Motif ID: EGR1..3.p2

Z-value: 1.391


Transcription factors associated with EGR1..3.p2:

Gene SymbolEntrez IDGene Name
EGR1 1958 early growth response 1
EGR2 1959 early growth response 2 (Krox-20 homolog, Drosophila)
EGR3 1960 early growth response 3



Activity profile for motif EGR1..3.p2.

activity profile for motif EGR1..3.p2


Sorted Z-values histogram for motif EGR1..3.p2

Sorted Z-values for motif EGR1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EGR1..3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_98919109 2.134 NM_207362
 C2orf55
chromosome 2 open reading frame 55
chr4_-_809879 1.968 NM_006651
 CPLX1
complexin 1
chr3_-_13896618 1.797 NM_004625
 WNT7A
wingless-type MMTV integration site family, member 7A
chr9_-_85622366 1.498 NM_001135953
NM_025211
 GKAP1

G kinase anchoring protein 1

chr14_-_104705753 1.369 JAG2
jagged 2
chr3_+_115149234 1.362 NM_173570
 ZDHHC23
zinc finger, DHHC-type containing 23
chr16_-_53520208 1.327 CRNDE
colorectal neoplasia differentially expressed (non-protein coding)
chr17_-_34015631 1.277 NM_025248
 SRCIN1
SRC kinase signaling inhibitor 1
chr3_-_172660545 1.238 NM_001161560
NM_001161561
NM_001161562
NM_001161563
NM_001161564
NM_001161565
NM_001161566
NM_015028
 TNIK







TRAF2 and NCK interacting kinase







chr15_+_38520594 1.159 NM_014952
 BAHD1
bromo adjacent homology domain containing 1
chr17_-_1029758 1.125 NM_021962
 ABR
active BCR-related gene
chr3_-_88190737 1.061 NM_001008390
NM_003663
 CGGBP1

CGG triplet repeat binding protein 1

chr9_+_133259330 1.055 PRRC2B
proline-rich coiled-coil 2B
chr19_+_1200882 1.042 MIDN
midnolin
chr4_-_35922288 1.011 NM_015230
 ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr1_-_240754620 1.008 NM_152666
 PLD5
phospholipase D family, member 5
chr7_-_526005 0.988 NM_002607
NM_033023
 PDGFA

platelet-derived growth factor alpha polypeptide

chr16_-_342399 0.955 NM_003502
NM_181050
 AXIN1

axin 1

chr21_+_16024241 0.891 NM_013396
 USP25
ubiquitin specific peptidase 25
chr1_+_32251988 0.856 NM_006559
 KHDRBS1
KH domain containing, RNA binding, signal transduction associated 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 144 entries
enrichment   p-value GO term description
3.20 1.00e-02 GO:0043489 RNA stabilization
3.20 1.00e-02 GO:0048255 mRNA stabilization
2.44 1.51e-02 GO:0060021 palate development
2.31 1.36e-03 GO:0016458 gene silencing
1.97 7.72e-03 GO:0040029 regulation of gene expression, epigenetic
1.93 6.88e-03 GO:0031098 stress-activated protein kinase signaling cascade
1.87 2.36e-03 GO:0016055 Wnt receptor signaling pathway
1.80 3.29e-02 GO:0006403 RNA localization
1.77 1.07e-02 GO:0031344 regulation of cell projection organization
1.74 7.94e-04 GO:0045664 regulation of neuron differentiation
1.74 1.66e-03 GO:0032582 negative regulation of gene-specific transcription
1.73 2.10e-02 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
1.73 4.76e-02 GO:0016311 dephosphorylation
1.69 1.03e-07 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.69 3.34e-04 GO:0050767 regulation of neurogenesis
1.69 1.33e-02 GO:0016569 covalent chromatin modification
1.67 3.11e-02 GO:0016570 histone modification
1.65 3.90e-11 GO:0010629 negative regulation of gene expression
1.65 4.18e-10 GO:0051253 negative regulation of RNA metabolic process
1.65 4.28e-06 GO:0016568 chromatin modification

Gene overrepresentation in compartment category:

Showing 1 to 20 of 49 entries
enrichment   p-value GO term description
3.24 6.12e-03 GO:0030530 heterogeneous nuclear ribonucleoprotein complex
3.06 1.54e-02 GO:0031519 PcG protein complex
2.39 3.86e-03 GO:0030672 synaptic vesicle membrane
2.34 9.33e-03 GO:0000792 heterochromatin
2.28 3.24e-03 GO:0035770 RNA granule
2.09 2.01e-04 GO:0016585 chromatin remodeling complex
2.08 4.24e-04 GO:0008021 synaptic vesicle
2.00 2.64e-03 GO:0030665 clathrin coated vesicle membrane
1.85 4.37e-05 GO:0030136 clathrin-coated vesicle
1.83 4.34e-03 GO:0030662 coated vesicle membrane
1.74 1.02e-04 GO:0030135 coated vesicle
1.58 2.95e-04 GO:0044456 synapse part
1.52 4.53e-04 GO:0048471 perinuclear region of cytoplasm
1.49 2.72e-04 GO:0045202 synapse
1.49 2.54e-02 GO:0030659 cytoplasmic vesicle membrane
1.47 3.30e-02 GO:0012506 vesicle membrane
1.44 3.15e-02 GO:0044433 cytoplasmic vesicle part
1.40 2.64e-05 GO:0044451 nucleoplasm part
1.39 2.01e-10 GO:0005654 nucleoplasm
1.35 1.85e-03 GO:0015630 microtubule cytoskeleton

Gene overrepresentation in function category:

Showing 1 to 20 of 36 entries
enrichment   p-value GO term description
1.92 1.16e-02 GO:0017016 Ras GTPase binding
1.78 1.96e-03 GO:0003714 transcription corepressor activity
1.75 4.20e-02 GO:0051020 GTPase binding
1.66 1.96e-02 GO:0004721 phosphoprotein phosphatase activity
1.63 1.04e-02 GO:0003682 chromatin binding
1.60 3.15e-06 GO:0003712 transcription cofactor activity
1.60 3.83e-06 GO:0000988 protein binding transcription factor activity
1.60 3.83e-06 GO:0000989 transcription factor binding transcription factor activity
1.57 4.05e-04 GO:0016564 transcription repressor activity
1.53 7.72e-15 GO:0030528 transcription regulator activity
1.52 3.65e-03 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.52 4.31e-02 GO:0019787 small conjugating protein ligase activity
1.50 2.17e-02 GO:0016881 acid-amino acid ligase activity
1.47 1.10e-02 GO:0003779 actin binding
1.47 1.35e-02 GO:0016563 transcription activator activity
1.47 2.75e-02 GO:0008134 transcription factor binding
1.43 3.62e-03 GO:0019904 protein domain specific binding
1.42 1.39e-08 GO:0001071 nucleic acid binding transcription factor activity
1.42 1.39e-08 GO:0003700 sequence-specific DNA binding transcription factor activity
1.42 1.43e-05 GO:0043565 sequence-specific DNA binding