Motif ID: FOX{D1,D2}.p2

Z-value: 1.268


Transcription factors associated with FOX{D1,D2}.p2:

Gene SymbolEntrez IDGene Name
FOXD1 2297 forkhead box D1
FOXD2 2306 forkhead box D2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOXD1chr5_-_72779585-0.468.6e-02Click!
FOXD2chr1_+_47674275-0.165.7e-01Click!


Activity profile for motif FOX{D1,D2}.p2.

activity profile for motif FOX{D1,D2}.p2


Sorted Z-values histogram for motif FOX{D1,D2}.p2

Sorted Z-values for motif FOX{D1,D2}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOX{D1,D2}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_116455898 2.260 NM_152367
MAB21L3
mab-21-like 3 (C. elegans)
chr5_-_142046175 2.069 NM_033136
FGF1
fibroblast growth factor 1 (acidic)
chr5_-_142045770 2.027 NM_000800
FGF1
fibroblast growth factor 1 (acidic)
chr10_+_104525877 1.740 NM_017787
C10orf26
chromosome 10 open reading frame 26
chr1_-_199732323 1.687 NM_001193572
CSRP1
cysteine and glycine-rich protein 1
chr3_-_71376919 1.432 FOXP1
forkhead box P1
chr2_-_192420168 1.392 NM_004657
SDPR
serum deprivation response
chr11_-_85074848 1.303 NM_152723
CCDC89
coiled-coil domain containing 89
chr2_-_165259334 1.268 COBLL1
COBL-like 1
chr16_+_54070302 1.213 NM_004530
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr2_-_162808123 1.177 NM_004460
FAP
fibroblast activation protein, alpha
chr4_-_152368492 1.141 SH3D19
SH3 domain containing 19
chr12_-_69837831 1.111 TSPAN8
tetraspanin 8
chr15_-_68781662 1.110 NM_001008224
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr5_+_154072654 1.093 NM_015315
LARP1
La ribonucleoprotein domain family, member 1
chr5_-_16795336 1.081 MYO10
myosin X
chr3_+_189413414 1.070 NM_005578
LPP
LIM domain containing preferred translocation partner in lipoma
chr2_-_192419896 1.069 SDPR
serum deprivation response
chr3_-_52844274 1.065 NM_205853
MUSTN1
musculoskeletal, embryonic nuclear protein 1
chr7_+_1543644 1.038 MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr7_+_134114701 1.030 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr10_-_92671005 1.026 NM_014391
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr2_+_132196533 1.024 NM_013310
C2orf27A
chromosome 2 open reading frame 27A
chr2_-_134042500 1.015 NM_207363
NM_207481
NCKAP5

NCK-associated protein 5

chr22_-_35835548 0.996 TMPRSS6
transmembrane protease, serine 6
chr1_-_20682541 0.950


chr17_-_36418869 0.924 NM_031958
KRTAP3-1
keratin associated protein 3-1
chr2_-_133895795 0.913 NCKAP5
NCK-associated protein 5
chr16_+_82540172 0.890 NM_013370
NM_182980
OSGIN1

oxidative stress induced growth inhibitor 1

chr2_-_165133239 0.887 GRB14
growth factor receptor-bound protein 14
chr17_-_43390108 0.863 NM_024320
PRR15L
proline rich 15-like
chr12_-_69838045 0.854 NM_004616
TSPAN8
tetraspanin 8
chrX_-_19598912 0.852 NM_001184960
SH3KBP1
SH3-domain kinase binding protein 1
chr17_+_9686572 0.850 GLP2R
glucagon-like peptide 2 receptor
chr20_-_1257782 0.825 SDCBP2
syndecan binding protein (syntenin) 2
chr7_+_134114912 0.825 CALD1
caldesmon 1
chr7_+_134114957 0.822 CALD1
caldesmon 1
chr7_+_134483305 0.814 NM_018295
TMEM140
transmembrane protein 140
chr20_-_1257809 0.809 NM_080489
SDCBP2
syndecan binding protein (syntenin) 2
chr8_+_40130143 0.801 NM_020130
C8orf4
chromosome 8 open reading frame 4
chr1_+_198278339 0.788 NR5A2
nuclear receptor subfamily 5, group A, member 2
chr7_-_50596238 0.781 NM_000790
DDC
dopa decarboxylase (aromatic L-amino acid decarboxylase)
chr2_+_71016503 0.781 NM_001692
ATP6V1B1
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1
chr3_+_173043832 0.758 NM_001164436
TMEM212
transmembrane protein 212
chr6_-_30151526 0.748 NM_170769
NM_025236
RNF39

ring finger protein 39

chr7_+_94377145 0.746 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory (inhibitor) subunit 9A


chr12_-_55990512 0.738 NM_014925
R3HDM2
R3H domain containing 2
chr4_+_15038726 0.735 NM_031911
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr10_-_92670764 0.733 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr14_+_85069217 0.726


chr3_-_114643008 0.719 NM_001164496
NM_018338
WDR52

WD repeat domain 52

chr3_-_150569574 0.717 TM4SF1
transmembrane 4 L six family member 1
chr11_-_56846246 0.706 TNKS1BP1
tankyrase 1 binding protein 1, 182kDa
chr1_+_183970093 0.700 NM_031935
HMCN1
hemicentin 1
chr16_+_52027020 0.696 RBL2
retinoblastoma-like 2 (p130)
chr2_-_213724577 0.687 NM_001079526
IKZF2
IKAROS family zinc finger 2 (Helios)
chr6_-_87861492 0.686 NM_000735
CGA
glycoprotein hormones, alpha polypeptide
chr7_+_113842470 0.684 FOXP2
forkhead box P2
chr2_-_213723298 0.678 NM_016260
IKZF2
IKAROS family zinc finger 2 (Helios)
chr18_+_30544193 0.678 NM_001198941
NM_032978
DTNA

dystrobrevin, alpha

chr1_-_24342158 0.677 NM_021258
IL22RA1
interleukin 22 receptor, alpha 1
chr9_+_27099138 0.675 NM_000459
TEK
TEK tyrosine kinase, endothelial
chr4_+_71126376 0.674 NM_152997
C4orf7
chromosome 4 open reading frame 7
chr5_-_158567411 0.667 NM_144726
RNF145
ring finger protein 145
chr12_+_13240868 0.651 NM_001423
EMP1
epithelial membrane protein 1
chr3_+_152970904 0.648 LOC201651
arylacetamide deacetylase (esterase) pseudogene
chr14_+_23937766 0.648 NM_025081
NYNRIN
NYN domain and retroviral integrase containing
chr2_-_180319013 0.645 NM_001113397
ZNF385B
zinc finger protein 385B
chr16_-_56389176 0.643 NM_001130099
KIFC3
kinesin family member C3
chr12_+_12935222 0.640 NM_003979
GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr3_+_101316463 0.637 NM_001167924
C3orf26
chromosome 3 open reading frame 26
chr11_-_76676110 0.633 NM_182833
GDPD4
glycerophosphodiester phosphodiesterase domain containing 4
chr5_+_78567604 0.615 NM_152405
JMY
junction mediating and regulatory protein, p53 cofactor
chr2_-_21084911 0.615 APOB
apolipoprotein B (including Ag(x) antigen)
chr9_-_14900992 0.612 NM_144966
FREM1
FRAS1 related extracellular matrix 1
chr4_+_14985272 0.603 NM_001135171
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr3_-_58497913 0.601 NM_003500
ACOX2
acyl-CoA oxidase 2, branched chain
chr2_+_188865796 0.599 GULP1
GULP, engulfment adaptor PTB domain containing 1
chr7_-_87180499 0.597 NM_000927
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr5_-_42847716 0.593 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr18_+_64616296 0.592 NM_024781
CCDC102B
coiled-coil domain containing 102B
chr6_+_74462226 0.591 NM_001159587
NM_001159588
NM_133493
CD109


CD109 molecule


chr4_-_140443061 0.588 NM_001184987
NM_001184988
NM_001184989
NM_001184990
NDUFC1



NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa



chr17_+_64922420 0.588 NM_002758
MAP2K6
mitogen-activated protein kinase kinase 6
chr10_+_123912930 0.575 TACC2
transforming, acidic coiled-coil containing protein 2
chr12_+_119900677 0.571 HNF1A
HNF1 homeobox A
chr11_-_102331643 0.571 NM_002427
MMP13
matrix metallopeptidase 13 (collagenase 3)
chr2_+_33514896 0.560 NM_170672
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr7_+_116238309 0.557 CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr12_+_13240983 0.557 EMP1
epithelial membrane protein 1
chr20_-_49612745 0.556 NFATC2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
chr12_+_13240987 0.552 EMP1
epithelial membrane protein 1
chr6_-_151754337 0.552 NM_020861
ZBTB2
zinc finger and BTB domain containing 2
chr10_+_82163568 0.544 C10orf58
chromosome 10 open reading frame 58
chrX_-_106033202 0.535 NM_001171706
NM_138382
RIPPLY1

ripply1 homolog (zebrafish)

chr21_+_29439768 0.534 C21orf7
chromosome 21 open reading frame 7
chr5_-_16561936 0.525 NM_019000
FAM134B
family with sequence similarity 134, member B
chr11_-_104421240 0.524 NM_001017534
NM_052889
CARD16

CASP1
caspase recruitment domain family, member 16

caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
chr11_+_20005704 0.523 NAV2
neuron navigator 2
chr17_+_56109940 0.521 NM_001099432
NM_017679
BCAS3

breast carcinoma amplified sequence 3

chr20_+_2030527 0.518 NM_080836
STK35
serine/threonine kinase 35
chr17_+_62804385 0.513 NM_012417
NM_181671
PITPNC1

phosphatidylinositol transfer protein, cytoplasmic 1

chr2_-_172458970 0.507 NM_003705
SLC25A12
solute carrier family 25 (mitochondrial carrier, Aralar), member 12
chr5_-_150441150 0.503 NM_006058
TNIP1
TNFAIP3 interacting protein 1
chr2_-_233586164 0.502 NM_019850
NGEF
neuronal guanine nucleotide exchange factor
chr10_+_123913094 0.500 NM_006997
NM_206860
TACC2

transforming, acidic coiled-coil containing protein 2

chr9_+_117955890 0.497 NM_002581
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr14_+_23654307 0.495 NM_181357
DCAF11
DDB1 and CUL4 associated factor 11
chr9_+_4782974 0.490 RCL1
RNA terminal phosphate cyclase-like 1
chr8_+_26206648 0.489 NM_001177591
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr3_+_190372456 0.484 NM_198485
TPRG1
tumor protein p63 regulated 1
chr2_-_233586145 0.481 NGEF
neuronal guanine nucleotide exchange factor
chr10_+_18729518 0.478 NM_201570
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr3_+_23962518 0.477 NM_001145425
NR1D2
nuclear receptor subfamily 1, group D, member 2
chr4_+_91375204 0.476 NM_207491
FAM190A
family with sequence similarity 190, member A
chr12_-_110410730 0.475 ATXN2
ataxin 2
chr2_-_188086612 0.473 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr9_-_8723893 0.473 NM_001040712
NM_001171025
NM_130391
NM_130392
NM_130393
PTPRD




protein tyrosine phosphatase, receptor type, D




chr11_-_114880275 0.471 NM_001098517
NM_014333
CADM1

cell adhesion molecule 1

chr12_+_50633430 0.470 NM_020327
ACVR1B
activin A receptor, type IB
chr20_+_21054623 0.469 NM_001163022
NM_001163023
NM_018474
PLK1S1


polo-like kinase 1 substrate 1


chr12_+_32578513 0.466 FGD4
FYVE, RhoGEF and PH domain containing 4
chr5_-_150440792 0.466 TNIP1
TNFAIP3 interacting protein 1
chr5_-_150440743 0.466 TNIP1
TNFAIP3 interacting protein 1
chr20_+_31613800 0.462 NM_001039709
NM_005093
CBFA2T2

core-binding factor, runt domain, alpha subunit 2; translocated to, 2

chr10_+_47875229 0.461 NM_001040084
NM_001098845
ANXA8L2
ANXA8
ANXA8L1
annexin A8-like 2
annexin A8
annexin A8-like 1
chr2_+_27288670 0.460 NM_001170795
NM_016085
C2orf28

chromosome 2 open reading frame 28

chr9_-_103237851 0.458 NM_000035
ALDOB
aldolase B, fructose-bisphosphate
chr1_+_13784553 0.455 NM_001006624
NM_001006625
PDPN

podoplanin

chr8_-_133841988 0.454 NM_001145153
NM_144649
TMEM71

transmembrane protein 71

chr10_+_114144512 0.450 ACSL5
acyl-CoA synthetase long-chain family member 5
chr2_+_168383427 0.449 NM_020981
B3GALT1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr13_+_112825113 0.449 NM_000504
F10
coagulation factor X
chr6_-_127822227 0.445 NM_014702
KIAA0408
KIAA0408
chr5_-_159778621 0.438 NM_006425
SLU7
SLU7 splicing factor homolog (S. cerevisiae)
chr10_-_54201400 0.434 NM_000242
MBL2
mannose-binding lectin (protein C) 2, soluble
chr13_-_37341859 0.431 NM_001135955
NM_001135956
NM_001135957
NM_001135958
NM_003306
NM_016179
TRPC4





transient receptor potential cation channel, subfamily C, member 4





chr5_+_90711887 0.430 LOC100129716
hypothetical LOC100129716
chr3_-_127138571 0.425 NM_001015050
NM_001195223
ALG1L

asparagine-linked glycosylation 1-like

chr3_+_64645819 0.424 LOC100507098
hypothetical LOC100507098
chr8_-_127639647 0.422 FAM84B
family with sequence similarity 84, member B
chr20_+_56397568 0.421 NM_001195677
NM_004738
VAPB

VAMP (vesicle-associated membrane protein)-associated protein B and C

chr14_+_93646831 0.419 NM_001130080
NM_005532
IFI27

interferon, alpha-inducible protein 27

chr3_+_187917791 0.416 NM_000893
NM_001102416
NM_001166451
KNG1


kininogen 1


chr17_+_62803824 0.414 PITPNC1
phosphatidylinositol transfer protein, cytoplasmic 1
chr1_-_150092702 0.414 NM_182578
THEM5
thioesterase superfamily member 5
chr18_+_27152049 0.414 NM_001942
DSG1
desmoglein 1
chr20_-_49612574 0.410 NM_001136021
NFATC2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
chr11_-_62753574 0.407 NM_199352
SLC22A25
solute carrier family 22, member 25
chr2_+_188865634 0.407 NM_016315
GULP1
GULP, engulfment adaptor PTB domain containing 1
chr17_+_34115383 0.406 NM_005937
MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr3_-_48931821 0.405 NM_001123040
C3orf71
chromosome 3 open reading frame 71
chr3_-_101316038 0.405 NM_001042459
NM_182909
FILIP1L

filamin A interacting protein 1-like

chr1_-_112333192 0.405 NM_004980
NM_172198
KCND3

potassium voltage-gated channel, Shal-related subfamily, member 3

chr17_+_62804036 0.404 PITPNC1
phosphatidylinositol transfer protein, cytoplasmic 1
chr6_+_135544214 0.404 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr11_-_102156531 0.402 NM_002425
MMP10
matrix metallopeptidase 10 (stromelysin 2)
chr12_+_119900931 0.402 NM_000545
HNF1A
HNF1 homeobox A
chr6_-_152664906 0.401 SYNE1
spectrin repeat containing, nuclear envelope 1
chr6_+_116956868 0.401 NM_153036
FAM26D
family with sequence similarity 26, member D
chr14_+_23654161 0.400 DCAF11
DDB1 and CUL4 associated factor 11
chr12_+_106692291 0.398 NM_203436
ASCL4
achaete-scute complex homolog 4 (Drosophila)
chr6_+_32229599 0.397 NM_005155
PPT2-EGFL8
PPT2
PPT2-EGFL8 read-through transcript
palmitoyl-protein thioesterase 2
chr7_+_142850667 0.396 NM_177437
TAS2R60
taste receptor, type 2, member 60
chr6_+_168161401 0.395 NM_005355
NM_030615
KIF25

kinesin family member 25

chr16_+_27248806 0.393 IL4R
interleukin 4 receptor
chr7_-_13997574 0.392 NM_001163148
ETV1
ets variant 1
chr12_+_99391681 0.391 NM_005123
NR1H4
nuclear receptor subfamily 1, group H, member 4
chr4_-_99283323 0.385 NM_174952
C4orf37
chromosome 4 open reading frame 37
chr10_+_31650069 0.384 NM_001128128
NM_001174094
ZEB1

zinc finger E-box binding homeobox 1

chr1_+_22176004 0.383 NM_007352
CELA3A
CELA3B
chymotrypsin-like elastase family, member 3A
chymotrypsin-like elastase family, member 3B
chr5_-_54317102 0.382 NM_001135604
NM_007036
ESM1

endothelial cell-specific molecule 1

chr10_-_79298876 0.381 DLG5
discs, large homolog 5 (Drosophila)
chr3_-_170348215 0.380 NM_001164000
MECOM
MDS1 and EVI1 complex locus
chr6_+_12398514 0.378 NM_001168319
NM_001955
EDN1

endothelin 1

chr3_-_71262405 0.375 FOXP1
forkhead box P1
chr6_-_56615544 0.374 NM_001723
NM_015548
DST

dystonin

chr2_-_189752575 0.374 NM_000393
COL5A2
collagen, type V, alpha 2
chr2_-_96351345 0.370


chr22_-_30018329 0.369 NM_001135911
NM_052880
PIK3IP1

phosphoinositide-3-kinase interacting protein 1

chr20_+_42777298 0.366 NM_003881
WISP2
WNT1 inducible signaling pathway protein 2
chr17_-_61655915 0.361 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr14_+_22136968 0.361 NM_022060
ABHD4
abhydrolase domain containing 4
chr2_-_21084077 0.360 APOB
apolipoprotein B (including Ag(x) antigen)
chr17_+_3326045 0.360 NM_000049
ASPA
aspartoacylase
chr19_+_46416971 0.358 AXL
AXL receptor tyrosine kinase
chr2_-_133145539 0.356 NM_001077427
LYPD1
LY6/PLAUR domain containing 1
chr8_+_22188754 0.356 NM_018068
PIWIL2
piwi-like 2 (Drosophila)
chr19_+_46416938 0.350 NM_001699
NM_021913
AXL

AXL receptor tyrosine kinase

chr15_-_81037554 0.347 NM_001079533
NM_001079534
NM_001079535
CPEB1


cytoplasmic polyadenylation element binding protein 1


chr6_-_105734535 0.347 NM_022361
POPDC3
popeye domain containing 3
chr20_-_48741481 0.342


chr15_-_50758100 0.342 NM_019600
KIAA1370
KIAA1370
chr8_-_127639892 0.340 NM_174911
FAM84B
family with sequence similarity 84, member B
chr6_+_12825818 0.334 NM_030948
PHACTR1
phosphatase and actin regulator 1
chr1_-_34404029 0.333 NM_052896
CSMD2
CUB and Sushi multiple domains 2
chr19_+_46416975 0.332 AXL
AXL receptor tyrosine kinase
chr6_+_74462485 0.331 CD109
CD109 molecule
chr20_-_33783409 0.331 RBM39
RNA binding motif protein 39
chr17_-_34262862 0.330 RPL23
ribosomal protein L23

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.14 3.70e-02 GO:0005515 protein binding