Motif ID: SOX{8,9,10}.p2

Z-value: 1.069


Transcription factors associated with SOX{8,9,10}.p2:

Gene SymbolEntrez IDGene Name
SOX10 6663 SRY (sex determining region Y)-box 10
SOX8 30812 SRY (sex determining region Y)-box 8
SOX9 6662 SRY (sex determining region Y)-box 9

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SOX10chr22_-_36710484-0.312.6e-01Click!
SOX9chr17_+_676287630.126.7e-01Click!
SOX8chr16_+_9718080.078.1e-01Click!


Activity profile for motif SOX{8,9,10}.p2.

activity profile for motif SOX{8,9,10}.p2


Sorted Z-values histogram for motif SOX{8,9,10}.p2

Sorted Z-values for motif SOX{8,9,10}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX{8,9,10}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_6103945 1.581 NM_000552
VWF
von Willebrand factor
chr11_+_129496792 1.175 APLP2
amyloid beta (A4) precursor-like protein 2
chr1_-_197173159 1.022 LOC100131234
familial acute myelogenous leukemia related factor
chr7_-_11838260 1.017 NM_015204
THSD7A
thrombospondin, type I, domain containing 7A
chr14_-_89490780 0.996 NM_145231
EFCAB11
EF-hand calcium binding domain 11
chr16_+_22432344 0.991 NM_001135865
LOC100132247
NPIPL3
nuclear pore complex interacting protein related gene
nuclear pore complex interacting protein-like 3
chrX_+_15428820 0.925 NM_203281
BMX
BMX non-receptor tyrosine kinase
chr16_-_21344158 0.913 NM_130464
NPIPL3
nuclear pore complex interacting protein-like 3
chr16_-_69876262 0.889 FTSJD1
FtsJ methyltransferase domain containing 1
chr6_-_139654807 0.863 NM_153235
TXLNB
taxilin beta
chrX_-_44945025 0.818 NM_024689
NM_176819
CXorf36

chromosome X open reading frame 36

chr17_-_71017509 0.815 NM_001142643
CASKIN2
CASK interacting protein 2
chr5_+_149960820 0.758 NM_001166208
SYNPO
synaptopodin
chr2_-_128138435 0.748 NM_017980
LIMS2
LIM and senescent cell antigen-like domains 2
chr19_-_17236522 0.734 NM_031941
USHBP1
Usher syndrome 1C binding protein 1
chr5_-_141318810 0.731 NM_016580
PCDH12
protocadherin 12
chr10_-_123346148 0.719 NM_001144915
FGFR2
fibroblast growth factor receptor 2
chr17_-_1359745 0.715 INPP5K
inositol polyphosphate-5-phosphatase K
chr8_-_70908130 0.714 NM_001146008
SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr3_+_182900081 0.693 SOX2OT
SOX2 overlapping transcript (non-protein coding)
chr20_-_38751289 0.675 NM_005461
MAFB
v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
chr6_-_29752909 0.661 NM_001109809
ZFP57
zinc finger protein 57 homolog (mouse)
chr7_+_129497808 0.658 KLHDC10
kelch domain containing 10
chr9_-_35101592 0.618 KIAA1539
KIAA1539
chr1_+_43539239 0.614 NM_005424
TIE1
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
chr17_+_8154280 0.614 NM_173728
ARHGEF15
Rho guanine nucleotide exchange factor (GEF) 15
chr17_+_65009986 0.613 MAP2K6
mitogen-activated protein kinase kinase 6
chr8_+_24207524 0.612 NM_014265
NM_021777
ADAM28

ADAM metallopeptidase domain 28

chr3_-_11598829 0.612 NM_001128220
VGLL4
vestigial like 4 (Drosophila)
chr14_+_62740878 0.608 NM_020663
RHOJ
ras homolog gene family, member J
chr16_+_64958060 0.606 CDH5
cadherin 5, type 2 (vascular endothelium)
chr17_-_18890963 0.602 NM_006613
GRAP
GRB2-related adaptor protein
chr5_-_137099602 0.600 NM_017415
KLHL3
kelch-like 3 (Drosophila)
chr9_+_4782974 0.597 RCL1
RNA terminal phosphate cyclase-like 1
chr3_-_150993299 0.590 NM_001144960
C3orf16
chromosome 3 open reading frame 16
chr6_+_148705421 0.581 NM_015278
SASH1
SAM and SH3 domain containing 1
chr10_+_24538094 0.579 KIAA1217
KIAA1217
chr5_-_146813343 0.578 NM_001387
DPYSL3
dihydropyrimidinase-like 3
chr3_+_179736917 0.571 NM_181361
KCNMB2
potassium large conductance calcium-activated channel, subfamily M, beta member 2
chr6_-_75972473 0.566 COL12A1
collagen, type XII, alpha 1
chr5_-_159478967 0.562 NM_001130864
NM_052927
PWWP2A

PWWP domain containing 2A

chr2_+_54536780 0.559 NM_003128
SPTBN1
spectrin, beta, non-erythrocytic 1
chr16_+_64958025 0.558 NM_001795
CDH5
cadherin 5, type 2 (vascular endothelium)
chr8_+_70541631 0.552 SULF1
sulfatase 1
chr9_+_115303527 0.549 NM_130795
RGS3
regulator of G-protein signaling 3
chr9_-_35101534 0.548 KIAA1539
KIAA1539
chr2_-_56266408 0.546 LOC100129434
hypothetical LOC100129434
chr9_-_129557373 0.546 NM_001142534
NM_001142533
SH2D3C

SH2 domain containing 3C

chr15_-_68781662 0.543 NM_001008224
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr15_-_39973566 0.543 NM_016642
SPTBN5
spectrin, beta, non-erythrocytic 5
chr9_+_4782833 0.541 NM_005772
RCL1
RNA terminal phosphate cyclase-like 1
chr5_+_178919298 0.541 NM_001040451
NM_001040452
RUFY1

RUN and FYVE domain containing 1

chr16_+_67131161 0.538 NM_133458
ZFP90
zinc finger protein 90 homolog (mouse)
chr12_-_10142779 0.536 NM_016511
CLEC1A
C-type lectin domain family 1, member A
chr3_+_190990142 0.532 NM_001114980
NM_001114981
NM_001114982
TP63


tumor protein p63


chr6_-_75972286 0.532 NM_004370
NM_080645
COL12A1

collagen, type XII, alpha 1

chr8_-_81155564 0.526 NM_001025252
TPD52
tumor protein D52
chr6_-_128883125 0.520 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr9_+_4782876 0.512 RCL1
RNA terminal phosphate cyclase-like 1
chr22_-_41672990 0.512 NM_007229
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chr1_-_152431175 0.512 NM_152263
TPM3
tropomyosin 3
chr9_+_90193807 0.511 SPIN1
spindlin 1
chr12_-_11399776 0.510 NM_005039
NM_199353
NM_199354
PRB1


proline-rich protein BstNI subfamily 1


chr13_-_32658215 0.509 NM_178007
STARD13
StAR-related lipid transfer (START) domain containing 13
chr16_+_64958086 0.505 CDH5
cadherin 5, type 2 (vascular endothelium)
chr10_+_24537725 0.505 NM_001098501
NM_019590
KIAA1217

KIAA1217

chr17_-_53335748 0.504 NM_017949
CUEDC1
CUE domain containing 1
chr10_-_91451102 0.504 NBAS
neuroblastoma amplified sequence
chr1_+_64012154 0.501 NM_001083592
NM_005012
ROR1

receptor tyrosine kinase-like orphan receptor 1

chr10_-_105835609 0.500 NM_000494
COL17A1
collagen, type XVII, alpha 1
chr13_-_74799898 0.499 TBC1D4
TBC1 domain family, member 4
chr3_-_14964861 0.497 LOC100505673
hypothetical LOC100505673
chr10_-_120091795 0.496 NM_001134672
NM_022063
C10orf84

chromosome 10 open reading frame 84

chr20_-_17610828 0.492 NM_001042576
NM_004587
RRBP1

ribosome binding protein 1 homolog 180kDa (dog)

chr12_-_120725210 0.489 LOC338799
hypothetical LOC338799
chr8_+_121892719 0.489


chr5_+_95093267 0.486


chr4_-_101658094 0.484 NM_001159694
NM_016242
EMCN

endomucin

chr8_+_70541412 0.476 NM_001128204
NM_015170
SULF1

sulfatase 1

chr5_-_137099361 0.474 KLHL3
kelch-like 3 (Drosophila)
chr21_-_31853160 0.473 NM_003253
TIAM1
T-cell lymphoma invasion and metastasis 1
chr3_-_27739201 0.467 EOMES
eomesodermin
chr1_-_23568854 0.464 NM_001077195
ZNF436
zinc finger protein 436
chr11_+_101488380 0.454 NM_001195045
YAP1
Yes-associated protein 1
chr13_-_29938029 0.453 NM_002128
HMGB1
high-mobility group box 1
chr12_-_69289889 0.451 NM_002837
PTPRB
protein tyrosine phosphatase, receptor type, B
chr1_+_47261826 0.447 NM_178033
CYP4X1
cytochrome P450, family 4, subfamily X, polypeptide 1
chr4_+_113372287 0.447 NM_001128426
NM_018569
AP1AR

adaptor-related protein complex 1 associated regulatory protein

chr5_-_16989371 0.444 NM_012334
MYO10
myosin X
chr12_-_10464308 0.441 NM_002261
NM_007333
KLRC3

killer cell lectin-like receptor subfamily C, member 3

chr5_-_132189762 0.441 NM_133456
SHROOM1
shroom family member 1
chr10_-_105835525 0.440 COL17A1
collagen, type XVII, alpha 1
chr8_-_70907957 0.438 NM_001146009
SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr6_+_30796064 0.432 TUBB
tubulin, beta
chr3_-_189354510 0.432 LOC339929
hypothetical LOC339929
chr8_-_38444398 0.431 NM_001174065
NM_001174066
NM_001174067
FGFR1


fibroblast growth factor receptor 1


chr12_-_11439752 0.426 NM_006248
PRB1
PRB2
proline-rich protein BstNI subfamily 1
proline-rich protein BstNI subfamily 2
chr11_-_46824364 0.426 CKAP5
cytoskeleton associated protein 5
chr2_+_228386800 0.423 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr1_+_176577228 0.422 NM_004841
RASAL2
RAS protein activator like 2
chr13_+_51927615 0.421 CKAP2
cytoskeleton associated protein 2
chr2_+_37425240 0.419 NM_012413
QPCT
glutaminyl-peptide cyclotransferase
chr12_-_10173947 0.418 NM_022570
NM_197947
NM_197948
NM_197949
NM_197950
NM_197954
CLEC7A





C-type lectin domain family 7, member A





chr10_-_13789628 0.418 FRMD4A
FERM domain containing 4A
chr1_+_149395728 0.415 NM_024575
TNFAIP8L2
tumor necrosis factor, alpha-induced protein 8-like 2
chr17_+_44325127 0.411 NM_001002027
NM_005175
ATP5G1

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)

chr14_-_63830830 0.408 NM_001040275
NM_001437
ESR2

estrogen receptor 2 (ER beta)

chr5_-_92942680 0.408 FLJ42709
hypothetical LOC441094
chr14_+_58725104 0.404 NM_014992
DAAM1
dishevelled associated activator of morphogenesis 1
chr17_-_36996611 0.400 NM_000526
KRT14
keratin 14
chr1_+_183970093 0.399 NM_031935
HMCN1
hemicentin 1
chr10_+_115300579 0.399 NM_001177660
HABP2
hyaluronan binding protein 2
chr10_+_104253706 0.397 NM_001178133
NM_016169
SUFU

suppressor of fused homolog (Drosophila)

chr4_-_186969202 0.395 NM_001145671
SORBS2
sorbin and SH3 domain containing 2
chr8_-_121892877 0.393 SNTB1
syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
chr1_+_200449905 0.391 NM_001017404
LGR6
leucine-rich repeat containing G protein-coupled receptor 6
chr12_-_57600564 0.390 LRIG3
leucine-rich repeats and immunoglobulin-like domains 3
chr12_+_14429499 0.389 ATF7IP
activating transcription factor 7 interacting protein
chr7_+_134114912 0.389 CALD1
caldesmon 1
chr3_-_101077605 0.388 NM_014890
FILIP1L
filamin A interacting protein 1-like
chr5_+_50714996 0.388 ISL1
ISL LIM homeobox 1
chr7_-_27206249 0.387 NM_000522
HOXA13
homeobox A13
chr7_-_27186400 0.387 NM_153715
HOXA10
homeobox A10
chr1_+_151270301 0.384 NM_003125
SPRR1B
small proline-rich protein 1B
chr3_+_44571600 0.382 NM_018651
NM_025169
ZNF167

zinc finger protein 167

chr10_-_103864579 0.379 LDB1
LIM domain binding 1
chr1_+_34997928 0.375 NM_153212
GJB4
gap junction protein, beta 4, 30.3kDa
chr20_-_17610704 0.374 RRBP1
ribosome binding protein 1 homolog 180kDa (dog)
chr4_-_175441192 0.373 FBXO8
F-box protein 8
chr6_+_21774624 0.369 FLJ22536
hypothetical locus LOC401237
chr4_-_186969041 0.368 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr6_-_64087806 0.368 NM_001143940
NM_016571
LGSN

lengsin, lens protein with glutamine synthetase domain

chr11_-_46824416 0.366 NM_001008938
NM_014756
CKAP5

cytoskeleton associated protein 5

chr7_-_13997389 0.366 NM_001163149
ETV1
ets variant 1
chr1_-_148124738 0.364 NM_003528
HIST2H2BE
histone cluster 2, H2be
chr15_-_70277163 0.363 NM_001012642
GRAMD2
GRAM domain containing 2
chr7_+_134114957 0.362 CALD1
caldesmon 1
chr1_+_159495140 0.359 NM_001102566
PCP4L1
Purkinje cell protein 4 like 1
chr5_+_60276695 0.358 NM_174889
NDUFAF2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 2
chr8_-_82557956 0.356 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr18_+_3437607 0.356 NM_173207
TGIF1
TGFB-induced factor homeobox 1
chr12_-_24606616 0.354 NM_152989
SOX5
SRY (sex determining region Y)-box 5
chr4_-_149582754 0.353 NR3C2
nuclear receptor subfamily 3, group C, member 2
chr9_+_90193058 0.352 NM_006717
SPIN1
spindlin 1
chr5_-_50714836 0.352 LOC642366
hypothetical LOC642366
chr4_-_151990061 0.351 LRBA
LPS-responsive vesicle trafficking, beach and anchor containing
chr17_-_59818033 0.350 PECAM1
platelet/endothelial cell adhesion molecule
chr10_+_83627422 0.348 NM_001165973
NRG3
neuregulin 3
chr14_-_72563497 0.345 NM_021260
ZFYVE1
zinc finger, FYVE domain containing 1
chr2_-_207739815 0.345 KLF7
Kruppel-like factor 7 (ubiquitous)
chr7_-_41709191 0.345 NM_002192
INHBA
inhibin, beta A
chr5_-_16989290 0.342 MYO10
myosin X
chr15_-_57013092 0.341 NM_001013843
NM_024755
SLTM

SAFB-like, transcription modulator

chr20_-_17459973 0.340 NM_001195
BFSP1
beaded filament structural protein 1, filensin
chr5_+_159781454 0.339 PTTG1
pituitary tumor-transforming 1
chr14_+_101297887 0.336 NM_001161725
NM_001161726
PPP2R5C

protein phosphatase 2, regulatory subunit B', gamma

chr7_-_13997574 0.336 NM_001163148
ETV1
ets variant 1
chr11_+_116608447 0.335 NM_207343
NM_001077239
RNF214

ring finger protein 214

chr12_-_47362254 0.334 NM_017822
C12orf41
chromosome 12 open reading frame 41
chr19_-_63205948 0.334 ZNF606
zinc finger protein 606
chr12_-_97812633 0.332 ANKS1B
ankyrin repeat and sterile alpha motif domain containing 1B
chr14_-_72523404 0.330 NM_178441
ZFYVE1
zinc finger, FYVE domain containing 1
chr6_+_27208763 0.329 NM_021064
HIST1H2AG
histone cluster 1, H2ag
chr9_+_123501186 0.328 DAB2IP
DAB2 interacting protein
chr6_-_116681863 0.328 NM_021648
TSPYL4
TSPY-like 4
chr14_-_54948290 0.328 NM_014924
ATG14
ATG14 autophagy related 14 homolog (S. cerevisiae)
chr14_+_90650466 0.327 C14orf159
chromosome 14 open reading frame 159
chr13_-_32678142 0.325 NM_052851
STARD13
StAR-related lipid transfer (START) domain containing 13
chr4_+_87070449 0.325 NM_031305
ARHGAP24
Rho GTPase activating protein 24
chr3_-_194118627 0.322 NM_178496
MB21D2
Mab-21 domain containing 2
chr2_-_96769502 0.322 LMAN2L
lectin, mannose-binding 2-like
chr3_+_115099007 0.322 NM_001172105
GRAMD1C
GRAM domain containing 1C
chr6_+_64289585 0.321 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr3_+_113200696 0.320 NM_001008273
TAGLN3
transgelin 3
chr10_-_103864651 0.316 NM_003893
LDB1
LIM domain binding 1
chr3_+_113200275 0.316 NM_001008272
NM_013259
TAGLN3

transgelin 3

chr3_+_189354167 0.315 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr10_-_94040779 0.315 NM_014912
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr4_+_57066131 0.314 NM_206919
ARL9
ADP-ribosylation factor-like 9
chr10_+_91451313 0.307 NM_016195
KIF20B
kinesin family member 20B
chr11_-_128567302 0.307 NM_001142685
ARHGAP32
Rho GTPase activating protein 32
chr4_+_175441402 0.307 NM_001040157
KIAA1712
KIAA1712
chr20_+_10363949 0.306 NM_001009608
C20orf94
chromosome 20 open reading frame 94
chr1_+_42701460 0.306 CCDC30
coiled-coil domain containing 30
chr14_-_94306104 0.306 NM_173849
GSC
goosecoid homeobox
chr6_-_72187168 0.305 C6orf155
chromosome 6 open reading frame 155
chr14_+_36196523 0.303 NM_006194
PAX9
paired box 9
chr6_+_26153590 0.302 NM_003531
HIST1H3C
histone cluster 1, H3c
chr4_-_106849252 0.301 NM_001142471
NM_020395
INTS12

integrator complex subunit 12

chr1_+_246635918 0.300 NM_030904
OR2T1
olfactory receptor, family 2, subfamily T, member 1
chr7_-_27108826 0.298 NM_006735
HOXA2
homeobox A2
chr5_+_15553288 0.298 NM_012304
FBXL7
F-box and leucine-rich repeat protein 7
chr9_-_98104206 0.298 NM_000197
HSD17B3
hydroxysteroid (17-beta) dehydrogenase 3
chr5_+_57914658 0.297 NM_138453
RAB3C
RAB3C, member RAS oncogene family
chr20_-_13567529 0.297 NM_017714
TASP1
taspase, threonine aspartase, 1
chr10_+_32896656 0.296 NM_024688
C10orf68
chromosome 10 open reading frame 68
chr1_-_24311212 0.296 NM_152372
MYOM3
myomesin family, member 3
chr4_+_41235077 0.295 LIMCH1
LIM and calponin homology domains 1
chr2_-_100088760 0.295 AFF3
AF4/FMR2 family, member 3
chr13_-_95094920 0.294 NM_014934
NM_198968
DZIP1

DAZ interacting protein 1


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.30 5.81e-06 GO:0007275 multicellular organismal development
1.27 1.11e-05 GO:0032502 developmental process
1.28 2.57e-04 GO:0048856 anatomical structure development
1.27 2.65e-04 GO:0016043 cellular component organization
1.29 3.27e-04 GO:0048731 system development
1.26 4.05e-04 GO:0071840 cellular component organization or biogenesis
1.15 8.32e-04 GO:0050794 regulation of cellular process
1.76 1.69e-03 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.18 1.85e-03 GO:0032501 multicellular organismal process
1.39 3.07e-03 GO:0007399 nervous system development
2.72 4.54e-03 GO:0006334 nucleosome assembly
1.56 5.47e-03 GO:0010557 positive regulation of macromolecule biosynthetic process
2.55 7.72e-03 GO:0065004 protein-DNA complex assembly
1.61 8.41e-03 GO:0045893 positive regulation of transcription, DNA-dependent
1.26 1.31e-02 GO:0071842 cellular component organization at cellular level
2.58 1.32e-02 GO:0031497 chromatin assembly
1.31 1.34e-02 GO:0030154 cell differentiation
1.30 1.35e-02 GO:0048869 cellular developmental process
1.13 1.39e-02 GO:0050789 regulation of biological process
1.12 1.99e-02 GO:0065007 biological regulation
2.41 2.41e-02 GO:0071824 protein-DNA complex subunit organization
1.55 2.71e-02 GO:0010628 positive regulation of gene expression
1.25 3.19e-02 GO:0071841 cellular component organization or biogenesis at cellular level
2.46 3.52e-02 GO:0034728 nucleosome organization
1.51 3.56e-02 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.28 3.83e-02 GO:0006323 DNA packaging
1.72 4.29e-02 GO:0007264 small GTPase mediated signal transduction

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.18 1.92e-04 GO:0005634 nucleus
3.14 9.54e-04 GO:0000786 nucleosome
1.38 2.28e-03 GO:0005654 nucleoplasm
1.54 1.04e-02 GO:0030054 cell junction
1.29 1.06e-02 GO:0031981 nuclear lumen
2.34 1.29e-02 GO:0030055 cell-substrate junction
2.41 1.60e-02 GO:0032993 protein-DNA complex
1.84 2.39e-02 GO:0000785 chromatin
1.51 4.48e-02 GO:0005694 chromosome

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.53 6.46e-05 GO:0001071 nucleic acid binding transcription factor activity
1.53 6.46e-05 GO:0003700 sequence-specific DNA binding transcription factor activity
1.32 8.03e-05 GO:0003677 DNA binding
1.08 7.53e-04 GO:0005488 binding
1.21 9.06e-03 GO:0003676 nucleic acid binding
1.12 1.02e-02 GO:0005515 protein binding
1.39 3.41e-02 GO:0030528 transcription regulator activity