Motif ID: HOX{A4,D4}.p2

Z-value: 1.814


Transcription factors associated with HOX{A4,D4}.p2:

Gene SymbolEntrez IDGene Name
HOXA4 3201 homeobox A4
HOXD4 3233 homeobox D4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HOXA4chr7_-_27136876-0.572.8e-02Click!
HOXD4chr2_+_1767243580.048.8e-01Click!


Activity profile for motif HOX{A4,D4}.p2.

activity profile for motif HOX{A4,D4}.p2


Sorted Z-values histogram for motif HOX{A4,D4}.p2

Sorted Z-values for motif HOX{A4,D4}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HOX{A4,D4}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_-_75259714 4.313 PEAK1
NKF3 kinase family member
chr11_-_16380967 2.622 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr10_+_126620681 2.602 NM_017580
ZRANB1
zinc finger, RAN-binding domain containing 1
chr1_+_149877955 2.498 SNX27
sorting nexin family member 27
chr7_-_132371208 2.418 EEF1G
eukaryotic translation elongation factor 1 gamma
chr1_+_165565006 2.337 POU2F1
POU class 2 homeobox 1
chr1_-_205161821 2.287 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr1_+_165564904 2.287 NM_001198783
POU2F1
POU class 2 homeobox 1
chr1_+_40631603 2.284 NM_001198979
SMAP2
small ArfGAP2
chr10_-_75085754 2.049 NM_001114133
SYNPO2L
synaptopodin 2-like
chr1_-_51660328 1.969 NM_001159969
EPS15
epidermal growth factor receptor pathway substrate 15
chr2_+_182558795 1.922 NM_001080545
PPP1R1C
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr12_-_52016270 1.843 NM_001173467
SP7
Sp7 transcription factor
chr13_+_45174446 1.839 NM_152719
SPERT
spermatid associated
chr2_+_170742900 1.756 NM_001083615
NM_001171642
NM_138995
MYO3B


myosin IIIB


chr11_-_117589283 1.737 NM_153206
AMICA1
adhesion molecule, interacts with CXADR antigen 1
chr11_-_5178505 1.732 NM_001004760
OR51V1
olfactory receptor, family 51, subfamily V, member 1
chr1_-_143708467 1.726 NM_001195260
PDE4DIP
phosphodiesterase 4D interacting protein
chr4_+_72423633 1.646 NM_003759
SLC4A4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
chr7_+_100037817 1.631 NM_002593
PCOLCE
procollagen C-endopeptidase enhancer
chr12_-_7793335 1.625 NM_130441
NM_203503
CLEC4C

C-type lectin domain family 4, member C

chr16_+_56286212 1.576 NM_032269
CCDC135
coiled-coil domain containing 135
chr1_+_46151845 1.564 MAST2
microtubule associated serine/threonine kinase 2
chr1_+_148511806 1.560 NM_024579
C1orf54
chromosome 1 open reading frame 54
chr19_-_7672978 1.556 NM_002002
FCER2
Fc fragment of IgE, low affinity II, receptor for (CD23)
chr17_-_1195096 1.510 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr11_-_5321329 1.507 NM_001005567
OR51B5
olfactory receptor, family 51, subfamily B, member 5
chr20_-_33706532 1.470 RBM12
RNA binding motif protein 12
chr20_-_30703219 1.431 NM_182584
C20orf203
chromosome 20 open reading frame 203
chr3_-_57209319 1.423 NM_003865
HESX1
HESX homeobox 1
chr5_-_168204430 1.403


chr2_+_61243132 1.400 NM_001143959
C2orf74
chromosome 2 open reading frame 74
chr17_+_23818922 1.400


chr11_-_83071084 1.379 NM_001142702
DLG2
discs, large homolog 2 (Drosophila)
chr7_-_135263737 1.348 MTPN
LUZP6
myotrophin
leucine zipper protein 6
chr15_-_74941339 1.324 NM_001145923
SCAPER
S-phase cyclin A-associated protein in the ER
chr5_+_67622242 1.315 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr11_+_5329313 1.302 NM_001004750
OR51B6
olfactory receptor, family 51, subfamily B, member 6
chr3_-_109730858 1.292 NM_014981
MYH15
myosin, heavy chain 15
chr4_+_100714995 1.283 MTTP
microsomal triglyceride transfer protein
chr6_+_6533932 1.273 NM_004271
LY86
lymphocyte antigen 86
chr1_+_159959072 1.257 NM_001002901
FCRLB
Fc receptor-like B
chr1_+_12728749 1.244 NM_152290
C1orf158
chromosome 1 open reading frame 158
chr17_-_35975227 1.234 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chr1_+_159943385 1.225 NM_001184866
NM_001184867
NM_001184870
NM_001184871
NM_001184872
NM_001184873
NM_032738
FCRLA






Fc receptor-like A






chr12_+_52105131 1.198 AMHR2
anti-Mullerian hormone receptor, type II
chr8_-_38324809 1.195 WHSC1L1
Wolf-Hirschhorn syndrome candidate 1-like 1
chr14_+_99555471 1.193 EVL
Enah/Vasp-like
chr16_+_10878539 1.178 NM_000246
CIITA
class II, major histocompatibility complex, transactivator
chr7_-_86433139 1.173 NM_152748
KIAA1324L
KIAA1324-like
chr6_+_44076281 1.159 NM_001171992
NM_153246
C6orf223

chromosome 6 open reading frame 223

chr9_+_263025 1.157 NM_001190458
NM_001193536
DOCK8

dedicator of cytokinesis 8

chr5_-_1050408 1.149 LOC100506688
hypothetical protein LOC100506688
chr15_+_32425357 1.145 NM_175741
C15orf55
chromosome 15 open reading frame 55
chr20_+_32763440 1.128 TP53INP2
tumor protein p53 inducible nuclear protein 2
chr11_-_73397929 1.126 NM_003356
NM_022803
UCP3

uncoupling protein 3 (mitochondrial, proton carrier)

chr4_+_38740246 1.123 NM_015990
NM_199039
KLHL5

kelch-like 5 (Drosophila)

chr11_-_5130174 1.113 NM_012375
OR52A1
olfactory receptor, family 52, subfamily A, member 1
chr3_+_122794859 1.096 NM_016298
FBXO40
F-box protein 40
chr22_-_36305883 1.096 NM_006498
LGALS2
lectin, galactoside-binding, soluble, 2
chrX_-_11194015 1.094 NM_013423
ARHGAP6
Rho GTPase activating protein 6
chr11_-_6418705 1.082 NM_000613
HPX
hemopexin
chr7_-_5429702 1.080 NM_001080495
TNRC18
trinucleotide repeat containing 18
chr13_+_42034871 1.079 NM_033012
TNFSF11
tumor necrosis factor (ligand) superfamily, member 11
chr19_+_4104593 1.068 NM_032607
CREB3L3
cAMP responsive element binding protein 3-like 3
chr9_+_96561750 1.029 NM_001193329
C9orf3
chromosome 9 open reading frame 3
chr10_+_35466715 1.019 NM_183011
NM_183012
CREM

cAMP responsive element modulator

chr3_+_63859114 1.003 NM_001177387
ATXN7
ataxin 7
chr6_+_64414389 0.999 NM_015153
PHF3
PHD finger protein 3
chr1_-_156013487 0.999 NM_030764
FCRL2
Fc receptor-like 2
chr1_-_149681265 0.985 NM_207171
POGZ
pogo transposable element with ZNF domain
chr2_-_190635566 0.983 NM_005259
MSTN
myostatin
chr19_+_17723285 0.982 NM_001161359
NM_015122
FCHO1

FCH domain only 1

chr3_-_46224791 0.979 NM_001295
CCR1
chemokine (C-C motif) receptor 1
chr3_-_69120188 0.978 C3orf64
chromosome 3 open reading frame 64
chr10_+_91488704 0.963 KIF20B
kinesin family member 20B
chr11_-_118405288 0.960 NM_001164280
SLC37A4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr4_-_40212670 0.953 NM_019027
RBM47
RNA binding motif protein 47
chrX_+_65300803 0.940 NM_001130860
NM_014799
HEPH

hephaestin

chr19_-_47498768 0.936 NM_001145939
NM_001145940
PAFAH1B3

platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)

chr3_-_180467483 0.907 NM_001163677
NM_171828
KCNMB3

potassium large conductance calcium-activated channel, subfamily M beta member 3

chr12_-_101398429 0.904 IGF1
insulin-like growth factor 1 (somatomedin C)
chr8_+_39911630 0.895 NM_194294
IDO2
indoleamine 2,3-dioxygenase 2
chr3_-_150903749 0.883 NM_001168278
WWTR1
WW domain containing transcription regulator 1
chr20_+_56912146 0.883 GNAS
GNAS complex locus
chr17_-_70039187 0.882 NM_174892
CD300LB
CD300 molecule-like family member b
chr5_-_132228375 0.881 NM_005260
GDF9
growth differentiation factor 9
chr11_+_59979857 0.867 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr13_+_47948586 0.865 RB1
retinoblastoma 1
chr1_-_36721501 0.862 NM_000760
NM_156039
NM_172313
CSF3R


colony stimulating factor 3 receptor (granulocyte)


chr19_+_52113772 0.862 NM_004491
GRLF1
glucocorticoid receptor DNA binding factor 1
chrX_+_109548940 0.860 NM_020769
RGAG1
retrotransposon gag domain containing 1
chr11_-_5110383 0.856 NM_001005160
OR52A5
olfactory receptor, family 52, subfamily A, member 5
chr9_-_112139908 0.855 NM_001003936
TXNDC8
thioredoxin domain containing 8 (spermatozoa)
chr1_+_190811479 0.854 NM_002922
RGS1
regulator of G-protein signaling 1
chr19_+_54621499 0.853 NM_001195256
LOC645971
hypothetical protein LOC645971
chr17_-_36232366 0.844 NM_000421
KRT10
keratin 10
chr3_+_188222337 0.837 NM_003032
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr6_-_27988152 0.837 NM_033057
OR2B2
olfactory receptor, family 2, subfamily B, member 2
chr8_-_38127489 0.831 NM_000349
STAR
steroidogenic acute regulatory protein
chr4_-_123761615 0.828 NM_021803
IL21
interleukin 21
chr7_-_75794919 0.821 YWHAG
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
chrX_+_65152004 0.816


chr1_+_54132447 0.814 NM_000792
NM_001039715
NM_001039716
NM_213593
DIO1



deiodinase, iodothyronine, type I



chr5_+_149131695 0.812 NM_001172699
PPARGC1B
peroxisome proliferator-activated receptor gamma, coactivator 1 beta
chr2_-_127817143 0.810 NM_006609
MAP3K2
mitogen-activated protein kinase kinase kinase 2
chr8_-_82536312 0.809 NM_001080526
FABP9
fatty acid binding protein 9, testis
chr12_-_101398451 0.801 IGF1
insulin-like growth factor 1 (somatomedin C)
chr1_+_63861474 0.795 NM_001172818
PGM1
phosphoglucomutase 1
chr12_-_101398470 0.793 IGF1
insulin-like growth factor 1 (somatomedin C)
chr18_+_53967544 0.787 NM_001144965
NM_001144968
NM_001144969
NM_001144971
NEDD4L



neural precursor cell expressed, developmentally down-regulated 4-like



chr16_+_31105579 0.786


chr9_+_109131814 0.775 RAD23B
RAD23 homolog B (S. cerevisiae)
chr7_-_13992351 0.775 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr6_+_152053323 0.774 NM_001122742
ESR1
estrogen receptor 1
chr9_+_94766379 0.772 FGD3
FYVE, RhoGEF and PH domain containing 3
chr22_-_40666168 0.772 NM_001110215
CENPM
centromere protein M
chr8_+_11388918 0.771 NM_001715
BLK
B lymphoid tyrosine kinase
chr19_-_55560686 0.768 NM_004851
NAPSA
napsin A aspartic peptidase
chr5_-_134290789 0.768


chrX_+_154880439 0.766 NM_002186
IL9R
interleukin 9 receptor
chr17_-_36276987 0.765 NM_000223
KRT12
keratin 12
chr12_-_4624536 0.753 NM_006422
AKAP3
A kinase (PRKA) anchor protein 3
chr8_-_21827057 0.751 NM_003974
DOK2
docking protein 2, 56kDa
chr10_-_69125932 0.748 NM_013266
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr5_+_125723686 0.740 NM_001146319
GRAMD3
GRAM domain containing 3
chr22_+_24468110 0.737 NM_032608
MYO18B
myosin XVIIIB
chr10_+_97461525 0.731 NM_001098175
ENTPD1
ectonucleoside triphosphate diphosphohydrolase 1
chr9_-_94206648 0.729 NM_014057
NM_033014
OGN

osteoglycin

chrX_-_70243362 0.728 NM_001025265
CXorf65
chromosome X open reading frame 65
chr19_-_40925151 0.726 NM_024660
TMEM149
transmembrane protein 149
chr5_+_171553780 0.722 NM_001171183
EFCAB9
EF-hand calcium binding domain 9
chr14_+_87560646 0.720 LOC283587
hypothetical protein LOC283587
chr12_+_1596482 0.719 NM_030775
WNT5B
wingless-type MMTV integration site family, member 5B
chr10_+_50177192 0.719 NM_001135196
NM_199459
C10orf71

chromosome 10 open reading frame 71

chr8_+_145158432 0.718 NM_001134374
NM_198572
SPATC1

spermatogenesis and centriole associated 1

chr19_+_17499064 0.715 FAM129C
family with sequence similarity 129, member C
chr6_+_28032997 0.715 NM_012367
OR2B6
olfactory receptor, family 2, subfamily B, member 6
chr9_-_99740243 0.710 NM_197978
HEMGN
hemogen
chr1_+_207944807 0.710 NM_005525
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr1_+_31655607 0.709 NM_001199037
SERINC2
serine incorporator 2
chr12_-_101398503 0.708 NM_000618
NM_001111283
NM_001111285
IGF1


insulin-like growth factor 1 (somatomedin C)


chr9_+_139758336 0.706 EHMT1
euchromatic histone-lysine N-methyltransferase 1
chr11_-_85074848 0.703 NM_152723
CCDC89
coiled-coil domain containing 89
chr19_+_41085221 0.702 NM_001007469
NM_014266
HCST

hematopoietic cell signal transducer

chr14_-_106249999 0.699 IGHA1
immunoglobulin heavy constant alpha 1
chr12_-_121277972 0.699 NM_019887
NM_138929
DIABLO

diablo homolog (Drosophila)

chr6_-_46401363 0.698 NM_005822
RCAN2
regulator of calcineurin 2
chr6_+_7524691 0.697 DSP
desmoplakin
chr3_+_63928459 0.693 NM_001128149
ATXN7
ataxin 7
chr1_+_239882202 0.692 NM_144625
WDR64
WD repeat domain 64
chr11_-_5227611 0.689 NM_000559
HBG1
HBG2
hemoglobin, gamma A
hemoglobin, gamma G
chr3_+_2528272 0.688 CNTN4
contactin 4
chr21_+_29322100 0.684 USP16
ubiquitin specific peptidase 16
chr22_+_24468168 0.682 MYO18B
myosin XVIIIB
chr17_-_53849888 0.682 RNF43
ring finger protein 43
chr2_+_172530120 0.681 HAT1
histone acetyltransferase 1
chr1_-_158759606 0.680 NM_001184714
NM_001184715
NM_001184716
NM_052931
SLAMF6



SLAM family member 6



chr15_-_48192804 0.679 ATP8B4
ATPase, class I, type 8B, member 4
chr10_+_86121526 0.676 FAM190B
family with sequence similarity 190, member B
chr9_+_126094388 0.674 NM_001166169
NEK6
NIMA (never in mitosis gene a)-related kinase 6
chr2_+_46560207 0.669 NM_001145051
LOC388946
transmembrane protein ENSP00000343375
chr7_+_106897737 0.668 NM_005295
GPR22
G protein-coupled receptor 22
chr19_+_59776293 0.664 LILRA2
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2
chr3_-_152585226 0.662 NM_022788
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr6_+_88026338 0.659 ZNF292
zinc finger protein 292
chr2_-_80384454 0.656 LRRTM1
leucine rich repeat transmembrane neuronal 1
chrX_+_12795111 0.656 NM_016562
TLR7
toll-like receptor 7
chr1_-_158883666 0.654 NM_003037
SLAMF1
signaling lymphocytic activation molecule family member 1
chr2_-_10860093 0.653 PDIA6
protein disulfide isomerase family A, member 6
chr14_-_20128721 0.653 NM_001024822
RNASE12
ribonuclease, RNase A family, 12 (non-active)
chr17_-_36181927 0.651 NM_181539
KRT26
keratin 26
chr7_+_113853790 0.651 NM_001172767
NM_148899
FOXP2

forkhead box P2

chr16_+_28850760 0.647 NM_001178098
NM_001770
CD19

CD19 molecule

chr4_+_71806538 0.643 NM_001037442
NM_014961
RUFY3

RUN and FYVE domain containing 3

chr12_-_101398288 0.642 IGF1
insulin-like growth factor 1 (somatomedin C)
chr19_-_6432765 0.642 NM_024898
DENND1C
DENN/MADD domain containing 1C
chr8_+_18123456 0.641 NM_001160174
NAT1
N-acetyltransferase 1 (arylamine N-acetyltransferase)
chr20_-_29524476 0.638 NM_001037500
DEFB124
defensin, beta 124
chr19_+_50137334 0.635 NM_001646
APOC4-APOC2
APOC4
APOC4-APOC2 read-through transcript
apolipoprotein C-IV
chr9_+_92629525 0.634 NM_001174167
SYK
spleen tyrosine kinase
chr8_-_145672525 0.633 NM_003923
FOXH1
forkhead box H1
chr11_+_71605466 0.633 NM_000803
NM_001113534
NM_001113535
NM_001113536
FOLR2



folate receptor 2 (fetal)



chr19_+_44886785 0.627 NM_020129
NM_203471
LGALS14

lectin, galactoside-binding, soluble, 14

chr10_-_35403173 0.627 NM_001198778
NM_001198779
CUL2

cullin 2

chr16_+_31178778 0.626 NM_000632
NM_001145808
ITGAM

integrin, alpha M (complement component 3 receptor 3 subunit)

chr19_+_52532210 0.625 NM_018485
GPR77
G protein-coupled receptor 77
chr6_-_154692906 0.621 NM_001130699
IPCEF1
interaction protein for cytohesin exchange factors 1
chr1_-_156078115 0.617 NM_005894
CD5L
CD5 molecule-like
chr5_+_156628929 0.616 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr17_-_36209672 0.614 NM_181535
KRT28
keratin 28
chr13_-_102517196 0.609 NM_000452
SLC10A2
solute carrier family 10 (sodium/bile acid cotransporter family), member 2
chr17_+_51585834 0.608 NM_153228
ANKFN1
ankyrin-repeat and fibronectin type III domain containing 1
chr9_+_123123364 0.602 GSN
gelsolin
chr19_-_56585603 0.600 NM_001193623
LOC147646
hypothetical protein LOC147646
chr15_+_72253077 0.599 NM_005545
ISLR
immunoglobulin superfamily containing leucine-rich repeat
chr17_+_38250122 0.599 NM_001158
NM_009590
AOC2

amine oxidase, copper containing 2 (retina-specific)

chr1_+_157067729 0.599 NM_002432
MNDA
myeloid cell nuclear differentiation antigen
chr7_-_107667728 0.597 NM_001037132
NRCAM
neuronal cell adhesion molecule
chrX_-_76824726 0.595 ATRX
alpha thalassemia/mental retardation syndrome X-linked

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.55 1.09e-02 GO:0002682 regulation of immune system process

Nothing significant found in compartment category.

Nothing significant found in function category.