Motif ID: TBX4,5.p2

Z-value: 0.758


Transcription factors associated with TBX4,5.p2:

Gene SymbolEntrez IDGene Name
TBX4 9496 T-box 4
TBX5 6910 T-box 5



Activity profile for motif TBX4,5.p2.

activity profile for motif TBX4,5.p2


Sorted Z-values histogram for motif TBX4,5.p2

Sorted Z-values for motif TBX4,5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TBX4,5.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_+_168936125 0.658 NM_001122752
NM_005025
SERPINI1

serpin peptidase inhibitor, clade I (neuroserpin), member 1

chr19_+_7647934 0.526 NM_174918
C19orf59
chromosome 19 open reading frame 59
chr2_-_127679812 0.504 NM_001001665
CYP27C1
cytochrome P450, family 27, subfamily C, polypeptide 1
chr5_-_44424423 0.491 NM_004465
FGF10
fibroblast growth factor 10
chr2_-_56003859 0.488 NM_004105
EFEMP1
EGF containing fibulin-like extracellular matrix protein 1
chr2_-_217268492 0.477 NM_000599
IGFBP5
insulin-like growth factor binding protein 5
chr11_+_1897374 0.471 NM_001042780
NM_001042781
NM_001042782
NM_006757
TNNT3



troponin T type 3 (skeletal, fast)



chr17_+_53769562 0.457 LOC100506779
hypothetical LOC100506779
chr6_-_40003295 0.436 NM_005943
MOCS1
molybdenum cofactor synthesis 1
chr19_-_14748655 0.435 EMR2
egf-like module containing, mucin-like, hormone receptor-like 2
chr3_-_49701085 0.429 NM_020998
MST1
macrophage stimulating 1 (hepatocyte growth factor-like)
chrX_+_69559605 0.420 NM_001171191
NM_001171192
NM_001171193
NM_017711
GDPD2



glycerophosphodiester phosphodiesterase domain containing 2



chr1_-_183553083 0.414 NM_006469
IVNS1ABP
influenza virus NS1A binding protein
chr12_+_6292077 0.408 NM_001144857
PLEKHG6
pleckstrin homology domain containing, family G (with RhoGef domain) member 6
chr7_+_89870707 0.398 CLDN12
claudin 12
chr16_-_65287967 0.397 NM_178818
NM_181521
CMTM4

CKLF-like MARVEL transmembrane domain containing 4

chrX_-_142551587 0.396 NM_001184749
SLITRK4
SLIT and NTRK-like family, member 4
chr17_+_52266451 0.393 NM_003647
DGKE
diacylglycerol kinase, epsilon 64kDa
chr1_+_34997928 0.392 NM_153212
GJB4
gap junction protein, beta 4, 30.3kDa
chr11_-_62445587 0.387 NM_000738
CHRM1
cholinergic receptor, muscarinic 1
chr13_+_48448628 0.384 FNDC3A
fibronectin type III domain containing 3A
chr12_+_52665196 0.378 NM_017409
HOXC10
homeobox C10
chr11_+_6216905 0.374 NM_001037329
CNGA4
cyclic nucleotide gated channel alpha 4
chr1_+_176748834 0.373 NM_001170722
NM_001170723
NM_001170724
NM_032126
C1orf49



chromosome 1 open reading frame 49



chr7_+_89870647 0.372 NM_001185072
NM_001185073
NM_012129
CLDN12


claudin 12


chr1_-_183552833 0.370 IVNS1ABP
influenza virus NS1A binding protein
chr15_+_88120592 0.370 NM_001039958
MESP2
mesoderm posterior 2 homolog (mouse)
chr19_-_4782711 0.367 NM_182919
TICAM1
toll-like receptor adaptor molecule 1
chr2_+_71149193 0.367 NAGK
N-acetylglucosamine kinase
chr1_-_205161821 0.365 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr19_+_54884252 0.362 C19orf76
chromosome 19 open reading frame 76
chr16_-_66523255 0.359 NM_001907
CTRL
chymotrypsin-like
chr12_+_54946815 0.355 NM_144576
COQ10A
coenzyme Q10 homolog A (S. cerevisiae)
chr7_+_29200850 0.353 CHN2
chimerin (chimaerin) 2
chr8_+_144428083 0.351 GLI4
GLI family zinc finger 4
chr8_+_144838608 0.348 NM_001100598
NM_001100599
NM_173831
ZNF707


zinc finger protein 707


chr9_+_35722490 0.347 CREB3
cAMP responsive element binding protein 3
chr17_+_4841923 0.342 NM_006612
KIF1C
kinesin family member 1C
chr2_+_220033777 0.340 NM_001173476
SPEG
SPEG complex locus
chr12_-_116112495 0.340 NM_015002
NM_033624
FBXO21

F-box protein 21

chr11_-_3620060 0.337 NM_053017
NM_001079536
ART5

ADP-ribosyltransferase 5

chr11_-_26550243 0.336 NM_001135091
NM_001135092
NM_145650
MUC15


mucin 15, cell surface associated


chr5_-_114543632 0.334 NM_001017397
NM_001017398
NM_018700
TRIM36


tripartite motif containing 36


chr3_+_114414064 0.330 NM_033254
BOC
Boc homolog (mouse)
chr1_+_43661383 0.327 NM_015284
KIAA0467
KIAA0467
chr12_+_54946991 0.324 COQ10A
coenzyme Q10 homolog A (S. cerevisiae)
chr8_+_144838659 0.322 ZNF707
zinc finger protein 707
chr19_-_60272708 0.321 NM_138412
RDH13
retinol dehydrogenase 13 (all-trans/9-cis)
chr17_-_45427565 0.315 NM_005220
DLX3
distal-less homeobox 3
chr4_+_3285671 0.310 NM_002926
NM_198229
RGS12

regulator of G-protein signaling 12

chr17_-_59349867 0.306 NM_000515
NM_022559
NM_022560
NM_022561
NM_022562
GH1




growth hormone 1




chr1_+_149221122 0.305 NM_003568
ANXA9
annexin A9
chr11_-_2138984 0.303 NM_000207
NM_001185097
NM_001185098
NM_001042376
INS


INS-IGF2
insulin


INS-IGF2 readthrough transcript
chr19_-_10074332 0.302 NM_031917
ANGPTL6
angiopoietin-like 6
chr11_+_19095215 0.301 NM_001001483
NM_019028
ZDHHC13

zinc finger, DHHC-type containing 13

chr3_-_50311666 0.300 NM_012191
NM_003549
NAT6
HYAL3
N-acetyltransferase 6 (GCN5-related)
hyaluronoglucosaminidase 3
chr21_+_37367432 0.300 NM_001001894
TTC3
tetratricopeptide repeat domain 3
chr12_+_54947293 0.299 NM_001099337
COQ10A
coenzyme Q10 homolog A (S. cerevisiae)
chr1_-_150862202 0.298 NM_178431
LCE3A
late cornified envelope 3A
chr17_+_22823151 0.295 NM_014238
KSR1
kinase suppressor of ras 1
chr3_+_127596471 0.294 NM_182628
CCDC37
coiled-coil domain containing 37
chr19_-_14748623 0.292 EMR2
egf-like module containing, mucin-like, hormone receptor-like 2
chr8_-_145132551 0.290 PARP10
poly (ADP-ribose) polymerase family, member 10
chr10_+_7900678 0.288 NM_031923
TAF3
TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa
chr12_+_51932252 0.284 MFSD5
major facilitator superfamily domain containing 5
chrX_+_122145776 0.282 NM_000828
NM_007325
GRIA3

glutamate receptor, ionotrophic, AMPA 3

chr1_-_199613427 0.282 NM_000364
NM_001001430
NM_001001431
NM_001001432
TNNT2



troponin T type 2 (cardiac)



chr9_-_32542550 0.281 TOPORS
topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
chr8_-_145132582 0.279 NM_032789
PARP10
poly (ADP-ribose) polymerase family, member 10
chr13_+_112704077 0.277 MCF2L
MCF.2 cell line derived transforming sequence-like
chr17_-_59342319 0.275 NM_001318
NM_022579
NM_022580
NM_022581
CSHL1



chorionic somatomammotropin hormone-like 1



chr1_-_23998515 0.275 NM_001127621
GALE
UDP-galactose-4-epimerase
chr3_-_182189999 0.274 NM_001190233
NM_145261
DNAJC19

DnaJ (Hsp40) homolog, subfamily C, member 19

chr17_-_8000362 0.271 PER1
period homolog 1 (Drosophila)
chr6_-_32184975 0.267 NM_019105
TNXB
tenascin XB
chr4_+_155884600 0.265 NM_004744
LRAT
lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
chr11_-_118405288 0.265 NM_001164280
SLC37A4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr12_+_112107747 0.265 NM_032848
C12orf52
chromosome 12 open reading frame 52
chr2_+_65070030 0.264 SLC1A4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr1_-_200395741 0.259 NM_080588
PTPN7
protein tyrosine phosphatase, non-receptor type 7
chr18_-_42490993 0.258 NM_144612
LOXHD1
lipoxygenase homology domains 1
chr1_+_117950029 0.258 NM_017709
FAM46C
family with sequence similarity 46, member C
chr5_+_133889584 0.258 NM_015288
PHF15
PHD finger protein 15
chr7_-_123460722 0.257 NM_001136002
TMEM229A
transmembrane protein 229A
chr2_-_56004366 0.256 NM_001039348
NM_001039349
EFEMP1

EGF containing fibulin-like extracellular matrix protein 1

chr8_-_145097031 0.256 NM_201380
PLEC
plectin
chr16_+_48865521 0.255 ADCY7
adenylate cyclase 7
chr17_+_23393744 0.255 NM_016231
NLK
nemo-like kinase
chr9_-_32542573 0.255 NM_001195622
NM_005802
TOPORS

topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase

chr17_+_4621924 0.254 NM_003963
TM4SF5
transmembrane 4 L six family member 5
chr2_+_208102860 0.252 NM_004379
NM_134442
CREB1

cAMP responsive element binding protein 1

chr7_-_150283794 0.251 NM_172057
KCNH2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr9_+_35722629 0.251 CREB3
cAMP responsive element binding protein 3
chr17_+_45488356 0.250 ITGA3
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
chr13_+_112704051 0.249 MCF2L
MCF.2 cell line derived transforming sequence-like
chr17_-_28644118 0.248 NM_183377
ACCN1
amiloride-sensitive cation channel 1, neuronal
chr3_-_10307408 0.248 NM_001134941
NM_016362
GHRL

ghrelin/obestatin prepropeptide

chrX_-_102234606 0.246 NM_022052
NXF3
nuclear RNA export factor 3
chr1_+_152644471 0.245 IL6R
interleukin 6 receptor
chr20_+_43531806 0.244 NM_006103
WFDC2
WAP four-disulfide core domain 2
chrX_+_95826507 0.242 DIAPH2
diaphanous homolog 2 (Drosophila)
chr12_+_54947180 0.240 COQ10A
coenzyme Q10 homolog A (S. cerevisiae)
chr14_+_20595820 0.239 NM_138331
RNASE8
ribonuclease, RNase A family, 8
chr1_+_116320641 0.239 NM_018420
SLC22A15
solute carrier family 22, member 15
chr4_-_149582754 0.239 NR3C2
nuclear receptor subfamily 3, group C, member 2
chr12_-_118725672 0.238 CIT
citron (rho-interacting, serine/threonine kinase 21)
chr4_-_147079410 0.237


chr2_-_63518589 0.236 NM_001042692
WDPCP
WD repeat containing planar cell polarity effector
chr12_-_56312696 0.235 B4GALNT1
beta-1,4-N-acetyl-galactosaminyl transferase 1
chr5_+_175597943 0.234 NM_198567
C5orf25
chromosome 5 open reading frame 25
chr22_-_34965612 0.234 NM_030882
APOL2
apolipoprotein L, 2
chr13_-_101852028 0.234 NM_175929
FGF14
fibroblast growth factor 14
chr22_-_49240594 0.233 SBF1
SET binding factor 1
chr14_+_19598043 0.232 NM_001004717
OR4L1
olfactory receptor, family 4, subfamily L, member 1
chr10_-_76538859 0.232 NM_001007271
NM_001007272
NM_001007273
DUSP13


dual specificity phosphatase 13


chr17_-_10682123 0.231 NM_001101387
PIRT
phosphoinositide-interacting regulator of transient receptor potential channels
chr19_+_50601708 0.229 CD3EAP
CD3e molecule, epsilon associated protein
chr14_-_106270497 0.229 IGHG3
immunoglobulin heavy constant gamma 3 (G3m marker)
chr17_+_69721095 0.227 NM_032646
TTYH2
tweety homolog 2 (Drosophila)
chr3_+_10832867 0.227 NM_014229
SLC6A11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr13_+_21143083 0.226 NM_002010
FGF9
fibroblast growth factor 9 (glia-activating factor)
chr16_+_84204424 0.226 NM_014615
KIAA0182
KIAA0182
chr9_-_94095787 0.225 NM_013417
IARS
isoleucyl-tRNA synthetase
chr5_-_140875591 0.225 DIAPH1
diaphanous homolog 1 (Drosophila)
chr9_-_94095807 0.225 IARS
isoleucyl-tRNA synthetase
chr8_-_142446546 0.224 NM_005293
GPR20
G protein-coupled receptor 20
chr1_+_15964045 0.222 NM_001024216
FBLIM1
filamin binding LIM protein 1
chr1_+_152644292 0.222 NM_000565
NM_181359
IL6R

interleukin 6 receptor

chr1_+_6226838 0.221 NM_001024598
HES3
hairy and enhancer of split 3 (Drosophila)
chr1_+_149750485 0.221 NM_020770
CGN
cingulin
chr16_+_65018316 0.220 NM_001136106
NM_001178020
NM_001197224
NM_001197225
BEAN1



brain expressed, associated with NEDD4, 1



chr1_+_26609893 0.220 LIN28A
lin-28 homolog A (C. elegans)
chr22_+_37823174 0.219 NM_001166002
NM_001166003
NM_001166004
NM_181773
APOBEC3H



apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H



chr12_+_53229625 0.219 PDE1B
phosphodiesterase 1B, calmodulin-dependent
chr13_+_112704028 0.217 MCF2L
MCF.2 cell line derived transforming sequence-like
chr4_-_75938710 0.216 NM_001729
BTC
betacellulin
chr13_+_48448912 0.215 FNDC3A
fibronectin type III domain containing 3A
chr1_-_199613406 0.215 TNNT2
troponin T type 2 (cardiac)
chr2_+_208102937 0.214 CREB1
cAMP responsive element binding protein 1
chr1_+_152644668 0.214 IL6R
interleukin 6 receptor
chr1_+_201711578 0.213 PRELP
proline/arginine-rich end leucine-rich repeat protein
chr1_-_247119516 0.213 NM_001136036
ZNF692
zinc finger protein 692
chr1_-_154215558 0.213 ARHGEF2
Rho/Rac guanine nucleotide exchange factor (GEF) 2
chr19_-_63092099 0.212 NM_001144989
ZNF814
zinc finger protein 814
chr1_-_203557379 0.210 NM_030952
NUAK2
NUAK family, SNF1-like kinase, 2
chr12_+_7039453 0.209


chr11_+_113815317 0.207 NM_015523
REXO2
REX2, RNA exonuclease 2 homolog (S. cerevisiae)
chr1_-_43606192 0.207 ELOVL1
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1
chr11_+_67532592 0.206 NM_001161473
ALDH3B1
aldehyde dehydrogenase 3 family, member B1
chr11_+_68818175 0.206 NM_138768
MYEOV
myeloma overexpressed (in a subset of t(11;14) positive multiple myelomas)
chr19_+_810673 0.206 CFD
complement factor D (adipsin)
chrX_+_100241453 0.206 NM_006733
CENPI
centromere protein I
chr17_-_3248453 0.205 NM_003553
OR1E1
olfactory receptor, family 1, subfamily E, member 1
chr9_-_138880530 0.205 NM_003792
NM_153200
EDF1

endothelial differentiation-related factor 1

chr11_+_68614059 0.204


chr5_+_140871107 0.203


chr17_+_39654808 0.202


chr10_-_71871364 0.201 NODAL
nodal homolog (mouse)
chr1_-_35143570 0.201 NM_001080418
DLGAP3
discs, large (Drosophila) homolog-associated protein 3
chr4_-_44423275 0.201 NM_138335
GNPDA2
glucosamine-6-phosphate deaminase 2
chr16_-_83095720 0.201 NM_020947
KIAA1609
KIAA1609
chr9_-_27519434 0.200 NM_024761
MOBKL2B
MOB1, Mps One Binder kinase activator-like 2B (yeast)
chr14_-_105644300 0.200 IGHV4-31
IGHA1
IGHA2
IGHG1
IGHG3
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
chr7_+_29200636 0.199 NM_004067
CHN2
chimerin (chimaerin) 2
chr12_-_46438447 0.197 NM_001098532
NM_006105
RAPGEF3

Rap guanine nucleotide exchange factor (GEF) 3

chr12_+_103375116 0.197 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr8_-_74822496 0.196 NM_001164384
STAU2
staufen, RNA binding protein, homolog 2 (Drosophila)
chr5_-_49772973 0.195 NM_198449
EMB
embigin
chr10_-_93382779 0.194 PPP1R3C
protein phosphatase 1, regulatory (inhibitor) subunit 3C
chr8_+_26569709 0.194 DPYSL2
dihydropyrimidinase-like 2
chr1_-_43606276 0.193 NM_022821
ELOVL1
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1
chr17_-_59304729 0.193 NM_020991
NM_022644
NM_022645
CSH2


chorionic somatomammotropin hormone 2


chr1_-_43605935 0.192 ELOVL1
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1
chr2_-_96311367 0.191 SNRNP200
small nuclear ribonucleoprotein 200kDa (U5)
chr5_+_96297101 0.191 NM_005575
LNPEP
leucyl/cystinyl aminopeptidase
chr12_-_51173238 0.191 NM_005554
KRT6A
keratin 6A
chrX_+_152891184 0.190 NM_003492
TMEM187
transmembrane protein 187
chr1_-_35879725 0.190 NM_002794
PSMB2
proteasome (prosome, macropain) subunit, beta type, 2
chrX_-_62921937 0.190 NM_001173479
ARHGEF9
Cdc42 guanine nucleotide exchange factor (GEF) 9
chr1_-_158091760 0.190 NM_001134233
C1orf204
chromosome 1 open reading frame 204
chr8_-_124622434 0.190 NM_058229
FBXO32
F-box protein 32
chr17_-_3408038 0.189 NM_145068
TRPV3
transient receptor potential cation channel, subfamily V, member 3
chr17_-_59327602 0.189 NM_001317
NM_022640
NM_022641
CSH1


CSH2
chorionic somatomammotropin hormone 1 (placental lactogen)


chorionic somatomammotropin hormone 2
chr9_-_94095810 0.188 NM_002161
IARS
isoleucyl-tRNA synthetase
chr2_+_241776596 0.188 NM_001001666
NM_001001891
ANO7

anoctamin 7

chr1_-_1701313 0.188 NM_001198994
NADK
NAD kinase
chr21_-_45786709 0.188 NM_194255
SLC19A1
solute carrier family 19 (folate transporter), member 1
chr3_+_127905727 0.188 NM_032343
CHCHD6
coiled-coil-helix-coiled-coil-helix domain containing 6
chr17_+_7283412 0.187 NM_004112
FGF11
fibroblast growth factor 11
chr9_+_128716867 0.187 NM_001190729
NM_001190730
NM_014636
RALGPS1


Ral GEF with PH domain and SH3 binding motif 1


chr15_+_83324651 0.187 PDE8A
phosphodiesterase 8A
chr18_-_57711283 0.187 NM_173557
RNF152
ring finger protein 152
chr22_+_36401558 0.187 NM_002305
LGALS1
lectin, galactoside-binding, soluble, 1
chr13_+_48448950 0.186 FNDC3A
fibronectin type III domain containing 3A
chr11_-_65869113 0.186 NM_001024957
NM_015399
BRMS1

breast cancer metastasis suppressor 1

chr19_-_46626474 0.185 NM_198540
B3GNT8
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8
chr22_+_36928011 0.185 MAFF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr10_+_75343352 0.184 PLAU
plasminogen activator, urokinase
chr5_-_49772940 0.184 EMB
embigin
chr4_+_48038095 0.183 SLAIN2
SLAIN motif family, member 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.07 2.08e-03 GO:0009987 cellular process
1.11 3.99e-03 GO:0065007 biological regulation
1.12 6.08e-03 GO:0050794 regulation of cellular process
1.11 1.22e-02 GO:0050789 regulation of biological process
1.38 2.19e-02 GO:0007154 cell communication
1.32 2.87e-02 GO:0051239 regulation of multicellular organismal process
2.08 3.69e-02 GO:0060537 muscle tissue development
1.17 4.77e-02 GO:0023052 signaling

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.77 2.41e-02 GO:0005911 cell-cell junction
1.21 2.88e-02 GO:0044459 plasma membrane part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.11 1.58e-03 GO:0005515 protein binding