Motif ID: NFKB1_REL_RELA.p2

Z-value: 1.784


Transcription factors associated with NFKB1_REL_RELA.p2:

Gene SymbolEntrez IDGene Name
NFKB1 4790 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
REL 5966 v-rel reticuloendotheliosis viral oncogene homolog (avian)
RELA 5970 v-rel reticuloendotheliosis viral oncogene homolog A (avian)



Activity profile for motif NFKB1_REL_RELA.p2.

activity profile for motif NFKB1_REL_RELA.p2


Sorted Z-values histogram for motif NFKB1_REL_RELA.p2

Sorted Z-values for motif NFKB1_REL_RELA.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFKB1_REL_RELA.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr20_-_4743768 2.525 NM_170774
 RASSF2
Ras association (RalGDS/AF-6) domain family member 2
chr20_-_697127 2.476 NM_033409
 C20orf54
chromosome 20 open reading frame 54
chr15_-_38185578 2.403 NM_001003942
NM_001003943
 BMF

Bcl2 modifying factor

chr1_-_200395741 2.084 NM_080588
 PTPN7
protein tyrosine phosphatase, non-receptor type 7
chr14_-_106202262 1.668 IGLJ3
IGHA1
immunoglobulin lambda joining 3
immunoglobulin heavy constant alpha 1
chr9_+_126094388 1.657 NM_001166169
 NEK6
NIMA (never in mitosis gene a)-related kinase 6
chr9_+_126094067 1.594 NM_001166170
NM_001166171
 NEK6

NIMA (never in mitosis gene a)-related kinase 6

chr2_-_231498184 1.572 NM_005683
 GPR55
G protein-coupled receptor 55
chr5_+_31675181 1.507 PDZD2
PDZ domain containing 2
chr19_-_4782711 1.490 NM_182919
 TICAM1
toll-like receptor adaptor molecule 1
chr7_-_44985084 1.444 MYO1G
myosin IG
chr19_-_46551172 1.404 TGFB1
transforming growth factor, beta 1
chr19_+_13066956 1.399 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr17_+_16259636 1.348 TRPV2
transient receptor potential cation channel, subfamily V, member 2
chr16_-_65516919 1.342 NM_001128850
NM_004165
 RRAD

Ras-related associated with diabetes

chr17_+_16259573 1.337 NM_016113
 TRPV2
transient receptor potential cation channel, subfamily V, member 2
chr19_+_447453 1.335 NM_130760
NM_130762
 MADCAM1

mucosal vascular addressin cell adhesion molecule 1

chr19_-_44427446 1.319 NM_172139
 IL28B
interleukin 28B (interferon, lambda 3)
chr22_-_35875890 1.297 NM_000878
 IL2RB
interleukin 2 receptor, beta
chr20_-_49592654 1.282 NM_012340
NM_173091
 NFATC2

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 40 entries
enrichment   p-value GO term description
6.57 4.58e-02 GO:0002828 regulation of type 2 immune response
3.01 1.59e-03 GO:0002699 positive regulation of immune effector process
2.29 1.37e-03 GO:0051251 positive regulation of lymphocyte activation
2.24 1.27e-02 GO:0002697 regulation of immune effector process
2.22 1.97e-04 GO:0051249 regulation of lymphocyte activation
2.21 5.20e-03 GO:0050863 regulation of T cell activation
2.19 3.59e-03 GO:0002696 positive regulation of leukocyte activation
2.15 5.71e-03 GO:0050867 positive regulation of cell activation
2.12 4.42e-02 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter
2.10 7.27e-04 GO:0002694 regulation of leukocyte activation
2.02 2.55e-03 GO:0050865 regulation of cell activation
1.87 1.18e-03 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.86 3.01e-02 GO:0001817 regulation of cytokine production
1.84 1.04e-02 GO:0031347 regulation of defense response
1.83 9.49e-03 GO:0045597 positive regulation of cell differentiation
1.82 3.50e-04 GO:0002684 positive regulation of immune system process
1.77 1.37e-06 GO:0002682 regulation of immune system process
1.73 4.82e-03 GO:0050776 regulation of immune response
1.72 2.55e-06 GO:0006955 immune response
1.71 1.74e-02 GO:0007243 intracellular protein kinase cascade

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Showing 1 to 5 of 5 entries
enrichment   p-value GO term description
3.29 2.98e-02 GO:0003823 antigen binding
1.49 3.70e-04 GO:0001071 nucleic acid binding transcription factor activity
1.49 3.70e-04 GO:0003700 sequence-specific DNA binding transcription factor activity
1.15 2.17e-05 GO:0005515 protein binding
1.07 1.30e-02 GO:0005488 binding