Motif ID: KLF4.p3

Z-value: 3.064


Transcription factors associated with KLF4.p3:

Gene SymbolEntrez IDGene Name
KLF4 9314 Kruppel-like factor 4 (gut)



Activity profile for motif KLF4.p3.

activity profile for motif KLF4.p3


Sorted Z-values histogram for motif KLF4.p3

Sorted Z-values for motif KLF4.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of KLF4.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_32992131 3.745


chr22_-_17546296 3.635 NM_005984
SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr22_-_17546276 2.954 SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr9_+_129962292 2.934 NM_024112
C9orf16
chromosome 9 open reading frame 16
chr6_-_31805547 2.760 DDAH2
dimethylarginine dimethylaminohydrolase 2
chr19_-_50975121 2.741


chr8_-_144887876 2.430 NM_198488
FAM83H
family with sequence similarity 83, member H
chr8_-_145609737 2.378 SLC39A4
solute carrier family 39 (zinc transporter), member 4
chr1_+_46485972 2.219 RAD54L
RAD54-like (S. cerevisiae)
chr22_-_17546234 2.208 SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr9_+_132961723 2.123 AIF1L
allograft inflammatory factor 1-like
chr19_-_6718417 2.118 NM_005490
SH2D3A
SH2 domain containing 3A
chr22_-_17489718 2.058 DGCR2
DiGeorge syndrome critical region gene 2
chr1_-_32574185 2.010 NM_023009
MARCKSL1
MARCKS-like 1
chr8_+_144888275 1.998 LOC100128338
hypothetical LOC100128338
chr1_-_1840564 1.933 NM_178545
TMEM52
transmembrane protein 52
chr6_-_31805932 1.917 DDAH2
dimethylarginine dimethylaminohydrolase 2
chr6_-_31806012 1.863 NM_013974
DDAH2
dimethylarginine dimethylaminohydrolase 2
chr22_-_17489912 1.861 NM_001173533
NM_001173534
NM_001184781
NM_005137
DGCR2



DiGeorge syndrome critical region gene 2



chr22_-_17545872 1.809 SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr18_+_586997 1.739 NM_014410
CLUL1
clusterin-like 1 (retinal)
chr1_+_984935 1.683 LOC100288175
hypothetical LOC100288175
chr1_-_159413833 1.681 NM_003779
B4GALT3
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3
chr22_+_21742727 1.681 GNAZ
guanine nucleotide binding protein (G protein), alpha z polypeptide
chr1_-_40903897 1.671 NM_014747
RIMS3
regulating synaptic membrane exocytosis 3
chr8_-_145661545 1.664 NM_032687
NM_001129888
CYHR1

cysteine/histidine-rich 1

chr1_-_40903700 1.635 RIMS3
regulating synaptic membrane exocytosis 3
chr22_+_21817512 1.615 NM_004914
RAB36
RAB36, member RAS oncogene family
chr17_+_24079924 1.614 NM_178170
NEK8
NIMA (never in mitosis gene a)- related kinase 8
chr1_+_46485946 1.600 NM_001142548
NM_003579
RAD54L

RAD54-like (S. cerevisiae)

chr19_-_43438818 1.594 PPP1R14A
protein phosphatase 1, regulatory (inhibitor) subunit 14A
chr1_+_46486020 1.571 RAD54L
RAD54-like (S. cerevisiae)
chr1_-_41100606 1.566 CITED4
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4
chr22_+_21742364 1.561 NM_002073
GNAZ
guanine nucleotide binding protein (G protein), alpha z polypeptide
chr19_+_54558798 1.555 NM_001197302
NM_001197301
NM_014419
DKKL1


dickkopf-like 1


chr6_-_6632197 1.518


chr21_+_46568894 1.509 PCNT
pericentrin
chr6_-_35572694 1.485 NM_003214
TEAD3
TEA domain family member 3
chr16_+_1143241 1.463 NM_001005407
NM_021098
CACNA1H

calcium channel, voltage-dependent, T type, alpha 1H subunit

chr7_+_73136254 1.435 LIMK1
LIM domain kinase 1
chr7_-_150305933 1.429 NM_000238
NM_172056
KCNH2

potassium voltage-gated channel, subfamily H (eag-related), member 2

chr22_-_20551937 1.419 MAPK1
mitogen-activated protein kinase 1
chr7_+_127015650 1.417 NM_001662
ARF5
ADP-ribosylation factor 5
chr12_-_129889569 1.396 NM_001980
NM_194356
STX2

syntaxin 2

chr6_+_37245860 1.392 NM_002648
PIM1
pim-1 oncogene
chr18_-_26935883 1.377 NM_004949
NM_024422
DSC2

desmocollin 2

chr22_-_20551953 1.370 NM_002745
NM_138957
MAPK1

mitogen-activated protein kinase 1

chr22_+_18081968 1.367 NM_002688
SEPT5
septin 5
chr2_+_10101081 1.360 NM_003597
NM_001177716
KLF11

Kruppel-like factor 11

chr15_-_81146188 1.360 AP3B2
adaptor-related protein complex 3, beta 2 subunit
chr17_+_77582774 1.335 NM_005052
RAC3
ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
chr19_-_43439011 1.331 NM_033256
PPP1R14A
protein phosphatase 1, regulatory (inhibitor) subunit 14A
chr17_+_75849221 1.268 NM_020914
NM_020954
RNF213

ring finger protein 213

chr1_-_27582368 1.263 NM_207397
CD164L2
CD164 sialomucin-like 2
chr6_+_44203335 1.261 NM_018426
TMEM63B
transmembrane protein 63B
chr1_-_38243716 1.259 FHL3
four and a half LIM domains 3
chr7_-_104440707 1.255 LOC100216545
hypothetical LOC100216545
chr19_+_40958206 1.255 NM_001172630
NM_052948
ARHGAP33

Rho GTPase activating protein 33

chr9_+_138805581 1.251 NM_032928
TMEM141
transmembrane protein 141
chr10_+_86078136 1.222 NM_018999
FAM190B
family with sequence similarity 190, member B
chr1_-_41100589 1.196 NM_133467
CITED4
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4
chr1_+_984972 1.180 LOC100288175
hypothetical LOC100288175
chr7_+_64136078 1.151 CCT6P3
chaperonin containing TCP1, subunit 6 (zeta) pseudogene 3
chr17_-_37586716 1.147 NM_012285
KCNH4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr7_+_128257698 1.142 NM_001127487
NM_001458
FLNC

filamin C, gamma

chr4_+_154606900 1.138 NM_001131007
NM_015196
KIAA0922

KIAA0922

chr5_-_176671897 1.131 NM_001142935
NM_031300
MXD3

MAX dimerization protein 3

chr19_+_45976001 1.127 NM_016154
RAB4B-EGLN2
RAB4B
RAB4B-EGLN2 read-through transcript
RAB4B, member RAS oncogene family
chr12_+_55896844 1.125 NM_007224
NXPH4
neurexophilin 4
chr1_+_205561439 1.122 NM_000574
NM_001114752
CD55

CD55 molecule, decay accelerating factor for complement (Cromer blood group)

chr11_+_133706977 1.113 NM_138342
GLB1L2
galactosidase, beta 1-like 2
chr15_-_76720598 1.110 NM_000750
CHRNB4
cholinergic receptor, nicotinic, beta 4
chr1_-_221383212 1.108 NM_003268
TLR5
toll-like receptor 5
chrX_-_48713194 1.106 NM_004979
KCND1
potassium voltage-gated channel, Shal-related subfamily, member 1
chr6_-_33393696 1.098 NM_001145338
ZBTB22
zinc finger and BTB domain containing 22
chr1_+_26728827 1.080 NM_002953
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chrX_-_134883798 1.078 NM_173470
MMGT1
membrane magnesium transporter 1
chrX_+_15666312 1.073 NM_007220
CA5B
carbonic anhydrase VB, mitochondrial
chr19_+_6690697 1.059 NM_004240
TRIP10
thyroid hormone receptor interactor 10
chr1_+_26728839 1.054 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr19_-_10540620 1.050 NM_001800
NM_079421
CDKN2D

cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)

chr19_-_43406621 1.043 NM_001135155
NM_004647
DPF1

D4, zinc and double PHD fingers family 1

chr3_-_38041281 1.040 NM_001130964
PLCD1
phospholipase C, delta 1
chr22_+_18085891 1.033 SEPT5
septin 5
chr22_+_18085990 1.025 SEPT5-GP1BB
SEPT5
SEPT5-GP1BB read-through transcript
septin 5
chr17_-_37196463 1.016 NM_002230
NM_021991
JUP

junction plakoglobin

chr11_-_69228286 1.016 NM_005117
FGF19
fibroblast growth factor 19
chr6_+_7052798 1.015 NM_001168344
RREB1
ras responsive element binding protein 1
chr2_+_46623396 1.011 RHOQ
ras homolog gene family, member Q
chr9_+_132961683 1.011 NM_001185095
NM_001185096
NM_031426
AIF1L


allograft inflammatory factor 1-like


chr9_+_130142746 1.000 SLC27A4
solute carrier family 27 (fatty acid transporter), member 4
chr1_+_30964199 1.000 LOC100129196
hypothetical LOC100129196
chr17_-_24062998 0.997 NM_152465
PROCA1
protein interacting with cyclin A1
chr7_-_97868362 0.990 NM_018842
BAIAP2L1
BAI1-associated protein 2-like 1
chr19_+_50041387 0.987 PVRL2
poliovirus receptor-related 2 (herpesvirus entry mediator B)
chr17_+_71033339 0.986 NM_001015002
NM_001031803
NM_004524
LLGL2


lethal giant larvae homolog 2 (Drosophila)


chr3_-_47180417 0.982 NM_014159
SETD2
SET domain containing 2
chr19_+_60283571 0.981 NM_017729
EPS8L1
EPS8-like 1
chr19_+_50041400 0.980 PVRL2
poliovirus receptor-related 2 (herpesvirus entry mediator B)
chr8_+_1699276 0.979 NM_018941
CLN8
ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
chr11_-_64268841 0.976 NM_001098670
RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr8_-_144722141 0.975 C8orf73
chromosome 8 open reading frame 73
chr1_+_37712716 0.971 ZC3H12A
zinc finger CCCH-type containing 12A
chr16_-_1404635 0.967 NM_001037125
NM_001193388
UNKL

unkempt homolog (Drosophila)-like

chr22_-_18384251 0.960 NM_001670
ARVCF
armadillo repeat gene deleted in velocardiofacial syndrome
chr15_+_61356801 0.955 NM_001145646
NM_031301
APH1B

anterior pharynx defective 1 homolog B (C. elegans)

chr20_+_32928065 0.952 ACSS2
acyl-CoA synthetase short-chain family member 2
chr1_-_54183833 0.950 NM_016126
HSPB11
heat shock protein family B (small), member 11
chr12_-_122415327 0.946 SBNO1
strawberry notch homolog 1 (Drosophila)
chr16_+_88422354 0.941 NM_032451
SPIRE2
spire homolog 2 (Drosophila)
chr1_-_38243747 0.941 NM_004468
FHL3
four and a half LIM domains 3
chr10_+_75427853 0.939 NM_003373
NM_014000
VCL

vinculin

chrX_+_148671394 0.937 NM_005365
NM_001080790
MAGEA9
MAGEA9B
melanoma antigen family A, 9
melanoma antigen family A, 9B
chr16_-_47873183 0.930 NM_004352
CBLN1
cerebellin 1 precursor
chr12_+_115455579 0.929 NCRNA00173
non-protein coding RNA 173
chr11_-_565848 0.921 LOC143666
hypothetical LOC143666
chr7_-_105712646 0.920 NM_005746
NAMPT
nicotinamide phosphoribosyltransferase
chr11_+_133707107 0.915 GLB1L2
galactosidase, beta 1-like 2
chr5_+_176726918 0.911 RGS14
regulator of G-protein signaling 14
chr20_+_32927988 0.910 NM_001076552
NM_018677
ACSS2

acyl-CoA synthetase short-chain family member 2

chr19_+_50535837 0.909 NM_177417
KLC3
kinesin light chain 3
chr5_+_133889584 0.909 NM_015288
PHF15
PHD finger protein 15
chr5_-_175969697 0.906 NM_052899
GPRIN1
G protein regulated inducer of neurite outgrowth 1
chr22_-_20419975 0.905 NM_013313
YPEL1
yippee-like 1 (Drosophila)
chr16_-_47872973 0.904 CBLN1
cerebellin 1 precursor
chr17_-_78199384 0.901 NM_019613
WDR45L
WDR45-like
chr22_-_18635614 0.884 NM_023004
RTN4R
reticulon 4 receptor
chr7_-_156378382 0.884 LMBR1
limb region 1 homolog (mouse)
chr1_+_205561632 0.878 CD55
CD55 molecule, decay accelerating factor for complement (Cromer blood group)
chr19_+_1199548 0.876 NM_177401
MIDN
midnolin
chr1_+_166172420 0.876 NM_001017977
NM_001198956
NM_001198957
NM_018442
DCAF6



DDB1 and CUL4 associated factor 6



chr8_-_96350575 0.872 NM_177965
C8orf37
chromosome 8 open reading frame 37
chr6_+_7052985 0.871 NM_001003698
NM_001003699
NM_001003700
RREB1


ras responsive element binding protein 1


chr21_+_46703192 0.866 NM_001146114
NM_001146115
NM_001146116
NM_015151
NM_206889
NM_206890
NM_206891
DIP2A






DIP2 disco-interacting protein 2 homolog A (Drosophila)






chr16_+_29725665 0.864


chr11_+_46256161 0.864 CREB3L1
cAMP responsive element binding protein 3-like 1
chr12_+_110328126 0.855 NM_005475
SH2B3
SH2B adaptor protein 3
chr6_+_31741635 0.855 NM_001320
CSNK2B
casein kinase 2, beta polypeptide
chr1_+_26728846 0.852 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr12_+_56202874 0.850 NM_052897
MBD6
methyl-CpG binding domain protein 6
chr9_+_90339835 0.850 NM_001161625
NM_145283
NXNL2

nucleoredoxin-like 2

chr11_+_46256130 0.847 CREB3L1
cAMP responsive element binding protein 3-like 1
chr7_-_150408785 0.842 FASTK
Fas-activated serine/threonine kinase
chr1_+_205561709 0.841 CD55
CD55 molecule, decay accelerating factor for complement (Cromer blood group)
chr1_+_205561693 0.838 CD55
CD55 molecule, decay accelerating factor for complement (Cromer blood group)
chr22_-_20551722 0.838 MAPK1
mitogen-activated protein kinase 1
chr1_+_172104115 0.838 NM_001122770
NM_032522
ZBTB37

zinc finger and BTB domain containing 37

chr12_+_119562737 0.836 NM_001033677
CABP1
calcium binding protein 1
chr11_-_63770716 0.835 PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr11_-_66482366 0.835 NM_000920
NM_001040716
PC

pyruvate carboxylase

chr2_+_46623325 0.835 NM_012249
RHOQ
ras homolog gene family, member Q
chr1_+_41022066 0.835 NM_004700
NM_172163
KCNQ4

potassium voltage-gated channel, KQT-like subfamily, member 4

chr10_+_49184658 0.832 MAPK8
mitogen-activated protein kinase 8
chr1_-_113059396 0.831 NM_005167
PPM1J
protein phosphatase, Mg2+/Mn2+ dependent, 1J
chr12_-_48508411 0.821 NM_001037806
NCKAP5L
NCK-associated protein 5-like
chr7_-_72771853 0.820 NM_001165903
NM_004603
STX1A

syntaxin 1A (brain)

chr7_-_97868101 0.817 BAIAP2L1
BAI1-associated protein 2-like 1
chr10_+_45189673 0.816 ALOX5
arachidonate 5-lipoxygenase
chr1_+_224317062 0.816 H3F3A
LOC440926
H3 histone, family 3A
H3 histone, family 3A pseudogene
chr1_+_28458546 0.814 NM_031459
SESN2
sestrin 2
chr15_-_26017994 0.814 NM_000275
OCA2
oculocutaneous albinism II
chr19_+_12805747 0.813 MAST1
microtubule associated serine/threonine kinase 1
chr1_-_164402575 0.812 NM_001017961
FAM78B
family with sequence similarity 78, member B
chr3_+_13496714 0.810 NM_024827
NM_001136041
HDAC11

histone deacetylase 11

chr1_-_38003391 0.807 NM_001099439
NM_173641
EPHA10

EPH receptor A10

chr11_-_94603857 0.807 NM_144665
SESN3
sestrin 3
chr11_-_2863536 0.806 NM_000076
NM_001122630
NM_001122631
CDKN1C


cyclin-dependent kinase inhibitor 1C (p57, Kip2)


chr6_-_136913235 0.805 MAP7
microtubule-associated protein 7
chr22_+_20316968 0.799 NM_152612
CCDC116
coiled-coil domain containing 116
chr7_-_86526880 0.798 NM_001142749
KIAA1324L
KIAA1324-like
chr19_-_51829778 0.796 NM_033258
GNG8
guanine nucleotide binding protein (G protein), gamma 8
chr18_+_12938010 0.791 SEH1L
SEH1-like (S. cerevisiae)
chr21_+_43267760 0.790 PKNOX1
PBX/knotted 1 homeobox 1
chr16_+_29725597 0.785


chr9_+_138805637 0.784 TMEM141
transmembrane protein 141
chrX_-_148476903 0.782 NM_005365
NM_001080790
MAGEA9
MAGEA9B
melanoma antigen family A, 9
melanoma antigen family A, 9B
chr3_+_47004457 0.779 NBEAL2
neurobeachin-like 2
chr7_+_73136085 0.778 NM_002314
LIMK1
LIM domain kinase 1
chr6_+_33352886 0.777 NM_003782
B3GALT4
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
chr22_+_18388633 0.776 C22orf25
chromosome 22 open reading frame 25
chr1_+_224317030 0.771 H3F3A
H3 histone, family 3A
chr11_+_63829616 0.769 NM_004451
ESRRA
estrogen-related receptor alpha
chr16_+_2419388 0.768 NM_001761
CCNF
cyclin F
chr16_+_2419418 0.765 CCNF
cyclin F
chr1_+_153557263 0.763 NM_001105203
NM_001105204
RUSC1

RUN and SH3 domain containing 1

chr12_+_48765300 0.763 SMARCD1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
chr5_+_176006993 0.762 NM_001006616
NM_012171
NM_130465
TSPAN17


tetraspanin 17


chr1_+_6596331 0.762 NM_153812
PHF13
PHD finger protein 13
chr1_+_224317056 0.761 H3F3A
LOC440926
H3 histone, family 3A
H3 histone, family 3A pseudogene
chrX_-_152642716 0.761 NM_001139457
NM_001139441
BCAP31

B-cell receptor-associated protein 31

chr3_+_140148765 0.760 NM_001040061
C3orf72
chromosome 3 open reading frame 72
chr6_-_44341222 0.757 NFKBIE
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
chr3_-_140148671 0.757 NM_023067
FOXL2
forkhead box L2
chr3_-_12983959 0.757 NM_014869
IQSEC1
IQ motif and Sec7 domain 1
chr20_-_14266200 0.757 NM_013281
NM_198391
FLRT3

fibronectin leucine rich transmembrane protein 3

chr1_+_3679168 0.757 NM_001163724
LOC388588
hypothetical protein LOC388588
chr3_+_38181972 0.756 NM_005109
OXSR1
oxidative-stress responsive 1
chr13_+_90848875 0.755 NM_004466
GPC5
glypican 5
chr7_+_44045202 0.754 FLJ35390
hypothetical LOC255031
chr21_+_46703397 0.749 DIP2A
DIP2 disco-interacting protein 2 homolog A (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.07 1.75e-19 GO:0009987 cellular process
1.11 1.30e-13 GO:0044237 cellular metabolic process
1.13 5.57e-12 GO:0044260 cellular macromolecule metabolic process
1.09 1.49e-09 GO:0044238 primary metabolic process
1.28 2.46e-09 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.11 4.92e-09 GO:0043170 macromolecule metabolic process
1.08 5.46e-09 GO:0050789 regulation of biological process
1.08 5.56e-09 GO:0008152 metabolic process
1.07 5.81e-08 GO:0065007 biological regulation
1.13 6.63e-08 GO:0031323 regulation of cellular metabolic process
1.08 1.05e-07 GO:0050794 regulation of cellular process
1.11 4.99e-07 GO:0019222 regulation of metabolic process
1.12 6.01e-07 GO:0080090 regulation of primary metabolic process
1.14 6.57e-07 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.14 1.48e-06 GO:0051171 regulation of nitrogen compound metabolic process
1.14 2.01e-06 GO:0048518 positive regulation of biological process
1.15 2.78e-06 GO:0051252 regulation of RNA metabolic process
1.15 3.32e-06 GO:0048522 positive regulation of cellular process
1.12 3.39e-06 GO:0060255 regulation of macromolecule metabolic process
1.16 4.28e-06 GO:0048523 negative regulation of cellular process
1.14 5.41e-06 GO:0010468 regulation of gene expression
1.14 8.13e-06 GO:0044267 cellular protein metabolic process
1.14 9.95e-06 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.15 1.06e-05 GO:0006355 regulation of transcription, DNA-dependent
1.19 1.80e-05 GO:0033036 macromolecule localization
1.14 1.88e-05 GO:0048519 negative regulation of biological process
1.11 1.98e-05 GO:0032502 developmental process
1.13 3.03e-05 GO:0031326 regulation of cellular biosynthetic process
1.11 3.50e-05 GO:0016043 cellular component organization
1.16 4.17e-05 GO:0006464 protein modification process
1.12 4.71e-05 GO:0048856 anatomical structure development
1.11 6.56e-05 GO:0006807 nitrogen compound metabolic process
1.13 6.85e-05 GO:0010556 regulation of macromolecule biosynthetic process
1.12 7.36e-05 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.13 8.66e-05 GO:0009889 regulation of biosynthetic process
1.24 2.26e-04 GO:0051173 positive regulation of nitrogen compound metabolic process
1.11 2.63e-04 GO:0034641 cellular nitrogen compound metabolic process
1.25 2.69e-04 GO:0010628 positive regulation of gene expression
1.15 2.71e-04 GO:0043412 macromolecule modification
1.19 2.98e-04 GO:0010604 positive regulation of macromolecule metabolic process
1.10 3.44e-04 GO:0051179 localization
1.26 3.44e-04 GO:0045893 positive regulation of transcription, DNA-dependent
1.11 3.54e-04 GO:0051234 establishment of localization
1.20 3.69e-04 GO:0008104 protein localization
1.11 4.22e-04 GO:0006810 transport
1.12 4.28e-04 GO:0071842 cellular component organization at cellular level
1.21 4.45e-04 GO:0010605 negative regulation of macromolecule metabolic process
1.25 4.50e-04 GO:0051254 positive regulation of RNA metabolic process
1.10 4.61e-04 GO:0007275 multicellular organismal development
1.10 5.63e-04 GO:0071840 cellular component organization or biogenesis
1.16 5.77e-04 GO:0009653 anatomical structure morphogenesis
1.17 6.92e-04 GO:0009056 catabolic process
1.23 8.25e-04 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.18 9.41e-04 GO:0009893 positive regulation of metabolic process
1.20 1.05e-03 GO:0009892 negative regulation of metabolic process
1.16 1.11e-03 GO:0007399 nervous system development
1.13 1.81e-03 GO:0030154 cell differentiation
1.18 1.81e-03 GO:0031325 positive regulation of cellular metabolic process
1.15 1.95e-03 GO:0023051 regulation of signaling
1.15 2.22e-03 GO:0006996 organelle organization
1.20 2.30e-03 GO:0031324 negative regulation of cellular metabolic process
1.20 2.40e-03 GO:0022008 neurogenesis
1.13 2.58e-03 GO:0048869 cellular developmental process
1.11 3.01e-03 GO:0048731 system development
1.22 3.22e-03 GO:0010557 positive regulation of macromolecule biosynthetic process
1.29 3.42e-03 GO:0008285 negative regulation of cell proliferation
1.17 3.61e-03 GO:0044248 cellular catabolic process
1.23 3.70e-03 GO:0009790 embryo development
1.24 5.04e-03 GO:0010629 negative regulation of gene expression
1.19 5.28e-03 GO:0048468 cell development
1.27 5.50e-03 GO:0031175 neuron projection development
1.11 7.33e-03 GO:0044249 cellular biosynthetic process
1.20 7.48e-03 GO:0048699 generation of neurons
1.10 7.75e-03 GO:0019538 protein metabolic process
1.11 7.75e-03 GO:0009058 biosynthetic process
1.11 7.89e-03 GO:0071841 cellular component organization or biogenesis at cellular level
1.23 8.02e-03 GO:0030030 cell projection organization
1.22 9.80e-03 GO:0031327 negative regulation of cellular biosynthetic process
1.26 1.03e-02 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.12 1.13e-02 GO:0090304 nucleic acid metabolic process
1.16 1.14e-02 GO:0051641 cellular localization
1.13 1.33e-02 GO:0010467 gene expression
1.23 1.46e-02 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.23 1.53e-02 GO:0009057 macromolecule catabolic process
1.15 1.69e-02 GO:0009966 regulation of signal transduction
1.24 1.69e-02 GO:0051253 negative regulation of RNA metabolic process
1.19 1.76e-02 GO:0006351 transcription, DNA-dependent
1.29 1.87e-02 GO:0030163 protein catabolic process
1.23 1.94e-02 GO:0048666 neuron development
1.23 2.03e-02 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.17 2.20e-02 GO:0007049 cell cycle
1.22 2.29e-02 GO:0051172 negative regulation of nitrogen compound metabolic process
1.21 2.57e-02 GO:0045595 regulation of cell differentiation
1.19 2.68e-02 GO:0008219 cell death
1.15 2.81e-02 GO:0035556 intracellular signal transduction
1.24 2.90e-02 GO:0045892 negative regulation of transcription, DNA-dependent
1.21 3.17e-02 GO:0030182 neuron differentiation
1.19 3.18e-02 GO:0031328 positive regulation of cellular biosynthetic process
1.19 3.20e-02 GO:0009891 positive regulation of biosynthetic process
1.21 3.24e-02 GO:0009890 negative regulation of biosynthetic process
1.13 3.75e-02 GO:0016070 RNA metabolic process
1.27 4.26e-02 GO:0007264 small GTPase mediated signal transduction
1.18 4.97e-02 GO:0016265 death

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.10 9.06e-42 GO:0044424 intracellular part
1.09 6.92e-41 GO:0005622 intracellular
1.10 1.31e-30 GO:0043226 organelle
1.10 2.11e-30 GO:0043229 intracellular organelle
1.11 2.14e-29 GO:0043227 membrane-bounded organelle
1.11 2.27e-29 GO:0043231 intracellular membrane-bounded organelle
1.11 1.15e-27 GO:0005737 cytoplasm
1.13 2.33e-18 GO:0005634 nucleus
1.12 7.08e-18 GO:0044444 cytoplasmic part
1.12 1.31e-15 GO:0044446 intracellular organelle part
1.12 5.64e-15 GO:0044422 organelle part
1.18 6.70e-10 GO:0005829 cytosol
1.17 3.16e-09 GO:0044428 nuclear part
1.03 1.27e-08 GO:0044464 cell part
1.03 1.43e-08 GO:0005623 cell
1.18 3.11e-07 GO:0012505 endomembrane system
1.17 3.94e-07 GO:0031981 nuclear lumen
1.14 2.32e-06 GO:0070013 intracellular organelle lumen
1.14 3.04e-06 GO:0043233 organelle lumen
1.14 6.47e-06 GO:0031974 membrane-enclosed lumen
1.18 1.35e-05 GO:0005654 nucleoplasm
1.26 4.55e-05 GO:0030054 cell junction
1.11 5.67e-05 GO:0043234 protein complex
1.22 7.79e-05 GO:0031982 vesicle
1.22 2.22e-04 GO:0031988 membrane-bounded vesicle
1.22 2.30e-04 GO:0031410 cytoplasmic vesicle
1.72 3.15e-04 GO:0000922 spindle pole
1.23 3.39e-04 GO:0015630 microtubule cytoskeleton
1.45 3.91e-04 GO:0070161 anchoring junction
1.12 4.07e-04 GO:0031090 organelle membrane
1.20 4.86e-04 GO:0042995 cell projection
1.09 4.89e-04 GO:0032991 macromolecular complex
1.21 6.97e-04 GO:0016023 cytoplasmic membrane-bounded vesicle
1.10 8.26e-04 GO:0043228 non-membrane-bounded organelle
1.10 8.26e-04 GO:0043232 intracellular non-membrane-bounded organelle
1.29 8.28e-04 GO:0043005 neuron projection
1.57 9.14e-04 GO:0005925 focal adhesion
1.45 1.50e-03 GO:0005912 adherens junction
1.53 2.11e-03 GO:0030055 cell-substrate junction
1.40 2.13e-03 GO:0005819 spindle
1.14 2.15e-03 GO:0005856 cytoskeleton
1.26 4.52e-03 GO:0045202 synapse
1.52 4.68e-03 GO:0005924 cell-substrate adherens junction
1.20 5.61e-03 GO:0044451 nucleoplasm part
1.17 5.77e-03 GO:0005794 Golgi apparatus
1.38 8.39e-03 GO:0030424 axon
1.30 1.06e-02 GO:0044456 synapse part
1.26 1.77e-02 GO:0048471 perinuclear region of cytoplasm
1.23 1.91e-02 GO:0000139 Golgi membrane
1.34 3.07e-02 GO:0030425 dendrite

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.14 4.74e-31 GO:0005515 protein binding
1.06 4.59e-19 GO:0005488 binding
1.14 9.11e-06 GO:0000166 nucleotide binding
1.21 9.48e-05 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.22 4.04e-04 GO:0016301 kinase activity
1.29 5.72e-04 GO:0019904 protein domain specific binding
1.22 5.95e-04 GO:0019899 enzyme binding
1.19 7.46e-04 GO:0030528 transcription regulator activity
1.22 2.24e-03 GO:0043565 sequence-specific DNA binding
1.12 4.03e-03 GO:0032553 ribonucleotide binding
1.12 4.03e-03 GO:0032555 purine ribonucleotide binding
1.12 4.53e-03 GO:0017076 purine nucleotide binding
1.12 6.48e-03 GO:0035639 purine ribonucleoside triphosphate binding
1.13 6.67e-03 GO:0016740 transferase activity
1.20 7.37e-03 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.27 1.11e-02 GO:0000988 protein binding transcription factor activity
1.27 1.11e-02 GO:0000989 transcription factor binding transcription factor activity
1.27 1.42e-02 GO:0003712 transcription cofactor activity
1.21 2.03e-02 GO:0004672 protein kinase activity
1.29 2.09e-02 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.30 3.33e-02 GO:0016881 acid-amino acid ligase activity
1.16 4.10e-02 GO:0001071 nucleic acid binding transcription factor activity
1.16 4.10e-02 GO:0003700 sequence-specific DNA binding transcription factor activity