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Motif ID: TFEB.p2

Z-value: 1.345

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr20_+_43953428	1.710		CTSA	cathepsin A
chr6_-_84994032	1.544	NM_014895	KIAA1009	KIAA1009
chr20_-_43953036	1.502	NM_080749	NEURL2	neuralized homolog 2 (Drosophila)
chr1_-_68470585	1.493	NM_001002292 NM_001193334 NM_024911	WLS	wntless homolog (Drosophila)
chr19_+_10625987	1.485		ILF3	interleukin enhancer binding factor 3, 90kDa
chr10_-_32257693	1.475		ARHGAP12	Rho GTPase activating protein 12
chr13_+_112999538	1.361		LAMP1	lysosomal-associated membrane protein 1
chr20_+_43953606	1.343		CTSA	cathepsin A
chr1_-_11788550	1.332		MTHFR	methylenetetrahydrofolate reductase (NAD(P)H)
chr17_-_7078446	1.329	NM_004422	DVL2	dishevelled, dsh homolog 2 (Drosophila)
chr19_-_10625449	1.328		LOC147727	hypothetical LOC147727
chr13_+_112999590	1.309		LAMP1	lysosomal-associated membrane protein 1
chr13_+_48582389	1.264	NM_014923	FNDC3A	fibronectin type III domain containing 3A
chr16_+_28893525	1.264	NM_001142448 NM_001142449 NM_001142450 NM_001142451 NM_032038	SPIN1 SPNS1	spindlin 1 spinster homolog 1 (Drosophila)
chr16_+_68542126	1.212	NM_001136214	CLEC18A	C-type lectin domain family 18, member A
chr2_+_176689737	1.202	NM_002148	HOXD10	homeobox D10
chr5_+_140200995	1.128	NM_018911 NM_031856	PCDHA8	protocadherin alpha 8
chr17_-_7078304	1.121		DVL2	dishevelled, dsh homolog 2 (Drosophila)
chr17_-_7078399	1.108		DVL2	dishevelled, dsh homolog 2 (Drosophila)
chr1_-_202595666	1.064	NM_014935	PLEKHA6	pleckstrin homology domain containing, family A member 6
chr14_-_19999475	1.064	NM_001100814 NM_144568	TMEM55B	transmembrane protein 55B
chr1_-_152459506	1.033		C1orf43	chromosome 1 open reading frame 43
chr10_-_32257768	1.030	NM_018287	ARHGAP12	Rho GTPase activating protein 12
chr13_+_112999462	1.023	NM_005561	LAMP1	lysosomal-associated membrane protein 1
chr1_-_152459667	1.016		C1orf43	chromosome 1 open reading frame 43
chr1_+_201364050	1.013		ADORA1	adenosine A1 receptor
chr11_-_85457469	1.003		PICALM	phosphatidylinositol binding clathrin assembly protein
chr9_+_130749791	0.964	NM_015354	NUP188	nucleoporin 188kDa
chr1_-_11788666	0.964	NM_005957	MTHFR	methylenetetrahydrofolate reductase (NAD(P)H)
chr8_+_71744153	0.949	NM_001011720	XKR9	XK, Kell blood group complex subunit-related family, member 9
chr20_+_43953372	0.928		CTSA	cathepsin A
chr4_-_164473107	0.926	NM_000909	NPY1R	neuropeptide Y receptor Y1
chr7_-_47588652	0.924		TNS3	tensin 3
chr9_-_130749604	0.911	NM_014908	DOLK	dolichol kinase
chr11_-_85457736	0.904		PICALM	phosphatidylinositol binding clathrin assembly protein
chr8_+_98857190	0.892		LAPTM4B	lysosomal protein transmembrane 4 beta
chr11_-_85457753	0.888	NM_001008660 NM_007166	PICALM	phosphatidylinositol binding clathrin assembly protein
chr9_+_130749812	0.876		NUP188	nucleoporin 188kDa
chr5_+_150807331	0.871	NM_078483	SLC36A1	solute carrier family 36 (proton/amino acid symporter), member 1
chr1_-_152797767	0.870		UBE2Q1	ubiquitin-conjugating enzyme E2Q family member 1
chr14_-_91642703	0.863	NM_001127696 NM_001127697 NM_001164774 NM_001164776 NM_001164777 NM_001164778 NM_001164779 NM_001164780 NM_001164781 NM_001164782 NM_004993 NM_030660	ATXN3	ataxin 3
chr18_+_9126742	0.851	NM_001083625 NM_015208	ANKRD12	ankyrin repeat domain 12
chr6_-_109810396	0.842	NM_001142401 NM_001142402 NM_001142403 NM_001142404 NM_006016	CD164	CD164 molecule, sialomucin
chr1_-_39097904	0.835	NM_022157	RRAGC	Ras-related GTP binding C
chr5_+_150807380	0.829		SLC36A1	solute carrier family 36 (proton/amino acid symporter), member 1
chr19_+_10625896	0.828	NM_001137673 NM_004516 NM_012218 NM_017620 NM_153464	ILF3	interleukin enhancer binding factor 3, 90kDa
chr3_-_127558747	0.815	NM_014079	KLF15	Kruppel-like factor 15
chr9_-_34038869	0.809		UBAP2	ubiquitin associated protein 2
chr1_-_94475840	0.809	NM_004815	ARHGAP29	Rho GTPase activating protein 29
chr1_+_159550789	0.807	NM_001035511 NM_001035512 NM_001035513 NM_003001	SDHC	succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
chr16_+_68542310	0.799	NM_182619	CLEC18C CLEC18A CLEC18B	C-type lectin domain family 18, member C C-type lectin domain family 18, member A C-type lectin domain family 18, member B
chr4_+_128773529	0.793	NM_015693	INTU	inturned planar cell polarity effector homolog (Drosophila)
chr20_-_32877029	0.791	NM_014071	NCOA6	nuclear receptor coactivator 6
chr1_-_152797820	0.789		UBE2Q1	ubiquitin-conjugating enzyme E2Q family member 1
chr8_-_68103339	0.789	NM_001013626	LRRC67	leucine rich repeat containing 67
chr8_+_133856738	0.784	NM_016018 NM_032205 NM_198513	PHF20L1	PHD finger protein 20-like 1
chr4_-_100461530	0.778	NM_000668	ADH1B	alcohol dehydrogenase 1B (class I), beta polypeptide
chr8_+_76059262	0.769	NM_031461	CRISPLD1	cysteine-rich secretory protein LCCL domain containing 1
chr14_-_91642641	0.757		ATXN3 ATXN8	ataxin 3 ataxin 8
chrX_+_54483565	0.757	NM_058163	TSR2	TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)
chr6_+_87921980	0.740	NM_015021	ZNF292	zinc finger protein 292
chr11_-_47427263	0.735	NM_005055 NM_032645	RAPSN	receptor-associated protein of the synapse
chr20_-_61317891	0.723	NM_017798	YTHDF1	YTH domain family, member 1
chr15_-_48766252	0.721		TRPM7	transient receptor potential cation channel, subfamily M, member 7
chr16_+_30952350	0.719		STX4	syntaxin 4
chr2_+_176761552	0.719	NM_024501	HOXD1	homeobox D1
chr8_+_133856793	0.714		PHF20L1	PHD finger protein 20-like 1
chr9_-_34038887	0.712	NM_018449	UBAP2	ubiquitin associated protein 2
chr8_-_54918099	0.706	NM_213620	ATP6V1H	ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
chr6_-_80713589	0.706	NM_022726	ELOVL4	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4
chr2_+_27659396	0.700	NM_032434	ZNF512	zinc finger protein 512
chr20_+_37024383	0.695	NM_001190809 NM_021931	DHX35	DEAH (Asp-Glu-Ala-His) box polypeptide 35
chr5_-_131160541	0.693		FNIP1	folliculin interacting protein 1
chr11_-_71491916	0.686		LAMTOR1	late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
chr3_-_171786468	0.681	NM_020949	SLC7A14	solute carrier family 7 (cationic amino acid transporter, y+ system), member 14
chr3_-_172109075	0.678		EIF5A2	eukaryotic translation initiation factor 5A2
chr1_-_152797760	0.672		UBE2Q1	ubiquitin-conjugating enzyme E2Q family member 1
chr3_+_185515013	0.672		EIF4G1	eukaryotic translation initiation factor 4 gamma, 1
chr15_+_46200460	0.667	NM_205850	SLC24A5	solute carrier family 24, member 5
chr6_+_127629677	0.667	NM_030963	RNF146	ring finger protein 146
chr12_-_56432385	0.666	NM_000075	CDK4	cyclin-dependent kinase 4
chrX_+_149487677	0.664	NM_000252	MTM1	myotubularin 1
chr17_-_64462976	0.663	NM_007168	ABCA8	ATP-binding cassette, sub-family A (ABC1), member 8
chr9_-_96395828	0.662	NM_003837	FBP2	fructose-1,6-bisphosphatase 2
chr14_-_54025414	0.659		GMFB	glia maturation factor, beta
chr14_-_54025464	0.651	NM_004124	GMFB	glia maturation factor, beta
chr13_-_109236897	0.649	NM_003749	IRS2	insulin receptor substrate 2
chr12_+_52713098	0.646	NM_018953	HOXC5	homeobox C5
chr15_-_48766213	0.646		TRPM7	transient receptor potential cation channel, subfamily M, member 7
chr16_+_30952382	0.642	NM_004604	STX4	syntaxin 4
chr3_+_186012670	0.639		VPS8	vacuolar protein sorting 8 homolog (S. cerevisiae)
chr3_-_172109119	0.626	NM_020390	EIF5A2	eukaryotic translation initiation factor 5A2
chr16_+_87450991	0.625	NM_016209	TRAPPC2L	trafficking protein particle complex 2-like
chr11_+_67532592	0.617	NM_001161473	ALDH3B1	aldehyde dehydrogenase 3 family, member B1
chr1_-_239587090	0.611	NM_002924	RGS7	regulator of G-protein signaling 7
chr4_+_128870968	0.608	NM_031291	SLC25A31	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31
chrX_+_149487741	0.608		MTM1	myotubularin 1
chr16_-_1465041	0.603	NM_001114331 NM_001287	CLCN7	chloride channel 7
chr7_+_150390566	0.602		SLC4A2	solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)
chr1_+_173235193	0.593	NM_001007214	CACYBP	calcyclin binding protein
chr2_-_133144094	0.592		LYPD1	LY6/PLAUR domain containing 1
chr1_-_94475504	0.591		ARHGAP29	Rho GTPase activating protein 29
chr11_+_9642226	0.586		SWAP70	SWAP switching B-cell complex 70kDa subunit
chr11_+_9642229	0.582		SWAP70	SWAP switching B-cell complex 70kDa subunit
chr5_-_141372721	0.581	NM_005471	GNPDA1	glucosamine-6-phosphate deaminase 1
chr10_+_70553936	0.579		VPS26A	vacuolar protein sorting 26 homolog A (S. pombe)
chr15_-_48766275	0.579	NM_017672	TRPM7	transient receptor potential cation channel, subfamily M, member 7
chr6_-_163754903	0.578		LOC100526820	hypothetical LOC100526820
chr2_-_39859912	0.574	NM_025264	THUMPD2	THUMP domain containing 2
chr6_-_109810246	0.574		CD164	CD164 molecule, sialomucin
chr11_-_71491942	0.570		LAMTOR1	late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
chr11_+_9642200	0.569	NM_015055	SWAP70	SWAP switching B-cell complex 70kDa subunit
chr2_+_26249463	0.568	NM_001168241	FAM59B	family with sequence similarity 59, member B
chr7_-_158304062	0.566		ESYT2	extended synaptotagmin-like protein 2
chr1_-_153195188	0.565	NM_020524	PBXIP1	pre-B-cell leukemia homeobox interacting protein 1
chr14_-_19999324	0.561		TMEM55B	transmembrane protein 55B
chrX_+_101862297	0.560	NM_001142524 NM_001142525 NM_001142526 NM_001142527 NM_001142528 NM_030639	BHLHB9	basic helix-loop-helix domain containing, class B, 9
chr5_+_150807397	0.556		SLC36A1	solute carrier family 36 (proton/amino acid symporter), member 1
chr19_+_45948598	0.553	NM_004596	SNRPA	small nuclear ribonucleoprotein polypeptide A
chr7_-_13997389	0.549	NM_001163149	ETV1	ets variant 1
chr15_-_71712711	0.546	NM_001161363 NM_001161364 NM_012428 NM_017455	NPTN	neuroplastin
chr3_-_158700036	0.542	NM_024621	VEPH1	ventricular zone expressed PH domain homolog 1 (zebrafish)
chr5_+_34692239	0.542		RAI14	retinoic acid induced 14
chr8_-_71743973	0.541	NM_016027	LACTB2	lactamase, beta 2
chr16_-_1465021	0.540		CLCN7	chloride channel 7
chr15_-_71712605	0.538		NPTN	neuroplastin
chr6_-_33822659	0.535	NM_001142883 NM_054111	IP6K3	inositol hexakisphosphate kinase 3
chr5_+_140194152	0.531	NM_018910 NM_031852	PCDHA7	protocadherin alpha 7
chr1_-_152459697	0.531	NM_001098616 NM_015449 NM_138740	C1orf43	chromosome 1 open reading frame 43
chr19_-_13088212	0.530	NM_001142554 NM_017722 NM_001136035	TRMT1	TRM1 tRNA methyltransferase 1 homolog (S. cerevisiae)
chr13_-_49057629	0.530		RCBTB1	regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
chr7_+_32501665	0.527	NM_015060	AVL9	AVL9 homolog (S. cerevisiase)
chr12_-_122415708	0.523		SBNO1	strawberry notch homolog 1 (Drosophila)
chr6_+_123152044	0.518		SMPDL3A	sphingomyelin phosphodiesterase, acid-like 3A
chr4_+_56414565	0.517	NM_001024924 NM_018261 NM_178237	EXOC1	exocyst complex component 1
chr10_+_51497660	0.516	NM_001005751	FAM21C FAM21A	family with sequence similarity 21, member C family with sequence similarity 21, member A
chr18_+_75967902	0.514	NM_014913	ADNP2	ADNP homeobox 2
chr13_-_35818603	0.514	NM_001142296 NM_015087	SPG20	spastic paraplegia 20 (Troyer syndrome)
chr5_+_52812236	0.509	NM_006350 NM_013409	FST	follistatin
chr2_-_27399405	0.509	NM_002437	MPV17	MpV17 mitochondrial inner membrane protein
chr19_-_3936460	0.508	NM_001961	EEF2	eukaryotic translation elongation factor 2
chr17_-_68769613	0.507	NM_001129885	CPSF4L	cleavage and polyadenylation specific factor 4-like
chr1_-_26105477	0.507	NM_001145454 NM_005563	STMN1	stathmin 1
chr20_-_60484420	0.506	NM_080473	GATA5	GATA binding protein 5
chr11_+_85017269	0.503	NM_001193537 NM_001193538 NM_018480	TMEM126B	transmembrane protein 126B
chr2_+_198073358	0.502		HSPE1	heat shock 10kDa protein 1 (chaperonin 10)
chr1_-_239587007	0.498		RGS7	regulator of G-protein signaling 7
chr1_-_153195219	0.497		PBXIP1	pre-B-cell leukemia homeobox interacting protein 1
chr3_-_121445831	0.493	NM_001168271 NM_153002	GPR156	G protein-coupled receptor 156
chr11_+_9642182	0.491		SWAP70	SWAP switching B-cell complex 70kDa subunit
chr3_+_134601479	0.487	NM_003571	BFSP2	beaded filament structural protein 2, phakinin
chr7_-_27149750	0.486	NM_019102	HOXA5	homeobox A5
chr9_-_138277467	0.486	NM_181701	QSOX2	quiescin Q6 sulfhydryl oxidase 2
chr7_+_32501577	0.485		AVL9	AVL9 homolog (S. cerevisiase)
chr5_-_131160589	0.483		FNIP1	folliculin interacting protein 1
chr1_-_26105230	0.483	NM_203401	STMN1	stathmin 1
chr17_+_44325127	0.482	NM_001002027 NM_005175	ATP5G1	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
chr9_+_124742932	0.481	NM_012197	RABGAP1	RAB GTPase activating protein 1
chr5_+_34692352	0.479	NM_001145520	RAI14	retinoic acid induced 14
chr10_+_51497716	0.479		FAM21A	family with sequence similarity 21, member A
chr1_-_152797707	0.475	NM_017582	UBE2Q1	ubiquitin-conjugating enzyme E2Q family member 1
chr10_-_120504445	0.474		C10orf46	chromosome 10 open reading frame 46
chr1_+_15725935	0.472	NM_015291	DNAJC16	DnaJ (Hsp40) homolog, subfamily C, member 16
chr11_-_71491983	0.468		LAMTOR1	late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
chr6_+_151815114	0.467	NM_024573	C6orf211	chromosome 6 open reading frame 211
chr10_+_121642204	0.466	NM_007190	SEC23IP	SEC23 interacting protein
chr20_+_43953331	0.466		CTSA	cathepsin A
chr2_-_148494732	0.466	NM_001190882 NM_001190879 NM_002552 NM_001190881 NM_181741	ORC4	origin recognition complex, subunit 4
chr10_-_14090459	0.465		FRMD4A	FERM domain containing 4A
chr10_+_45542653	0.464	NM_001169106 NM_001169107 NM_015262	FAM21C FAM21A	family with sequence similarity 21, member C family with sequence similarity 21, member A
chr1_-_178113517	0.462	NM_022347 NM_145034	TOR1AIP2	torsin A interacting protein 2
chr10_-_120504267	0.459
chr13_-_20533703	0.457	NM_014572	LATS2	LATS, large tumor suppressor, homolog 2 (Drosophila)
chr10_+_70553993	0.456		VPS26A	vacuolar protein sorting 26 homolog A (S. pombe)
chr11_+_32993973	0.454	NM_001077242	DEPDC7	DEP domain containing 7
chr5_-_131160608	0.454		FNIP1	folliculin interacting protein 1
chr3_-_135131207	0.452	NM_025041	C3orf36	chromosome 3 open reading frame 36
chr11_-_72141064	0.450	NM_001040118	ARAP1	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr6_-_84475424	0.449		SNAP91	synaptosomal-associated protein, 91kDa homolog (mouse)
chrX_-_101284026	0.448	NM_001006938	TCEAL6	transcription elongation factor A (SII)-like 6
chr10_+_70553862	0.447	NM_001035260 NM_004896	VPS26A	vacuolar protein sorting 26 homolog A (S. pombe)
chr4_+_17225344	0.447	NM_025205	MED28	mediator complex subunit 28
chr3_+_185515108	0.445		EIF4G1	eukaryotic translation initiation factor 4 gamma, 1
chr15_-_38000379	0.445	NM_007223	GPR176	G protein-coupled receptor 176
chr5_-_133734616	0.444		CDKL3	cyclin-dependent kinase-like 3
chr8_-_126173055	0.438		KIAA0196	KIAA0196
chr20_+_30871357	0.438	NM_012325	MAPRE1	microtubule-associated protein, RP/EB family, member 1
chr7_-_95789204	0.436	NM_001160210 NM_014251	SLC25A13	solute carrier family 25, member 13 (citrin)
chr16_-_1465007	0.436		CLCN7	chloride channel 7
chr2_+_148495043	0.433	NM_018328	MBD5	methyl-CpG binding domain protein 5
chr9_+_116389814	0.433	NM_004888	ATP6V1G1	ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
chrX_+_102356659	0.432	NM_001080425 NM_001127688	BEX4	brain expressed, X-linked 4
chr8_-_71743908	0.431		LACTB2	lactamase, beta 2
chr5_+_133734768	0.429	NM_003337	UBE2B	ubiquitin-conjugating enzyme E2B (RAD6 homolog)
chr8_+_109525050	0.429		TTC35	tetratricopeptide repeat domain 35
chr10_+_70553983	0.428		VPS26A	vacuolar protein sorting 26 homolog A (S. pombe)
chr1_-_32054164	0.428	NM_144569	SPOCD1	SPOC domain containing 1
chr11_-_8849485	0.424		ST5	suppression of tumorigenicity 5
chr2_-_39859689	0.424		THUMPD2	THUMP domain containing 2
chr1_-_197173159	0.423		LOC100131234	familial acute myelogenous leukemia related factor

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.38	9.42e-04	GO:0006807	nitrogen compound metabolic process
1.38	1.80e-03	GO:0034641	cellular nitrogen compound metabolic process
1.40	5.56e-03	GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.60	9.15e-03	GO:0033036	macromolecule localization
1.80	9.32e-03	GO:0046907	intracellular transport
1.58	2.04e-02	GO:0051641	cellular localization
1.34	3.18e-02	GO:0006810	transport
1.34	3.53e-02	GO:0051234	establishment of localization
1.61	4.20e-02	GO:0051649	establishment of localization in cell
1.30	4.99e-02	GO:0051179	localization

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.29	9.50e-07	GO:0044444	cytoplasmic part
2.71	2.30e-06	GO:0005773	vacuole
1.29	6.33e-06	GO:0044422	organelle part
1.13	7.74e-06	GO:0005622	intracellular
1.14	8.48e-06	GO:0044424	intracellular part
1.29	9.90e-06	GO:0044446	intracellular organelle part
1.19	1.98e-05	GO:0043227	membrane-bounded organelle
1.19	2.47e-05	GO:0043231	intracellular membrane-bounded organelle
1.16	1.23e-04	GO:0043226	organelle
1.15	1.95e-04	GO:0043229	intracellular organelle
1.47	3.23e-04	GO:0044428	nuclear part
1.51	5.05e-04	GO:0031981	nuclear lumen
1.17	6.05e-04	GO:0005737	cytoplasm
2.49	6.66e-04	GO:0000323	lytic vacuole
2.49	6.66e-04	GO:0005764	lysosome
1.57	2.36e-03	GO:0005654	nucleoplasm
2.86	4.85e-03	GO:0005774	vacuolar membrane
2.73	9.77e-03	GO:0044437	vacuolar part
7.14	1.01e-02	GO:0033176	proton-transporting V-type ATPase complex
1.38	1.08e-02	GO:0031974	membrane-enclosed lumen
1.38	1.09e-02	GO:0043233	organelle lumen
1.38	1.42e-02	GO:0070013	intracellular organelle lumen
1.39	2.21e-02	GO:0005829	cytosol
1.90	2.85e-02	GO:0005768	endosome
3.21	3.60e-02	GO:0042470	melanosome
3.21	3.60e-02	GO:0048770	pigment granule
1.26	4.45e-02	GO:0032991	macromolecular complex

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.20	3.78e-04	GO:0005515	protein binding
2.08	1.71e-02	GO:0022804	active transmembrane transporter activity
1.09	5.00e-02	GO:0005488	binding