11_-_116199145 0.226 NM_000482
APOA4
apolipoprotein A-IV
chr2_+_189547358 0.222 COL3A1
collagen, type III, alpha 1
chr12_-_66905802 0.218 NM_018402
IL26
interleukin 26
chr19_-_58086410 0.218 NM_207333
ZNF320
zinc finger protein 320
chr11_-_67163600 0.217 NM_005995
TBX10
T-box 10

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.87 3.00e-10 GO:0007608 sensory perception of smell
3.47 1.05e-08 GO:0007606 sensory perception of chemical stimulus
2.39 2.65e-05 GO:0007600 sensory perception
1.76 1.97e-03 GO:0003008 system process
1.80 1.01e-02 GO:0050877 neurological system process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.47 2.47e-05 GO:0005886 plasma membrane
1.46 3.62e-05 GO:0071944 cell periphery
1.31 4.19e-04 GO:0044425 membrane part
2.62 2.89e-03 GO:0031012 extracellular matrix
2.73 5.16e-03 GO:0005578 proteinaceous extracellular matrix
1.27 2.93e-02 GO:0031224 intrinsic to membrane
1.27 3.21e-02 GO:0016021 integral to membrane
1.20 4.08e-02 GO:0016020 membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
4.06 1.45e-11 GO:0004984 olfactory receptor activity
2.55 1.13e-07 GO:0004930 G-protein coupled receptor activity
1.94 1.47e-04 GO:0004888 transmembrane receptor activity
1.66 4.96e-04 GO:0004871 signal transducer activity
1.66 4.96e-04 GO:0060089 molecular transducer activity
1.74 5.52e-04 GO:0004872 receptor activity
2.17 3.49e-03 GO:0005509 calcium ion binding