Motif ID: STAT5{A,B}.p2

Z-value: 1.663


Transcription factors associated with STAT5{A,B}.p2:

Gene SymbolEntrez IDGene Name
STAT5A 6776 signal transducer and activator of transcription 5A
STAT5B 6777 signal transducer and activator of transcription 5B

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
STAT5Bchr17_-_37681917-0.582.2e-02Click!
STAT5Achr17_+_37694007-0.165.6e-01Click!


Activity profile for motif STAT5{A,B}.p2.

activity profile for motif STAT5{A,B}.p2


Sorted Z-values histogram for motif STAT5{A,B}.p2

Sorted Z-values for motif STAT5{A,B}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of STAT5{A,B}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_203503214 2.330 TMCC2
transmembrane and coiled-coil domain family 2
chr19_+_49361054 1.976 NM_001146220
NM_001032373
NM_001032374
NM_015919
NM_001032372
ZNF226




zinc finger protein 226




chr19_+_49309350 1.771 NM_013362
ZNF225
zinc finger protein 225
chr3_+_66094324 1.664 NM_173471
SLC25A26
solute carrier family 25, member 26
chr1_-_206125877 1.594


chr19_-_53941835 1.585 NM_182575
IZUMO1
izumo sperm-egg fusion 1
chr13_+_51334117 1.483 NM_031290
CCDC70
coiled-coil domain containing 70
chr19_+_49290319 1.383 NM_013398
ZNF224
zinc finger protein 224
chr4_-_77176163 1.337 NM_005409
CXCL11
chemokine (C-X-C motif) ligand 11
chr14_-_19951417 1.298 NM_007110
TEP1
telomerase-associated protein 1
chr3_+_171422940 1.287 PRKCI
protein kinase C, iota
chr11_+_36572615 1.286 NM_138787
C11orf74
chromosome 11 open reading frame 74
chr19_+_49180171 1.204 NM_003445
NM_198089
ZNF155

zinc finger protein 155

chr19_+_49408523 1.200 NM_182490
ZNF227
zinc finger protein 227
chr2_+_95195260 1.187 ZNF2
zinc finger protein 2
chr3_+_171422917 1.155 PRKCI
protein kinase C, iota
chr19_-_49500966 1.129 NM_004234
ZNF235
zinc finger protein 235
chr19_+_42400908 1.103 ZNF383
zinc finger protein 383
chr19_+_49248003 1.076 NM_013361
ZNF223
zinc finger protein 223
chr8_-_66708954 1.044 ARMC1
armadillo repeat containing 1
chr7_+_89870707 1.033 CLDN12
claudin 12
chr3_+_171422908 1.028 NM_002740
PRKCI
protein kinase C, iota
chr8_-_66708948 1.025 ARMC1
armadillo repeat containing 1
chr19_-_49552638 1.010 NM_001083335
NM_013380
ZFP112

zinc finger protein 112 homolog (mouse)

chr15_+_39853923 0.992 NM_001128608
NM_014994
MAPKBP1

mitogen-activated protein kinase binding protein 1

chr19_+_62972861 0.980 ZNF586
zinc finger protein 586
chr7_-_93471463 0.949 NM_005868
BET1
blocked early in transport 1 homolog (S. cerevisiae)
chr7_-_112545840 0.943 LOC401397
hypothetical LOC401397
chr12_+_100795213 0.941 NM_018370
DRAM1
DNA-damage regulated autophagy modulator 1
chr8_-_66708967 0.926 NM_018120
ARMC1
armadillo repeat containing 1
chr17_+_29606408 0.921 NM_002982
CCL2
chemokine (C-C motif) ligand 2
chr1_+_38250995 0.918 UTP11L
UTP11-like, U3 small nucleolar ribonucleoprotein, (yeast)
chr15_+_39853982 0.900 MAPKBP1
mitogen-activated protein kinase binding protein 1
chr11_-_82674546 0.887 CCDC90B
coiled-coil domain containing 90B
chr7_+_89870647 0.872 NM_001185072
NM_001185073
NM_012129
CLDN12


claudin 12


chr7_-_132417374 0.846 CHCHD3
coiled-coil-helix-coiled-coil-helix domain containing 3
chr1_+_54291847 0.824 NM_153035
TCEANC2
transcription elongation factor A (SII) N-terminal and central domain containing 2
chr9_+_103200939 0.804 NM_003452
NM_197977
ZNF189

zinc finger protein 189

chr15_+_64661560 0.799


chr6_+_139136349 0.795 NM_015439
CCDC28A
coiled-coil domain containing 28A
chr1_-_33275051 0.764 AK2
adenylate kinase 2
chr1_-_33275015 0.762 AK2
adenylate kinase 2
chr1_-_33275039 0.755 AK2
adenylate kinase 2
chr19_+_62950001 0.752 ZNF776
zinc finger protein 776
chr1_+_40769877 0.744 ZNF684
zinc finger protein 684
chr18_-_45241014 0.723 NM_017653
DYM
dymeclin
chr19_-_49131250 0.713 NM_003425
ZNF45
zinc finger protein 45
chr17_-_35464137 0.712 MED24
mediator complex subunit 24
chr6_+_84626146 0.704 CYB5R4
cytochrome b5 reductase 4
chr4_+_2853434 0.699 ADD1
adducin 1 (alpha)
chr1_+_38250953 0.698 NM_016037
UTP11L
UTP11-like, U3 small nucleolar ribonucleoprotein, (yeast)
chr2_-_85435074 0.693 NM_017750
RETSAT
retinol saturase (all-trans-retinol 13,14-reductase)
chr2_+_173394560 0.684 NM_001100397
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr16_-_219111 0.680


chr9_-_103200697 0.671 NM_019051
MRPL50
mitochondrial ribosomal protein L50
chr19_+_9112052 0.670 NM_001190791
NM_020933
ZNF317

zinc finger protein 317

chr1_-_33275071 0.649 NM_013411
AK2
adenylate kinase 2
chr7_-_112545847 0.645 LOC401397
hypothetical LOC401397
chr17_+_36636404 0.643 NM_031961
KRTAP9-2
keratin associated protein 9-2
chr19_-_49309102 0.643 LOC100379224
hypothetical LOC100379224
chr9_-_133944877 0.639 MED27
mediator complex subunit 27
chr6_+_84626113 0.625 CYB5R4
cytochrome b5 reductase 4
chr11_-_133628348 0.604 NM_001037304
NM_001037305
NM_014174
NM_199297
NM_199298
THYN1




thymocyte nuclear protein 1




chr1_-_33275057 0.597 NM_001625
AK2
adenylate kinase 2
chr7_-_132417237 0.595 NM_017812
CHCHD3
coiled-coil-helix-coiled-coil-helix domain containing 3
chr10_-_98315090 0.586 TM9SF3
transmembrane 9 superfamily member 3
chr19_-_42777486 0.580 NM_016536
ZNF571
zinc finger protein 571
chr19_+_49337568 0.578 ZNF234
zinc finger protein 234
chr14_-_76958984 0.575 NM_138791
NM_001113475
C14orf148

chromosome 14 open reading frame 148

chr19_-_61596681 0.569 NM_144690
ZNF582
zinc finger protein 582
chr16_+_52295545 0.568 FTO
fat mass and obesity associated
chr19_+_39860398 0.568 NM_001012320
NM_018443
ZNF302

zinc finger protein 302

chr19_-_41672176 0.562 NM_032838
NM_001145343
NM_001145344
NM_001145345
ZNF566



zinc finger protein 566



chr19_+_45168872 0.556 NM_006503
NM_153001
PSMC4

proteasome (prosome, macropain) 26S subunit, ATPase, 4

chr19_+_17239264 0.549 BABAM1
BRISC and BRCA1 A complex member 1
chr17_-_44847215 0.547 NM_002634
PHB
prohibitin
chr19_+_55844446 0.545 NM_001195076
LOC342918
hypothetical protein LOC342918
chr3_+_140545528 0.543 NM_020191
MRPS22
mitochondrial ribosomal protein S22
chr19_+_62638474 0.543 NM_001023561
ZNF749
zinc finger protein 749
chr5_+_14493905 0.541 TRIO
triple functional domain (PTPRF interacting)
chr17_-_23721468 0.539 VTN
vitronectin
chr6_+_84626083 0.539 NM_016230
CYB5R4
cytochrome b5 reductase 4
chr3_-_158695832 0.535 NM_001167917
VEPH1
ventricular zone expressed PH domain homolog 1 (zebrafish)
chr11_+_133628616 0.515 NM_014384
ACAD8
acyl-CoA dehydrogenase family, member 8
chr17_-_23721485 0.515 NM_000638
VTN
vitronectin
chr10_+_93548048 0.515 TNKS2
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
chr1_+_151897768 0.508 NM_012437
SNAPIN
SNAP-associated protein
chr3_+_199161446 0.503 NM_000996
RPL35A
ribosomal protein L35a
chr19_+_49198916 0.502 NM_006300
ZNF230
zinc finger protein 230
chr18_+_41938295 0.495 NM_138443
HAUS1
HAUS augmin-like complex, subunit 1
chr2_+_95194903 0.492 NM_001017396
NM_021088
ZNF2

zinc finger protein 2

chr7_-_133652289 0.484 NM_032826
SLC35B4
solute carrier family 35, member B4
chr12_+_12857516 0.478 NM_016355
NM_201224
DDX47

DEAD (Asp-Glu-Ala-Asp) box polypeptide 47

chr5_-_102926349 0.473 NM_031438
NUDT12
nudix (nucleoside diphosphate linked moiety X)-type motif 12
chr17_+_5264195 0.471 RPAIN
RPA interacting protein
chr17_-_18526296 0.467 NM_001145045
ZNF286B
zinc finger protein 286B
chr19_-_41711009 0.466 NM_001012756
NM_001166036
NM_001166037
NM_001166038
ZNF260



zinc finger protein 260



chr17_+_7457988 0.463 SHBG
sex hormone-binding globulin
chr19_+_62949972 0.460 NM_173632
ZNF776
zinc finger protein 776
chr6_-_30766621 0.460 NM_007243
NRM
nurim (nuclear envelope membrane protein)
chr19_+_49337548 0.459 NM_001144824
NM_006630
ZNF234

zinc finger protein 234

chr19_-_49097774 0.453 LOC100505715
hypothetical LOC100505715
chr2_+_171999042 0.452 DCAF17
DDB1 and CUL4 associated factor 17
chr11_+_5466490 0.451 NM_001005163
OR52D1
olfactory receptor, family 52, subfamily D, member 1
chr17_-_44847214 0.449 PHB
prohibitin
chr6_-_27548438 0.440 NM_007149
ZNF184
zinc finger protein 184
chr13_-_24395054 0.439 NM_018451
CENPJ
centromere protein J
chr6_+_20642665 0.437 NM_017774
CDKAL1
CDK5 regulatory subunit associated protein 1-like 1
chr18_+_54958095 0.435 NM_033280
SEC11C
SEC11 homolog C (S. cerevisiae)
chr17_+_15543771 0.429 ZNF286A
zinc finger protein 286A
chr1_-_120737466 0.427 NM_001004340
NM_001017986
FCGR1A
FCGR1B

Fc fragment of IgG, high affinity Ia, receptor (CD64)
Fc fragment of IgG, high affinity Ib, receptor (CD64)

chr21_-_35174742 0.423 RUNX1
runt-related transcription factor 1
chr11_+_2877486 0.421 NM_183233
SLC22A18
solute carrier family 22, member 18
chr3_+_185537969 0.414 NM_144635
FAM131A
family with sequence similarity 131, member A
chr19_+_50601708 0.413 CD3EAP
CD3e molecule, epsilon associated protein
chr1_-_120737416 0.411 FCGR1B
Fc fragment of IgG, high affinity Ib, receptor (CD64)
chr9_-_133945064 0.401 NM_004269
CRSP8P
MED27
mediator complex subunit 27 pseudogene
mediator complex subunit 27
chr10_+_93548162 0.400 TNKS2
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
chr8_-_109330116 0.399 NM_001568
EIF3E
eukaryotic translation initiation factor 3, subunit E
chr17_+_36515166 0.396 NM_001146041
KRTAP4-9
keratin associated protein 4-9
chr17_-_23721430 0.394 VTN
vitronectin
chr19_+_49268106 0.384 NM_001037813
ZNF284
zinc finger protein 284
chr5_-_95184121 0.383 GLRX
glutaredoxin (thioltransferase)
chr7_-_133652042 0.380 SLC35B4
solute carrier family 35, member B4
chr19_+_40900965 0.377 MLL4
myeloid/lymphoid or mixed-lineage leukemia 4
chr1_+_40769819 0.375 NM_152373
ZNF684
zinc finger protein 684
chr3_+_132228383 0.371 NM_001146003
NM_024800
NM_145910
NEK11


NIMA (never in mitosis gene a)- related kinase 11


chr2_+_43854681 0.366 NM_001193464
NM_015522
NM_016008
DYNC2LI1


dynein, cytoplasmic 2, light intermediate chain 1


chr19_+_63508569 0.363 LOC100506584
hypothetical protein LOC100506584
chr11_-_123918759 0.361 NM_001005195
OR8B12
olfactory receptor, family 8, subfamily B, member 12
chr11_+_71317736 0.361 RNF121
ring finger protein 121
chr15_+_72540655 0.360 LOC440288
similar to FLJ16518 protein
chr1_+_161305188 0.358 NM_005613
RGS4
regulator of G-protein signaling 4
chr8_-_102034730 0.356 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr4_+_130236731 0.356 NM_001099783
C4orf33
chromosome 4 open reading frame 33
chr1_+_174698929 0.345 NM_020318
NM_021936
PAPPA2

pappalysin 2

chr16_+_10945815 0.344 NM_015226
CLEC16A
C-type lectin domain family 16, member A
chr12_+_4700012 0.344 NM_017417
GALNT8
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)
chr4_-_89299034 0.342 NM_004827
ABCG2
ATP-binding cassette, sub-family G (WHITE), member 2
chr2_+_63669596 0.341 NM_005917
MDH1
malate dehydrogenase 1, NAD (soluble)
chr15_+_73102984 0.341 PPCDC
phosphopantothenoylcysteine decarboxylase
chr5_-_137542198 0.340 NM_001164326
NM_006696
NM_139199
BRD8


bromodomain containing 8


chr14_+_67356248 0.339 NM_002877
NM_133509
NM_133510
RAD51L1


RAD51-like 1 (S. cerevisiae)


chr3_+_129682434 0.338


chr10_+_93548119 0.335 NM_025235
TNKS2
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
chr10_+_86174665 0.332 FAM190B
family with sequence similarity 190, member B
chr19_+_49023283 0.331 NM_181845
ZNF283
zinc finger protein 283
chr5_-_95184221 0.329 NM_001118890
NM_002064
GLRX

glutaredoxin (thioltransferase)

chr22_+_37407921 0.326 TOMM22
translocase of outer mitochondrial membrane 22 homolog (yeast)
chr18_-_41938196 0.325 NM_001001937
ATP5A1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
chr15_+_73102979 0.324 NM_021823
PPCDC
phosphopantothenoylcysteine decarboxylase
chr22_+_37407906 0.321 TOMM22
translocase of outer mitochondrial membrane 22 homolog (yeast)
chr9_-_129226312 0.319


chr19_+_39916964 0.313 ZNF181
zinc finger protein 181
chr17_-_16038607 0.311 NM_001190438
NM_001190440
NCOR1

nuclear receptor corepressor 1

chr5_+_32621361 0.302 NM_006713
SUB1
SUB1 homolog (S. cerevisiae)
chr3_+_123882355 0.302 NM_017554
PARP14
poly (ADP-ribose) polymerase family, member 14
chr3_+_197951121 0.299 NM_002577
PAK2
p21 protein (Cdc42/Rac)-activated kinase 2
chr17_-_23721351 0.298 VTN
vitronectin
chr19_-_49644470 0.295 NM_014518
ZNF229
zinc finger protein 229
chr1_+_161305558 0.288 NM_001113381
RGS4
regulator of G-protein signaling 4
chr17_-_23721420 0.285 VTN
vitronectin
chr11_+_113672378 0.285 NNMT
nicotinamide N-methyltransferase
chr19_+_17391841 0.285 FAM125A
family with sequence similarity 125, member A
chr19_+_44082410 0.280 NM_001001716
NM_002503
NFKBIB

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta

chr1_+_109827975 0.278 NM_153340
ATXN7L2
ataxin 7-like 2
chr1_-_3763620 0.277 NM_014704
KIAA0562
KIAA0562
chr19_+_63508526 0.276 LOC100506584
hypothetical protein LOC100506584
chr5_+_178383381 0.275 NM_001136116
ZNF879
zinc finger protein 879
chr8_-_102034777 0.274 NM_003406
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr6_+_100075572 0.268 NM_001195131
LOC100130890
hypothetical protein LOC100130890
chr7_+_92699588 0.267 NM_017667
NM_024553
CCDC132

coiled-coil domain containing 132

chr13_-_24394913 0.267 CENPJ
centromere protein J
chr19_+_17239148 0.266 NM_001033549
NM_014173
BABAM1

BRISC and BRCA1 A complex member 1

chr1_-_54291634 0.266 NM_004872
TMEM59
transmembrane protein 59
chr10_-_38305458 0.265 NM_145011
ZNF25
zinc finger protein 25
chr8_-_109330101 0.264 EIF3E
eukaryotic translation initiation factor 3, subunit E
chr2_-_63669022 0.262 WDPCP
WD repeat containing planar cell polarity effector
chr15_-_27901628 0.261 TJP1
tight junction protein 1 (zona occludens 1)
chr19_+_42033564 0.261 ZNF345
zinc finger protein 345
chr9_-_112139908 0.260 NM_001003936
TXNDC8
thioredoxin domain containing 8 (spermatozoa)
chr19_-_39859997 0.251


chr8_+_18293034 0.251 NM_000015
NAT2
N-acetyltransferase 2 (arylamine N-acetyltransferase)
chr6_-_83960351 0.249 PGM3
phosphoglucomutase 3
chr17_+_36665161 0.247 NM_030975
KRTAP9-9
keratin associated protein 9-9
chr19_+_13090101 0.244 NM_052876
NACC1
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
chr19_+_3713650 0.236 NM_172251
MRPL54
mitochondrial ribosomal protein L54
chr8_+_124154079 0.234 NM_001145088
NM_145647
WDR67

WD repeat domain 67

chr3_+_197951203 0.234 PAK2
p21 protein (Cdc42/Rac)-activated kinase 2
chr8_-_99375739 0.233 NM_024759
NIPAL2
NIPA-like domain containing 2
chr6_+_135860631 0.232 NCRNA00271
non-protein coding RNA 271
chr2_+_27740254 0.227 SLC4A1AP
solute carrier family 4 (anion exchanger), member 1, adaptor protein
chr2_-_171998681 0.226 METTL8
methyltransferase like 8
chr22_+_37407925 0.222 TOMM22
translocase of outer mitochondrial membrane 22 homolog (yeast)
chr17_+_15543615 0.221 NM_001130842
NM_020652
ZNF286A

zinc finger protein 286A

chr19_+_17391856 0.221 NM_138401
FAM125A
family with sequence similarity 125, member A
chr17_+_30938470 0.218 AP2B1
adaptor-related protein complex 2, beta 1 subunit
chr1_+_153374900 0.218 NM_001122837
NM_001122839
NM_018845
SLC50A1


solute carrier family 50 (sugar transporter), member 1


chr1_+_177317827 0.216 TOR3A
torsin family 3, member A
chr19_+_49221333 0.214 NM_001129996
NM_013360
ZNF284
ZNF222

zinc finger protein 284
zinc finger protein 222


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.65 1.41e-04 GO:0060255 regulation of macromolecule metabolic process
1.75 7.37e-04 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.73 1.01e-03 GO:0010556 regulation of macromolecule biosynthetic process
1.67 1.93e-03 GO:0051171 regulation of nitrogen compound metabolic process
1.76 2.31e-03 GO:0006355 regulation of transcription, DNA-dependent
1.55 3.15e-03 GO:0031323 regulation of cellular metabolic process
1.66 3.44e-03 GO:0009889 regulation of biosynthetic process
1.65 4.30e-03 GO:0031326 regulation of cellular biosynthetic process
1.50 4.45e-03 GO:0019222 regulation of metabolic process
1.66 6.10e-03 GO:0010468 regulation of gene expression
1.70 8.49e-03 GO:0051252 regulation of RNA metabolic process
1.52 1.01e-02 GO:0080090 regulation of primary metabolic process
1.61 1.52e-02 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.49 1.46e-06 GO:0005634 nucleus
1.30 1.13e-05 GO:0043231 intracellular membrane-bounded organelle
1.30 1.26e-05 GO:0043227 membrane-bounded organelle
1.26 1.93e-05 GO:0043229 intracellular organelle
1.26 2.33e-05 GO:0043226 organelle
1.18 1.31e-03 GO:0044424 intracellular part
1.16 6.83e-03 GO:0005622 intracellular

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.01 4.09e-07 GO:0008270 zinc ion binding
1.84 1.09e-05 GO:0046914 transition metal ion binding
1.79 4.65e-05 GO:0003677 DNA binding
1.49 8.42e-03 GO:0003676 nucleic acid binding
9.08 4.44e-02 GO:0015035 protein disulfide oxidoreductase activity