Motif ID: GLI1..3.p2

Z-value: 1.793


Transcription factors associated with GLI1..3.p2:

Gene SymbolEntrez IDGene Name
GLI1 2735 glioma-associated oncogene homolog 1 (zinc finger protein)
GLI2 2736 GLI-Kruppel family member GLI2
GLI3 2737 GLI-Kruppel family member GLI3



Activity profile for motif GLI1..3.p2.

activity profile for motif GLI1..3.p2


Sorted Z-values histogram for motif GLI1..3.p2

Sorted Z-values for motif GLI1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GLI1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_3732614 1.896 NM_001144958
NM_001144959
NM_032680
EFCAB4B


EF-hand calcium binding domain 4B


chr22_+_18090118 1.680 SEPT5-GP1BB
SEPT5-GP1BB read-through transcript
chr7_-_110989582 1.654 NM_032549
IMMP2L
IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr1_-_209818675 1.650 NM_021194
SLC30A1
solute carrier family 30 (zinc transporter), member 1
chr12_-_3732478 1.590 EFCAB4B
EF-hand calcium binding domain 4B
chr1_-_209818576 1.556 SLC30A1
solute carrier family 30 (zinc transporter), member 1
chr9_+_130056513 1.483


chr19_+_13124889 1.370 IER2
immediate early response 2
chr11_-_85053709 1.295 CREBZF
CREB/ATF bZIP transcription factor
chr11_-_64268126 1.281 NM_001098671
RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr19_+_3490154 1.245 NM_001135580
C19orf71
chromosome 19 open reading frame 71
chr12_-_113330574 1.220 NM_000192
NM_080717
TBX5

T-box 5

chr16_+_56259657 1.192 NM_170776
GPR97
G protein-coupled receptor 97
chr17_+_77582774 1.182 NM_005052
RAC3
ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
chr1_-_75854281 1.181 SLC44A5
solute carrier family 44, member 5
chr19_-_54618410 1.181 NM_178449
PTH2
parathyroid hormone 2
chr19_+_13124870 1.170 IER2
immediate early response 2
chr1_-_1300680 1.150 NM_017900
AURKAIP1
aurora kinase A interacting protein 1
chr11_-_32413486 1.097 WT1
Wilms tumor 1
chr16_-_3049336 1.090


chr3_-_46734317 1.063 NM_013270
PRSS50
protease, serine, 50
chr11_+_32870935 1.048 NM_001076786
QSER1
glutamine and serine rich 1
chr6_+_3009120 0.999 RIPK1
receptor (TNFRSF)-interacting serine-threonine kinase 1
chr1_+_153560351 0.980 NM_001105205
RUSC1
RUN and SH3 domain containing 1
chr22_-_17546296 0.966 NM_005984
SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr1_-_209818342 0.965 SLC30A1
solute carrier family 30 (zinc transporter), member 1
chr22_-_17546276 0.957 SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr7_-_99518294 0.942 ZNF3
zinc finger protein 3
chr19_-_53832381 0.927 NM_001352
DBP
D site of albumin promoter (albumin D-box) binding protein
chr17_+_15788955 0.912 NM_000676
ADORA2B
adenosine A2b receptor
chr7_-_99518106 0.907


chr1_-_210939727 0.907


chr7_-_112513379 0.902 NM_001146266
NM_001146267
GPR85

G protein-coupled receptor 85

chr3_+_47004457 0.891 NBEAL2
neurobeachin-like 2
chr11_+_19691397 0.884 NM_145117
NM_182964
NAV2

neuron navigator 2

chr19_+_54309423 0.867 NM_022165
LIN7B
lin-7 homolog B (C. elegans)
chr17_+_45008473 0.838 NXPH3
neurexophilin 3
chr16_+_705080 0.836 NM_024042
METRN
meteorin, glial cell differentiation regulator
chr5_-_156935317 0.823 NM_033274
ADAM19
ADAM metallopeptidase domain 19
chr2_+_96845704 0.822 NM_017623
NM_199078
CNNM3

cyclin M3

chr5_-_149515331 0.816 PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr8_+_21972631 0.805 NM_001114138
NM_001978
EPB49

erythrocyte membrane protein band 4.9 (dematin)

chr1_-_32574185 0.805 NM_023009
MARCKSL1
MARCKS-like 1
chr14_-_105862080 0.795 IGHV4-31
IGHA1
IGHD
IGHG1
IGHG2
IGHG3
IGHM
SCFV
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 2 (G2m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
single-chain Fv fragment
chr7_+_149733309 0.788


chrX_+_152562013 0.781 DUSP9
dual specificity phosphatase 9
chrX_-_138114100 0.775 FGF13
fibroblast growth factor 13
chr7_-_142369519 0.768 KEL
Kell blood group, metallo-endopeptidase
chr16_+_66236512 0.756 NM_001013838
RLTPR
RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
chr1_-_1300416 0.754 NM_001127230
NM_001127229
AURKAIP1

aurora kinase A interacting protein 1

chr19_+_10404110 0.750 NM_001111309
PDE4A
phosphodiesterase 4A, cAMP-specific
chr3_+_38010081 0.745 NM_015873
VILL
villin-like
chr6_-_32929390 0.744 TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr8_+_21972804 0.735 EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr1_-_1300385 0.732 AURKAIP1
aurora kinase A interacting protein 1
chr19_+_55844446 0.728 NM_001195076
LOC342918
hypothetical protein LOC342918
chr22_-_17546234 0.726 SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr11_+_566482 0.721 NM_020901
PHRF1
PHD and ring finger domains 1
chr7_-_92303865 0.720 NM_001145306
CDK6
cyclin-dependent kinase 6
chr1_-_39877883 0.719 HEYL
hairy/enhancer-of-split related with YRPW motif-like
chr6_-_32929570 0.715 TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr16_+_66236559 0.715 RLTPR
RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
chr17_+_45703765 0.706 NM_001168215
TMEM92
transmembrane protein 92
chr13_+_112789669 0.705 MCF2L
MCF.2 cell line derived transforming sequence-like
chr1_-_39877928 0.699 NM_014571
HEYL
hairy/enhancer-of-split related with YRPW motif-like
chr14_+_28306633 0.695 FOXG1
forkhead box G1
chr3_-_195835298 0.681 NM_001011655
NM_001166305
NM_001166306
NM_138399
TMEM44



transmembrane protein 44



chr8_-_41774296 0.679 NM_000037
NM_020475
NM_020476
NM_020477
ANK1



ankyrin 1, erythrocytic



chr5_-_1647617 0.678 SDHAP3
succinate dehydrogenase complex, subunit A, flavoprotein pseudogene 3
chr10_+_106103503 0.674 NM_001008723
CCDC147
coiled-coil domain containing 147
chr19_-_46551172 0.668 TGFB1
transforming growth factor, beta 1
chr11_+_61943082 0.667 NM_003357
SCGB1A1
secretoglobin, family 1A, member 1 (uteroglobin)
chr7_-_92303812 0.666 CDK6
cyclin-dependent kinase 6
chr19_+_40900757 0.658 NM_014727
MLL4
myeloid/lymphoid or mixed-lineage leukemia 4
chr9_-_97318760 0.657 PTCH1
patched 1
chr3_+_45042754 0.657 NM_003278
CLEC3B
C-type lectin domain family 3, member B
chr11_+_58967192 0.650 NM_001004728
OR5A1
olfactory receptor, family 5, subfamily A, member 1
chr2_+_85683473 0.649 USP39
ubiquitin specific peptidase 39
chr7_-_142369534 0.648 NM_000420
KEL
Kell blood group, metallo-endopeptidase
chr7_-_100262971 0.647 NM_004444
EPHB4
EPH receptor B4
chr7_-_142695392 0.646


chr7_+_142695570 0.642 CASP2
caspase 2, apoptosis-related cysteine peptidase
chr19_+_54309443 0.639 LIN7B
lin-7 homolog B (C. elegans)
chr7_+_44207094 0.639 NM_006555
YKT6
YKT6 v-SNARE homolog (S. cerevisiae)
chr9_-_97319067 0.638 NM_001083602
NM_001083603
PTCH1

patched 1

chr5_-_36277656 0.637 NM_001085411
C5orf33
chromosome 5 open reading frame 33
chr1_+_89871212 0.634 LRRC8C
leucine rich repeat containing 8 family, member C
chr7_+_99793561 0.628 NM_178238
PILRB
paired immunoglobin-like type 2 receptor beta
chr19_+_811615 0.624 CFD
complement factor D (adipsin)
chr6_-_31870809 0.624


chr4_-_176970895 0.618 GPM6A
glycoprotein M6A
chr7_+_44207080 0.618 YKT6
YKT6 v-SNARE homolog (S. cerevisiae)
chr22_-_17545872 0.616 SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr7_-_23476156 0.614


chr7_-_126819953 0.614 NM_176814
ZNF800
zinc finger protein 800
chr10_+_71060008 0.611 NM_145306
C10orf35
chromosome 10 open reading frame 35
chr6_+_34313347 0.603 HMGA1
high mobility group AT-hook 1
chr22_+_18388633 0.602 C22orf25
chromosome 22 open reading frame 25
chr7_+_99809068 0.597 PILRA
paired immunoglobin-like type 2 receptor alpha
chr7_+_142695511 0.597 NM_032982
NM_032983
CASP2

caspase 2, apoptosis-related cysteine peptidase

chr1_+_11646735 0.595 NM_018438
FBXO6
F-box protein 6
chr7_-_150515851 0.593 NM_080871
ASB10
ankyrin repeat and SOCS box containing 10
chr7_-_4889772 0.593 NM_018059
RADIL
Ras association and DIL domains
chr17_-_8474733 0.592 NM_005964
MYH10
myosin, heavy chain 10, non-muscle
chr7_+_120416103 0.585 C7orf58
chromosome 7 open reading frame 58
chr4_-_176970407 0.583 GPM6A
glycoprotein M6A
chr5_-_95323353 0.581 NM_012081
ELL2
elongation factor, RNA polymerase II, 2
chr2_-_85683268 0.578 NM_001031738
TMEM150A
transmembrane protein 150A
chr21_-_45786709 0.577 NM_194255
SLC19A1
solute carrier family 19 (folate transporter), member 1
chr16_+_76690664 0.573 NM_016373
NM_130791
NM_130844
WWOX


WW domain containing oxidoreductase


chr10_+_99488223 0.573 NM_001002261
ZFYVE27
zinc finger, FYVE domain containing 27
chr7_-_23476497 0.573 NM_006547
IGF2BP3
insulin-like growth factor 2 mRNA binding protein 3
chr7_+_30970160 0.571 NM_000823
GHRHR
growth hormone releasing hormone receptor
chr15_-_59308770 0.569 NM_134261
RORA
RAR-related orphan receptor A
chr12_-_46438447 0.567 NM_001098532
NM_006105
RAPGEF3

Rap guanine nucleotide exchange factor (GEF) 3

chr5_-_36277441 0.556 C5orf33
chromosome 5 open reading frame 33
chr22_+_18388656 0.552 C22orf25
chromosome 22 open reading frame 25
chr17_+_23875085 0.549 NM_003593
FOXN1
forkhead box N1
chr4_-_140696740 0.546 NM_030648
SETD7
SET domain containing (lysine methyltransferase) 7
chr7_-_124192265 0.545 GPR37
G protein-coupled receptor 37 (endothelin receptor type B-like)
chr4_-_176970372 0.544 GPM6A
glycoprotein M6A
chr1_+_153513810 0.544 NM_020897
HCN3
hyperpolarization activated cyclic nucleotide-gated potassium channel 3
chr17_-_53920699 0.543 NM_001080439
HSF5
heat shock transcription factor family member 5
chr11_-_85053807 0.542 NM_001039618
CREBZF
CREB/ATF bZIP transcription factor
chr9_+_139292094 0.536 NM_017723
C9orf167
chromosome 9 open reading frame 167
chr1_-_3556420 0.534 NM_017818
WDR8
WD repeat domain 8
chr6_+_69401660 0.534 NM_001704
BAI3
brain-specific angiogenesis inhibitor 3
chr7_-_106088565 0.529 NM_175884
FLJ36031
hypothetical protein FLJ36031
chr9_-_34448477 0.528 NM_001184940
NM_001184941
NM_001184942
NM_001184943
NM_001184944
NM_001184945
NM_147202
C9orf25






chromosome 9 open reading frame 25






chr3_-_195835197 0.527 TMEM44
transmembrane protein 44
chr9_-_138757175 0.527 NM_001001712
LCN10
lipocalin 10
chr3_-_33734544 0.527 CLASP2
cytoplasmic linker associated protein 2
chr6_+_44076281 0.523 NM_001171992
NM_153246
C6orf223

chromosome 6 open reading frame 223

chr6_-_26140266 0.522 NM_003537
HIST1H3B
histone cluster 1, H3b
chr14_+_100365162 0.521 MEG3
maternally expressed 3 (non-protein coding)
chr22_-_20637212 0.520 NM_014634
PPM1F
protein phosphatase, Mg2+/Mn2+ dependent, 1F
chr19_+_1334877 0.518 NM_024407
NDUFS7
NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase)
chr15_-_59308708 0.517 RORA
RAR-related orphan receptor A
chr19_+_16296632 0.515 NM_016270
KLF2
Kruppel-like factor 2 (lung)
chr19_-_50834483 0.510 EML2
echinoderm microtubule associated protein like 2
chr22_+_18388602 0.509 NM_152906
C22orf25
chromosome 22 open reading frame 25
chr1_+_166414839 0.506 TIPRL
TIP41, TOR signaling pathway regulator-like (S. cerevisiae)
chr10_+_32775027 0.505 NM_001026383
NM_145023
CCDC7

coiled-coil domain containing 7

chr1_+_201862548 0.505 NM_001001396
NM_001684
ATP2B4

ATPase, Ca++ transporting, plasma membrane 4

chr1_+_205561439 0.503 NM_000574
NM_001114752
CD55

CD55 molecule, decay accelerating factor for complement (Cromer blood group)

chr11_+_13646727 0.503 NM_032228
FAR1
fatty acyl CoA reductase 1
chr14_-_73296387 0.502 C14orf43
chromosome 14 open reading frame 43
chr3_+_16901455 0.502 NM_001144382
PLCL2
phospholipase C-like 2
chr1_+_205561632 0.500 CD55
CD55 molecule, decay accelerating factor for complement (Cromer blood group)
chr1_+_205561693 0.500 CD55
CD55 molecule, decay accelerating factor for complement (Cromer blood group)
chr19_-_46551359 0.498 TGFB1
transforming growth factor, beta 1
chr1_-_39929654 0.497 NM_016257
HPCAL4
hippocalcin like 4
chr16_+_85169615 0.495 NM_005250
FOXL1
forkhead box L1
chr5_-_156935283 0.494


chr16_+_66153810 0.493 NM_001191022
NM_006565
CTCF

CCCTC-binding factor (zinc finger protein)

chr7_+_142695584 0.492 CASP2
caspase 2, apoptosis-related cysteine peptidase
chr1_-_152202574 0.492 SLC39A1
solute carrier family 39 (zinc transporter), member 1
chr11_-_64268841 0.490 NM_001098670
RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr11_+_13646822 0.490 FAR1
fatty acyl CoA reductase 1
chr5_-_131854325 0.487 NM_002198
IRF1
interferon regulatory factor 1
chr19_-_63565890 0.487 NM_198458
ZNF497
zinc finger protein 497
chr17_+_37693090 0.487 NM_003152
STAT5A
signal transducer and activator of transcription 5A
chr17_+_45617676 0.486


chr9_-_130006309 0.484 NM_001131015
NM_012127
CIZ1

CDKN1A interacting zinc finger protein 1

chr11_-_32413635 0.481 NM_000378
NM_024424
NM_024426
WT1


Wilms tumor 1


chr10_+_129237602 0.479 NM_001030013
NPS
neuropeptide S
chr8_-_145671947 0.478 FOXH1
forkhead box H1
chr19_+_3536541 0.476 NM_133261
GIPC3
GIPC PDZ domain containing family, member 3
chr10_+_50557689 0.475 NM_001042427
NM_182554
C10orf53

chromosome 10 open reading frame 53

chr8_+_90983268 0.475 NM_004337
OSGIN2
oxidative stress induced growth inhibitor family member 2
chr17_-_3766441 0.475 P2RX1
purinergic receptor P2X, ligand-gated ion channel, 1
chr19_-_50834502 0.474 NM_012155
EML2
echinoderm microtubule associated protein like 2
chr22_+_21559959 0.469 NM_001178126
IGLL5
IGLC1
immunoglobulin lambda-like polypeptide 5
immunoglobulin lambda constant 1 (Mcg marker)
chr7_+_91713347 0.469 NM_019004
ANKIB1
ankyrin repeat and IBR domain containing 1
chr22_-_20637188 0.468 PPM1F
protein phosphatase, Mg2+/Mn2+ dependent, 1F
chr11_+_113351006 0.467 NM_000869
NM_213621
HTR3A

5-hydroxytryptamine (serotonin) receptor 3A

chr16_+_83618804 0.467 NM_014732
KIAA0513
KIAA0513
chr17_+_42686248 0.465


chr20_+_61622985 0.464 PPDPF
pancreatic progenitor cell differentiation and proliferation factor homolog (zebrafish)
chr11_+_13646806 0.463 FAR1
fatty acyl CoA reductase 1
chr5_-_95323180 0.462 ELL2
elongation factor, RNA polymerase II, 2
chr22_-_40652724 0.461 NM_052945
TNFRSF13C
tumor necrosis factor receptor superfamily, member 13C
chr1_+_26986996 0.461 NM_017837
PIGV
phosphatidylinositol glycan anchor biosynthesis, class V
chr11_+_44044304 0.459 NM_001127219
NM_032592
ACCS

1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)

chr19_-_46551093 0.458 TGFB1
transforming growth factor, beta 1
chr11_-_289518 0.456 NM_001025295
IFITM5
interferon induced transmembrane protein 5
chr17_-_45617899 0.456 COL1A1
collagen, type I, alpha 1
chr2_+_9900933 0.454 NM_005680
TAF1B
TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa
chr1_-_45081190 0.451 NM_001166292
NM_003738
PTCH2

patched 2

chr11_+_67984758 0.449 NM_001164160
NM_001164161
NM_001164162
NM_001164163
NM_001164164
NM_018312
PPP6R3





protein phosphatase 6, regulatory subunit 3





chr14_+_49157150 0.447 NM_002408
MGAT2
mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
chr20_+_48032918 0.445 NM_005985
SNAI1
snail homolog 1 (Drosophila)
chr3_+_142979639 0.445 NM_139209
GRK7
G protein-coupled receptor kinase 7
chr7_+_99809003 0.444 NM_013439
NM_178272
NM_178273
PILRA


paired immunoglobin-like type 2 receptor alpha


chr11_+_9736408 0.441 LOC283104
hypothetical LOC283104
chr16_+_48865521 0.440 ADCY7
adenylate cyclase 7
chr2_+_46623325 0.439 NM_012249
RHOQ
ras homolog gene family, member Q
chrX_-_19815586 0.436 NM_031892
SH3KBP1
SH3-domain kinase binding protein 1
chr22_+_20899155 0.435


chr18_-_17434811 0.433 ESCO1
establishment of cohesion 1 homolog 1 (S. cerevisiae)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.15 1.10e-08 GO:0065007 biological regulation
1.15 2.89e-07 GO:0050789 regulation of biological process
1.15 1.10e-06 GO:0050794 regulation of cellular process
1.25 3.90e-04 GO:0048518 positive regulation of biological process
1.29 4.98e-04 GO:0048523 negative regulation of cellular process
1.27 6.22e-04 GO:0048519 negative regulation of biological process
1.19 7.04e-04 GO:0019222 regulation of metabolic process
1.53 1.08e-03 GO:0010628 positive regulation of gene expression
1.20 1.12e-03 GO:0031323 regulation of cellular metabolic process
1.19 3.96e-03 GO:0080090 regulation of primary metabolic process
1.07 6.13e-03 GO:0009987 cellular process
1.24 6.53e-03 GO:0048522 positive regulation of cellular process
1.46 6.92e-03 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.19 7.27e-03 GO:0060255 regulation of macromolecule metabolic process
1.50 9.86e-03 GO:0045893 positive regulation of transcription, DNA-dependent
1.44 1.40e-02 GO:0051173 positive regulation of nitrogen compound metabolic process
1.31 2.08e-02 GO:0009966 regulation of signal transduction
1.21 2.23e-02 GO:0031326 regulation of cellular biosynthetic process
1.21 2.23e-02 GO:0009889 regulation of biosynthetic process
1.28 2.34e-02 GO:0023051 regulation of signaling
1.25 3.62e-02 GO:0048583 regulation of response to stimulus
1.21 3.88e-02 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.45 4.13e-02 GO:0051254 positive regulation of RNA metabolic process
1.22 4.19e-02 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.20 4.82e-02 GO:0051171 regulation of nitrogen compound metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.07 7.27e-04 GO:0044424 intracellular part
1.06 2.35e-03 GO:0005622 intracellular
1.08 1.17e-02 GO:0005737 cytoplasm

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.17 3.94e-10 GO:0005515 protein binding
1.72 1.41e-03 GO:0016563 transcription activator activity
1.44 7.10e-03 GO:0043565 sequence-specific DNA binding
1.35 1.19e-02 GO:0001071 nucleic acid binding transcription factor activity
1.35 1.19e-02 GO:0003700 sequence-specific DNA binding transcription factor activity