Motif ID: TP53.p2

Z-value: 0.890


Transcription factors associated with TP53.p2:

Gene SymbolEntrez IDGene Name
TP53 7157 tumor protein p53



Activity profile for motif TP53.p2.

activity profile for motif TP53.p2


Sorted Z-values histogram for motif TP53.p2

Sorted Z-values for motif TP53.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TP53.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_36752244 1.367 NM_078467
CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr19_-_8670054 1.036 NM_178525
ACTL9
actin-like 9
chr1_+_32443822 0.989 NM_001160042
NM_018134
IQCC

IQ motif containing C

chr19_-_47619992 0.953 LIPE
lipase, hormone-sensitive
chr12_+_54832470 0.879 NM_002475
MYL6B
myosin, light chain 6B, alkali, smooth muscle and non-muscle
chr22_-_18687511 0.765 NM_033257
DGCR6L
DiGeorge syndrome critical region gene 6-like
chr7_+_72206961 0.759 GTF2IP1
general transcription factor IIi, pseudogene 1
chr8_-_23138517 0.728 TNFRSF10A
tumor necrosis factor receptor superfamily, member 10a
chr6_-_138470160 0.697 NM_022121
PERP
PERP, TP53 apoptosis effector
chr9_+_114953087 0.683 SLC31A2
solute carrier family 31 (copper transporters), member 2
chr10_+_11824361 0.660 NM_024693
ECHDC3
enoyl CoA hydratase domain containing 3
chr1_+_3597092 0.653 NM_001126240
NM_001126241
NM_001126242
TP73


tumor protein p73


chr2_+_171998988 0.648 NM_001164821
NM_025000
DCAF17

DDB1 and CUL4 associated factor 17

chr2_-_171998681 0.629 METTL8
methyltransferase like 8
chr18_-_26876622 0.603 NM_001941
NM_024423
DSC3

desmocollin 3

chr16_-_1410710 0.596 C16orf91
chromosome 16 open reading frame 91
chr16_-_31013626 0.590 NM_024006
NM_206824
VKORC1

vitamin K epoxide reductase complex, subunit 1

chr2_+_197212522 0.582 NM_001080539
CCDC150
coiled-coil domain containing 150
chr2_-_26058941 0.566 NM_002254
KIF3C
kinesin family member 3C
chr20_-_62151216 0.559 NM_018419
SOX18
SRY (sex determining region Y)-box 18
chr2_-_120697382 0.546 TMEM185B
transmembrane protein 185B (pseudogene)
chr4_-_40211324 0.543 RBM47
RNA binding motif protein 47
chr16_-_14695930 0.538 NM_003561
PLA2G10
phospholipase A2, group X
chr1_-_10455100 0.534 DFFA
DNA fragmentation factor, 45kDa, alpha polypeptide
chr4_+_48683021 0.523 NM_025087
CWH43
cell wall biogenesis 43 C-terminal homolog (S. cerevisiae)
chr2_+_171999042 0.516 DCAF17
DDB1 and CUL4 associated factor 17
chr19_-_47438583 0.509 GSK3A
glycogen synthase kinase 3 alpha
chr19_-_43406621 0.498 NM_001135155
NM_004647
DPF1

D4, zinc and double PHD fingers family 1

chr20_-_33007243 0.478 NM_000178
GSS
glutathione synthetase
chr1_-_10455190 0.471 NM_004401
NM_213566
DFFA

DNA fragmentation factor, 45kDa, alpha polypeptide

chr12_+_22669352 0.464 ETNK1
ethanolamine kinase 1
chr1_-_207892420 0.459 NM_000228
LAMB3
laminin, beta 3
chr2_-_26058831 0.457 KIF3C
kinesin family member 3C
chr2_+_47021816 0.454 NM_020458
TTC7A
tetratricopeptide repeat domain 7A
chr2_-_175741096 0.446 NM_001880
ATF2
activating transcription factor 2
chr1_+_43084846 0.441 NM_015911
ZNF691
zinc finger protein 691
chr9_+_129962292 0.431 NM_024112
C9orf16
chromosome 9 open reading frame 16
chr15_+_86965526 0.421 NM_022767
AEN
apoptosis enhancing nuclease
chr20_-_33007242 0.402 GSS
glutathione synthetase
chr17_-_59304729 0.401 NM_020991
NM_022644
NM_022645
CSH2


chorionic somatomammotropin hormone 2


chr7_-_74291367 0.396 GTF2IP1
general transcription factor IIi, pseudogene 1
chr19_+_15644885 0.394 NM_023944
CYP4F12
cytochrome P450, family 4, subfamily F, polypeptide 12
chr20_-_33007209 0.390 GSS
glutathione synthetase
chr15_+_38319326 0.390 NM_020168
PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr1_-_40903897 0.386 NM_014747
RIMS3
regulating synaptic membrane exocytosis 3
chr20_-_60435983 0.384 NM_080833
C20orf151
chromosome 20 open reading frame 151
chr8_-_22982351 0.381 TNFRSF10B
tumor necrosis factor receptor superfamily, member 10b
chr19_-_47438518 0.371 GSK3A
glycogen synthase kinase 3 alpha
chr2_+_47021866 0.367 TTC7A
tetratricopeptide repeat domain 7A
chr19_-_47438563 0.366 NM_019884
GSK3A
glycogen synthase kinase 3 alpha
chr16_-_66555449 0.363 NM_001145963
SLC12A4
solute carrier family 12 (potassium/chloride transporters), member 4
chr19_+_47056162 0.357 RPS19
ribosomal protein S19
chr19_+_17766907 0.357 NM_014256
B3GNT3
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
chr2_+_233443237 0.354 NM_206895
C2orf82
chromosome 2 open reading frame 82
chr1_-_6375949 0.350 ACOT7
acyl-CoA thioesterase 7
chr20_+_56900116 0.349 NM_001077488
GNAS
GNAS complex locus
chr20_-_61676003 0.345 NM_001037335
PRIC285
peroxisomal proliferator-activated receptor A interacting complex 285
chr19_-_15869870 0.340 NM_001082
CYP4F2
cytochrome P450, family 4, subfamily F, polypeptide 2
chr19_-_47438548 0.337 GSK3A
glycogen synthase kinase 3 alpha
chr1_+_11718764 0.336 AGTRAP
angiotensin II receptor-associated protein
chr20_-_44468607 0.335 ELMO2
engulfment and cell motility 2
chr4_+_6835388 0.334 KIAA0232
KIAA0232
chr7_-_74705276 0.330 NM_001145064
GATSL2
GATS protein-like 2
chr12_+_54784681 0.324 PA2G4
proliferation-associated 2G4, 38kDa
chr19_+_7859380 0.323 NM_025061
LRRC8E
leucine rich repeat containing 8 family, member E
chr12_+_51932136 0.316 NM_032889
MFSD5
major facilitator superfamily domain containing 5
chr1_+_154318954 0.314 LMNA
lamin A/C
chr19_+_47056102 0.312 RPS19
ribosomal protein S19
chr12_+_52181643 0.311 NM_134324
TARBP2
TAR (HIV-1) RNA binding protein 2
chr1_+_27925054 0.305 NM_001143912
NM_001143913
NM_001143914
NM_001143915
NM_152660
FAM76A




family with sequence similarity 76, member A




chr19_+_17766935 0.304 B3GNT3
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
chr12_+_51932252 0.303 MFSD5
major facilitator superfamily domain containing 5
chr20_-_44468641 0.303 ELMO2
engulfment and cell motility 2
chr16_+_2901995 0.301 FLYWCH1
FLYWCH-type zinc finger 1
chr21_+_45649429 0.298 NM_130445
COL18A1
collagen, type XVIII, alpha 1
chr19_+_13090101 0.296 NM_052876
NACC1
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
chr1_-_2447848 0.293 NM_018216
PANK4
pantothenate kinase 4
chr2_+_171999082 0.292 DCAF17
DDB1 and CUL4 associated factor 17
chr4_+_6726699 0.291 LOC93622
hypothetical LOC93622
chr18_+_29412538 0.288 NM_030632
ASXL3
additional sex combs like 3 (Drosophila)
chr1_+_25471470 0.282 NM_001127691
NM_016124
RHD

Rh blood group, D antigen

chr1_+_11718798 0.281 AGTRAP
angiotensin II receptor-associated protein
chr11_-_64327197 0.277 NM_004579
MAP4K2
mitogen-activated protein kinase kinase kinase kinase 2
chr3_-_42892195 0.276 CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr19_-_44618375 0.276 NM_001020
RPS16
ribosomal protein S16
chr6_+_32229599 0.275 NM_005155
PPT2-EGFL8
PPT2
PPT2-EGFL8 read-through transcript
palmitoyl-protein thioesterase 2
chr17_+_22645268 0.273 WSB1
WD repeat and SOCS box containing 1
chr3_-_52454082 0.273 NM_020163
SEMA3G
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
chr19_-_6432765 0.271 NM_024898
DENND1C
DENN/MADD domain containing 1C
chr19_-_5741913 0.270 DUS3L
dihydrouridine synthase 3-like (S. cerevisiae)
chr22_+_18085990 0.268 SEPT5-GP1BB
SEPT5
SEPT5-GP1BB read-through transcript
septin 5
chr20_+_30409649 0.267 NM_001164603
NM_015338
ASXL1

additional sex combs like 1 (Drosophila)

chr2_+_112372651 0.267 NM_006343
MERTK
c-mer proto-oncogene tyrosine kinase
chr1_-_247119516 0.266 NM_001136036
ZNF692
zinc finger protein 692
chr4_-_9727384 0.264


chr11_+_817584 0.264 NM_173584
EFCAB4A
EF-hand calcium binding domain 4A
chr8_-_22982435 0.262 NM_003842
NM_147187
TNFRSF10B

tumor necrosis factor receptor superfamily, member 10b

chr3_-_46012303 0.262 NM_024513
FYCO1
FYVE and coiled-coil domain containing 1
chr6_+_36206239 0.261 NM_002754
MAPK13
mitogen-activated protein kinase 13
chrX_+_151837064 0.261 NM_001178113
ZNF185
zinc finger protein 185 (LIM domain)
chr4_+_153676857 0.260 DKFZP434I0714
hypothetical protein DKFZP434I0714
chr5_+_72830029 0.258 BTF3
basic transcription factor 3
chr5_-_131854325 0.251 NM_002198
IRF1
interferon regulatory factor 1
chr1_+_11718715 0.251 NM_001040194
NM_001040195
NM_001040196
NM_001040197
NM_020350
AGTRAP




angiotensin II receptor-associated protein




chr8_-_145671947 0.249 FOXH1
forkhead box H1
chr12_+_51932173 0.248 MFSD5
major facilitator superfamily domain containing 5
chr12_-_46385991 0.247 RPAP3
RNA polymerase II associated protein 3
chr22_+_21852551 0.244 NM_004327
NM_021574
BCR

breakpoint cluster region

chr4_+_6835363 0.242 KIAA0232
KIAA0232
chr22_-_16637221 0.241 BID
BH3 interacting domain death agonist
chr15_-_62242145 0.240 PPIB
peptidylprolyl isomerase B (cyclophilin B)
chr12_+_54784632 0.239 PA2G4
proliferation-associated 2G4, 38kDa
chr12_-_14612057 0.238 NM_024829
PLBD1
phospholipase B domain containing 1
chr1_-_54291634 0.235 NM_004872
TMEM59
transmembrane protein 59
chr5_-_175721320 0.234 NM_001079684
NM_001079685
NM_020444
KIAA1191


KIAA1191


chr12_+_6808025 0.231 LEPREL2
leprecan-like 2
chr20_-_23755297 0.231 NM_001322
CST2
cystatin SA
chr1_+_23568028 0.229 C1orf213
chromosome 1 open reading frame 213
chr22_-_16637160 0.229 BID
BH3 interacting domain death agonist
chr19_+_43557264 0.229 PSMD8
proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
chr16_+_387176 0.227 NM_005009
NME4
non-metastatic cells 4, protein expressed in
chr9_-_168913 0.226 NM_001145355
NM_001145356
NM_018491
CBWD2
CBWD1


COBW domain containing 2
COBW domain containing 1


chr20_+_61760084 0.222 NM_016434
NM_032957
RTEL1

regulator of telomere elongation helicase 1

chr1_+_45578464 0.220 TOE1
target of EGR1, member 1 (nuclear)
chr3_+_14141633 0.219 TMEM43
transmembrane protein 43
chr15_-_62242259 0.219 PPIB
peptidylprolyl isomerase B (cyclophilin B)
chr2_+_169021039 0.218 NM_203463
LASS6
LAG1 homolog, ceramide synthase 6
chr15_-_62242243 0.218 PPIB
peptidylprolyl isomerase B (cyclophilin B)
chr19_+_54149941 0.217 BAX
BCL2-associated X protein
chr8_-_145672525 0.215 NM_003923
FOXH1
forkhead box H1
chr1_-_54291474 0.213 TMEM59
transmembrane protein 59
chr6_+_33486750 0.213 NM_002636
NM_024165
PHF1

PHD finger protein 1

chr7_+_100792841 0.213 NM_133457
EMID2
EMI domain containing 2
chr19_+_54149963 0.213 BAX
BCL2-associated X protein
chr1_-_114249158 0.212 NM_006594
AP4B1
adaptor-related protein complex 4, beta 1 subunit
chr22_+_23753940 0.212 NM_001145206
KIAA1671
KIAA1671
chr10_-_118755077 0.212 NM_001127211
NM_018330
KIAA1598

KIAA1598

chr7_-_72077805 0.211 NM_198853
TRIM73
TRIM74
tripartite motif containing 73
tripartite motif containing 74
chr3_+_161601040 0.209 NM_005496
SMC4
structural maintenance of chromosomes 4
chr4_+_6835354 0.208 NM_001100590
NM_014743
KIAA0232

KIAA0232

chr1_-_54291378 0.207 TMEM59
transmembrane protein 59
chr15_-_40173949 0.207 NM_178034
PLA2G4D
phospholipase A2, group IVD (cytosolic)
chr15_-_62242237 0.207 PPIB
peptidylprolyl isomerase B (cyclophilin B)
chr3_+_14141583 0.206 TMEM43
transmembrane protein 43
chr22_-_22422951 0.206 NM_021916
ZNF70
zinc finger protein 70
chr16_-_31013594 0.206 VKORC1
vitamin K epoxide reductase complex, subunit 1
chr11_-_9243408 0.206 NM_015213
DENND5A
DENN/MADD domain containing 5A
chr22_-_16637194 0.205 BID
BH3 interacting domain death agonist
chr12_+_97563049 0.205 NM_001160
NM_013229
NM_181861
NM_181868
NM_181869
APAF1




apoptotic peptidase activating factor 1




chr1_-_25619863 0.199 NM_020485
NM_138616
NM_138617
NM_138618
RHCE



RHD
Rh blood group, CcEe antigens



Rh blood group, D antigen
chr22_-_21231421 0.197 NM_206955
NM_206956
NM_006115
NM_206953
NM_206954
PRAME




preferentially expressed antigen in melanoma




chr1_-_45578193 0.197 NM_001048174
NM_001048172
NM_001048173
NM_001048171
NM_001128425
NM_012222
MUTYH





mutY homolog (E. coli)





chr4_-_9727394 0.196 WDR1
WD repeat domain 1
chr20_+_29931257 0.194 TTLL9
tubulin tyrosine ligase-like family, member 9
chr19_-_18515376 0.194 NM_012181
FKBP8
FK506 binding protein 8, 38kDa
chr7_-_72380020 0.193 NM_178125
TRIM50
tripartite motif containing 50
chr11_-_107969554 0.191 NM_015065
EXPH5
exophilin 5
chr8_-_10625352 0.191 NM_031439
SOX7
SRY (sex determining region Y)-box 7
chr3_+_9766901 0.190 OGG1
8-oxoguanine DNA glycosylase
chr8_+_23016271 0.190 NM_003841
TNFRSF10C
tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
chr2_+_169021001 0.188 LASS6
LAG1 homolog, ceramide synthase 6
chr19_+_17766609 0.188 B3GNT3
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
chr16_-_15057328 0.187 NM_173474
NTAN1
N-terminal asparagine amidase
chr1_-_247119908 0.187 NM_001193328
NM_017865
ZNF692

zinc finger protein 692

chr1_-_54291503 0.186 TMEM59
transmembrane protein 59
chr21_+_29593607 0.186 NM_206866
BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr8_-_57286412 0.185 NM_001114634
NM_001114635
NM_002655
PLAG1


pleiomorphic adenoma gene 1


chr3_-_186454509 0.185 NM_001166415
NM_001966
EHHADH

enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase

chr3_-_24511456 0.184 THRB
thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)
chr11_+_63758550 0.183 NM_003377
VEGFB
vascular endothelial growth factor B
chr1_+_226261374 0.182 NM_033131
WNT3A
wingless-type MMTV integration site family, member 3A
chr11_+_93917214 0.182 FUT4
fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
chr20_+_56899904 0.181 GNAS
GNAS complex locus
chr17_+_69939130 0.181 NM_022036
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr19_+_778821 0.181 NM_001700
AZU1
azurocidin 1
chr12_+_54784614 0.180 PA2G4
proliferation-associated 2G4, 38kDa
chr12_+_54784625 0.179 PA2G4
proliferation-associated 2G4, 38kDa
chr20_+_34667566 0.179 NM_018840
NM_199483
C20orf24

chromosome 20 open reading frame 24

chr4_-_9727456 0.177 WDR1
WD repeat domain 1
chr6_+_117910472 0.176 NM_173674
DCBLD1
discoidin, CUB and LCCL domain containing 1
chr18_-_32662942 0.176 C18orf10
chromosome 18 open reading frame 10
chr22_-_29231597 0.175 NM_001161368
NM_174977
SEC14L4

SEC14-like 4 (S. cerevisiae)

chr4_+_6726555 0.175 LOC93622
hypothetical LOC93622
chr19_+_32976717 0.175


chr1_+_45578370 0.174 TOE1
target of EGR1, member 1 (nuclear)
chr3_+_14141553 0.173 TMEM43
transmembrane protein 43
chr22_+_27498679 0.173 CCDC117
coiled-coil domain containing 117
chr7_+_72380090 0.172 NM_001135211
NM_003602
FKBP6

FK506 binding protein 6, 36kDa

chr4_-_9727598 0.171 NM_005112
NM_017491
WDR1

WD repeat domain 1

chr11_-_47356562 0.170 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr19_-_32976642 0.170 LOC148189
hypothetical LOC148189
chr11_-_47356479 0.169 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr9_-_93225961 0.168 NM_005384
NFIL3
nuclear factor, interleukin 3 regulated
chr3_+_14141544 0.167 TMEM43
transmembrane protein 43
chr9_-_114814286 0.166 NM_001101338
ZNF883
zinc finger protein 883
chr4_+_52403922 0.166 NM_001040402
NM_015115
DCUN1D4

DCN1, defective in cullin neddylation 1, domain containing 4 (S. cerevisiae)

chr22_-_16637238 0.165 NM_001196
NM_197967
BID

BH3 interacting domain death agonist

chr16_+_88280594 0.165 CDK10
cyclin-dependent kinase 10
chr18_+_32663056 0.164 NM_020776
KIAA1328
KIAA1328
chr5_-_10360873 0.164 CMBL
carboxymethylenebutenolidase homolog (Pseudomonas)

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.26 3.22e-04 GO:0044444 cytoplasmic part
1.42 1.31e-02 GO:0031090 organelle membrane

Nothing significant found in function category.