Motif ID: PRRX1,2.p2

Z-value: 3.145


Transcription factors associated with PRRX1,2.p2:

Gene SymbolEntrez IDGene Name
PRRX1 5396 paired related homeobox 1
PRRX2 51450 paired related homeobox 2



Activity profile for motif PRRX1,2.p2.

activity profile for motif PRRX1,2.p2


Sorted Z-values histogram for motif PRRX1,2.p2

Sorted Z-values for motif PRRX1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PRRX1,2.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_+_113853790 11.910 NM_001172767
NM_148899
FOXP2

forkhead box P2

chr8_-_28403652 9.585 NM_172366
FBXO16
ZNF395
F-box protein 16
zinc finger protein 395
chr7_+_106897737 8.981 NM_005295
GPR22
G protein-coupled receptor 22
chr10_-_95231933 8.584 NM_013451
NM_133337
MYOF

myoferlin

chr4_-_41579325 7.718


chr5_-_169340321 7.268 NM_001129891
FAM196B
family with sequence similarity 196, member B
chr9_+_109131814 7.130 RAD23B
RAD23 homolog B (S. cerevisiae)
chr11_-_128567302 6.884 NM_001142685
ARHGAP32
Rho GTPase activating protein 32
chr12_+_14429499 6.582 ATF7IP
activating transcription factor 7 interacting protein
chr2_-_206790871 6.365 NM_001098199
NM_005279
GPR1

G protein-coupled receptor 1

chr4_+_70831387 5.972 NM_001025104
NM_001890
CSN1S1

casein alpha s1

chr2_+_165804157 5.855 NM_001040142
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr18_+_19826734 5.852 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chr18_-_55136673 5.708 NM_181654
CPLX4
complexin 4
chr15_+_22832198 5.705 SNRPN
small nuclear ribonucleoprotein polypeptide N
chr8_+_54926920 5.686 NM_170587
RGS20
regulator of G-protein signaling 20
chr9_+_674193 5.566


chr13_+_22653059 5.416 NM_000231
SGCG
sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
chr5_+_6799100 5.391 NM_001171806
PAPD7
PAP associated domain containing 7
chr3_-_121065112 5.357


chr7_-_7724762 4.962 NM_002947
RPA3
replication protein A3, 14kDa
chr15_+_32048380 4.889 NM_012125
CHRM5
cholinergic receptor, muscarinic 5
chr7_+_90177082 4.844 CDK14
cyclin-dependent kinase 14
chr9_-_28709302 4.828 NM_152570
LINGO2
leucine rich repeat and Ig domain containing 2
chr4_+_86968069 4.767 ARHGAP24
Rho GTPase activating protein 24
chr13_+_75232797 4.732 NM_015842
LMO7
LIM domain 7
chr5_+_147775652 4.616 FBXO38
F-box protein 38
chr9_+_108726257 4.610 ZNF462
zinc finger protein 462
chr3_+_138132006 4.488 NM_001190796
NCK1
NCK adaptor protein 1
chr10_+_126620681 4.432 NM_017580
ZRANB1
zinc finger, RAN-binding domain containing 1
chr10_-_32707549 4.427 EPC1
enhancer of polycomb homolog 1 (Drosophila)
chr2_-_98646367 4.409 NM_001160154
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr12_+_100512877 4.354 NM_002465
NM_206819
NM_206820
NM_206821
MYBPC1



myosin binding protein C, slow type



chr3_+_29297806 4.336 NM_001003792
NM_001003793
NM_001177711
NM_001177712
NM_014483
RBMS3




RNA binding motif, single stranded interacting protein 3




chr5_-_124108672 4.310 NM_020747
ZNF608
zinc finger protein 608
chr9_+_108665168 4.288 NM_021224
ZNF462
zinc finger protein 462
chr15_+_91244563 4.283 CHD2
chromodomain helicase DNA binding protein 2
chr17_-_10362583 4.249 NM_005963
MYH1
myosin, heavy chain 1, skeletal muscle, adult
chr1_+_169421011 4.225 NM_001460
FMO2
flavin containing monooxygenase 2 (non-functional)
chr12_+_73217817 4.205 NM_001136262
ATXN7L3B
ataxin 7-like 3B
chr4_+_74505710 4.201


chr2_+_234490781 4.193 NM_024080
TRPM8
transient receptor potential cation channel, subfamily M, member 8
chr12_-_9804682 4.185 NM_001781
CD69
CD69 molecule
chr5_-_111340421 4.178 NM_001142474
NM_001142475
C5orf13

chromosome 5 open reading frame 13

chr1_+_198263352 4.148 NM_003822
NM_205860
NR5A2

nuclear receptor subfamily 5, group A, member 2

chr1_-_58920315 4.137


chr4_+_71096830 4.120 NM_017855
ODAM
odontogenic, ameloblast asssociated
chr7_-_76667045 4.118 NM_006682
FGL2
fibrinogen-like 2
chr15_+_91244422 4.028 NM_001042572
NM_001271
CHD2

chromodomain helicase DNA binding protein 2

chr1_+_97033103 3.998


chr12_-_15706340 3.973 EPS8
epidermal growth factor receptor pathway substrate 8
chr13_-_59223074 3.954


chr12_-_23993830 3.952 NM_006940
SOX5
SRY (sex determining region Y)-box 5
chr1_+_84402962 3.946 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr12_+_73217889 3.945 ATXN7L3B
ataxin 7-like 3B
chr4_-_152368492 3.919 SH3D19
SH3 domain containing 19
chr3_-_71860958 3.893 NM_001134650
EIF4E3
eukaryotic translation initiation factor 4E family member 3
chr7_-_104696678 3.876 NM_182691
SRPK2
SRSF protein kinase 2
chr17_-_1195096 3.875 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr3_-_115585178 3.846 NM_001164342
ZBTB20
zinc finger and BTB domain containing 20
chr16_+_7322751 3.805 NM_145891
NM_145892
NM_145893
RBFOX1


RNA binding protein, fox-1 homolog (C. elegans) 1


chr5_-_160044844 3.791 ATP10B
ATPase, class V, type 10B
chr7_-_30032649 3.751 NM_017946
FKBP14
FK506 binding protein 14, 22 kDa
chr4_+_3341521 3.740 NM_198227
RGS12
regulator of G-protein signaling 12
chr16_+_10878539 3.722 NM_000246
CIITA
class II, major histocompatibility complex, transactivator
chr7_+_111908143 3.713 NM_001134468
NM_182597
C7orf53

chromosome 7 open reading frame 53

chr14_+_66901237 3.697 EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr3_-_69212192 3.680 NM_003968
NM_198195
UBA3

ubiquitin-like modifier activating enzyme 3

chr1_-_197173159 3.669 LOC100131234
familial acute myelogenous leukemia related factor
chr3_+_133798770 3.661 NM_016557
CCRL1
chemokine (C-C motif) receptor-like 1
chr3_-_47073910 3.658 SETD2
SET domain containing 2
chr1_+_62835759 3.649 NM_014495
ANGPTL3
angiopoietin-like 3
chr13_+_47948586 3.602 RB1
retinoblastoma 1
chr5_+_127012611 3.587 NM_001048252
CTXN3
cortexin 3
chr15_+_47502666 3.528 NM_002009
FGF7
fibroblast growth factor 7
chr8_-_17599438 3.506 NM_020749
MTUS1
microtubule associated tumor suppressor 1
chr14_-_94669547 3.476 NM_001195573
DICER1
dicer 1, ribonuclease type III
chr4_-_100359353 3.465 NM_000672
NM_001102470
ADH6

alcohol dehydrogenase 6 (class V)

chr7_-_13992351 3.451 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr8_+_67201684 3.427 NM_033058
NM_184085
NM_184086
NM_184087
TRIM55



tripartite motif containing 55



chr1_+_93072947 3.414 RPL5
ribosomal protein L5
chr6_+_144654565 3.397 NM_007124
UTRN
utrophin
chr8_-_110689396 3.372 SYBU
syntabulin (syntaxin-interacting)
chr10_-_56230953 3.349 NM_001142763
NM_001142764
NM_001142765
NM_001142766
NM_001142767
NM_001142768
NM_001142769
NM_001142770
NM_001142771
NM_001142772
NM_001142773
NM_033056
PCDH15











protocadherin-related 15











chr4_+_78651929 3.323 NM_006419
CXCL13
chemokine (C-X-C motif) ligand 13
chr6_-_29451042 3.311 NM_030959
OR12D3
olfactory receptor, family 12, subfamily D, member 3
chr10_+_94584449 3.295 NM_001013848
EXOC6
exocyst complex component 6
chr7_+_90176647 3.292 NM_012395
CDK14
cyclin-dependent kinase 14
chr13_-_98428244 3.289 NM_001130048
NM_001130050
DOCK9

dedicator of cytokinesis 9

chr10_+_90474280 3.289 NM_001080518
LIPK
lipase, family member K
chr10_-_69125932 3.267 NM_013266
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr17_-_36436979 3.263 NM_031957
KRTAP1-5
keratin associated protein 1-5
chr6_-_33016561 3.244 NM_002118
HLA-DMB
major histocompatibility complex, class II, DM beta
chr2_-_55090759 3.213 NM_007008
RTN4
reticulon 4
chr1_-_103269356 3.202 COL11A1
collagen, type XI, alpha 1
chr9_+_6205804 3.191 IL33
interleukin 33
chr6_+_55300225 3.184 NM_207410
GFRAL
GDNF family receptor alpha like
chr1_+_13903936 3.179 NM_012231
NM_015866
PRDM2

PR domain containing 2, with ZNF domain

chr17_+_3326045 3.140 NM_000049
ASPA
aspartoacylase
chr15_-_75364387 3.140 NM_024776
PEAK1
NKF3 kinase family member
chr5_+_174084137 3.117 NM_002449
MSX2
msh homeobox 2
chr1_-_171441234 3.112 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr3_-_115380539 3.108 NM_000796
NM_033663
DRD3

dopamine receptor D3

chr20_+_56369012 3.097


chr7_-_87180499 3.092 NM_000927
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr11_-_85103438 3.086 NM_032379
SYTL2
synaptotagmin-like 2
chr17_-_10265991 3.061 NM_002472
MYH8
myosin, heavy chain 8, skeletal muscle, perinatal
chr10_+_69539255 3.059 NM_032578
MYPN
myopalladin
chr3_+_142525744 3.047 NM_001080412
ZBTB38
zinc finger and BTB domain containing 38
chr6_+_73133152 3.009 NM_001168411
RIMS1
regulating synaptic membrane exocytosis 1
chr2_+_17861266 3.003 NM_001105569
MSGN1
mesogenin 1
chr21_-_35174742 2.955 RUNX1
runt-related transcription factor 1
chr6_-_123999640 2.942 NM_006073
TRDN
triadin
chr6_+_72982865 2.928 NM_001168409
RIMS1
regulating synaptic membrane exocytosis 1
chr12_-_66839589 2.926 NM_000619
IFNG
interferon, gamma
chr4_-_153493133 2.919 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr3_+_176059763 2.907 NM_207015
NAALADL2
N-acetylated alpha-linked acidic dipeptidase-like 2
chr10_+_90414125 2.904 NM_001198828
NM_001198829
NM_001198830
NM_004190
LIPF



lipase, gastric



chr3_-_74652952 2.903 NM_020872
CNTN3
contactin 3 (plasmacytoma associated)
chr11_-_58099884 2.901 NM_004811
LPXN
leupaxin
chr2_-_175170674 2.900 WIPF1
WAS/WASL interacting protein family, member 1
chr5_+_128468785 2.892 ISOC1
isochorismatase domain containing 1
chr12_-_10464308 2.854 NM_002261
NM_007333
KLRC3

killer cell lectin-like receptor subfamily C, member 3

chr12_+_10054492 2.853 NM_001129998
NM_205852
CLEC12B

C-type lectin domain family 12, member B

chr17_+_46176105 2.853 LUC7L3
LUC7-like 3 (S. cerevisiae)
chr12_+_9871343 2.852 NM_016523
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chr10_+_116687904 2.842 NM_139169
TRUB1
TruB pseudouridine (psi) synthase homolog 1 (E. coli)
chr9_-_94338072 2.840 NM_001197295
NM_001197296
NM_001393
ECM2


extracellular matrix protein 2, female organ and adipocyte specific


chr3_+_69895310 2.830 NM_001184967
MITF
microphthalmia-associated transcription factor
chr8_+_17440664 2.815 NM_001164771
NM_003046
SLC7A2

solute carrier family 7 (cationic amino acid transporter, y+ system), member 2

chr8_+_9990471 2.814 NM_001135671
MSRA
methionine sulfoxide reductase A
chr6_-_138581319 2.810 NM_021635
PBOV1
prostate and breast cancer overexpressed 1
chr12_-_48902692 2.808 NM_001113547
LIMA1
LIM domain and actin binding 1
chr11_-_55815113 2.805 NM_001005199
OR8H1
olfactory receptor, family 8, subfamily H, member 1
chrX_+_37777730 2.797 NM_001163334
SYTL5
synaptotagmin-like 5
chr20_-_14266200 2.791 NM_013281
NM_198391
FLRT3

fibronectin leucine rich transmembrane protein 3

chr13_-_43101608 2.790 NM_001127615
ENOX1
ecto-NOX disulfide-thiol exchanger 1
chr7_+_94135384 2.785 PEG10
paternally expressed 10
chr8_-_120720200 2.768 NM_001040092
NM_001130863
NM_006209
ENPP2


ectonucleotide pyrophosphatase/phosphodiesterase 2


chr14_-_46882144 2.767 NM_182830
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
chr12_+_49922592 2.766 DAZAP2
DAZ associated protein 2
chr2_-_213723298 2.760 NM_016260
IKZF2
IKAROS family zinc finger 2 (Helios)
chr12_-_15005761 2.759 NM_001175
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr5_+_56545657 2.756 NM_001127236
GPBP1
GC-rich promoter binding protein 1
chr3_+_63859114 2.747 NM_001177387
ATXN7
ataxin 7
chr12_-_41269679 2.720 NM_153026
PRICKLE1
prickle homolog 1 (Drosophila)
chr4_-_39199527 2.709 UGDH
UDP-glucose 6-dehydrogenase
chr4_-_105635499 2.700 CXXC4
CXXC finger protein 4
chr7_-_26198673 2.676 HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr3_-_57288019 2.663 NM_130387
ASB14
ankyrin repeat and SOCS box containing 14
chr9_+_5646582 2.654 NM_020829
KIAA1432
KIAA1432
chr9_-_19368815 2.642 RPS6
ribosomal protein S6
chr4_+_71054492 2.625 NM_214711
C4orf40
chromosome 4 open reading frame 40
chr3_+_190831909 2.624 NM_001114978
NM_001114979
NM_003722
TP63


tumor protein p63


chr1_-_68470585 2.624 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr11_-_114593838 2.615 CADM1
cell adhesion molecule 1
chr5_-_126437070 2.613 NM_001164478
NM_001164479
FLJ44606

glutaredoxin-like protein YDR286C homolog

chr5_-_75954807 2.608 NM_004101
F2RL2
coagulation factor II (thrombin) receptor-like 2
chr7_+_17349425 2.607 AHR
aryl hydrocarbon receptor
chr7_-_84589182 2.606 NM_152754
SEMA3D
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
chr4_+_68107039 2.604 NM_012108
STAP1
signal transducing adaptor family member 1
chr13_-_74799898 2.598 TBC1D4
TBC1 domain family, member 4
chr4_+_109763119 2.592 RPL34
ribosomal protein L34
chr4_+_88748704 2.588 NM_014208
DSPP
dentin sialophosphoprotein
chr6_+_64289585 2.577 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr11_+_69176391 2.567 CCND1
cyclin D1
chr3_+_73193499 2.559 NM_018029
EBLN2
endogenous Borna-like N element-2
chr7_+_129771865 2.552 NM_001127441
NM_001127442
NM_080385
CPA5


carboxypeptidase A5


chr6_-_76838944 2.545 NM_001563
IMPG1
interphotoreceptor matrix proteoglycan 1
chr4_+_119174947 2.541 NM_004784
NDST3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr11_-_3759886 2.530 NUP98
nucleoporin 98kDa
chr11_-_102156531 2.524 NM_002425
MMP10
matrix metallopeptidase 10 (stromelysin 2)
chr2_-_178461710 2.523 NM_001077196
PDE11A
phosphodiesterase 11A
chr1_+_15862887 2.519


chr18_-_62422195 2.518 NM_021153
CDH19
cadherin 19, type 2
chr12_+_8866416 2.509 NM_144670
A2ML1
alpha-2-macroglobulin-like 1
chr11_+_5024331 2.500 NM_001001916
OR52J3
olfactory receptor, family 52, subfamily J, member 3
chr8_+_67751007 2.490 NM_019607
C8orf44
chromosome 8 open reading frame 44
chr17_-_60439764 2.487 GNA13
guanine nucleotide binding protein (G protein), alpha 13
chr6_+_152053323 2.484 NM_001122742
ESR1
estrogen receptor 1
chr4_-_120462705 2.467 NM_000134
FABP2
fatty acid binding protein 2, intestinal
chr13_+_31211678 2.465 NM_001166058
NM_130806
RXFP2

relaxin/insulin-like family peptide receptor 2

chr7_-_83116414 2.464 NM_012431
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr12_+_32546243 2.455 NM_139241
FGD4
FYVE, RhoGEF and PH domain containing 4
chr9_-_85773899 2.452 HNRNPK
heterogeneous nuclear ribonucleoprotein K
chr15_+_46285789 2.445 NM_000338
NM_001184832
SLC12A1

solute carrier family 12 (sodium/potassium/chloride transporters), member 1

chr14_+_51025604 2.438 NM_001042481
FRMD6
FERM domain containing 6
chr10_+_127419021 2.431 C10orf137
chromosome 10 open reading frame 137
chr7_+_102340579 2.387 NM_001031692
NM_005824
LRRC17

leucine rich repeat containing 17

chr8_-_11891168 2.370 NM_001033019
DEFB134
defensin, beta 134
chr22_-_34564611 2.359 RPL41P5
ribosomal protein L41 pseudogene 5
chr2_-_180135559 2.344 NM_001113398
ZNF385B
zinc finger protein 385B
chr2_-_225086564 2.331 CUL3
cullin 3
chr3_-_113495763 2.328 NM_183061
SLC9A10
solute carrier family 9, member 10
chr14_+_55148488 2.322 KTN1
kinectin 1 (kinesin receptor)
chr4_+_38740246 2.320 NM_015990
NM_199039
KLHL5

kelch-like 5 (Drosophila)

chr5_+_69356827 2.318 NM_001178087
NM_022978
NM_021967
NM_022968
SERF1B

SERF1A

small EDRK-rich factor 1B (centromeric)

small EDRK-rich factor 1A (telomeric)

chr3_-_56673113 2.316 NM_015224
C3orf63
chromosome 3 open reading frame 63
chr2_+_135312655 2.310 NM_138326
ACMSD
aminocarboxymuconate semialdehyde decarboxylase
chr4_+_109033868 2.309 NM_001136257
NM_152621
SGMS2

sphingomyelin synthase 2


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.17 1.40e-08 GO:0032501 multicellular organismal process
1.66 2.31e-08 GO:0007606 sensory perception of chemical stimulus
1.67 2.61e-07 GO:0007608 sensory perception of smell
1.41 3.57e-05 GO:0007600 sensory perception
1.27 6.20e-05 GO:0003008 system process
1.29 2.44e-04 GO:0050877 neurological system process
1.11 1.18e-03 GO:0050896 response to stimulus
1.54 2.24e-02 GO:0016337 cell-cell adhesion

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.16 2.51e-06 GO:0071944 cell periphery
1.16 4.76e-06 GO:0005886 plasma membrane
1.59 2.21e-02 GO:0045111 intermediate filament cytoskeleton

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.70 3.05e-08 GO:0004984 olfactory receptor activity
1.45 1.55e-07 GO:0004930 G-protein coupled receptor activity
1.30 1.76e-07 GO:0004872 receptor activity
1.35 3.69e-07 GO:0004888 transmembrane receptor activity
1.26 4.77e-07 GO:0004871 signal transducer activity
1.26 4.77e-07 GO:0060089 molecular transducer activity