Motif ID: SPIB.p2

Z-value: 2.121


Transcription factors associated with SPIB.p2:

Gene SymbolEntrez IDGene Name
SPIB 6689 Spi-B transcription factor (Spi-1/PU.1 related)



Activity profile for motif SPIB.p2.

activity profile for motif SPIB.p2


Sorted Z-values histogram for motif SPIB.p2

Sorted Z-values for motif SPIB.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SPIB.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_175207521 1.555 NM_003387
 WIPF1
WAS/WASL interacting protein family, member 1
chr10_-_98470164 1.275 NM_152309
 PIK3AP1
phosphoinositide-3-kinase adaptor protein 1
chr17_-_40843530 1.124 ARHGAP27
Rho GTPase activating protein 27
chr11_-_60880799 1.099 NM_001161452
 CYBASC3
cytochrome b, ascorbate dependent 3
chr1_-_59020875 1.041 JUN
jun proto-oncogene
chr5_+_140772691 1.001 NM_018913
NM_032090
 PCDHGA10

protocadherin gamma subfamily A, 10

chr6_+_31661934 0.952 NM_205838
NM_205839
 LST1

leukocyte specific transcript 1

chr22_-_39964001 0.909 CHADL
chondroadherin-like
chr9_+_130942029 0.898 PPP2R4
protein phosphatase 2A activator, regulatory subunit 4
chr17_-_18890963 0.890 NM_006613
 GRAP
GRB2-related adaptor protein
chr6_-_56824672 0.871 DST
dystonin
chr11_+_63864263 0.868 NM_032251
 CCDC88B
coiled-coil domain containing 88B
chr6_-_154719560 0.850 NM_001130700
NM_015553
 IPCEF1

interaction protein for cytohesin exchange factors 1

chr2_-_47986160 0.846 NM_001190274
 FBXO11
F-box protein 11
chr5_+_75734759 0.810 NM_006633
 IQGAP2
IQ motif containing GTPase activating protein 2
chr6_-_25044156 0.810 FAM65B
family with sequence similarity 65, member B
chr13_-_32678142 0.810 NM_052851
 STARD13
StAR-related lipid transfer (START) domain containing 13
chr14_+_99601498 0.783 NM_016337
 EVL
Enah/Vasp-like
chr1_-_45988901 0.778 NM_001145349
NM_005897
 IPP

intracisternal A particle-promoted polypeptide

chrX_-_47374187 0.768 NM_001145252
 CFP
complement factor properdin

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 38 entries
enrichment   p-value GO term description
2.23 8.41e-04 GO:0031294 lymphocyte costimulation
2.23 8.41e-04 GO:0031295 T cell costimulation
1.87 1.75e-02 GO:0050851 antigen receptor-mediated signaling pathway
1.85 2.17e-04 GO:0050870 positive regulation of T cell activation
1.83 2.11e-05 GO:0051251 positive regulation of lymphocyte activation
1.76 6.47e-05 GO:0050867 positive regulation of cell activation
1.76 2.52e-04 GO:0050863 regulation of T cell activation
1.75 1.52e-04 GO:0002696 positive regulation of leukocyte activation
1.68 2.27e-04 GO:0051249 regulation of lymphocyte activation
1.67 2.10e-02 GO:0050900 leukocyte migration
1.61 9.94e-04 GO:0002694 regulation of leukocyte activation
1.60 9.43e-04 GO:0050865 regulation of cell activation
1.60 3.18e-02 GO:0002764 immune response-regulating signaling pathway
1.44 1.41e-02 GO:0051056 regulation of small GTPase mediated signal transduction
1.40 1.22e-02 GO:0002684 positive regulation of immune system process
1.38 1.48e-02 GO:0001775 cell activation
1.37 1.06e-09 GO:0002376 immune system process
1.37 8.92e-05 GO:0006955 immune response
1.37 2.51e-02 GO:0007599 hemostasis
1.37 2.64e-02 GO:0007596 blood coagulation

Gene overrepresentation in compartment category:

Showing 1 to 7 of 7 entries
enrichment   p-value GO term description
1.18 1.33e-03 GO:0005829 cytosol
1.16 4.43e-02 GO:0031981 nuclear lumen
1.06 3.33e-02 GO:0005737 cytoplasm
1.04 6.66e-03 GO:0005622 intracellular
1.04 2.12e-02 GO:0044424 intracellular part
1.03 1.43e-03 GO:0005623 cell
1.03 1.73e-03 GO:0044464 cell part

Gene overrepresentation in function category:

Showing 1 to 5 of 5 entries
enrichment   p-value GO term description
1.44 2.27e-02 GO:0005083 small GTPase regulator activity
1.36 1.24e-02 GO:0030695 GTPase regulator activity
1.35 1.60e-02 GO:0060589 nucleoside-triphosphatase regulator activity
1.31 3.82e-04 GO:0003723 RNA binding
1.10 4.25e-07 GO:0005515 protein binding