Motif ID: SOX{8,9,10}.p2

Z-value: 1.069


Transcription factors associated with SOX{8,9,10}.p2:

Gene SymbolEntrez IDGene Name
SOX10 6663 SRY (sex determining region Y)-box 10
SOX8 30812 SRY (sex determining region Y)-box 8
SOX9 6662 SRY (sex determining region Y)-box 9

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SOX10chr22_-_36710484-0.312.6e-01Click!
SOX9chr17_+_676287630.126.7e-01Click!
SOX8chr16_+_9718080.078.1e-01Click!


Activity profile for motif SOX{8,9,10}.p2.

activity profile for motif SOX{8,9,10}.p2


Sorted Z-values histogram for motif SOX{8,9,10}.p2

Sorted Z-values for motif SOX{8,9,10}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX{8,9,10}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_6103945 1.581 NM_000552
 VWF
von Willebrand factor
chr11_+_129496792 1.175 APLP2
amyloid beta (A4) precursor-like protein 2
chr1_-_197173159 1.022 LOC100131234
familial acute myelogenous leukemia related factor
chr7_-_11838260 1.017 NM_015204
 THSD7A
thrombospondin, type I, domain containing 7A
chr14_-_89490780 0.996 NM_145231
 EFCAB11
EF-hand calcium binding domain 11
chr16_+_22432344 0.991 NM_001135865
 LOC100132247
NPIPL3
nuclear pore complex interacting protein related gene
nuclear pore complex interacting protein-like 3
chrX_+_15428820 0.925 NM_203281
 BMX
BMX non-receptor tyrosine kinase
chr16_-_21344158 0.913 NM_130464
 NPIPL3
nuclear pore complex interacting protein-like 3
chr16_-_69876262 0.889 FTSJD1
FtsJ methyltransferase domain containing 1
chr6_-_139654807 0.863 NM_153235
 TXLNB
taxilin beta
chrX_-_44945025 0.818 NM_024689
NM_176819
 CXorf36

chromosome X open reading frame 36

chr17_-_71017509 0.815 NM_001142643
 CASKIN2
CASK interacting protein 2
chr5_+_149960820 0.758 NM_001166208
 SYNPO
synaptopodin
chr2_-_128138435 0.748 NM_017980
 LIMS2
LIM and senescent cell antigen-like domains 2
chr19_-_17236522 0.734 NM_031941
 USHBP1
Usher syndrome 1C binding protein 1
chr5_-_141318810 0.731 NM_016580
 PCDH12
protocadherin 12
chr10_-_123346148 0.719 NM_001144915
 FGFR2
fibroblast growth factor receptor 2
chr17_-_1359745 0.715 INPP5K
inositol polyphosphate-5-phosphatase K
chr8_-_70908130 0.714 NM_001146008
 SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr3_+_182900081 0.693 SOX2OT
SOX2 overlapping transcript (non-protein coding)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 27 entries
enrichment   p-value GO term description
2.72 4.54e-03 GO:0006334 nucleosome assembly
2.58 1.32e-02 GO:0031497 chromatin assembly
2.55 7.72e-03 GO:0065004 protein-DNA complex assembly
2.46 3.52e-02 GO:0034728 nucleosome organization
2.41 2.41e-02 GO:0071824 protein-DNA complex subunit organization
2.28 3.83e-02 GO:0006323 DNA packaging
1.76 1.69e-03 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.72 4.29e-02 GO:0007264 small GTPase mediated signal transduction
1.61 8.41e-03 GO:0045893 positive regulation of transcription, DNA-dependent
1.56 5.47e-03 GO:0010557 positive regulation of macromolecule biosynthetic process
1.55 2.71e-02 GO:0010628 positive regulation of gene expression
1.51 3.56e-02 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.39 3.07e-03 GO:0007399 nervous system development
1.31 1.34e-02 GO:0030154 cell differentiation
1.30 5.81e-06 GO:0007275 multicellular organismal development
1.30 1.35e-02 GO:0048869 cellular developmental process
1.29 3.27e-04 GO:0048731 system development
1.28 2.57e-04 GO:0048856 anatomical structure development
1.27 1.11e-05 GO:0032502 developmental process
1.27 2.65e-04 GO:0016043 cellular component organization

Gene overrepresentation in compartment category:

Showing 1 to 9 of 9 entries
enrichment   p-value GO term description
3.14 9.54e-04 GO:0000786 nucleosome
2.41 1.60e-02 GO:0032993 protein-DNA complex
2.34 1.29e-02 GO:0030055 cell-substrate junction
1.84 2.39e-02 GO:0000785 chromatin
1.54 1.04e-02 GO:0030054 cell junction
1.51 4.48e-02 GO:0005694 chromosome
1.38 2.28e-03 GO:0005654 nucleoplasm
1.29 1.06e-02 GO:0031981 nuclear lumen
1.18 1.92e-04 GO:0005634 nucleus

Gene overrepresentation in function category:

Showing 1 to 7 of 7 entries
enrichment   p-value GO term description
1.53 6.46e-05 GO:0001071 nucleic acid binding transcription factor activity
1.53 6.46e-05 GO:0003700 sequence-specific DNA binding transcription factor activity
1.39 3.41e-02 GO:0030528 transcription regulator activity
1.32 8.03e-05 GO:0003677 DNA binding
1.21 9.06e-03 GO:0003676 nucleic acid binding
1.12 1.02e-02 GO:0005515 protein binding
1.08 7.53e-04 GO:0005488 binding