Motif ID: HIC1.p2

Z-value: 3.669


Transcription factors associated with HIC1.p2:

Gene SymbolEntrez IDGene Name
HIC1 3090 hypermethylated in cancer 1



Activity profile for motif HIC1.p2.

activity profile for motif HIC1.p2


Sorted Z-values histogram for motif HIC1.p2

Sorted Z-values for motif HIC1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HIC1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr21_-_43671355 10.635 NM_173354
 SIK1
salt-inducible kinase 1
chr1_-_48235148 9.233 NM_001194986
 LOC388630
UPF0632 protein A
chr6_-_112301123 8.030 NM_002037
 FYN
FYN oncogene related to SRC, FGR, YES
chr18_+_7557313 7.580 NM_001105244
NM_002845
 PTPRM

protein tyrosine phosphatase, receptor type, M

chr6_+_1556543 7.138 FOXC1
forkhead box C1
chr19_+_10843244 6.907 NM_199141
 CARM1
coactivator-associated arginine methyltransferase 1
chr8_+_32525269 6.680 NM_001160002
NM_001160004
NM_001160005
NM_001160007
NM_001160008
NM_004495
NM_013956
NM_013957
NM_013958
NM_013960
NM_013964
 NRG1










neuregulin 1










chr22_-_45037882 6.616 NM_006071
 PKDREJ
polycystic kidney disease (polycystin) and REJ homolog (sperm receptor for egg jelly homolog, sea urchin)
chr8_+_1937711 6.159 KBTBD11
kelch repeat and BTB (POZ) domain containing 11
chr11_+_101485946 6.050 NM_001130145
NM_001195044
NM_006106
 YAP1


Yes-associated protein 1


chrX_-_151996613 5.923 NM_032882
 PNMA6A
paraneoplastic antigen like 6A
chr6_+_147871477 5.867 NM_001030060
 SAMD5
sterile alpha motif domain containing 5
chr6_+_159510416 5.858 NM_032532
 FNDC1
fibronectin type III domain containing 1
chr10_-_45488162 5.485 NM_001128324
NM_174890
 ANUBL1

AN1, ubiquitin-like, homolog (Xenopus laevis)

chr17_+_75689955 5.478 GAA
glucosidase, alpha; acid
chr19_+_3175700 5.474 NM_021938
NM_001172673
 CELF5

CUGBP, Elav-like family member 5

chr11_-_63292688 5.438 NM_001144936
 C11orf95
chromosome 11 open reading frame 95
chr15_+_89300995 5.380 RCCD1
RCC1 domain containing 1
chr19_+_3175734 5.328 CELF5
CUGBP, Elav-like family member 5
chr12_-_122321640 5.316 CDK2AP1
cyclin-dependent kinase 2 associated protein 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 172 entries
enrichment   p-value GO term description
2.44 2.74e-05 GO:0090090 negative regulation of canonical Wnt receptor signaling pathway
2.40 1.70e-09 GO:0060828 regulation of canonical Wnt receptor signaling pathway
2.33 2.64e-03 GO:0001704 formation of primary germ layer
2.27 1.44e-02 GO:0030177 positive regulation of Wnt receptor signaling pathway
2.22 2.69e-02 GO:0045995 regulation of embryonic development
2.17 1.44e-02 GO:0001841 neural tube formation
2.11 9.99e-07 GO:0010720 positive regulation of cell development
2.10 9.42e-09 GO:0030111 regulation of Wnt receptor signaling pathway
2.08 4.84e-04 GO:0016331 morphogenesis of embryonic epithelium
2.06 2.47e-04 GO:0060485 mesenchyme development
2.05 1.74e-02 GO:0001838 embryonic epithelial tube formation
2.03 8.70e-03 GO:0014031 mesenchymal cell development
2.02 1.06e-03 GO:0030178 negative regulation of Wnt receptor signaling pathway
2.02 2.85e-02 GO:0072175 epithelial tube formation
2.01 3.44e-03 GO:0007173 epidermal growth factor receptor signaling pathway
1.94 2.77e-02 GO:0031346 positive regulation of cell projection organization
1.94 2.77e-02 GO:0048762 mesenchymal cell differentiation
1.93 1.06e-02 GO:0050769 positive regulation of neurogenesis
1.91 4.27e-02 GO:0007498 mesoderm development
1.76 7.64e-07 GO:0048011 nerve growth factor receptor signaling pathway

Gene overrepresentation in compartment category:

Showing 1 to 20 of 28 entries
enrichment   p-value GO term description
1.70 2.54e-02 GO:0005925 focal adhesion
1.67 9.07e-04 GO:0005912 adherens junction
1.56 6.35e-03 GO:0031252 cell leading edge
1.56 1.45e-02 GO:0070161 anchoring junction
1.48 1.32e-05 GO:0045202 synapse
1.42 1.29e-02 GO:0044456 synapse part
1.33 1.32e-03 GO:0030054 cell junction
1.32 2.45e-02 GO:0000139 Golgi membrane
1.28 2.61e-02 GO:0044431 Golgi apparatus part
1.27 1.53e-03 GO:0005626 insoluble fraction
1.27 3.60e-03 GO:0005624 membrane fraction
1.24 5.25e-03 GO:0005794 Golgi apparatus
1.24 3.74e-02 GO:0031982 vesicle
1.24 4.56e-02 GO:0031988 membrane-bounded vesicle
1.24 4.74e-02 GO:0031410 cytoplasmic vesicle
1.19 4.36e-05 GO:0005829 cytosol
1.14 3.20e-02 GO:0044459 plasma membrane part
1.12 1.53e-14 GO:0005737 cytoplasm
1.12 2.74e-08 GO:0044444 cytoplasmic part
1.09 1.41e-15 GO:0044424 intracellular part

Gene overrepresentation in function category:

Showing 1 to 20 of 28 entries
enrichment   p-value GO term description
2.01 9.24e-04 GO:0005089 Rho guanyl-nucleotide exchange factor activity
1.81 8.04e-03 GO:0005088 Ras guanyl-nucleotide exchange factor activity
1.77 3.43e-03 GO:0017124 SH3 domain binding
1.68 5.47e-04 GO:0005085 guanyl-nucleotide exchange factor activity
1.64 1.66e-04 GO:0010843 promoter binding
1.63 1.47e-04 GO:0000975 regulatory region DNA binding
1.63 1.47e-04 GO:0001067 regulatory region nucleic acid binding
1.63 1.47e-04 GO:0044212 transcription regulatory region DNA binding
1.59 1.28e-02 GO:0004721 phosphoprotein phosphatase activity
1.49 6.75e-03 GO:0016791 phosphatase activity
1.48 2.29e-06 GO:0030695 GTPase regulator activity
1.47 2.30e-06 GO:0060589 nucleoside-triphosphatase regulator activity
1.47 3.44e-04 GO:0042578 phosphoric ester hydrolase activity
1.46 2.06e-03 GO:0016563 transcription activator activity
1.45 5.59e-03 GO:0005083 small GTPase regulator activity
1.44 3.34e-02 GO:0005096 GTPase activator activity
1.38 3.29e-03 GO:0019904 protein domain specific binding
1.36 2.20e-02 GO:0008047 enzyme activator activity
1.34 1.71e-04 GO:0043565 sequence-specific DNA binding
1.32 2.36e-06 GO:0001071 nucleic acid binding transcription factor activity