Motif ID: NFE2.p2

Z-value: 1.389


Transcription factors associated with NFE2.p2:

Gene SymbolEntrez IDGene Name
NFE2 4778 nuclear factor (erythroid-derived 2), 45kDa



Activity profile for motif NFE2.p2.

activity profile for motif NFE2.p2


Sorted Z-values histogram for motif NFE2.p2

Sorted Z-values for motif NFE2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFE2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr22_+_21495273 3.030


chr22_+_21370394 1.951 IGL@
immunoglobulin lambda locus
chr22_+_21042091 1.951 IGLV1-44
IGL@
immunoglobulin lambda variable 1-44
immunoglobulin lambda locus
chr22_+_21393107 1.841 IGLJ3
immunoglobulin lambda joining 3
chr19_+_59107802 1.802 NM_031896
CACNG7
calcium channel, voltage-dependent, gamma subunit 7
chr22_+_20715340 1.777


chr11_+_67107852 1.655 GSTP1
glutathione S-transferase pi 1
chr11_+_67107641 1.651 NM_000852
GSTP1
glutathione S-transferase pi 1
chr22_+_21116283 1.474


chr22_+_21065202 1.459


chr22_+_21053972 1.375


chr10_-_76538859 1.372 NM_001007271
NM_001007272
NM_001007273
DUSP13


dual specificity phosphatase 13


chr8_-_145097031 1.344 NM_201380
PLEC
plectin
chr22_+_21359175 1.322 IGLV3-25
immunoglobulin lambda variable 3-25
chr22_+_21065134 1.312 LOC100290481
immunoglobulin lambda light chain-like
chr22_+_21065207 1.293 IGLJ3
immunoglobulin lambda joining 3
chr15_+_38849450 1.272 NM_001130448
C15orf62
chromosome 15 open reading frame 62
chr7_-_86526880 1.225 NM_001142749
KIAA1324L
KIAA1324-like
chr22_+_21340757 1.199


chr22_+_21464980 1.176


chr1_+_12046020 1.174 NM_001243
TNFRSF8
tumor necrosis factor receptor superfamily, member 8
chr22_+_19699441 1.155 NM_001159554
NM_005446
P2RX6

purinergic receptor P2X, ligand-gated ion channel, 6

chr10_-_31328426 1.144 NM_001143769
ZNF438
zinc finger protein 438
chr16_-_1369613 1.104 NM_001193389
NM_023076
UNKL

unkempt homolog (Drosophila)-like

chr6_-_31853027 1.058 NM_025258
C6orf27
chromosome 6 open reading frame 27
chr22_+_21552897 1.037 LOC100290481
immunoglobulin lambda light chain-like
chr22_+_20880159 1.030 IGLV6-57
immunoglobulin lambda variable 6-57
chr16_-_27806978 1.022 NM_144675
GSG1L
GSG1-like
chr9_-_130006309 1.013 NM_001131015
NM_012127
CIZ1

CDKN1A interacting zinc finger protein 1

chr22_+_21094094 0.950


chr17_+_27795598 0.919 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chrX_+_9391314 0.910 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr22_+_20899155 0.907


chr1_+_12698704 0.904 NM_001103169
NM_001103170
AADACL3

arylacetamide deacetylase-like 3

chr7_+_22733290 0.899 NM_000600
IL6
interleukin 6 (interferon, beta 2)
chr17_+_27795635 0.898 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr8_-_42742729 0.886 NM_004198
CHRNA6
cholinergic receptor, nicotinic, alpha 6
chr6_+_44302973 0.854 SLC29A1
solute carrier family 29 (nucleoside transporters), member 1
chr9_-_139042526 0.853 NM_001606
ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr22_+_21079355 0.841


chr1_+_27591738 0.833 NM_005281
GPR3
G protein-coupled receptor 3
chr17_+_27795607 0.827 NM_002815
PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr17_+_27795632 0.819 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr17_+_27795633 0.817 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr5_+_176807931 0.816 NM_001174102
PRR7
proline rich 7 (synaptic)
chr12_-_51585004 0.810 NM_002273
KRT8
keratin 8
chr6_+_34314545 0.802 NM_145905
HMGA1
high mobility group AT-hook 1
chr10_-_6059460 0.798 NM_002189
NM_172200
IL15RA

interleukin 15 receptor, alpha

chr21_+_31953803 0.788 NM_000454
SOD1
superoxide dismutase 1, soluble
chr17_+_27795645 0.781 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr11_-_117305277 0.780 NM_001077263
TMPRSS13
transmembrane protease, serine 13
chr1_-_11841476 0.770 NM_002521
NPPB
natriuretic peptide B
chrX_+_37315934 0.761 LANCL3
LanC lantibiotic synthetase component C-like 3 (bacterial)
chr1_-_93030538 0.748 NM_005665
EVI5
ecotropic viral integration site 5
chr1_+_221966835 0.745 CAPN2
calpain 2, (m/II) large subunit
chr1_-_232810443 0.737


chr1_+_221966849 0.723 CAPN2
calpain 2, (m/II) large subunit
chr6_+_32229599 0.718 NM_005155
PPT2-EGFL8
PPT2
PPT2-EGFL8 read-through transcript
palmitoyl-protein thioesterase 2
chrX_+_153423652 0.717 NM_001099856
IKBKG
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
chr9_-_139042416 0.711 ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr22_+_21011653 0.700


chr7_-_99517128 0.695 NM_017715
NM_032924
ZNF3

zinc finger protein 3

chr3_-_39170105 0.692 NM_033027
CSRNP1
cysteine-serine-rich nuclear protein 1
chr8_-_143805371 0.690 LOC100288181
hypothetical LOC100288181
chr1_-_232810478 0.686


chr15_+_78520634 0.684 ARNT2
aryl-hydrocarbon receptor nuclear translocator 2
chr1_+_17507276 0.683 NM_012387
PADI4
peptidyl arginine deiminase, type IV
chr3_+_154035425 0.679 NM_002563
P2RY1
purinergic receptor P2Y, G-protein coupled, 1
chr16_+_82544327 0.667 NM_182981
OSGIN1
oxidative stress induced growth inhibitor 1
chr19_-_43926953 0.661 NM_144691
CAPN12
calpain 12
chrX_-_15421279 0.656 NM_001018109
NM_003662
PIR

pirin (iron-binding nuclear protein)

chr22_+_18388656 0.656 C22orf25
chromosome 22 open reading frame 25
chr21_-_35181956 0.655 RUNX1
runt-related transcription factor 1
chr1_-_232810111 0.644 IRF2BP2
interferon regulatory factor 2 binding protein 2
chr22_+_20880112 0.630


chr6_+_44322831 0.625 HSP90AB1
heat shock protein 90kDa alpha (cytosolic), class B member 1
chr1_+_226399026 0.622 NM_001159391
GUK1
guanylate kinase 1
chr7_+_139175420 0.622 NM_001061
NM_001166253
NM_030984
TBXAS1


thromboxane A synthase 1 (platelet)


chr7_-_38355949 0.616


chr6_+_44322764 0.615 NM_007355
HSP90AB1
heat shock protein 90kDa alpha (cytosolic), class B member 1
chr3_-_39170038 0.613 CSRNP1
cysteine-serine-rich nuclear protein 1
chr7_+_26298018 0.604 NM_013322
SNX10
sorting nexin 10
chr7_-_150352484 0.596 NM_173681
ATG9B
ATG9 autophagy related 9 homolog B (S. cerevisiae)
chr3_+_185377341 0.592 AP2M1
adaptor-related protein complex 2, mu 1 subunit
chr3_+_49002285 0.591 NM_177938
NM_177939
P4HTM

prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)

chr19_+_1199548 0.588 NM_177401
MIDN
midnolin
chr1_+_40399618 0.584 NM_012421
RLF
rearranged L-myc fusion
chr13_-_98757634 0.582 NM_004951
GPR183
G protein-coupled receptor 183
chrX_-_53327473 0.579 NM_015075
IQSEC2
IQ motif and Sec7 domain 2
chrX_-_154216929 0.577 NM_001289
CLIC2
chloride intracellular channel 2
chr17_-_26665213 0.575 EVI2B
ecotropic viral integration site 2B
chr19_+_43486640 0.574 NM_033520
C19orf33
chromosome 19 open reading frame 33
chr6_-_29563657 0.574 NM_052967
MAS1L
MAS1 oncogene-like
chr7_+_142788521 0.572 ZYX
zyxin
chr7_+_142788517 0.568 ZYX
zyxin
chr6_-_24985432 0.568 NM_015864
FAM65B
family with sequence similarity 65, member B
chr2_+_169634330 0.567 DHRS9
dehydrogenase/reductase (SDR family) member 9
chr1_+_221955876 0.564 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr17_-_26665194 0.564 EVI2B
ecotropic viral integration site 2B
chr1_+_40399642 0.563 RLF
rearranged L-myc fusion
chr1_+_35019376 0.559 NM_024009
GJB3
gap junction protein, beta 3, 31kDa
chr10_-_21502993 0.554 NEBL
nebulette
chr10_-_73281047 0.552 PSAP
prosaposin
chr7_+_26298136 0.551 SNX10
sorting nexin 10
chr1_-_35879725 0.550 NM_002794
PSMB2
proteasome (prosome, macropain) subunit, beta type, 2
chr4_-_38710376 0.549 NM_024943
TMEM156
transmembrane protein 156
chr17_-_39700960 0.540 NM_000342
SLC4A1
solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)
chr21_-_35343331 0.540 RUNX1
runt-related transcription factor 1
chrX_-_100527799 0.538 NM_000061
BTK
Bruton agammaglobulinemia tyrosine kinase
chr4_+_170817787 0.535 CLCN3
chloride channel 3
chr3_-_39209075 0.534 NM_194293
NM_001198621
XIRP1

xin actin-binding repeat containing 1

chr10_-_73281056 0.533 NM_001042465
NM_001042466
NM_002778
PSAP


prosaposin


chr7_-_5536783 0.533 ACTB
actin, beta
chr15_-_63290839 0.530 NM_003613
CILP
cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
chr19_+_45564549 0.530 PLD3
phospholipase D family, member 3
chr1_-_35879619 0.520 PSMB2
proteasome (prosome, macropain) subunit, beta type, 2
chr22_+_20316968 0.509 NM_152612
CCDC116
coiled-coil domain containing 116
chr9_+_139292094 0.508 NM_017723
C9orf167
chromosome 9 open reading frame 167
chr17_+_72827227 0.504 SEPT9
septin 9
chr17_-_26665144 0.502 EVI2B
ecotropic viral integration site 2B
chr19_-_54350457 0.502 NM_002152
HRC
histidine rich calcium binding protein
chrX_+_37315740 0.502 NM_001170331
NM_198511
LANCL3

LanC lantibiotic synthetase component C-like 3 (bacterial)

chr19_-_54636425 0.501 NM_020309
SLC17A7
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7
chr11_+_118463906 0.501 NM_001024382
HMBS
hydroxymethylbilane synthase
chrX_-_76824726 0.499 ATRX
alpha thalassemia/mental retardation syndrome X-linked
chr7_-_5533621 0.497 ACTB
actin, beta
chr17_+_71109734 0.495 MYO15B
myosin XVB pseudogene
chr7_+_99865189 0.494 NM_019606
MEPCE
methylphosphate capping enzyme
chr5_+_179180447 0.493 NM_003900
SQSTM1
sequestosome 1
chr5_+_179180517 0.491 SQSTM1
sequestosome 1
chr1_-_240228987 0.491 NM_001004343
MAP1LC3C
microtubule-associated protein 1 light chain 3 gamma
chr19_-_48976852 0.490 KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr1_-_7923464 0.487 NM_001561
TNFRSF9
tumor necrosis factor receptor superfamily, member 9
chr6_-_30792830 0.483 MDC1
mediator of DNA-damage checkpoint 1
chr21_-_35343065 0.481 RUNX1
runt-related transcription factor 1
chr10_+_70745615 0.481 NM_033496
HK1
hexokinase 1
chr7_+_111850367 0.481 NM_001007245
NM_001197080
IFRD1

interferon-related developmental regulator 1

chr11_+_62136788 0.478 NM_000327
ROM1
retinal outer segment membrane protein 1
chr8_-_70907957 0.477 NM_001146009
SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr8_+_67505091 0.475 RRS1
RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
chr5_-_169657312 0.469 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr11_-_65424385 0.469 FOSL1
FOS-like antigen 1
chr15_-_58477407 0.467 NM_001002857
NM_001002858
NM_001136015
NM_004039
ANXA2



annexin A2



chr15_+_72315719 0.457 NM_025055
CCDC33
coiled-coil domain containing 33
chr8_-_70908130 0.457 NM_001146008
SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr5_+_179180509 0.453 SQSTM1
sequestosome 1
chr12_-_46439127 0.452 NM_001098531
RAPGEF3
Rap guanine nucleotide exchange factor (GEF) 3
chr16_-_3025542 0.449 NM_001103175
CCDC64B
coiled-coil domain containing 64B
chr6_+_32229278 0.448 NM_138717
PPT2
palmitoyl-protein thioesterase 2
chr11_-_62136778 0.442 NM_153265
EML3
echinoderm microtubule associated protein like 3
chr10_-_73281011 0.439 PSAP
prosaposin
chr10_-_73280964 0.439 PSAP
prosaposin
chr9_+_139255563 0.437 TUBB2C
tubulin, beta 2C
chr11_+_47386621 0.437 NM_001128225
NM_152264
SLC39A13

solute carrier family 39 (zinc transporter), member 13

chr22_-_25343959 0.435 NM_001887
CRYBB1
crystallin, beta B1
chr12_-_51629874 0.434 KRT8
keratin 8
chr17_-_77474597 0.430 NM_032711
MAFG
v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)
chr2_-_85494639 0.426 CAPG
capping protein (actin filament), gelsolin-like
chr18_+_59405513 0.423 NM_012397
SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chr9_-_113286046 0.422 KIAA0368
KIAA0368
chr17_-_26665220 0.420 NM_006495
EVI2B
ecotropic viral integration site 2B
chr7_-_150561233 0.418


chrX_+_133952633 0.417 NM_001163438
LOC644538
hypothetical protein LOC644538
chr11_-_65424434 0.414 FOSL1
FOS-like antigen 1
chr9_+_139255519 0.413 NM_006088
TUBB2C
tubulin, beta 2C
chr22_-_17846711 0.413 UFD1L
ubiquitin fusion degradation 1 like (yeast)
chrX_+_65299157 0.412 NM_138737
HEPH
hephaestin
chr20_+_41621119 0.410 SGK2
serum/glucocorticoid regulated kinase 2
chr9_-_139202855 0.409 NM_013366
ANAPC2
anaphase promoting complex subunit 2
chr1_-_89261021 0.408 NM_018284
GBP3
guanylate binding protein 3
chr5_-_169657395 0.406 NM_005565
LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr11_+_46358909 0.405 NM_001012334
MDK
midkine (neurite growth-promoting factor 2)
chr22_+_21006814 0.405


chr6_+_41712907 0.405 MDFI
MyoD family inhibitor
chrX_-_2896285 0.403 ARSE
arylsulfatase E (chondrodysplasia punctata 1)
chr12_+_47205681 0.403 NM_001005203
OR8S1
olfactory receptor, family 8, subfamily S, member 1
chr9_+_139255559 0.402 TUBB2C
tubulin, beta 2C
chr11_+_62405736 0.402 SLC3A2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
chr8_-_11242408 0.401 LOC100129129
hypothetical LOC100129129
chr8_-_125453815 0.401 TMEM65
transmembrane protein 65
chr1_-_223683141 0.400 NM_194442
LBR
lamin B receptor
chr1_-_114855281 0.400 NM_015906
NM_033020
TRIM33

tripartite motif containing 33

chr6_+_84626113 0.397 CYB5R4
cytochrome b5 reductase 4
chr21_-_35343448 0.397 RUNX1
runt-related transcription factor 1
chr8_+_86344984 0.397 CA13
carbonic anhydrase XIII
chr9_+_130231027 0.396 CERCAM
cerebral endothelial cell adhesion molecule
chr1_+_181421984 0.394 LAMC2
laminin, gamma 2
chr2_-_85494664 0.394 CAPG
capping protein (actin filament), gelsolin-like
chr6_-_41781655 0.393 TFEB
transcription factor EB
chr8_+_86344945 0.391 NM_198584
CA13
carbonic anhydrase XIII
chr1_-_205272619 0.391 NM_001083924
NM_023938
C1orf116

chromosome 1 open reading frame 116

chr4_+_74825138 0.391 NM_000584
IL8
interleukin 8
chr9_+_131291144 0.387


chrX_-_152938456 0.385 IRAK1
interleukin-1 receptor-associated kinase 1
chr6_+_50894397 0.384 NM_003221
TFAP2B
transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
chr1_-_221604023 0.384 NM_001037175
NM_017982
SUSD4

sushi domain containing 4

chr1_-_172258129 0.381


chr1_+_229365296 0.380 NM_001004342
TRIM67
tripartite motif containing 67
chr11_+_62405801 0.379 SLC3A2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
chr7_+_142788566 0.379 ZYX
zyxin

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
4.06 1.38e-02 GO:0071158 positive regulation of cell cycle arrest
2.90 1.51e-02 GO:0034330 cell junction organization
3.96 3.97e-02 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
3.96 3.97e-02 GO:0072395 signal transduction involved in cell cycle checkpoint
3.96 3.97e-02 GO:0072401 signal transduction involved in DNA integrity checkpoint
3.96 3.97e-02 GO:0072404 signal transduction involved in G1/S transition checkpoint
3.96 3.97e-02 GO:0072413 signal transduction involved in mitotic cell cycle checkpoint
3.96 3.97e-02 GO:0072422 signal transduction involved in DNA damage checkpoint
3.96 3.97e-02 GO:0072431 signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint
3.96 3.97e-02 GO:0072474 signal transduction involved in mitotic cell cycle G1/S checkpoint
4.20 4.34e-02 GO:0006521 regulation of cellular amino acid metabolic process
3.66 4.88e-02 GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
4.72 5.36e-05 GO:0000502 proteasome complex
1.36 1.68e-02 GO:0044459 plasma membrane part
1.60 3.63e-02 GO:0005626 insoluble fraction

Nothing significant found in function category.