Mean activities

Top 10 and bottom 10 mean activities.

 Mean activities

Mean activities sorted by motif Z-value.

 Mean activities

Sorted mean activities for every motif.
Motif nameMean activityZ-ValueAssociated genesLogo
CTCF.p2 1.743 13.634 CTCF
GZF1.p2 0.320 0.365 GZF1 (dJ322G13.2, ZBTB23)
HOXA9_MEIS1.p2 0.096 0.237 MEIS1
HOXA9
POU2F1..3.p2 0.094 0.536 POU2F2 (OCT2)
POU2F1 (OCT1)
POU2F3 (OCT11, PLA-1, Skn-1a, Epoc-1)
AR.p2 0.085 0.149 AR (AIS, NR3C4, SMAX1, HUMARA)
ZNF238.p2 0.076 0.382 ZNF238 (C2H2-171, TAZ-1, RP58, ZBTB18)
STAT5{A,B}.p2 0.071 0.290 STAT5B
STAT5A (MGF)
ATF4.p2 0.051 0.443 ATF4 (TAXREB67, CREB-2)
NFKB1_REL_RELA.p2 0.050 0.562 RELA (p65)
REL (I-Rel)
NFKB1 (KBF1, p105)
TFAP4.p2 0.050 0.692 TFAP4 (AP-4)
TBP.p2 0.048 0.285 TBP (TFIID)
SREBF1,2.p2 0.045 0.315 SREBF1 (SREBP1, bHLHd1)
SREBF2 (SREBP2, bHLHd2)
LEF1_TCF7_TCF7L1,2.p2 0.045 0.325 TCF7 (TCF-1)
TCF7L2 (TCF-4)
LEF1 (TCF1ALPHA)
TCF7L1
NFIL3.p2 0.043 0.153 NFIL3 (E4BP4, NFIL3A, NF-IL3A)
FOXN1.p2 0.042 0.325 FOXN1 (FKHL20)
SPZ1.p2 0.040 0.772 SPZ1 (NYD-TSP1, FLJ25709)
bHLH_family.p2 0.038 0.598 ARNTL (MOP3, JAP3, BMAL1, PASD3, bHLHe5)
MITF (WS2A, MI, bHLHe32)
MXI1 (MXD2, MAD2, MXI, bHLHc11)
TFE3 (TFEA, bHLHe33)
CLOCK (KIAA0334, KAT13D, bHLHe8)
OLIG2 (RACK17, OLIGO2, bHLHe19)
MXD4 (MAD4, MSTP149, MST149, bHLHc12)
HEY2 (bHLHb32)
HEY1 (HESR-1, CHF2, HESR1, HRT-1, CHF-2, HERP2, BHLHb31)
HEYL (bHLHb33)
MLXIPL (WS-bHLH, MIO, CHREBP, MONDOB)
HES6 (bHLHc23)
MXD3 (MAD3, bHLHc13)
ARNTL2 (BMAL2, MOP9, CLIF, PASD9, bHLHe6)
ID1 (dJ857M17.1.2, bHLHb24)
MNT (ROX, MXD6, MAD6, bHLHd3)
OLIG1 (BHLHB6, bHLHe21)
NPAS2 (MOP4, PASD4, bHLHe9)
SRF.p3 0.035 0.130 SRF (MCM1)
GLI1..3.p2 0.035 0.345 GLI1
GLI2 (THP2, HPE9, THP1)
GLI3 (PAP-A, PAPA, PAPA1, PAPB, ACLS, PPDIV)
ESRRA.p2 0.033 0.227 ESRRA (ERR1, ERRalpha, NR3B1, ERRa)
CRX.p2 0.032 0.235 CRX (CRD, LCA7, OTX3)
FOS_FOS{B,L1}_JUN{B,D}.p2 0.032 0.236 FOS (c-fos, AP-1)
JUNB
FOSL1 (fra-1)
JUND (AP-1)
FOSB (G0S3, GOSB, GOS3, AP-1, MGC42291, DKFZp686C0818)
MYBL2.p2 0.032 0.157 MYBL2 (BMYB, B-MYB)
PAX2.p2 0.031 0.423 PAX2
NKX6-1,2.p2 0.029 0.176 NKX6-1 (Nkx6.1)
NKX6-2 (NKX6B, GTX, NKX6.1)
STAT2,4,6.p2 0.028 0.398 STAT2 (STAT113)
STAT4
STAT6 (D12S1644, IL-4-STAT)
SOX{8,9,10}.p2 0.027 0.251 SOX9 (SRA1)
SOX8
SOX10 (DOM, WS4, WS2E)
SRY.p2 0.026 0.273 SRY (TDF)
STAT1,3.p3 0.025 0.074 STAT1 (STAT91, ISGF-3)
STAT3 (APRF)
T.p2 0.024 0.063 T
EP300.p2 0.022 0.361 EP300 (p300, KAT3B)
PRDM1.p3 0.020 0.075 PRDM1 (PRDI-BF1)
FOX{D1,D2}.p2 0.020 0.140 FOXD2 (FREAC9)
FOXD1 (FREAC4)
ELK1,4_GABP{A,B1}.p3 0.020 0.392 GABPA (E4TF1A, NFT2, NRF2, E4TF1-60, NRF2A)
GABPB1 (E4TF1-47, GABPB)
ELK4 (SAP1)
ELK1
IKZF1.p2 0.020 0.172 IKZF1 (hIk-1, LyF-1, Hs.54452, IKAROS)
HES1.p2 0.018 0.313 HES1 (FLJ20408, HES-1, Hes1, bHLHb39)
CREB1.p2 0.017 0.163 CREB1
MYOD1.p2 0.016 0.225 MYOD1 (PUM, MYOD, bHLHc1)
FOXO1,3,4.p2 0.015 0.122 FOXO1 (FKH1)
FOXO4 (AFX1)
FOXO3 (AF6q21, FOXO2)
PRRX1,2.p2 0.014 0.312 PRRX2 (PRX2, PMX2)
PRRX1 (PHOX1)
BPTF.p2 0.014 0.348 BPTF (FAC1, NURF301)
SOX17.p2 0.014 0.153 SOX17
HMX1.p2 0.013 0.127 HMX1 (H6, NKX5-3)
GFI1.p2 0.013 0.168 GFI1
RXRA_VDR{dimer}.p2 0.012 0.038 VDR (NR1I1)
NFE2L2.p2 0.011 0.053 NFE2L2 (NRF2)
MEF2{A,B,C,D}.p2 0.010 0.090 MEF2A (RSRFC4, RSRFC9)
MEF2C
MEF2D
MEF2BNB-MEF2B (MEF2B, LOC729991-MEF2B)
MEF2B (RSRFR2, FLJ32648)
FOXD3.p2 0.010 0.154 FOXD3 (Genesis, HFH2)
EWSR1-FLI1.p2 0.007 0.037 FLI1 (EWSR2, SIC-1)
EWSR1 (EWS, K984G1.4)
TFAP2{A,C}.p2 0.006 0.440 TFAP2C (AP2-GAMMA, ERF1, TFAP2G, hAP-2g)
TFAP2A (AP-2)
ZBTB16.p2 0.006 0.063 ZBTB16 (PLZF)
TCF4_dimer.p2 0.005 0.119 TCF4 (E2-2, ITF2, PTHS, SEF2, SEF2-1, SEF2-1A, SEF2-1B, bHLHb19, MGC149723, MGC149724)
RORA.p2 0.005 0.012 RORA (RZRA, ROR1, ROR2, ROR3, NR1F1)
SPIB.p2 0.004 0.110 SPIB (SPI-B)
RFX1..5_RFXANK_RFXAP.p2 0.004 0.044 RFX1 (EF-C)
RFXAP
RFX5
RFXANK (BLS, RFX-B, ANKRA1, F14150_1, MGC138628)
RFX4
RFX3
RFX2 (FLJ14226)
PAX4.p2 0.004 0.023 PAX4
GTF2I.p2 0.004 0.141 GTF2I (TFII-I, BAP-135, SPIN, BTKAP1, DIWS, IB291)
ETS1,2.p2 0.003 0.049 ETS2
ETS1 (FLJ10768, ETS-1)
NKX3-1.p2 0.003 0.014 NKX3-1 (NKX3.1, BAPX2)
CDX1,2,4.p2 0.002 0.019 CDX1
CDX2
CDX4
FOXQ1.p2 0.001 0.009 FOXQ1 (HFH1)
AHR_ARNT_ARNT2.p2 0.001 0.021 ARNT (HIF-1beta, bHLHe2)
AHR
ARNT2 (KIAA0307, bHLHe1)
RBPJ.p2 0.001 0.005 RBPJ (SUH, IGKJRB, RBPJK, KBF2, RBP-J, CBF1)
JUN.p2 0.001 0.006 JUN (c-Jun, AP-1)
JUND (AP-1)
JUNB
HIC1.p2 0.001 0.021 HIC1 (ZBTB29)
NHLH1,2.p2 0.000 0.010 NHLH1 (NSCL, NSCL1, bHLHa35)
NHLH2 (NSCL2, bHLHa34)
HLF.p2 0.000 0.001 HLF (MGC33822)
KLF4.p3 0.000 0.012 KLF4 (EZF, GKLF)
SNAI1..3.p2 -0.000 -0.007 SNAI2 (SLUGH1)
SNAI1 (SNA, SLUGH2, SNAH)
SNAI3 (SMUC, Zfp293)
PAX5.p2 -0.001 -0.035 PAX5 (BSAP)
IRF1,2,7.p3 -0.001 -0.006 IRF1 (MAR, IRF-1)
IRF2 (IRF-2, DKFZp686F0244)
IRF7 (IRF7A, IRF-7H)
TFDP1.p2 -0.001 -0.061 TFDP1 (Dp-1, DRTF1, DP1)
MAFB.p2 -0.001 -0.028 MAFB
POU5F1.p2 -0.001 -0.016 POU5F1 (OCT3, Oct4, MGC22487)
SP1.p2 -0.002 -0.093 SP1
MTF1.p2 -0.002 -0.051 MTF1
ZNF384.p2 -0.003 -0.033 ZNF384 (CAGH1A, CIZ, NMP4, NP)
HOX{A6,A7,B6,B7}.p2 -0.003 -0.078 HOXB6
HOXA7
HOXB7
HOXA6
NFIX.p2 -0.003 -0.017 NFIX (NF1A)
ZBTB6.p2 -0.003 -0.045 ZBTB6 (ZID)
NKX3-2.p2 -0.003 -0.041 NKX3-2 (NKX3B, NKX3.2)
NRF1.p2 -0.003 -0.087 NRF1 (EWG, ALPHA-PAL)
BACH2.p2 -0.004 -0.019 BACH2
MZF1.p2 -0.004 -0.213 MZF1 (MZF1B, ZSCAN6, MZF-1, Zfp98)
YY1.p2 -0.005 -0.152 YY1 (NF-E1, DELTA, UCRBP, YIN-YANG-1, INO80S)
RXR{A,B,G}.p2 -0.005 -0.068 RXRA (NR2B1)
RXRB (NR2B2, H-2RIIBP, RCoR-1)
RXRG (NR2B3)
HBP1_HMGB_SSRP1_UBTF.p2 -0.005 -0.052 HMGB2
HMGB3 (HMG2A, MGC90319)
SSRP1 (FACT80)
UBTF (UBF, NOR-90)
HBP1
ELF1,2,4.p2 -0.005 -0.121 ELF2 (EU32, NERF, NERF-2, NERF-1A, NERF-1B)
ELF1
ELF4 (MEF, ELFR)
TFAP2B.p2 -0.005 -0.262 TFAP2B (AP2-B)
PITX1..3.p2 -0.005 -0.088 PITX2 (IGDS, RS, Brx1, Otlx2, ARP1)
PITX3
PITX1 (PTX1, POTX)
LMO2.p2 -0.006 -0.083 LMO2 (TTG2, RHOM2, RBTN2)
TEAD1.p2 -0.006 -0.037 TEAD1 (TEF-1)
TEAD2 (ETF, TEF4, TEF-4, TEAD-2)
TEAD3 (TEF5, TEAD5, TEF-5, DTEF-1, ETFR-1, TEAD-3)
TEAD4 (TEF3, RTEF1, TEF-3, EFTR-2, TEFR-1, TCF13L1, hRTEF-1B)
ZEB1.p2 -0.006 -0.110 ZEB1 (BZP, ZEB, AREB6, NIL-2-A, Zfhep, Zfhx1a)
ADNP_IRX_SIX_ZHX.p2 -0.006 -0.063 SIX5
ZHX1
IRX4
ADNP (KIAA0784, ADNP1)
ZHX3 (KIAA0395)
ZHX2 (KIAA0854)
IRX5 (IRX-2a)
SIX2
ZNF423.p2 -0.007 -0.055 ZNF423 (KIAA0760, OAZ, Roaz, Ebfaz, Zfp104)
ZFP161.p2 -0.007 -0.196 ZFP161 (ZNF478, ZBTB14)
ZNF148.p2 -0.007 -0.161 ZNF148 (BERF-1, ZBP-89, BFCOL1, HT-BETA, ZFP148, pHZ-52)
PATZ1.p2 -0.008 -0.357 PATZ1 (MAZR, dJ400N23, ZBTB19, ZSG, RIAZ, PATZ)
RUNX1..3.p2 -0.008 -0.070 RUNX1 (PEBP2A2, AMLCR1)
RUNX3 (AML2, PEBP2A3)
RUNX2 (AML3, PEBP2A1, PEBP2aA1)
IKZF2.p2 -0.008 -0.093 IKZF2 (Helios)
FOX{F1,F2,J1}.p2 -0.008 -0.042 FOXF2 (FREAC2)
FOXJ1 (HFH-4, HFH4)
FOXF1 (FREAC1)
NFATC1..3.p2 -0.009 -0.097 NFATC3 (NFAT4, NFATX)
NFATC2 (NF-ATP, NFATp, NFAT1)
NFATC1 (NF-ATC, NFATc, NFAT2)
EBF1.p2 -0.009 -0.112 EBF1 (OLF1)
SPI1.p2 -0.009 -0.275 SPI1 (PU.1, SPI-A, OF, SFPI1, SPI-1)
MYFfamily.p2 -0.009 -0.260 MYOD1 (PUM, MYOD, bHLHc1)
MYF6 (MRF4, bHLHc4)
MYF5 (bHLHc2)
MYOG (bHLHc3)
HSF1,2.p2 -0.010 -0.097 HSF1 (HSTF1)
HSF2
TLX2.p2 -0.011 -0.108 TLX2 (Enx, Tlx2, NCX)
ATF6.p2 -0.011 -0.100 ATF6 (ATF6A)
ATF5_CREB3.p2 -0.011 -0.135 ATF5
CREB3 (LZIP, Luman)
ZNF143.p2 -0.011 -0.195 ZNF143 (SBF, pHZ-1, STAF)
POU3F1..4.p2 -0.011 -0.045 POU3F1 (OCT6, SCIP)
POU3F3 (BRN1, OTF8)
POU3F2 (POUF3, BRN2, OCT7)
POU3F4 (BRN4, OTF9)
MSX1,2.p2 -0.011 -0.026 MSX1 (HYD1, OFC5)
MSX2 (CRS2, FPP, HOX8, MSH, PFM)
E2F1..5.p2 -0.012 -0.124 E2F4 (E2F-4)
E2F5
E2F2 (E2F-2)
E2F1 (RBP3)
E2F3
NKX2-3_NKX2-5.p2 -0.013 -0.083 NKX2-5 (CSX1, NKX2.5, NKX4-1)
NKX2-3 (NKX2.3, CSX3, NKX4-3)
MAZ.p2 -0.013 -0.670 MAZ (ZF87, Pur-1, Zif87, ZNF801)
GATA1..3.p2 -0.013 -0.301 GATA1 (ERYF1, NFE1)
GATA2 (NFE1B)
GATA3 (HDR)
MYB.p2 -0.014 -0.176 MYB (c-myb)
ZIC1..3.p2 -0.014 -0.150 ZIC1 (ZIC, ZNF201)
ZIC2 (HPE5)
ZIC3 (HTX, ZNF203)
FOXL1.p2 -0.014 -0.123 FOXL1 (FREAC7, FKH6)
EHF.p2 -0.015 -0.230 EHF
ONECUT1,2.p2 -0.015 -0.089 ONECUT2 (OC-2)
ONECUT1 (HNF-6)
DMAP1_NCOR{1,2}_SMARC.p2 -0.016 -0.099 SMARCA1 (SNF2LB, NURF140, ISWI, SWI)
SMARCC2 (BAF170, Rsc8, CRACC2)
SMARCA5 (hSNF2H, hISWI, ISWI)
NCOR1 (N-CoR, hCIT529I10, TRAC1, hN-CoR, KIAA1047, MGC104216)
NCOR2 (SMRT, SMRTE, TRAC-1, CTG26, TNRC14)
DMAP1 (DNMAP1, FLJ11543, KIAA1425, DNMTAP1, EAF2, SWC4)
TBX4,5.p2 -0.016 -0.157 TBX5
TBX4
GFI1B.p2 -0.017 -0.068 GFI1B
KLF12.p2 -0.018 -0.391 KLF12 (AP-2rep, HSPC122, AP2REP)
SOX2.p2 -0.018 -0.194 SOX2
SOX5.p2 -0.018 -0.149 SOX5 (L-SOX5, MGC35153)
TFCP2.p2 -0.019 -0.388 TFCP2 (CP2, LSF, LBP-1C, TFCP2C)
HIF1A.p2 -0.021 -0.269 HIF1A (MOP1, HIF-1alpha, PASD8, HIF1)
FOX{I1,J2}.p2 -0.023 -0.273 FOXI1 (FREAC6)
FOXJ2 (FHX)
ESR1.p2 -0.024 -0.239 ESR1 (NR3A1, Era)
RREB1.p2 -0.025 -0.776 RREB1 (HNT)
NR3C1.p2 -0.025 -0.095 NR3C1 (GR)
EGR1..3.p2 -0.025 -0.746 EGR3 (PILOT)
EGR1 (TIS8, G0S30, NGFI-A, KROX-24, ZIF-268, AT225, ZNF225)
EGR2
SMAD1..7,9.p2 -0.027 -0.285 SMAD5 (Dwfc, JV5-1)
SMAD1 (MADR1, JV4-1)
SMAD3 (JV15-2, HsT17436)
SMAD4 (DPC4)
SMAD2 (MADR2, JV18-1)
SMAD6 (HsT17432)
SMAD7
SMAD9
NR1H4.p2 -0.028 -0.184 NR1H4 (FXR, RIP14, HRR1, HRR-1)
NFE2.p2 -0.029 -0.146 NFE2 (NF-E2)
HNF4A_NR2F1,2.p2 -0.030 -0.406 NR2F1 (EAR-3, COUP-TFI, TCFCOUP1, SVP44)
NR2F2 (COUP-TFII, COUPTFB, SVP40)
HNF4A (NR2A1, HNF4)
NFE2L1.p2 -0.031 -0.629 NFE2L1 (NRF1, LCR-F1, FLJ00380, TCF11)
NANOG.p2 -0.033 -0.143 NANOG (FLJ12581, FLJ40451)
ATF2.p2 -0.033 -0.256 ATF2 (TREB7, CRE-BP1, HB16)
HOX{A4,D4}.p2 -0.035 -0.304 HOXA4
HOXD4
NFY{A,B,C}.p2 -0.036 -0.644 NFYC (CBF-C)
NFYB (CBF-A, HAP3)
NFYA (HAP2, CBF-B)
FEV.p2 -0.037 -0.730 FEV (PET-1, HSRNAFEV)
NR5A1,2.p2 -0.037 -0.471 NR5A1 (FTZ1, SF-1, ELP, AD4BP)
NR5A2 (FTZ-F1beta, hB1F, LRH-1, FTZ-F1, hB1F-2, B1F2)
LHX3,4.p2 -0.038 -0.229 LHX3
LHX4 (Gsh4)
HMGA1,2.p2 -0.041 -0.568 HMGA1
HMGA2 (BABL, LIPO)
PBX1.p2 -0.041 -0.207 PBX1
ARNT_ARNT2_BHLHB2_MAX_MYC_USF1.p2 -0.042 -0.387 ARNT (HIF-1beta, bHLHe2)
MAX (bHLHd4)
MYC (c-Myc, bHLHe39)
USF1 (UEF, MLTFI, bHLHb11)
BHLHB2 (DEC1, bHLHe40)
ARNT2 (KIAA0307, bHLHe1)
FOXA2.p3 -0.045 -0.291 FOXA2
PPARG.p2 -0.046 -0.128 PPARG (PPARG1, PPARG2, NR1C3, PPARgamma)
NKX2-2,8.p2 -0.047 -0.280 NKX2-2 (NKX2.2)
NKX2-8 (NKX2.8, Nkx2-9)
TLX1..3_NFIC{dimer}.p2 -0.049 -0.315 TLX1
TLX3 (RNX)
XBP1.p3 -0.051 -0.229 XBP1
EOMES.p2 -0.053 -0.279 EOMES (TBR2)
ALX1.p2 -0.053 -0.285 ALX1
ARID5B.p2 -0.054 -0.172 ARID5B (FLJ21150, MRF2)
FOXP3.p2 -0.054 -0.160 FOXP3 (JM2, XPID, AIID, PIDX, DIETER, SCURFIN)
TP53.p2 -0.055 -0.295 TP53 (p53, LFS1)
DBP.p2 -0.056 -0.596 DBP (DABP)
HOX{A5,B5}.p2 -0.058 -0.307 HOXB5
HOXA5
FOSL2.p2 -0.058 -0.333 FOSL2 (FRA2, FLJ23306)
NANOG{mouse}.p2 -0.058 -0.247 NANOG (FLJ12581, FLJ40451)
AIRE.p2 -0.059 -0.217 AIRE (PGA1, APS1)
GTF2A1,2.p2 -0.061 -0.504 GTF2A1 (TFIIA)
GTF2A2 (TFIIA, HsT18745)
TGIF1.p2 -0.064 -0.516 TGIF1
TFEB.p2 -0.068 -0.667 TFEB
CDC5L.p2 -0.070 -0.340 CDC5L (PCDC5RP, hCDC5, CEF1)
POU1F1.p2 -0.071 -0.391 POU1F1 (GHF-1)
EVI1.p2 -0.073 -0.545 EVI1 (MDS1-EVI1, PRDM3)
POU5F1_SOX2{dimer}.p2 -0.076 -0.352 POU5F1 (OCT3, Oct4, MGC22487)
SOX2
HAND1,2.p2 -0.079 -0.387 HAND1 (eHand, Thing1, Hxt, bHLHa27)
HAND2 (dHand, Thing2, Hed, bHLHa26)
CEBPA,B_DDIT3.p2 -0.085 -0.277 DDIT3 (CHOP10, GADD153, CHOP)
CEBPA (C/EBP-alpha)
CEBPB (LAP, CRP2, NFIL6, IL6DBP)
CUX2.p2 -0.090 -0.179 CUX2 (KIAA0293, CDP2)
RXRG_dimer.p3 -0.092 -0.340 NR1H2 (NER, NER-I, RIP15, LXR-b)
RXRA (NR2B1)
PPARG (PPARG1, PPARG2, NR1C3, PPARgamma)
PPARA (hPPAR, NR1C1)
RXRB (NR2B2, H-2RIIBP, RCoR-1)
RXRG (NR2B3)
VSX1,2.p2 -0.094 -0.167 VSX2 (RET1)
VSX1 (PPD)
FOX{C1,C2}.p2 -0.095 -0.316 FOXC1 (FREAC3, ARA, IGDA, IHG1)
FOXC2 (MFH-1)
PDX1.p2 -0.122 -0.208 PDX1 (IDX-1, STF-1, PDX-1, MODY4)
PAX8.p2 -0.124 -0.074 PAX8
HNF1A.p2 -0.128 -0.509 HNF1A (HNF1, LFB1)
GATA6.p2 -0.128 -0.681 GATA6
NKX2-1,4.p2 -0.145 -0.384 NKX2-1 (TTF-1)
NKX2-4 (NKX2.4)
NR6A1.p2 -0.151 -0.333 NR6A1 (GCNF1, RTR)
POU6F1.p2 -0.156 -0.576 POU6F1 (BRN5, MPOU, TCFB1)
TAL1_TCF{3,4,12}.p2 -0.165 -0.458 TCF3 (E2A, ITF1, MGC129647, MGC129648, bHLHb21)
TCF4 (SEF2-1B, ITF2, bHLHb19)
TAL1 (SCL, bHLHa17)
TCF12 (HEB, HTF4, HsT17266, bHLHb20)
EN1,2.p2 -0.169 -0.879 EN1
EN2
PAX6.p2 -0.200 -0.316 PAX6 (D11S812E, AN, WAGR)
REST.p3 -0.239 -0.807 REST (NRSF, XBR)
PAX3,7.p2 -0.902 -0.488 PAX7 (Hup1)
PAX3 (HUP2)