Motif ID: TAL1_TCF{3,4,12}.p2

Z-value: 0.996


Transcription factors associated with TAL1_TCF{3,4,12}.p2:

Gene SymbolEntrez IDGene Name
TAL1 6886 T-cell acute lymphocytic leukemia 1
TCF12 6938 transcription factor 12
TCF3 6929 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
TCF4 6925 transcription factor 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TCF3chr19_-_16012460.684.9e-03Click!
TCF12chr15_+_54998181-0.621.4e-02Click!
TCF4chr18_-_51219880-0.293.0e-01Click!
TAL1chr1_-_47468029-0.126.6e-01Click!


Activity profile for motif TAL1_TCF{3,4,12}.p2.

activity profile for motif TAL1_TCF{3,4,12}.p2


Sorted Z-values histogram for motif TAL1_TCF{3,4,12}.p2

Sorted Z-values for motif TAL1_TCF{3,4,12}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TAL1_TCF{3,4,12}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_46405477 2.388 NM_001172439
NM_001172440
NM_006025
ENDOU


endonuclease, polyU-specific


chr22_+_38652555 1.635 GRAP2
GRB2-related adaptor protein 2
chr17_+_38256886 1.521


chr19_+_17499064 1.290 FAM129C
family with sequence similarity 129, member C
chr17_+_38256710 1.280 NM_003734
AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr16_+_56286212 1.280 NM_032269
CCDC135
coiled-coil domain containing 135
chr1_+_179164195 1.235


chr10_-_73518772 1.224 NM_001134434
NM_014767
SPOCK2

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2

chr10_+_85923473 1.069 NM_207373
C10orf99
chromosome 10 open reading frame 99
chr17_+_45617676 1.036


chr1_+_221168388 1.020 NM_032890
DISP1
dispatched homolog 1 (Drosophila)
chr2_+_191009265 0.979 MFSD6
major facilitator superfamily domain containing 6
chr11_-_5212168 0.952 NM_000519
HBD
hemoglobin, delta
chr1_-_205272619 0.926 NM_001083924
NM_023938
C1orf116

chromosome 1 open reading frame 116

chr2_+_169367345 0.900 NM_001039724
NM_001171632
NM_052946
NOSTRIN


nitric oxide synthase trafficker


chrX_-_154216929 0.876 NM_001289
CLIC2
chloride intracellular channel 2
chr17_-_53761119 0.795 NM_004758
NM_024418
BZRAP1

benzodiazapine receptor (peripheral) associated protein 1

chr16_+_11966464 0.760 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr4_-_185921384 0.748 ACSL1
acyl-CoA synthetase long-chain family member 1
chr11_+_46651090 0.730 ATG13
ATG13 autophagy related 13 homolog (S. cerevisiae)
chr3_+_134976965 0.729 TF
transferrin
chr6_-_30188845 0.724 NM_007028
TRIM31
tripartite motif containing 31
chr12_+_115481568 0.692 NM_001085481
MAP1LC3B2
microtubule-associated protein 1 light chain 3 beta 2
chr22_+_23309717 0.690 NM_013430
GGT1
gamma-glutamyltransferase 1
chr2_-_25320299 0.662 DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr14_-_93493519 0.661 NM_016150
ASB2
ankyrin repeat and SOCS box containing 2
chr12_-_101835183 0.626 PAH
phenylalanine hydroxylase
chr5_+_53787187 0.625 NM_006308
HSPB3
heat shock 27kDa protein 3
chr2_-_157892391 0.617 NM_001009959
ERMN
ermin, ERM-like protein
chr1_-_144426918 0.614 NM_007053
CD160
CD160 molecule
chr1_+_19807168 0.590


chr20_-_39199936 0.582


chr22_+_22907443 0.572 NM_019601
SUSD2
sushi domain containing 2
chr17_-_43390108 0.571 NM_024320
PRR15L
proline rich 15-like
chr8_-_68821131 0.569 NM_020361
CPA6
carboxypeptidase A6
chr19_+_4442610 0.566 HDGFRP2
hepatoma-derived growth factor-related protein 2
chr17_-_9863929 0.557 GAS7
growth arrest-specific 7
chr1_-_169888373 0.555 NM_000261
MYOC
myocilin, trabecular meshwork inducible glucocorticoid response
chrX_+_46825179 0.547 RGN
regucalcin (senescence marker protein-30)
chr16_+_4546491 0.545 NM_001145011
LOC342346
hypothetical protein LOC342346
chr2_-_158008763 0.536 NM_004288
CYTIP
cytohesin 1 interacting protein
chr12_-_101835510 0.519 NM_000277
PAH
phenylalanine hydroxylase
chr11_+_5367182 0.515 NM_001004756
OR51M1
olfactory receptor, family 51, subfamily M, member 1
chr19_+_61624 0.504 NM_001005240
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr10_+_80743769 0.499 ZMIZ1
zinc finger, MIZ-type containing 1
chr3_+_120982020 0.498 NM_003889
NM_033013
NR1I2

nuclear receptor subfamily 1, group I, member 2

chr1_-_224143389 0.487 NM_020997
LEFTY1
left-right determination factor 1
chr22_-_34930705 0.486 NM_030643
NM_145660
APOL4

apolipoprotein L, 4

chr7_+_94953148 0.486 NM_016116
NM_145872
ASB4

ankyrin repeat and SOCS box containing 4

chr21_-_33107813 0.474 NM_001162495
NM_001162496
NM_019596
C21orf62


chromosome 21 open reading frame 62


chr1_+_207926172 0.474 NM_181755
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr22_+_22907417 0.474 SUSD2
sushi domain containing 2
chr20_-_44612619 0.471 NM_080721
C20orf123
chromosome 20 open reading frame 123
chr8_-_81155564 0.468 NM_001025252
TPD52
tumor protein D52
chr1_-_176205672 0.460 NM_033127
SEC16B
SEC16 homolog B (S. cerevisiae)
chr1_-_158948176 0.455 NM_001778
CD48
CD48 molecule
chr7_-_92693716 0.452 NM_001039372
HEPACAM2
HEPACAM family member 2
chr12_-_101835026 0.433 PAH
phenylalanine hydroxylase
chr12_-_52016270 0.431 NM_001173467
SP7
Sp7 transcription factor
chr19_+_58239802 0.427 NM_001191055
HERV-V2
envelope glycoprotein ENVV2
chr2_-_183611470 0.426 NM_013436
NM_205842
NCKAP1

NCK-associated protein 1

chr5_-_134810696 0.425 NM_130848
C5orf20
chromosome 5 open reading frame 20
chr6_+_167456230 0.423 NM_031409
CCR6
chemokine (C-C motif) receptor 6
chr2_-_55131157 0.421 RTN4
reticulon 4
chr6_-_66473790 0.413 NM_001142800
NM_001142801
EYS

eyes shut homolog (Drosophila)

chr19_+_15699833 0.410 NM_013939
OR10H2
olfactory receptor, family 10, subfamily H, member 2
chr1_-_24179326 0.400 SRSF10
serine/arginine-rich splicing factor 10
chr1_+_54786394 0.394 NM_015547
NM_147161
ACOT11

acyl-CoA thioesterase 11

chr5_-_131907071 0.386 NM_000879
IL5
interleukin 5 (colony-stimulating factor, eosinophil)
chr1_-_199613427 0.382 NM_000364
NM_001001430
NM_001001431
NM_001001432
TNNT2



troponin T type 2 (cardiac)



chr16_-_79811475 0.380 NM_001076780
NM_052892
PKD1L2

polycystic kidney disease 1-like 2

chr17_+_53769562 0.377 LOC100506779
hypothetical LOC100506779
chr2_-_133256097 0.376 NCKAP5
NCK-associated protein 5
chr21_+_17841297 0.374 CXADR
coxsackie virus and adenovirus receptor
chr2_-_55131124 0.372 RTN4
reticulon 4
chr9_+_95886625 0.370 PTPDC1
protein tyrosine phosphatase domain containing 1
chr1_-_203657803 0.367 NM_001001552
NM_001199050
NM_001199051
NM_001199052
LEMD1



LEM domain containing 1



chr9_+_114376709 0.363 KIAA1958
KIAA1958
chr7_-_36992221 0.358 NM_130442
ELMO1
engulfment and cell motility 1
chr2_+_46560207 0.357 NM_001145051
LOC388946
transmembrane protein ENSP00000343375
chrX_-_111809929 0.354 NM_178175
LHFPL1
lipoma HMGIC fusion partner-like 1
chr17_-_9864048 0.353 GAS7
growth arrest-specific 7
chr9_+_6318348 0.351 NM_001001874
NM_001001875
NM_033516
TPD52L3


tumor protein D52-like 3


chr2_-_151854619 0.351 NM_004688
NMI
N-myc (and STAT) interactor
chr2_-_55131176 0.349 RTN4
reticulon 4
chr12_-_6615348 0.349 NM_020400
LPAR5
lysophosphatidic acid receptor 5
chr4_+_14985272 0.343 NM_001135171
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr15_+_56511466 0.334 NM_000236
LIPC
lipase, hepatic
chr11_-_68505030 0.334 NM_198923
MRGPRD
MAS-related GPR, member D
chr14_-_93919305 0.333 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr6_+_52159143 0.332 NM_002190
IL17A
interleukin 17A
chr8_+_21967008 0.326 NM_001114137
EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr3_+_73193499 0.326 NM_018029
EBLN2
endogenous Borna-like N element-2
chr10_+_11246934 0.323 NM_001025076
NM_001083591
CELF2

CUGBP, Elav-like family member 2

chr16_-_67943157 0.312 NM_144676
TMED6
transmembrane emp24 protein transport domain containing 6
chr5_-_88235624 0.307 NM_001131005
NM_001193347
MEF2C

myocyte enhancer factor 2C

chr9_+_95886558 0.307 NM_152422
PTPDC1
protein tyrosine phosphatase domain containing 1
chr3_-_10307408 0.304 NM_001134941
NM_016362
GHRL

ghrelin/obestatin prepropeptide

chr10_+_44726635 0.303 NM_001123376
TMEM72
transmembrane protein 72
chr12_+_56114724 0.301 NM_005538
INHBC
inhibin, beta C
chr7_+_129807467 0.301 NM_001868
CPA1
carboxypeptidase A1 (pancreatic)
chr10_+_5228756 0.301 NM_001818
AKR1C4
aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
chr19_+_40224480 0.298 HPN
hepsin
chr16_+_31105579 0.297


chr11_+_66979393 0.295 NM_145200
CABP4
calcium binding protein 4
chr22_+_34979118 0.285 APOL1
apolipoprotein L, 1
chr1_-_53972464 0.284 NM_147193
GLIS1
GLIS family zinc finger 1
chr17_-_64568641 0.277 NM_080283
ABCA9
ATP-binding cassette, sub-family A (ABC1), member 9
chr7_+_138695236 0.276 LUC7L2
LUC7-like 2 (S. cerevisiae)
chr19_-_44060729 0.274 NM_001195833
NM_198445
RINL

Ras and Rab interactor-like

chr5_+_155686750 0.272 SGCD
sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
chr1_+_205328834 0.271 NM_001017365
NM_001017366
C4BPB

complement component 4 binding protein, beta

chr17_-_59342319 0.271 NM_001318
NM_022579
NM_022580
NM_022581
CSHL1



chorionic somatomammotropin hormone-like 1



chr3_+_23904086 0.270 UBE2E1
ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)
chr2_-_188086612 0.270 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr17_+_72827227 0.270 SEPT9
septin 9
chr7_+_113853790 0.269 NM_001172767
NM_148899
FOXP2

forkhead box P2

chr3_-_115960807 0.267 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr6_+_36318922 0.266 NM_173676
NM_001145716
PNPLA1

patatin-like phospholipase domain containing 1

chr12_-_53064723 0.263 NM_015481
ZNF385A
zinc finger protein 385A
chr2_-_55131096 0.258 RTN4
reticulon 4
chr20_-_42457717 0.252


chr6_-_127822227 0.252 NM_014702
KIAA0408
KIAA0408
chr22_+_20880112 0.243


chr1_+_100099353 0.243 NM_000645
AGL
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
chr14_+_19735334 0.242 NM_001005503
OR11G2
olfactory receptor, family 11, subfamily G, member 2
chr14_+_19513442 0.241 NM_001005486
OR4K15
olfactory receptor, family 4, subfamily K, member 15
chr17_-_16816113 0.240 NM_012452
TNFRSF13B
tumor necrosis factor receptor superfamily, member 13B
chr5_-_180560535 0.235 NM_203297
TRIM7
tripartite motif containing 7
chr22_-_14829803 0.233 NM_001005239
OR11H1
olfactory receptor, family 11, subfamily H, member 1
chr1_+_6537924 0.231 NM_138697
NM_177540
TAS1R1

taste receptor, type 1, member 1

chr9_-_99746923 0.231 NM_018437
HEMGN
hemogen
chr20_-_3635774 0.227 NM_023068
SIGLEC1
sialic acid binding Ig-like lectin 1, sialoadhesin
chr11_-_116168316 0.224 NM_001166598
NM_052968
APOA5

apolipoprotein A-V

chr3_+_35697432 0.223 NM_198399
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr19_-_12858956 0.222 NM_006563
KLF1
Kruppel-like factor 1 (erythroid)
chr2_-_25320582 0.222 DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr7_+_31693155 0.221 NM_001145123
NM_006658
C7orf16

chromosome 7 open reading frame 16

chr17_+_71975224 0.219 NM_001088
AANAT
aralkylamine N-acetyltransferase
chr6_-_11490487 0.218 NM_001142393
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr2_-_55130925 0.217 RTN4
reticulon 4
chr16_+_76613912 0.215 NM_005752
CLEC3A
C-type lectin domain family 3, member A
chr12_-_121753795 0.214 NM_177551
GPR109A
G protein-coupled receptor 109A
chr7_+_138695209 0.214 LUC7L2
LUC7-like 2 (S. cerevisiae)
chr19_+_56452775 0.214 NM_173635
C19orf75
chromosome 19 open reading frame 75
chr22_-_16127520 0.211 CECR3
cat eye syndrome chromosome region, candidate 3
chr11_-_71424614 0.211


chr12_-_53064565 0.209 ZNF385A
zinc finger protein 385A
chr17_+_35471971 0.207 NM_001190919
THRA
thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)
chr1_+_213245507 0.207 NM_001017424
KCNK2
potassium channel, subfamily K, member 2
chr3_+_52788976 0.207 NM_001166435
NM_001166436
ITIH1

inter-alpha (globulin) inhibitor H1

chr10_-_121286034 0.206 NM_002925
RGS10
regulator of G-protein signaling 10
chr3_+_46894239 0.204 NM_000316
PTH1R
parathyroid hormone 1 receptor
chr22_+_34979062 0.202 NM_001136540
NM_001136541
NM_003661
NM_145343
APOL1



apolipoprotein L, 1



chr12_+_99274987 0.200 NM_001145288
NM_139319
SLC17A8

solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8

chr3_-_129668780 0.200 NM_153330
DNAJB8
DnaJ (Hsp40) homolog, subfamily B, member 8
chr11_+_5558682 0.198 NM_001005162
OR52B6
olfactory receptor, family 52, subfamily B, member 6
chr12_+_27511009 0.197 NM_001145010
C12orf70
chromosome 12 open reading frame 70
chr7_+_94130752 0.196 PEG10
paternally expressed 10
chr19_-_56537189 0.195 NM_001163922
VSIG10L
V-set and immunoglobulin domain containing 10 like
chr1_-_199613406 0.194 TNNT2
troponin T type 2 (cardiac)
chr19_-_11549484 0.194 ACP5
acid phosphatase 5, tartrate resistant
chr2_-_55130963 0.194 RTN4
reticulon 4
chr3_+_142525744 0.193 NM_001080412
ZBTB38
zinc finger and BTB domain containing 38
chr11_-_56914668 0.192 NM_002728
PRG2
proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
chr9_-_135435165 0.191 NM_001080515
FAM163B
family with sequence similarity 163, member B
chr11_-_16454493 0.190 NM_033326
SOX6
SRY (sex determining region Y)-box 6
chr6_-_27988152 0.190 NM_033057
OR2B2
olfactory receptor, family 2, subfamily B, member 2
chr11_-_614901 0.189 NM_001171968
NM_021924
NM_031264
CDHR5


cadherin-related family member 5


chr20_-_30795463 0.189 NM_001099339
NM_053041
COMMD7

COMM domain containing 7

chr2_-_65013070 0.186 LOC400958
hypothetical LOC400958
chr7_+_138695241 0.185 LUC7L2
LUC7-like 2 (S. cerevisiae)
chr17_+_36642240 0.183 NM_031962
KRTAP9-9
KRTAP9-3
keratin associated protein 9-9
keratin associated protein 9-3
chr12_+_1608672 0.181 NM_032642
WNT5B
wingless-type MMTV integration site family, member 5B
chr17_-_10362583 0.181 NM_005963
MYH1
myosin, heavy chain 1, skeletal muscle, adult
chr6_-_41811916 0.179 NM_001167827
TFEB
transcription factor EB
chr10_-_921694 0.178 NM_015155
LARP4B
La ribonucleoprotein domain family, member 4B
chr1_+_158063278 0.177 SLAMF8
SLAM family member 8
chr12_-_2814410 0.176 NM_031474
NRIP2
nuclear receptor interacting protein 2
chr6_+_163068991 0.176 NM_001080379
PACRG
PARK2 co-regulated
chr6_+_126282078 0.174 NCOA7
nuclear receptor coactivator 7
chr19_-_11549441 0.173 ACP5
acid phosphatase 5, tartrate resistant
chr10_-_105427898 0.173 SH3PXD2A
SH3 and PX domains 2A
chr1_-_156800017 0.170 NM_001160325
OR6P1
olfactory receptor, family 6, subfamily P, member 1
chr22_+_43451600 0.167 PRR5
proline rich 5 (renal)
chr2_-_10860093 0.166 PDIA6
protein disulfide isomerase family A, member 6
chr2_-_55131202 0.165 NM_020532
NM_153828
NM_207520
RTN4


reticulon 4


chr14_-_93512818 0.164 ASB2
ankyrin repeat and SOCS box containing 2
chrX_-_55037235 0.163 NM_002625
PFKFB1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr5_-_158690047 0.162 NM_002187
IL12B
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
chr6_-_30236667 0.161 NM_006778
NM_052828
TRIM10

tripartite motif containing 10

chr10_-_98311813 0.160 TM9SF3
transmembrane 9 superfamily member 3
chr1_+_242283129 0.160 NM_006352
ZNF238
zinc finger protein 238
chr19_-_38052481 0.160 NM_001126335
NM_014270
SLC7A9

solute carrier family 7 (cationic amino acid transporter, y+ system), member 9

chr2_+_187173176 0.157 NM_001144999
ITGAV
integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
chr6_-_163068749 0.155 PARK2
parkinson protein 2, E3 ubiquitin protein ligase (parkin)
chrX_+_128741562 0.155 NM_018990
SASH3
SAM and SH3 domain containing 3
chr17_-_46479127 0.153 SPAG9
sperm associated antigen 9
chr6_-_41811323 0.153 TFEB
transcription factor EB
chr11_-_2279642 0.153 NM_001142946
C11orf21
chromosome 11 open reading frame 21

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.57 6.27e-07 GO:0007608 sensory perception of smell
3.39 6.71e-07 GO:0007606 sensory perception of chemical stimulus
2.53 1.92e-05 GO:0007600 sensory perception
1.93 2.18e-03 GO:0050877 neurological system process
1.75 1.24e-02 GO:0003008 system process

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.74 4.00e-08 GO:0004984 olfactory receptor activity
2.19 1.67e-06 GO:0004888 transmembrane receptor activity
1.98 3.23e-06 GO:0004872 receptor activity
2.44 1.16e-05 GO:0004930 G-protein coupled receptor activity
1.71 4.72e-04 GO:0004871 signal transducer activity
1.71 4.72e-04 GO:0060089 molecular transducer activity