Motif ID: NFIX.p2

Z-value: 1.342


Transcription factors associated with NFIX.p2:

Gene SymbolEntrez IDGene Name
NFIX 4784 nuclear factor I/X (CCAAT-binding transcription factor)



Activity profile for motif NFIX.p2.

activity profile for motif NFIX.p2


Sorted Z-values histogram for motif NFIX.p2

Sorted Z-values for motif NFIX.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFIX.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_89597257 2.343 NM_016323
HERC5
hect domain and RLD 5
chr21_+_44818033 2.212 NM_198687
KRTAP10-4
keratin associated protein 10-4
chr4_-_75938710 2.091 NM_001729
BTC
betacellulin
chr2_-_56266408 1.768 LOC100129434
hypothetical LOC100129434
chr16_+_65790514 1.479 NM_024712
ELMO3
engulfment and cell motility 3
chr19_-_3752809 1.468 NM_002378
MATK
megakaryocyte-associated tyrosine kinase
chr6_+_53767251 1.374 LRRC1
leucine rich repeat containing 1
chr6_-_26125939 1.368 NM_005325
HIST1H1A
histone cluster 1, H1a
chr21_+_32706615 1.344 NM_058187
C21orf63
chromosome 21 open reading frame 63
chr10_+_88718167 1.306 NM_006829
C10orf116
chromosome 10 open reading frame 116
chr14_+_23575460 1.281 NM_001082488
DHRS4L1
dehydrogenase/reductase (SDR family) member 4 like 1
chr21_-_44836811 1.197 NM_198688
KRTAP10-6
keratin associated protein 10-6
chr21_-_27139563 1.147 NM_006988
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr21_-_44795769 1.124 NM_198693
KRTAP10-2
keratin associated protein 10-2
chr9_+_111582317 1.114 NM_053016
NM_007203
NM_147150
PALM2
PALM2-AKAP2

paralemmin 2
PALM2-AKAP2 readthrough

chr12_+_106236281 1.077 NM_001018072
BTBD11
BTB (POZ) domain containing 11
chr21_+_44871467 1.043 NM_198690
KRTAP10-9
keratin associated protein 10-9
chr1_+_219026661 1.007 NM_022746
MOSC1
MOCO sulphurase C-terminal domain containing 1
chr3_-_197103848 0.975 TNK2
tyrosine kinase, non-receptor, 2
chr12_+_81604752 0.935 TMTC2
transmembrane and tetratricopeptide repeat containing 2
chr8_-_101227203 0.928 NM_001029860
FBXO43
F-box protein 43
chr10_-_128884411 0.914 NM_001039762
FAM196A
family with sequence similarity 196, member A
chr5_+_178919298 0.907 NM_001040451
NM_001040452
RUFY1

RUN and FYVE domain containing 1

chr5_+_132111034 0.895 NM_001039780
CCNI2
cyclin I family, member 2
chr7_-_123460722 0.882 NM_001136002
TMEM229A
transmembrane protein 229A
chr17_-_25587079 0.869 NM_001045
SLC6A4
solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
chr17_-_68100537 0.839 LOC100499467
hypothetical LOC100499467
chr5_+_148941228 0.831 NM_001001669
ARHGEF37
Rho guanine nucleotide exchange factor (GEF) 37
chr2_+_37425240 0.784 NM_012413
QPCT
glutaminyl-peptide cyclotransferase
chr11_+_10428799 0.763 NM_000480
AMPD3
adenosine monophosphate deaminase 3
chr17_-_5428491 0.763 NM_001033053
NM_014922
NM_033004
NM_033006
NM_033007
NLRP1




NLR family, pyrin domain containing 1




chr22_+_44828338 0.741


chr3_+_191714533 0.738 NM_001167928
NM_001167929
NM_001167930
NM_001167931
NM_002182
NM_134470
IL1RAP





interleukin 1 receptor accessory protein





chr1_-_115433570 0.725 NM_005725
TSPAN2
tetraspanin 2
chr21_+_44844924 0.689 NM_198689
KRTAP10-7
keratin associated protein 10-7
chr15_+_38849450 0.678 NM_001130448
C15orf62
chromosome 15 open reading frame 62
chr9_-_25668230 0.676 TUSC1
tumor suppressor candidate 1
chr10_+_122206455 0.667 NM_001030059
PPAPDC1A
phosphatidic acid phosphatase type 2 domain containing 1A
chr9_-_19092648 0.662 HAUS6
HAUS augmin-like complex, subunit 6
chr20_-_4177519 0.660 NM_000678
ADRA1D
adrenergic, alpha-1D-, receptor
chr5_-_111121150 0.658 NM_001142479
NM_001142480
NM_001142478
C5orf13


chromosome 5 open reading frame 13


chr17_+_35587767 0.638 NM_016339
RAPGEFL1
Rap guanine nucleotide exchange factor (GEF)-like 1
chr5_+_94981735 0.621 NM_199243
GPR150
G protein-coupled receptor 150
chr10_-_45488162 0.616 NM_001128324
NM_174890
ANUBL1

AN1, ubiquitin-like, homolog (Xenopus laevis)

chr5_-_111120764 0.615 C5orf13
chromosome 5 open reading frame 13
chr21_-_27139143 0.610 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr5_-_169340321 0.599 NM_001129891
FAM196B
family with sequence similarity 196, member B
chr4_-_99798563 0.597 NM_005723
TSPAN5
tetraspanin 5
chr9_+_70926205 0.594 TJP2
tight junction protein 2 (zona occludens 2)
chr19_-_15869870 0.583 NM_001082
CYP4F2
cytochrome P450, family 4, subfamily F, polypeptide 2
chr7_+_33911636 0.581 NM_133468
BMPER
BMP binding endothelial regulator
chr14_+_51025604 0.579 NM_001042481
FRMD6
FERM domain containing 6
chr4_-_85638410 0.573 NM_006168
NKX6-1
NK6 homeobox 1
chr3_-_162305319 0.570 NM_033169
NM_001038628
NM_003781
NM_033167
NM_033168
B3GALNT1




beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)




chr21_+_44881700 0.569 NM_181688
KRTAP10-10
keratin associated protein 10-10
chr7_-_80386602 0.568 NM_006379
SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chrX_-_100070553 0.565 NM_212559
XKRX
XK, Kell blood group complex subunit-related, X-linked
chr21_+_44941514 0.562 NM_198699
KRTAP10-12
keratin associated protein 10-12
chr11_-_30564338 0.559 NM_001145399
MPPED2
metallophosphoesterase domain containing 2
chr8_-_6722848 0.548 NM_005218
DEFB1
defensin, beta 1
chr1_-_150232900 0.545 S100A10
S100 calcium binding protein A10
chr21_-_43671355 0.540 NM_173354
SIK1
salt-inducible kinase 1
chr4_+_77446700 0.538 NM_003943
STBD1
starch binding domain 1
chr19_+_7505037 0.538 NM_006702
NM_001166112
PNPLA6

patatin-like phospholipase domain containing 6

chr19_-_1188840 0.532 NM_152769
C19orf26
chromosome 19 open reading frame 26
chr5_-_111120929 0.531 NM_001142482
NM_001142481
C5orf13

chromosome 5 open reading frame 13

chr20_-_43370333 0.530 NM_003833
NM_030590
NM_030592
MATN4


matrilin 4


chr9_-_21549696 0.519 LOC554202
hypothetical LOC554202
chr9_+_70926009 0.519 NM_001170414
TJP2
tight junction protein 2 (zona occludens 2)
chr9_+_77695334 0.516 NM_001190482
NM_006200
PCSK5

proprotein convertase subtilisin/kexin type 5

chr18_-_24010944 0.513 CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr15_-_68971665 0.512 NM_020147
THAP10
THAP domain containing 10
chr13_+_27392136 0.505 NM_000209
PDX1
pancreatic and duodenal homeobox 1
chr8_+_79740813 0.501 NM_016010
FAM164A
family with sequence similarity 164, member A
chr9_-_25668855 0.499 NM_001004125
TUSC1
tumor suppressor candidate 1
chr10_+_124210980 0.493 NM_002775
HTRA1
HtrA serine peptidase 1
chr1_+_20788027 0.492 NM_001785
CDA
cytidine deaminase
chr5_-_157011665 0.491


chr16_-_73830480 0.490 NM_001170721
BCAR1
breast cancer anti-estrogen resistance 1
chr21_+_44890758 0.487 NM_198692
KRTAP10-11
keratin associated protein 10-11
chr5_-_179162480 0.486 NM_054013
MGAT4B
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
chr3_+_63928459 0.483 NM_001128149
ATXN7
ataxin 7
chr1_-_153514124 0.477 CLK2
CDC-like kinase 2
chr1_+_156417302 0.468 CD1D
CD1d molecule
chr5_+_34720368 0.466 NM_001145521
NM_001145525
RAI14

retinoic acid induced 14

chr3_+_129117007 0.466 KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr3_+_44571600 0.465 NM_018651
NM_025169
ZNF167

zinc finger protein 167

chr17_+_29621352 0.461 NM_006273
CCL7
chemokine (C-C motif) ligand 7
chr1_-_205272619 0.457 NM_001083924
NM_023938
C1orf116

chromosome 1 open reading frame 116

chr16_-_29818334 0.457 SEZ6L2
seizure related 6 homolog (mouse)-like 2
chr1_-_150232927 0.452 S100A10
S100 calcium binding protein A10
chr3_-_46481346 0.442 NM_002343
LTF
lactotransferrin
chr9_-_32516164 0.441 NM_014314
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr14_-_89490780 0.438 NM_145231
EFCAB11
EF-hand calcium binding domain 11
chr11_+_27019084 0.437 NM_003986
BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr2_+_17923404 0.435 NM_002252
KCNS3
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3
chr9_+_111850770 0.432 AKAP2
A kinase (PRKA) anchor protein 2
chr17_+_34574844 0.431 LOC284108
hypothetical protein LOC284108
chr9_+_111850698 0.431 NM_001004065
NM_001198656
AKAP2

A kinase (PRKA) anchor protein 2

chr4_+_77446906 0.422 STBD1
starch binding domain 1
chr6_-_150285838 0.419 NM_001001788
RAET1G
retinoic acid early transcript 1G
chr17_-_37960295 0.417


chr13_-_76358370 0.415 KCTD12
potassium channel tetramerisation domain containing 12
chr5_-_111120817 0.413 NM_004772
C5orf13
chromosome 5 open reading frame 13
chr2_+_241023703 0.411 NM_002081
GPC1
glypican 1
chr4_+_158216631 0.404 NM_000824
NM_001166061
NM_001166060
GLRB


glycine receptor, beta


chr17_-_43470134 0.403 NM_016429
COPZ2
coatomer protein complex, subunit zeta 2
chr10_-_123346148 0.399 NM_001144915
FGFR2
fibroblast growth factor receptor 2
chr9_-_97308687 0.397 PTCH1
patched 1
chr17_+_72795567 0.392 NM_001113492
SEPT9
septin 9
chr14_-_104507862 0.391 AHNAK2
AHNAK nucleoprotein 2
chr5_+_76418214 0.390 LOC728723
hypothetical LOC728723
chr3_-_129882607 0.388 RPN1
ribophorin I
chr7_+_94377145 0.385 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory (inhibitor) subunit 9A


chr3_+_50279993 0.384 NM_001005914
NM_004636
SEMA3B

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B

chr21_-_44803049 0.381 NM_198696
KRTAP10-3
keratin associated protein 10-3
chr4_+_8493396 0.378 NM_152544
METTL19
methyltransferase like 19
chr3_+_185762233 0.373 NM_004443
EPHB3
EPH receptor B3
chr11_-_68537243 0.370 NM_001098515
NM_145015
MRGPRF

MAS-related GPR, member F

chr1_+_77105746 0.369 NM_030965
ST6GALNAC5
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chr9_-_112840801 0.367 LPAR1
lysophosphatidic acid receptor 1
chr1_-_234295293 0.366 NID1
nidogen 1
chr1_+_77105709 0.362 ST6GALNAC5
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chr11_+_112690460 0.358 NM_017868
TTC12
tetratricopeptide repeat domain 12
chr10_-_88843806 0.356 GLUD1
glutamate dehydrogenase 1
chr11_-_75057299 0.354 MAP6
microtubule-associated protein 6
chr17_-_37960136 0.353 HSD17B1
hydroxysteroid (17-beta) dehydrogenase 1
chr12_-_41269679 0.351 NM_153026
PRICKLE1
prickle homolog 1 (Drosophila)
chr19_-_20540380 0.346 NM_001159293
ZNF737
zinc finger protein 737
chr1_-_72520735 0.340 NM_173808
NEGR1
neuronal growth regulator 1
chr10_-_105352098 0.337 SH3PXD2A
SH3 and PX domains 2A
chr1_+_24701886 0.334 NM_013441
RCAN3
RCAN family member 3
chr1_-_68470585 0.332 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr5_+_35653702 0.332 NM_024867
NM_144722
SPEF2

sperm flagellar 2

chr5_-_157011949 0.332 NM_007017
NM_178424
SOX30

SRY (sex determining region Y)-box 30

chr4_+_155707089 0.330 FGB
fibrinogen beta chain
chr22_+_29974368 0.328 LIMK2
LIM domain kinase 2
chr6_+_150326802 0.326 NM_025218
ULBP1
UL16 binding protein 1
chr4_-_11039600 0.325 NM_005114
HS3ST1
heparan sulfate (glucosamine) 3-O-sulfotransferase 1
chr14_+_58174489 0.325 NM_001079520
NM_016651
DACT1

dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)

chr11_+_71613472 0.324 NM_001567
INPPL1
inositol polyphosphate phosphatase-like 1
chr1_-_19487790 0.323 NM_012067
AKR7A3
aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
chr9_-_83493415 0.322 NM_005077
TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr4_-_143987053 0.322 NM_001101669
NM_003866
INPP4B

inositol polyphosphate-4-phosphatase, type II, 105kDa

chr7_-_80386258 0.317 SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr1_+_63832067 0.315 NM_001172819
PGM1
phosphoglucomutase 1
chr7_-_100630912 0.313 NM_178176
MOGAT3
monoacylglycerol O-acyltransferase 3
chr11_-_117203937 0.311 NM_021603
FXYD2
FXYD domain containing ion transport regulator 2
chr12_+_6179736 0.311 NM_001769
CD9
CD9 molecule
chr11_-_119514011 0.310 TRIM29
tripartite motif containing 29
chr1_+_157408000 0.309 NM_021189
NM_001127173
CADM3

cell adhesion molecule 3

chr1_+_2313152 0.309 RER1
RER1 retention in endoplasmic reticulum 1 homolog (S. cerevisiae)
chr5_+_76418545 0.309 LOC728723
hypothetical LOC728723
chrX_+_154264931 0.309 NM_001007523
NM_001007524
NM_012151
F8A2
F8A3
F8A1
coagulation factor VIII-associated (intronic transcript) 2
coagulation factor VIII-associated (intronic transcript) 3
coagulation factor VIII-associated (intronic transcript) 1
chr12_+_51730101 0.307 NM_170754
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr5_-_80725704 0.307 NM_130767
ACOT12
acyl-CoA thioesterase 12
chr4_-_120768563 0.304 NM_033437
PDE5A
phosphodiesterase 5A, cGMP-specific
chr10_+_102782151 0.303 SFXN3
sideroflexin 3
chr5_-_156935283 0.302


chrX_-_107866262 0.302 NM_003604
IRS4
insulin receptor substrate 4
chr5_+_122452739 0.302 NM_001136239
PRDM6
PR domain containing 6
chr2_-_162883062 0.301 NM_022168
IFIH1
interferon induced with helicase C domain 1
chr6_-_119512035 0.300 NM_001100411
FAM184A
family with sequence similarity 184, member A
chr2_+_241023880 0.298


chr2_-_110231431 0.298 NM_005434
MALL
mal, T-cell differentiation protein-like
chr11_-_119514058 0.297 NM_012101
TRIM29
tripartite motif containing 29
chr17_+_6879960 0.296 NM_201566
SLC16A13
solute carrier family 16, member 13 (monocarboxylic acid transporter 13)
chr8_-_68037378 0.292 NM_001193502
TCF24
transcription factor 24
chr11_-_119513948 0.292 TRIM29
tripartite motif containing 29
chr11_+_113280727 0.291 NM_006028
HTR3B
5-hydroxytryptamine (serotonin) receptor 3B
chr5_-_125958503 0.288 NM_001182
ALDH7A1
aldehyde dehydrogenase 7 family, member A1
chr11_+_696607 0.288 EPS8L2
EPS8-like 2
chr9_+_15412875 0.287 SNAPC3
small nuclear RNA activating complex, polypeptide 3, 50kDa
chr10_-_101759630 0.285 NM_015221
DNMBP
dynamin binding protein
chr4_-_8493327 0.285 NM_001101667
NM_003501
ACOX3

acyl-CoA oxidase 3, pristanoyl

chr19_+_48808092 0.283 NM_001145641
SRRM5
serine/arginine repetitive matrix 5
chr12_+_81605032 0.282 NM_152588
TMTC2
transmembrane and tetratricopeptide repeat containing 2
chr11_+_60916394 0.282 NM_001173990
NM_001173991
NM_016499
TMEM216


transmembrane protein 216


chr17_+_6495694 0.282 NM_001105520
C17orf100
chromosome 17 open reading frame 100
chr9_-_74169649 0.282 NM_001102420
NM_001102421
NM_006007
ZFAND5


zinc finger, AN1-type domain 5


chr8_-_7200278 0.280 FAM66B
family with sequence similarity 66, member B
chr3_-_46710137 0.278 NM_001190707
NM_147129
ALS2CL

ALS2 C-terminal like

chr8_+_101239407 0.277 NM_172218
SPAG1
sperm associated antigen 1
chr3_-_50349830 0.277 RASSF1
Ras association (RalGDS/AF-6) domain family member 1
chr17_+_74531873 0.277 C1QTNF1
C1q and tumor necrosis factor related protein 1
chr5_-_37875538 0.276 NM_000514
GDNF
glial cell derived neurotrophic factor
chr16_-_29817841 0.276 NM_001114099
NM_001114100
NM_012410
NM_201575
SEZ6L2



seizure related 6 homolog (mouse)-like 2



chr14_+_104785936 0.276 BTBD6
BTB (POZ) domain containing 6
chr1_+_2313135 0.273 RER1
RER1 retention in endoplasmic reticulum 1 homolog (S. cerevisiae)
chr1_+_149286796 0.272 NM_017860
C1orf56
chromosome 1 open reading frame 56
chr14_+_23968979 0.270 NM_015299
KHNYN
KH and NYN domain containing
chr4_-_1980756 0.267 NM_005663
WHSC2
Wolf-Hirschhorn syndrome candidate 2
chr5_-_9683462 0.267 NM_019599
TAS2R1
taste receptor, type 2, member 1
chr15_+_68971835 0.266 NM_001199017
NM_017691
NM_001199018
LRRC49


leucine rich repeat containing 49


chr6_+_3696224 0.266


chr6_+_155579788 0.266 NM_001010927
TIAM2
T-cell lymphoma invasion and metastasis 2
chr16_-_70053589 0.263 NM_145911
ZNF23
zinc finger protein 23 (KOX 16)
chr17_+_17952744 0.261 NM_016239
MYO15A
myosin XVA
chr9_-_32991518 0.260 NM_001195249
NM_001195254
NM_001195248
NM_001195250
NM_001195251
NM_001195252
NM_175069
NM_175073
APTX







aprataxin







chr12_+_50271283 0.258 NM_014191
SCN8A
sodium channel, voltage gated, type VIII, alpha subunit

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.10 4.25e-03 GO:0009987 cellular process
1.41 9.68e-03 GO:0023051 regulation of signaling

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.12 7.22e-03 GO:0005737 cytoplasm
1.16 8.32e-03 GO:0044444 cytoplasmic part
1.08 4.02e-02 GO:0044424 intracellular part

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.39 1.21e-02 GO:0005539 glycosaminoglycan binding
2.57 2.17e-02 GO:0008201 heparin binding
2.21 4.98e-02 GO:0001871 pattern binding
2.21 4.98e-02 GO:0030247 polysaccharide binding