Motif ID: EGR1..3.p2

Z-value: 1.391


Transcription factors associated with EGR1..3.p2:

Gene SymbolEntrez IDGene Name
EGR1 1958 early growth response 1
EGR2 1959 early growth response 2 (Krox-20 homolog, Drosophila)
EGR3 1960 early growth response 3



Activity profile for motif EGR1..3.p2.

activity profile for motif EGR1..3.p2


Sorted Z-values histogram for motif EGR1..3.p2

Sorted Z-values for motif EGR1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EGR1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_98919109 2.134 NM_207362
C2orf55
chromosome 2 open reading frame 55
chr4_-_809879 1.968 NM_006651
CPLX1
complexin 1
chr3_-_13896618 1.797 NM_004625
WNT7A
wingless-type MMTV integration site family, member 7A
chr9_-_85622366 1.498 NM_001135953
NM_025211
GKAP1

G kinase anchoring protein 1

chr14_-_104705753 1.369 JAG2
jagged 2
chr3_+_115149234 1.362 NM_173570
ZDHHC23
zinc finger, DHHC-type containing 23
chr16_-_53520208 1.327 CRNDE
colorectal neoplasia differentially expressed (non-protein coding)
chr17_-_34015631 1.277 NM_025248
SRCIN1
SRC kinase signaling inhibitor 1
chr3_-_172660545 1.238 NM_001161560
NM_001161561
NM_001161562
NM_001161563
NM_001161564
NM_001161565
NM_001161566
NM_015028
TNIK







TRAF2 and NCK interacting kinase







chr15_+_38520594 1.159 NM_014952
BAHD1
bromo adjacent homology domain containing 1
chr17_-_1029758 1.125 NM_021962
ABR
active BCR-related gene
chr3_-_88190737 1.061 NM_001008390
NM_003663
CGGBP1

CGG triplet repeat binding protein 1

chr9_+_133259330 1.055 PRRC2B
proline-rich coiled-coil 2B
chr19_+_1200882 1.042 MIDN
midnolin
chr4_-_35922288 1.011 NM_015230
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr1_-_240754620 1.008 NM_152666
PLD5
phospholipase D family, member 5
chr7_-_526005 0.988 NM_002607
NM_033023
PDGFA

platelet-derived growth factor alpha polypeptide

chr16_-_342399 0.955 NM_003502
NM_181050
AXIN1

axin 1

chr21_+_16024241 0.891 NM_013396
USP25
ubiquitin specific peptidase 25
chr1_+_32251988 0.856 NM_006559
KHDRBS1
KH domain containing, RNA binding, signal transduction associated 1
chrX_+_49531209 0.847 NM_001145073
USP27X
ubiquitin specific peptidase 27, X-linked
chr20_-_30636535 0.791 LOC284804
hypothetical protein LOC284804
chr19_+_38979502 0.781 NM_001129994
NM_001129995
NM_024076
KCTD15


potassium channel tetramerisation domain containing 15


chr9_-_138277467 0.779 NM_181701
QSOX2
quiescin Q6 sulfhydryl oxidase 2
chr14_-_104706159 0.769 NM_002226
NM_145159
JAG2

jagged 2

chr7_+_150414704 0.768 NM_001042535
NM_031946
AGAP3

ArfGAP with GTPase domain, ankyrin repeat and PH domain 3

chr2_+_42128521 0.752 NM_138370
PKDCC
protein kinase domain containing, cytoplasmic homolog (mouse)
chr11_+_2422747 0.743 NM_000218
KCNQ1
potassium voltage-gated channel, KQT-like subfamily, member 1
chr7_-_100331417 0.729 NM_000665
NM_015831
ACHE

acetylcholinesterase

chr19_+_40451842 0.727 USF2
upstream transcription factor 2, c-fos interacting
chr16_+_29724926 0.723 MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
chr20_-_26137755 0.718 LOC284801
hypothetical protein LOC284801
chr1_-_221604023 0.714 NM_001037175
NM_017982
SUSD4

sushi domain containing 4

chr1_-_31154023 0.713 NM_014654
SDC3
syndecan 3
chr4_-_38342824 0.699 FLJ13197
hypothetical FLJ13197
chr8_-_111056099 0.697 NM_014379
KCNV1
potassium channel, subfamily V, member 1
chr19_+_1226510 0.692 NM_017914
C19orf24
chromosome 19 open reading frame 24
chr15_+_29406335 0.685 NM_015995
KLF13
Kruppel-like factor 13
chr22_+_18081968 0.667 NM_002688
SEPT5
septin 5
chr21_-_37260488 0.662 HLCS
holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
chr6_+_84799969 0.659 NM_138409
MRAP2
melanocortin 2 receptor accessory protein 2
chr7_-_106088565 0.651 NM_175884
FLJ36031
hypothetical protein FLJ36031
chr7_+_73341640 0.651 NM_003388
NM_032421
CLIP2

CAP-GLY domain containing linker protein 2

chr7_-_120823591 0.645 NM_001040020
NM_014888
FAM3C

family with sequence similarity 3, member C

chr6_-_151754337 0.644 NM_020861
ZBTB2
zinc finger and BTB domain containing 2
chr6_-_36272951 0.639


chr5_-_148013908 0.633 NM_000870
HTR4
5-hydroxytryptamine (serotonin) receptor 4
chr21_-_39642712 0.633 HMGN1
high-mobility group nucleosome binding domain 1
chr1_+_39229474 0.630 NM_001136275
NM_024595
AKIRIN1

akirin 1

chr7_-_140270749 0.627 NM_004333
BRAF
v-raf murine sarcoma viral oncogene homolog B1
chr11_+_107304344 0.626 NM_017516
RAB39
RAB39, member RAS oncogene family
chr7_+_33135376 0.624 NM_001033604
NM_001033605
NM_014451
NM_198428
BBS9



Bardet-Biedl syndrome 9



chr10_+_72245629 0.623 NM_003901
SGPL1
sphingosine-1-phosphate lyase 1
chr7_-_130069399 0.616 NM_138693
KLF14
Kruppel-like factor 14
chr3_-_15875932 0.612 NM_015199
ANKRD28
ankyrin repeat domain 28
chr15_-_91433165 0.610 NM_020211
RGMA
RGM domain family, member A
chr7_-_120823556 0.610 FAM3C
family with sequence similarity 3, member C
chr7_-_156378382 0.610 LMBR1
limb region 1 homolog (mouse)
chr3_+_50687675 0.610 NM_004947
DOCK3
dedicator of cytokinesis 3
chr22_+_20101661 0.608 NM_015094
HIC2
hypermethylated in cancer 2
chr1_+_6596331 0.605 NM_153812
PHF13
PHD finger protein 13
chr20_+_34357604 0.604 DLGAP4
discs, large (Drosophila) homolog-associated protein 4
chrX_+_24077649 0.603 NM_001178086
NM_001178095
NM_001178084
NM_001178085
NM_003410
ZFX




zinc finger protein, X-linked




chr7_+_119700924 0.596 NM_012281
KCND2
potassium voltage-gated channel, Shal-related subfamily, member 2
chrX_-_19815370 0.596 SH3KBP1
SH3-domain kinase binding protein 1
chr1_+_35507145 0.596 NM_005095
ZMYM4
zinc finger, MYM-type 4
chrX_-_68301974 0.589 NM_001032396
NM_022368
NM_145119
PJA1


praja ring finger 1


chrX_-_135161185 0.586 NM_001173517
NM_024597
MAP7D3

MAP7 domain containing 3

chr2_-_183610992 0.583 NCKAP1
NCK-associated protein 1
chrX_-_19918958 0.575 LOC729609
hypothetical LOC729609
chr21_-_39642935 0.561 HMGN1
high-mobility group nucleosome binding domain 1
chr21_-_39642808 0.558 HMGN1
high-mobility group nucleosome binding domain 1
chr4_-_55686503 0.551 NM_002253
KDR
kinase insert domain receptor (a type III receptor tyrosine kinase)
chr19_+_40451720 0.551 NM_003367
NM_207291
USF2

upstream transcription factor 2, c-fos interacting

chr7_+_6380614 0.546 NM_006908
NM_018890
RAC1

ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)

chr12_+_19484387 0.539 AEBP2
AE binding protein 2
chr17_-_58877276 0.539 NM_001017916
NM_001915
CYB561

cytochrome b-561

chr2_+_181554048 0.536 UBE2E3
ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)
chr15_+_83092854 0.534 ZNF592
zinc finger protein 592
chr11_+_279113 0.534 NM_025092
ATHL1
ATH1, acid trehalase-like 1 (yeast)
chr5_-_168660293 0.533 NM_003062
SLIT3
slit homolog 3 (Drosophila)
chr19_+_47480445 0.533 NM_015125
CIC
capicua homolog (Drosophila)
chr11_+_66643311 0.528 NM_012308
KDM2A
lysine (K)-specific demethylase 2A
chr3_-_57088332 0.521 NM_001128615
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr1_+_38032045 0.518 NM_001031740
NM_001113482
MANEAL

mannosidase, endo-alpha-like

chr18_+_75895333 0.515 NM_001171967
NM_024805
RBFA

ribosome binding factor A (putative)

chr19_-_54314090 0.514 NM_018111
C19orf73
chromosome 19 open reading frame 73
chr2_+_96790298 0.512 NM_020184
CNNM4
cyclin M4
chrX_-_152853402 0.510 NM_003491
NAA10
N(alpha)-acetyltransferase 10, NatA catalytic subunit
chr20_-_57942063 0.506 SYCP2
synaptonemal complex protein 2
chr6_+_37895570 0.504 ZFAND3
zinc finger, AN1-type domain 3
chr10_+_72245730 0.502 SGPL1
sphingosine-1-phosphate lyase 1
chr6_+_2945025 0.501 NM_000904
NQO2
NAD(P)H dehydrogenase, quinone 2
chr16_-_3870686 0.498 CREBBP
CREB binding protein
chr20_-_49592444 0.498 NFATC2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
chr9_-_15500209 0.496 NM_021144
PSIP1
PC4 and SFRS1 interacting protein 1
chr13_-_19633182 0.495 NM_021954
GJA3
gap junction protein, alpha 3, 46kDa
chr6_+_37245860 0.493 NM_002648
PIM1
pim-1 oncogene
chr22_-_18384251 0.491 NM_001670
ARVCF
armadillo repeat gene deleted in velocardiofacial syndrome
chr5_-_40834232 0.490 PRKAA1
protein kinase, AMP-activated, alpha 1 catalytic subunit
chr19_-_1518875 0.489 NM_001174118
NM_203304
MEX3D

mex-3 homolog D (C. elegans)

chr4_-_41579325 0.488


chr1_-_51198506 0.486 NM_007051
FAF1
Fas (TNFRSF6) associated factor 1
chr2_-_96899396 0.484 NM_017789
SEMA4C
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
chr16_-_3870714 0.481 CREBBP
CREB binding protein
chr19_+_12810258 0.479 NM_014975
MAST1
microtubule associated serine/threonine kinase 1
chr1_+_27025717 0.477 NM_032283
ZDHHC18
zinc finger, DHHC-type containing 18
chr18_-_12874140 0.476 NM_002828
NM_080422
NM_080423
PTPN2


protein tyrosine phosphatase, non-receptor type 2


chr3_-_47180417 0.475 NM_014159
SETD2
SET domain containing 2
chr9_+_127549437 0.473 NM_006195
PBX3
pre-B-cell leukemia homeobox 3
chr11_+_124114985 0.472 NM_001126181
NM_006176
NRGN

neurogranin (protein kinase C substrate, RC3)

chr2_+_132890616 0.471 NM_001508
GPR39
G protein-coupled receptor 39
chr12_+_48303607 0.469 NM_012272
PRPF40B
PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae)
chr17_-_60345364 0.466 NM_199340
LRRC37A3
leucine rich repeat containing 37, member A3
chr9_+_89302239 0.465 DAPK1
death-associated protein kinase 1
chr9_-_122679283 0.463 PHF19
PHD finger protein 19
chr4_-_74343169 0.462


chr19_+_1236766 0.462 NM_001405
EFNA2
ephrin-A2
chr3_+_58452560 0.461 NM_001128214
KCTD6
potassium channel tetramerisation domain containing 6
chr9_-_122679387 0.460 NM_001009936
NM_015651
PHF19

PHD finger protein 19

chr22_-_18807805 0.460 PI4KAP2
PI4KAP1
phosphatidylinositol 4-kinase, catalytic, alpha pseudogene 2
phosphatidylinositol 4-kinase, catalytic, alpha pseudogene 1
chr17_-_75427644 0.457 NM_003655
CBX4
chromobox homolog 4
chr3_-_39170038 0.454 CSRNP1
cysteine-serine-rich nuclear protein 1
chr1_-_33108876 0.450 NM_001171940
NM_153756
FNDC5

fibronectin type III domain containing 5

chr19_+_34994701 0.450 NM_001238
CCNE1
cyclin E1
chr14_+_101297887 0.450 NM_001161725
NM_001161726
PPP2R5C

protein phosphatase 2, regulatory subunit B', gamma

chr22_-_22074716 0.448 ZDHHC8P1
zinc finger, DHHC-type containing 8 pseudogene 1
chr9_+_130354490 0.446 NM_001130438
NM_001195532
NM_003127
SPTAN1


spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)


chr11_-_16992524 0.445 NM_175058
PLEKHA7
pleckstrin homology domain containing, family A member 7
chr1_-_172258129 0.445


chr10_+_35665614 0.444 NM_145012
CCNY
cyclin Y
chr13_+_41744255 0.442 NM_016248
AKAP11
A kinase (PRKA) anchor protein 11
chr19_+_38556414 0.441 NM_001806
CEBPG
CCAAT/enhancer binding protein (C/EBP), gamma
chr17_+_70431964 0.440 NM_178160
OTOP2
otopetrin 2
chr16_-_27982277 0.438 NM_001109763
GSG1L
GSG1-like
chr1_-_54644663 0.433 NM_001009955
SSBP3
single stranded DNA binding protein 3
chr8_-_145119627 0.431 NM_201378
PLEC
plectin
chr5_+_137829077 0.428 NM_001964
EGR1
early growth response 1
chr1_-_53566171 0.426 NM_001018054
NM_004631
NM_017522
LRP8


low density lipoprotein receptor-related protein 8, apolipoprotein e receptor


chrX_+_153339814 0.426 NM_017514
PLXNA3
plexin A3
chr21_-_43400672 0.425 U2AF1
U2 small nuclear RNA auxiliary factor 1
chr1_-_54644566 0.423 NM_018070
NM_145716
SSBP3

single stranded DNA binding protein 3

chr17_+_34140030 0.423 NM_001136498
CISD3
CDGSH iron sulfur domain 3
chr17_-_24253821 0.423 NM_144683
DHRS13
dehydrogenase/reductase (SDR family) member 13
chr19_+_40451807 0.421 USF2
upstream transcription factor 2, c-fos interacting
chr11_+_119887630 0.419 LOC100293636
GRIK4
hypothetical protein LOC100293636
glutamate receptor, ionotropic, kainate 4
chr2_-_182253457 0.417 NM_002500
NEUROD1
neurogenic differentiation 1
chr15_+_72620570 0.416 NM_006465
ARID3B
AT rich interactive domain 3B (BRIGHT-like)
chr11_+_65576379 0.416 NM_006842
SF3B2
splicing factor 3b, subunit 2, 145kDa
chr18_-_44189625 0.414 ZBTB7C
zinc finger and BTB domain containing 7C
chr18_+_29412538 0.413 NM_030632
ASXL3
additional sex combs like 3 (Drosophila)
chr19_+_60487345 0.412 NM_032430
BRSK1
BR serine/threonine kinase 1
chr18_+_12397894 0.410 NM_001142405
NM_006553
SLMO1

slowmo homolog 1 (Drosophila)

chr3_-_39170105 0.410 NM_033027
CSRNP1
cysteine-serine-rich nuclear protein 1
chr5_-_172594691 0.407 NM_001166175
NM_001166176
NM_004387
NKX2-5


NK2 transcription factor related, locus 5 (Drosophila)


chr11_-_112851051 0.407 NM_000795
NM_016574
DRD2

dopamine receptor D2

chr10_+_76541351 0.407 NM_001174156
NM_144660
SAMD8

sterile alpha motif domain containing 8

chrX_-_23835868 0.407 NM_024122
APOO
apolipoprotein O
chr12_+_110328126 0.406 NM_005475
SH2B3
SH2B adaptor protein 3
chr20_-_49592654 0.405 NM_012340
NM_173091
NFATC2

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2

chr9_+_130491668 0.405 SET
SET nuclear oncogene
chr1_+_95355415 0.403 NM_152487
TMEM56
transmembrane protein 56
chr7_+_150387686 0.401 SLC4A2
solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)
chr8_-_75396016 0.399 NM_020647
JPH1
junctophilin 1
chr13_+_24844084 0.399 NM_016529
ATP8A2
ATPase, aminophospholipid transporter, class I, type 8A, member 2
chr19_-_2002222 0.398 NM_017572
NM_199054
MKNK2

MAP kinase interacting serine/threonine kinase 2

chr22_-_20551722 0.398 MAPK1
mitogen-activated protein kinase 1
chr12_-_122322117 0.397 NM_004642
CDK2AP1
cyclin-dependent kinase 2 associated protein 1
chr6_+_118335381 0.397 NM_001029858
SLC35F1
solute carrier family 35, member F1
chr9_+_98252200 0.396 NM_014282
HABP4
hyaluronan binding protein 4
chr21_-_39642880 0.396 NM_004965
HMGN1
high-mobility group nucleosome binding domain 1
chr2_+_102602579 0.395 NM_003048
SLC9A2
solute carrier family 9 (sodium/hydrogen exchanger), member 2
chr16_-_47201588 0.395 NM_153029
N4BP1
NEDD4 binding protein 1
chr2_+_181553613 0.390 UBE2E3
ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)
chr4_-_109308893 0.390 NM_001130713
NM_001130714
NM_016269
LEF1


lymphoid enhancer-binding factor 1


chr6_+_71434305 0.387 SMAP1
small ArfGAP 1
chr1_-_200380321 0.386 ARL8A
ADP-ribosylation factor-like 8A
chr1_-_53566331 0.386 NM_033300
LRP8
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
chr6_-_107542328 0.386 NM_001080450
BEND3
BEN domain containing 3
chr19_+_4920126 0.386 KDM4B
lysine (K)-specific demethylase 4B
chr21_-_43368963 0.384 NM_000071
CBS
cystathionine-beta-synthase
chr12_-_91847042 0.383 EEA1
early endosome antigen 1
chr11_+_65781646 0.383 NM_001134776
NM_001134774
NM_022822
KLC2


kinesin light chain 2


chr17_+_2443652 0.381 NM_000430
PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr3_-_33456505 0.378 UBP1
upstream binding protein 1 (LBP-1a)
chr11_-_2863536 0.378 NM_000076
NM_001122630
NM_001122631
CDKN1C


cyclin-dependent kinase inhibitor 1C (p57, Kip2)


chr3_-_184180985 0.378 NM_020640
DCUN1D1
DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)
chr19_+_10392128 0.377 NM_001111307
PDE4A
phosphodiesterase 4A, cAMP-specific
chr19_-_1814425 0.377 KLF16
Kruppel-like factor 16
chr22_-_19180075 0.377 NM_032775
KLHL22
kelch-like 22 (Drosophila)
chr21_-_43400750 0.374 NM_001025203
NM_001025204
NM_006758
U2AF1


U2 small nuclear RNA auxiliary factor 1


chr9_+_123501186 0.374 DAB2IP
DAB2 interacting protein
chr1_-_206484258 0.373 NM_025179
PLXNA2
plexin A2
chr6_+_20510019 0.373 NM_001949
E2F3
E2F transcription factor 3
chr8_-_103735194 0.372 NM_001032282
KLF10
Kruppel-like factor 10
chr4_-_105631915 0.372 NM_025212
CXXC4
CXXC finger protein 4
chr14_-_92651260 0.372 ITPK1
inositol 1,3,4-triphosphate 5/6 kinase
chr1_-_108308997 0.371 NM_006113
VAV3
vav 3 guanine nucleotide exchange factor
chr1_-_41480368 0.370 SCMH1
sex comb on midleg homolog 1 (Drosophila)
chr14_+_106009489 0.368 NCRNA00221
non-protein coding RNA 221

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.28 3.90e-16 GO:0031323 regulation of cellular metabolic process
1.24 4.66e-15 GO:0044260 cellular macromolecule metabolic process
1.55 5.78e-14 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.34 6.48e-14 GO:0051252 regulation of RNA metabolic process
1.26 1.12e-13 GO:0080090 regulation of primary metabolic process
1.27 1.22e-13 GO:0060255 regulation of macromolecule metabolic process
1.16 1.30e-13 GO:0050794 regulation of cellular process
1.24 3.61e-13 GO:0019222 regulation of metabolic process
1.31 5.54e-13 GO:0010468 regulation of gene expression
1.31 3.41e-12 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.15 4.58e-12 GO:0050789 regulation of biological process
1.32 1.81e-11 GO:0006355 regulation of transcription, DNA-dependent
1.28 2.49e-11 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.30 3.42e-11 GO:0010556 regulation of macromolecule biosynthetic process
1.65 3.90e-11 GO:0010629 negative regulation of gene expression
1.27 1.24e-10 GO:0051171 regulation of nitrogen compound metabolic process
1.09 1.46e-10 GO:0009987 cellular process
1.39 2.22e-10 GO:0007399 nervous system development
1.31 2.44e-10 GO:0048523 negative regulation of cellular process
1.13 3.10e-10 GO:0065007 biological regulation
1.65 4.18e-10 GO:0051253 negative regulation of RNA metabolic process
1.27 7.95e-10 GO:0031326 regulation of cellular biosynthetic process
1.49 8.14e-10 GO:0022008 neurogenesis
1.27 9.02e-10 GO:0071842 cellular component organization at cellular level
1.26 1.02e-09 GO:0009889 regulation of biosynthetic process
1.26 1.55e-09 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.64 1.95e-09 GO:0045892 negative regulation of transcription, DNA-dependent
1.49 2.88e-09 GO:0048699 generation of neurons
1.18 3.02e-09 GO:0043170 macromolecule metabolic process
1.28 4.25e-09 GO:0048519 negative regulation of biological process
1.58 5.85e-09 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.15 7.03e-09 GO:0044237 cellular metabolic process
1.25 9.64e-09 GO:0071841 cellular component organization or biogenesis at cellular level
1.56 3.95e-08 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.28 4.24e-08 GO:0090304 nucleic acid metabolic process
1.53 4.79e-08 GO:0031327 negative regulation of cellular biosynthetic process
1.55 7.34e-08 GO:0051172 negative regulation of nitrogen compound metabolic process
1.53 9.23e-08 GO:0010558 negative regulation of macromolecule biosynthetic process
1.69 1.03e-07 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.31 1.07e-07 GO:0016070 RNA metabolic process
1.51 1.26e-07 GO:0009890 negative regulation of biosynthetic process
1.30 1.47e-07 GO:0006464 protein modification process
1.28 5.36e-07 GO:0043412 macromolecule modification
1.48 1.01e-06 GO:0030182 neuron differentiation
1.30 1.42e-06 GO:0023051 regulation of signaling
1.39 3.34e-06 GO:0009892 negative regulation of metabolic process
1.13 3.56e-06 GO:0044238 primary metabolic process
1.56 3.80e-06 GO:0031175 neuron projection development
1.40 3.92e-06 GO:0010605 negative regulation of macromolecule metabolic process
1.41 4.02e-06 GO:0006351 transcription, DNA-dependent
1.48 4.09e-06 GO:0051254 positive regulation of RNA metabolic process
1.65 4.28e-06 GO:0016568 chromatin modification
1.40 7.63e-06 GO:0031324 negative regulation of cellular metabolic process
1.58 8.06e-06 GO:0048812 neuron projection morphogenesis
1.46 1.01e-05 GO:0010628 positive regulation of gene expression
1.29 1.07e-05 GO:0006996 organelle organization
1.57 1.58e-05 GO:0048667 cell morphogenesis involved in neuron differentiation
1.58 1.62e-05 GO:0007409 axonogenesis
1.30 1.70e-05 GO:0009653 anatomical structure morphogenesis
1.19 2.47e-05 GO:0048856 anatomical structure development
1.22 2.81e-05 GO:0048522 positive regulation of cellular process
1.18 3.02e-05 GO:0016043 cellular component organization
1.46 3.52e-05 GO:0045893 positive regulation of transcription, DNA-dependent
1.46 3.64e-05 GO:0030030 cell projection organization
1.19 4.17e-05 GO:0034641 cellular nitrogen compound metabolic process
1.21 5.37e-05 GO:0044267 cellular protein metabolic process
1.51 6.24e-05 GO:0048858 cell projection morphogenesis
1.51 6.64e-05 GO:0032990 cell part morphogenesis
1.20 1.00e-04 GO:0048518 positive regulation of biological process
1.50 1.06e-04 GO:0000904 cell morphogenesis involved in differentiation
1.47 1.09e-04 GO:0048666 neuron development
1.40 1.39e-04 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.17 1.42e-04 GO:0071840 cellular component organization or biogenesis
1.32 1.65e-04 GO:0010604 positive regulation of macromolecule metabolic process
1.10 1.66e-04 GO:0008152 metabolic process
1.17 1.92e-04 GO:0006807 nitrogen compound metabolic process
1.16 1.98e-04 GO:0032502 developmental process
1.28 2.03e-04 GO:0009966 regulation of signal transduction
1.19 2.16e-04 GO:0048731 system development
1.30 2.18e-04 GO:0051641 cellular localization
1.35 2.19e-04 GO:0048468 cell development
1.34 3.25e-04 GO:0032774 RNA biosynthetic process
1.69 3.34e-04 GO:0050767 regulation of neurogenesis
1.17 3.41e-04 GO:0007275 multicellular organismal development
1.29 3.46e-04 GO:0009893 positive regulation of metabolic process
1.30 3.49e-04 GO:0031325 positive regulation of cellular metabolic process
1.41 4.06e-04 GO:0045595 regulation of cell differentiation
1.38 4.62e-04 GO:0051173 positive regulation of nitrogen compound metabolic process
1.35 5.08e-04 GO:0050793 regulation of developmental process
1.43 7.72e-04 GO:0000902 cell morphogenesis
1.74 7.94e-04 GO:0045664 regulation of neuron differentiation
1.38 8.60e-04 GO:0010557 positive regulation of macromolecule biosynthetic process
1.22 1.02e-03 GO:0030154 cell differentiation
1.21 1.25e-03 GO:0048869 cellular developmental process
1.41 1.27e-03 GO:0032989 cellular component morphogenesis
2.31 1.36e-03 GO:0016458 gene silencing
1.23 1.57e-03 GO:0010467 gene expression
1.37 1.60e-03 GO:0016192 vesicle-mediated transport
1.74 1.66e-03 GO:0032582 negative regulation of gene-specific transcription
1.87 2.36e-03 GO:0016055 Wnt receptor signaling pathway
1.46 2.45e-03 GO:0006325 chromatin organization
1.23 3.03e-03 GO:0034645 cellular macromolecule biosynthetic process
1.33 3.51e-03 GO:0009891 positive regulation of biosynthetic process
1.30 3.68e-03 GO:0032268 regulation of cellular protein metabolic process
1.44 3.80e-03 GO:0007417 central nervous system development
1.29 4.49e-03 GO:0051649 establishment of localization in cell
1.33 4.60e-03 GO:0031328 positive regulation of cellular biosynthetic process
1.41 6.19e-03 GO:0016071 mRNA metabolic process
1.44 6.19e-03 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.93 6.88e-03 GO:0031098 stress-activated protein kinase signaling cascade
1.54 6.93e-03 GO:0060284 regulation of cell development
1.15 7.24e-03 GO:0051179 localization
1.57 7.67e-03 GO:0051960 regulation of nervous system development
1.97 7.72e-03 GO:0040029 regulation of gene expression, epigenetic
1.62 9.37e-03 GO:0051129 negative regulation of cellular component organization
3.20 1.00e-02 GO:0043489 RNA stabilization
3.20 1.00e-02 GO:0048255 mRNA stabilization
1.52 1.01e-02 GO:0007411 axon guidance
1.29 1.02e-02 GO:0006793 phosphorus metabolic process
1.29 1.02e-02 GO:0006796 phosphate metabolic process
1.37 1.05e-02 GO:0007167 enzyme linked receptor protein signaling pathway
1.42 1.05e-02 GO:0019226 transmission of nerve impulse
1.42 1.05e-02 GO:0035637 multicellular organismal signaling
1.77 1.07e-02 GO:0031344 regulation of cell projection organization
1.45 1.11e-02 GO:0032583 regulation of gene-specific transcription
1.22 1.16e-02 GO:0009059 macromolecule biosynthetic process
1.69 1.33e-02 GO:0016569 covalent chromatin modification
1.37 1.45e-02 GO:0051276 chromosome organization
2.44 1.51e-02 GO:0060021 palate development
1.27 2.00e-02 GO:0010646 regulation of cell communication
1.73 2.10e-02 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
1.27 2.85e-02 GO:0051246 regulation of protein metabolic process
1.34 2.96e-02 GO:0009790 embryo development
1.67 3.11e-02 GO:0016570 histone modification
1.32 3.12e-02 GO:2000026 regulation of multicellular organismal development
1.39 3.29e-02 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.80 3.29e-02 GO:0006403 RNA localization
1.30 3.60e-02 GO:0051128 regulation of cellular component organization
1.48 3.86e-02 GO:0045597 positive regulation of cell differentiation
1.15 4.02e-02 GO:0019538 protein metabolic process
1.30 4.03e-02 GO:0033554 cellular response to stress
1.73 4.76e-02 GO:0016311 dephosphorylation
1.33 4.97e-02 GO:0019220 regulation of phosphate metabolic process
1.33 4.97e-02 GO:0051174 regulation of phosphorus metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.14 2.19e-41 GO:0005622 intracellular
1.15 5.75e-40 GO:0044424 intracellular part
1.15 8.20e-28 GO:0043226 organelle
1.15 1.01e-27 GO:0043229 intracellular organelle
1.25 1.36e-27 GO:0005634 nucleus
1.16 2.62e-24 GO:0043231 intracellular membrane-bounded organelle
1.16 2.63e-24 GO:0043227 membrane-bounded organelle
1.15 1.60e-17 GO:0005737 cytoplasm
1.31 7.57e-12 GO:0044428 nuclear part
1.05 1.20e-11 GO:0005623 cell
1.05 1.70e-11 GO:0044464 cell part
1.34 2.22e-11 GO:0031981 nuclear lumen
1.39 2.01e-10 GO:0005654 nucleoplasm
1.15 1.03e-08 GO:0044446 intracellular organelle part
1.14 7.14e-08 GO:0044422 organelle part
1.13 1.45e-07 GO:0044444 cytoplasmic part
1.25 5.86e-07 GO:0005829 cytosol
1.23 2.14e-06 GO:0070013 intracellular organelle lumen
1.22 4.41e-06 GO:0043233 organelle lumen
1.19 1.01e-05 GO:0043234 protein complex
1.21 1.76e-05 GO:0031974 membrane-enclosed lumen
1.16 2.19e-05 GO:0032991 macromolecular complex
1.40 2.64e-05 GO:0044451 nucleoplasm part
1.85 4.37e-05 GO:0030136 clathrin-coated vesicle
1.74 1.02e-04 GO:0030135 coated vesicle
2.09 2.01e-04 GO:0016585 chromatin remodeling complex
1.49 2.72e-04 GO:0045202 synapse
1.58 2.95e-04 GO:0044456 synapse part
2.08 4.24e-04 GO:0008021 synaptic vesicle
1.34 4.52e-04 GO:0031982 vesicle
1.52 4.53e-04 GO:0048471 perinuclear region of cytoplasm
1.34 6.34e-04 GO:0031410 cytoplasmic vesicle
1.35 1.85e-03 GO:0015630 microtubule cytoskeleton
2.00 2.64e-03 GO:0030665 clathrin coated vesicle membrane
1.16 2.89e-03 GO:0043228 non-membrane-bounded organelle
1.16 2.89e-03 GO:0043232 intracellular non-membrane-bounded organelle
1.33 3.22e-03 GO:0016023 cytoplasmic membrane-bounded vesicle
2.28 3.24e-03 GO:0035770 RNA granule
2.39 3.86e-03 GO:0030672 synaptic vesicle membrane
1.83 4.34e-03 GO:0030662 coated vesicle membrane
1.31 5.49e-03 GO:0031988 membrane-bounded vesicle
3.24 6.12e-03 GO:0030530 heterogeneous nuclear ribonucleoprotein complex
2.34 9.33e-03 GO:0000792 heterochromatin
1.34 1.04e-02 GO:0030054 cell junction
3.06 1.54e-02 GO:0031519 PcG protein complex
1.49 2.54e-02 GO:0030659 cytoplasmic vesicle membrane
1.44 3.15e-02 GO:0044433 cytoplasmic vesicle part
1.47 3.30e-02 GO:0012506 vesicle membrane
1.19 5.00e-02 GO:0005856 cytoskeleton

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.20 5.56e-27 GO:0005515 protein binding
1.11 2.18e-24 GO:0005488 binding
1.27 4.16e-15 GO:0003676 nucleic acid binding
1.53 7.72e-15 GO:0030528 transcription regulator activity
1.30 3.43e-12 GO:0003677 DNA binding
1.42 1.39e-08 GO:0001071 nucleic acid binding transcription factor activity
1.42 1.39e-08 GO:0003700 sequence-specific DNA binding transcription factor activity
1.60 3.15e-06 GO:0003712 transcription cofactor activity
1.60 3.83e-06 GO:0000988 protein binding transcription factor activity
1.60 3.83e-06 GO:0000989 transcription factor binding transcription factor activity
1.42 1.43e-05 GO:0043565 sequence-specific DNA binding
1.22 6.78e-05 GO:0008270 zinc ion binding
1.57 4.05e-04 GO:0016564 transcription repressor activity
1.78 1.96e-03 GO:0003714 transcription corepressor activity
1.18 2.09e-03 GO:0000166 nucleotide binding
1.42 2.99e-03 GO:0030695 GTPase regulator activity
1.39 3.59e-03 GO:0008092 cytoskeletal protein binding
1.43 3.62e-03 GO:0019904 protein domain specific binding
1.52 3.65e-03 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.31 4.61e-03 GO:0003723 RNA binding
1.17 5.04e-03 GO:0046914 transition metal ion binding
1.13 5.05e-03 GO:0046872 metal ion binding
1.12 8.64e-03 GO:0043167 ion binding
1.40 8.81e-03 GO:0060589 nucleoside-triphosphatase regulator activity
1.63 1.04e-02 GO:0003682 chromatin binding
1.47 1.10e-02 GO:0003779 actin binding
1.92 1.16e-02 GO:0017016 Ras GTPase binding
1.12 1.25e-02 GO:0043169 cation binding
1.47 1.35e-02 GO:0016563 transcription activator activity
1.66 1.96e-02 GO:0004721 phosphoprotein phosphatase activity
1.50 2.17e-02 GO:0016881 acid-amino acid ligase activity
1.29 2.59e-02 GO:0016301 kinase activity
1.47 2.75e-02 GO:0008134 transcription factor binding
1.29 3.50e-02 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.75 4.20e-02 GO:0051020 GTPase binding
1.52 4.31e-02 GO:0019787 small conjugating protein ligase activity