Motif ID: NKX2-3_NKX2-5.p2

Z-value: 0.783


Transcription factors associated with NKX2-3_NKX2-5.p2:

Gene SymbolEntrez IDGene Name
NKX2-3 159296 NK2 transcription factor related, locus 3 (Drosophila)
NKX2-5 1482 NK2 transcription factor related, locus 5 (Drosophila)



Activity profile for motif NKX2-3_NKX2-5.p2.

activity profile for motif NKX2-3_NKX2-5.p2


Sorted Z-values histogram for motif NKX2-3_NKX2-5.p2

Sorted Z-values for motif NKX2-3_NKX2-5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-3_NKX2-5.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_79899748 0.936 NM_002941
 ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr19_-_46504831 0.776


chr13_-_45323757 0.658 NM_198849
 SIAH3
seven in absentia homolog 3 (Drosophila)
chr11_-_40272239 0.582 NM_020929
 LRRC4C
leucine rich repeat containing 4C
chr6_+_50789215 0.550 NM_172238
 TFAP2D
transcription factor AP-2 delta (activating enhancer binding protein 2 delta)
chr7_+_94135384 0.507 PEG10
paternally expressed 10
chr10_-_123346148 0.482 NM_001144915
 FGFR2
fibroblast growth factor receptor 2
chr13_-_102517196 0.448 NM_000452
 SLC10A2
solute carrier family 10 (sodium/bile acid cotransporter family), member 2
chr9_+_12683385 0.441 NM_000550
 TYRP1
tyrosinase-related protein 1
chr2_+_102456193 0.422 NM_001011552
 SLC9A4
solute carrier family 9 (sodium/hydrogen exchanger), member 4
chr17_+_38412267 0.422 NM_005533
 IFI35
interferon-induced protein 35
chrX_-_10504852 0.410 NM_001193277
 MID1
midline 1 (Opitz/BBB syndrome)
chr13_+_77213295 0.399 NM_144595
 SLAIN1
SLAIN motif family, member 1
chr6_+_29187565 0.396 NM_001005216
 OR2J3
olfactory receptor, family 2, subfamily J, member 3
chr8_-_110724594 0.379 NM_001099756
 SYBU
syntabulin (syntaxin-interacting)
chr10_-_105835609 0.374 NM_000494
 COL17A1
collagen, type XVII, alpha 1
chr7_-_26202626 0.364 HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr4_-_152368492 0.348 SH3D19
SH3 domain containing 19
chr5_+_140227951 0.346 NM_018902
NM_031861
 PCDHA11

protocadherin alpha 11

chr6_-_50045296 0.333 NM_001037729
 DEFB113
defensin, beta 113

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 9 of 9 entries
enrichment   p-value GO term description
2.77 2.71e-02 GO:0007156 homophilic cell adhesion
2.19 3.11e-05 GO:0007606 sensory perception of chemical stimulus
2.11 9.90e-04 GO:0007608 sensory perception of smell
1.68 1.21e-02 GO:0007600 sensory perception
1.66 4.73e-02 GO:0007155 cell adhesion
1.66 4.73e-02 GO:0022610 biological adhesion
1.44 1.66e-02 GO:0003008 system process
1.30 1.66e-06 GO:0032501 multicellular organismal process
1.21 2.96e-03 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

Showing 1 to 8 of 8 entries
enrichment   p-value GO term description
3.81 1.63e-02 GO:0031983 vesicle lumen
2.47 8.16e-03 GO:0005882 intermediate filament
1.67 2.45e-03 GO:0005615 extracellular space
1.56 4.40e-03 GO:0044421 extracellular region part
1.49 9.30e-06 GO:0005576 extracellular region
1.27 3.96e-04 GO:0071944 cell periphery
1.26 1.27e-03 GO:0005886 plasma membrane
1.18 2.36e-02 GO:0031224 intrinsic to membrane

Gene overrepresentation in function category:

Showing 1 to 4 of 4 entries
enrichment   p-value GO term description
2.17 1.38e-04 GO:0004984 olfactory receptor activity
1.40 2.05e-02 GO:0004872 receptor activity
1.36 1.77e-02 GO:0004871 signal transducer activity
1.36 1.77e-02 GO:0060089 molecular transducer activity