Motif ID: RUNX1..3.p2

Z-value: 2.510


Transcription factors associated with RUNX1..3.p2:

Gene SymbolEntrez IDGene Name
RUNX1 861 runt-related transcription factor 1
RUNX2 860 runt-related transcription factor 2
RUNX3 864 runt-related transcription factor 3



Activity profile for motif RUNX1..3.p2.

activity profile for motif RUNX1..3.p2


Sorted Z-values histogram for motif RUNX1..3.p2

Sorted Z-values for motif RUNX1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RUNX1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_+_19883745 5.906 NM_001005241
OR4N4
olfactory receptor, family 4, subfamily N, member 4
chr14_-_106154332 2.317 LOC100126583
IGHG1
hypothetical LOC100126583
immunoglobulin heavy constant gamma 1 (G1m marker)
chr14_-_105900687 2.260 IGHA1
IGHD
IGHG3
IGHM
SKAP2
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
src kinase associated phosphoprotein 2
chr15_-_19974402 2.185


chr22_+_20326572 2.162 SDF2L1
stromal cell-derived factor 2-like 1
chr22_+_21318779 2.151 NM_199127
GGTLC2
gamma-glutamyltransferase light chain 2
chr6_-_32121784 2.144 NM_032470
TNXB
tenascin XB
chr22_+_20326615 2.112 SDF2L1
stromal cell-derived factor 2-like 1
chr22_+_20326591 2.084 SDF2L1
stromal cell-derived factor 2-like 1
chr22_+_20326541 2.066 NM_022044
SDF2L1
stromal cell-derived factor 2-like 1
chr14_+_19681734 1.985 NM_001004724
OR4N5
olfactory receptor, family 4, subfamily N, member 5
chr15_-_63290839 1.688 NM_003613
CILP
cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
chr17_+_71292437 1.652 UNK
unkempt homolog (Drosophila)
chr16_+_23754997 1.624 PRKCB
protein kinase C, beta
chr10_+_51242369 1.595 NM_005437
NCOA4
nuclear receptor coactivator 4
chr2_+_127892459 1.570 NM_000312
PROC
protein C (inactivator of coagulation factors Va and VIIIa)
chr17_+_71292535 1.481


chr5_-_160044844 1.478 ATP10B
ATPase, class V, type 10B
chr1_+_226069968 1.477 NM_183062
PRSS38
protease, serine, 38
chr6_+_45404031 1.401 NM_001015051
NM_001024630
RUNX2

runt-related transcription factor 2

chr11_-_65860450 1.391 NM_004292
RIN1
Ras and Rab interactor 1
chr22_-_17798998 1.364 HIRA
HIR histone cell cycle regulation defective homolog A (S. cerevisiae)
chr17_+_77910411 1.338 NM_207459
TEX19
testis expressed 19
chr14_+_19365447 1.331 NM_001004723
OR4N2
olfactory receptor, family 4, subfamily N, member 2
chr6_-_68655708 1.316


chr19_-_48976852 1.296 KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr17_+_23818922 1.286


chr1_+_26389638 1.282 NM_198137
CATSPER4
cation channel, sperm associated 4
chrX_-_49347279 1.245 NM_003785
PAGE1
P antigen family, member 1 (prostate associated)
chr3_+_46894239 1.245 NM_000316
PTH1R
parathyroid hormone 1 receptor
chr22_+_21552897 1.238 LOC100290481
immunoglobulin lambda light chain-like
chr1_+_32489426 1.234 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chr3_+_134978615 1.216 TF
transferrin
chr22_+_20350272 1.197 NM_014337
NM_148175
NM_148176
PPIL2


peptidylprolyl isomerase (cyclophilin)-like 2


chr19_-_6671585 1.193 NM_000064
C3
complement component 3
chr11_+_63864263 1.193 NM_032251
CCDC88B
coiled-coil domain containing 88B
chr22_+_21384862 1.182 IGLV3-21
IGLJ3
IGLC1
immunoglobulin lambda variable 3-21
immunoglobulin lambda joining 3
immunoglobulin lambda constant 1 (Mcg marker)
chr22_+_21484240 1.182


chr2_-_26554413 1.173 NM_004802
NM_194322
NM_194323
OTOF


otoferlin


chr12_+_52696908 1.158 NM_014620
NM_153693
HOXC4
HOXC6
homeobox C4
homeobox C6
chr17_+_71292275 1.146 NM_001080419
UNK
unkempt homolog (Drosophila)
chr2_+_127892489 1.137 PROC
protein C (inactivator of coagulation factors Va and VIIIa)
chr16_+_29582069 1.103 NM_003123
SPN
sialophorin
chr20_-_48741481 1.098


chr1_+_205038837 1.082 NM_153758
IL19
interleukin 19
chr14_-_105549177 1.079 IGHV4-31
IGHD
IGHG3
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
chr11_-_56761250 1.076 NM_005161
APLNR
apelin receptor
chr2_-_73781974 1.073 NM_016347
NAT8B
N-acetyltransferase 8B (GCN5-related, putative, gene/pseudogene)
chr3_+_40522533 1.069 NM_175888
ZNF620
zinc finger protein 620
chr6_-_41276901 1.063 NM_024807
TREML2
triggering receptor expressed on myeloid cells-like 2
chr20_+_54420574 1.060 NM_001164116
NM_001164114
NM_001164115
NM_020356
CASS4



Cas scaffolding protein family member 4



chr2_+_169367345 1.049 NM_001039724
NM_001171632
NM_052946
NOSTRIN


nitric oxide synthase trafficker


chr11_-_5232480 1.036 NM_000184
HBG1
HBG2
hemoglobin, gamma A
hemoglobin, gamma G
chr15_-_100280784 1.024 NM_001004195
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr22_-_17799177 1.020 HIRA
HIR histone cell cycle regulation defective homolog A (S. cerevisiae)
chr14_-_105785639 1.010


chr12_+_52697160 0.977 HOXC5
HOXC6
homeobox C5
homeobox C6
chr1_-_25164061 0.976 NM_001031680
RUNX3
runt-related transcription factor 3
chr6_-_31740466 0.960 GPANK1
G patch domain and ankyrin repeats 1
chr6_-_149847809 0.955 NM_207360
ZC3H12D
zinc finger CCCH-type containing 12D
chr20_-_23915431 0.952 NM_178312
GGTLC1
gamma-glutamyltransferase light chain 1
chr17_+_21249040 0.947 NM_001194958
KCNJ18
potassium inwardly-rectifying channel, subfamily J, member 18
chr22_+_20101661 0.945 NM_015094
HIC2
hypermethylated in cancer 2
chr6_-_34632061 0.943 NM_012391
SPDEF
SAM pointed domain containing ets transcription factor
chr22_+_17799341 0.912 MRPL40
mitochondrial ribosomal protein L40
chr4_-_151993422 0.907


chr22_+_21116283 0.901


chr16_+_23754822 0.894 PRKCB
protein kinase C, beta
chr16_+_23754772 0.890 NM_002738
NM_212535
PRKCB

protein kinase C, beta

chr22_-_18807805 0.884 PI4KAP2
PI4KAP1
phosphatidylinositol 4-kinase, catalytic, alpha pseudogene 2
phosphatidylinositol 4-kinase, catalytic, alpha pseudogene 1
chr5_-_145232723 0.882 NM_001080516
GRXCR2
glutaredoxin, cysteine rich 2
chr22_-_17799215 0.882 NM_003325
HIRA
HIR histone cell cycle regulation defective homolog A (S. cerevisiae)
chr5_+_75734759 0.879 NM_006633
IQGAP2
IQ motif containing GTPase activating protein 2
chr22_-_18635614 0.875 NM_023004
RTN4R
reticulon 4 receptor
chr16_+_29582065 0.866 SPN
sialophorin
chr9_-_98368913 0.864 NM_001077181
CDC14B
CDC14 cell division cycle 14 homolog B (S. cerevisiae)
chr21_-_35343331 0.863 RUNX1
runt-related transcription factor 1
chrX_-_39921525 0.855 NM_001123383
NM_001123384
BCOR

BCL6 corepressor

chr3_+_47004457 0.852 NBEAL2
neurobeachin-like 2
chr5_+_140537554 0.840 NM_019120
PCDHB8
protocadherin beta 8
chrX_-_49008115 0.836 NM_001114377
NM_014009
FOXP3

forkhead box P3

chr1_-_166779825 0.818 NM_003175
XCL1
XCL2
chemokine (C motif) ligand 1
chemokine (C motif) ligand 2
chr20_-_34841107 0.796 KIAA0889
KIAA0889
chr2_-_158008763 0.794 NM_004288
CYTIP
cytohesin 1 interacting protein
chr6_+_30212488 0.771 NM_138700
TRIM40
tripartite motif containing 40
chr19_+_17923110 0.767 NM_002248
KCNN1
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1
chr16_+_28413421 0.762 NM_018690
APOBR
apolipoprotein B receptor
chr7_-_92686773 0.761 NM_198151
HEPACAM2
HEPACAM family member 2
chrX_-_118889603 0.760 NM_006978
RNF113A
ring finger protein 113A
chr14_-_19572756 0.760 NM_001004714
OR4K13
olfactory receptor, family 4, subfamily K, member 13
chr11_-_66897584 0.754 NM_013246
CLCF1
cardiotrophin-like cytokine factor 1
chr10_-_48036698 0.746 NM_016204
GDF2
growth differentiation factor 2
chr11_+_123625632 0.745 NM_001002905
OR8G1
olfactory receptor, family 8, subfamily G, member 1
chr22_+_21042091 0.739 IGLV1-44
IGL@
immunoglobulin lambda variable 1-44
immunoglobulin lambda locus
chr20_+_31713750 0.739 NM_080825
C20orf144
chromosome 20 open reading frame 144
chr16_-_28515868 0.734 NM_001054
SULT1A2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr1_-_114215768 0.730 NM_001193431
NM_012411
NM_015967
PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chr6_-_149847718 0.729 ZC3H12D
zinc finger CCCH-type containing 12D
chr12_-_101396459 0.726 NM_001111284
IGF1
insulin-like growth factor 1 (somatomedin C)
chr11_+_58967192 0.724 NM_001004728
OR5A1
olfactory receptor, family 5, subfamily A, member 1
chr12_+_56206692 0.723 MBD6
methyl-CpG binding domain protein 6
chr8_-_38324809 0.717 WHSC1L1
Wolf-Hirschhorn syndrome candidate 1-like 1
chrX_+_118889761 0.717 NM_004541
NDUFA1
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa
chr5_+_140559366 0.708 NM_018931
PCDHB11
protocadherin beta 11
chr4_-_26100986 0.704 NM_000730
CCKAR
cholecystokinin A receptor
chr6_-_31853027 0.702 NM_025258
C6orf27
chromosome 6 open reading frame 27
chr1_-_156937065 0.693 NM_001005279
OR6K2
olfactory receptor, family 6, subfamily K, member 2
chr7_+_150321771 0.689 NM_001160109
NM_001160110
NM_001160111
NOS3


nitric oxide synthase 3 (endothelial cell)


chr19_-_8473473 0.686 NM_032152
PRAM1
PML-RARA regulated adaptor molecule 1
chr17_+_58915909 0.684 NM_001178057
NM_152830
ACE

angiotensin I converting enzyme (peptidyl-dipeptidase A) 1

chr2_+_119416214 0.680 NM_006770
MARCO
macrophage receptor with collagenous structure
chr4_-_113656762 0.677 NM_024019
NEUROG2
neurogenin 2
chr16_+_23754860 0.670 PRKCB
protein kinase C, beta
chr20_-_1548589 0.668 NM_001083910
NM_001135844
NM_006065
SIRPB1


signal-regulatory protein beta 1


chr21_-_35343500 0.666 RUNX1
runt-related transcription factor 1
chr19_+_52504914 0.663 NM_001736
C5AR1
complement component 5a receptor 1
chr8_-_21827057 0.662 NM_003974
DOK2
docking protein 2, 56kDa
chr1_-_157313179 0.653 NM_004833
AIM2
absent in melanoma 2
chr17_-_71285992 0.651 H3F3B
H3 histone, family 3B (H3.3B)
chr5_+_140594121 0.650 PCDHB18
protocadherin beta 18 pseudogene
chr17_-_71352017 0.639 UNC13D
unc-13 homolog D (C. elegans)
chrX_+_23836043 0.639 NM_001169574
NM_152761
CXorf58

chromosome X open reading frame 58

chrX_+_118889817 0.635 NDUFA1
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa
chr1_-_159413833 0.632 NM_003779
B4GALT3
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3
chrX_+_71280758 0.632 NM_207422
FLJ44635
TPT1-like protein
chr4_-_145159889 0.631 NM_002100
GYPB
glycophorin B (MNS blood group)
chr19_+_43616167 0.628 NM_000540
NM_001042723
RYR1

ryanodine receptor 1 (skeletal)

chr16_-_70475381 0.624 ZNF821
zinc finger protein 821
chr17_-_53961709 0.624 NM_004574
SEPT4
septin 4
chr22_+_37708350 0.622 NM_004900
APOBEC3B
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
chr7_+_120416103 0.620 C7orf58
chromosome 7 open reading frame 58
chr6_+_160247962 0.614 NM_002377
MAS1
MAS1 oncogene
chr6_-_150109324 0.610 NM_198887
NUP43
nucleoporin 43kDa
chr3_+_15618455 0.609 BTD
biotinidase
chrX_-_77801480 0.595 NM_152694
ZCCHC5
zinc finger, CCHC domain containing 5
chr1_-_30969016 0.594 NM_002379
MATN1
matrilin 1, cartilage matrix protein
chr9_+_34642125 0.593 NM_001142784
IL11RA
interleukin 11 receptor, alpha
chr7_-_75280962 0.592 NM_002991
CCL24
chemokine (C-C motif) ligand 24
chr6_+_157140733 0.590 NM_017519
NM_020732
ARID1B

AT rich interactive domain 1B (SWI1-like)

chr8_+_144173674 0.585 LY6E
lymphocyte antigen 6 complex, locus E
chrX_+_9391314 0.580 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr11_+_6762823 0.577 NM_001004489
OR2AG1
olfactory receptor, family 2, subfamily AG, member 1
chr9_+_129066576 0.576 NM_032293
GARNL3
GTPase activating Rap/RanGAP domain-like 3
chr4_+_88790477 0.575 NM_001079911
NM_004407
DMP1

dentin matrix acidic phosphoprotein 1

chr17_-_9749221 0.574 NM_002903
RCVRN
recoverin
chr21_-_35343448 0.574 RUNX1
runt-related transcription factor 1
chr21_-_35343456 0.573 NM_001754
RUNX1
runt-related transcription factor 1
chr4_-_80466177 0.570 NM_032693
NAA11
N(alpha)-acetyltransferase 11, NatA catalytic subunit
chr7_+_120415958 0.570 NM_024913
C7orf58
chromosome 7 open reading frame 58
chr17_+_25910709 0.570 NM_015594
TBC1D29
TBC1 domain family, member 29
chr10_-_72215116 0.568 NM_152710
C10orf27
chromosome 10 open reading frame 27
chrX_-_48213508 0.563 SLC38A5
solute carrier family 38, member 5
chr20_+_16676997 0.561 NM_020157
OTOR
otoraplin
chr7_+_99809068 0.560 PILRA
paired immunoglobin-like type 2 receptor alpha
chrX_-_23835868 0.554 NM_024122
APOO
apolipoprotein O
chr1_-_156816312 0.548 NM_001004477
OR10X1
olfactory receptor, family 10, subfamily X, member 1
chr21_+_43024936 0.548 PDE9A
phosphodiesterase 9A
chrX_-_48213545 0.546 NM_033518
SLC38A5
solute carrier family 38, member 5
chr11_+_120036237 0.545 NM_014619
GRIK4
glutamate receptor, ionotropic, kainate 4
chr1_+_144124547 0.542 NM_145277
NM_202004
NM_213652
NM_213653
HFE2



hemochromatosis type 2 (juvenile)



chr1_-_92724181 0.541 NM_001127216
GFI1
growth factor independent 1 transcription repressor
chr16_+_7322751 0.539 NM_145891
NM_145892
NM_145893
RBFOX1


RNA binding protein, fox-1 homolog (C. elegans) 1


chr14_-_22549168 0.539 NM_001130706
NM_001130708
NM_021944
C14orf93


chromosome 14 open reading frame 93


chr1_-_157014048 0.536 NM_001005278
OR6N2
olfactory receptor, family 6, subfamily N, member 2
chr6_+_26070957 0.535 NM_006355
TRIM38
tripartite motif containing 38
chr10_-_74384485 0.535 NM_032562
PLA2G12B
phospholipase A2, group XIIB
chr7_-_141048358 0.532 NM_001080392
KIAA1147
KIAA1147
chr11_-_6600385 0.532 DCHS1
dachsous 1 (Drosophila)
chr7_+_116447499 0.531 ST7
suppression of tumorigenicity 7
chr10_-_11614279 0.528 NM_001080491
USP6NL
USP6 N-terminal like
chr4_-_174686918 0.525 HAND2
heart and neural crest derivatives expressed 2
chr6_+_7052985 0.524 NM_001003698
NM_001003699
NM_001003700
RREB1


ras responsive element binding protein 1


chr6_+_52159143 0.519 NM_002190
IL17A
interleukin 17A
chr22_+_21464980 0.518


chr6_-_119137923 0.518 NM_001178035
C6orf204
chromosome 6 open reading frame 204
chr17_-_40380553 0.513 NM_001080443
KIF18B
kinesin family member 18B
chr7_+_116447527 0.511 ST7
suppression of tumorigenicity 7
chr11_-_123261549 0.508 NM_001013743
TMEM225
transmembrane protein 225
chr6_-_128263868 0.507 NM_001010923
NM_001164685
THEMIS

thymocyte selection associated

chr14_+_38720085 0.505 PNN
pinin, desmosome associated protein
chr4_-_174687104 0.504 HAND2
heart and neural crest derivatives expressed 2
chr6_+_31647854 0.504 NM_001159740
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr5_-_39238818 0.501 FYB
FYN binding protein
chr15_+_56511466 0.499 NM_000236
LIPC
lipase, hepatic
chr10_-_74384569 0.497 PLA2G12B
phospholipase A2, group XIIB
chr20_+_44070946 0.496 NM_004994
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr14_-_105948734 0.495 LOC100126583
IGHV4-31
IGHA1
IGHA2
IGHG1
IGHG4
IGHM
hypothetical LOC100126583
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 4 (G4m marker)
immunoglobulin heavy constant mu
chr6_+_31648071 0.495 NM_000595
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr3_+_40493605 0.495 NM_001145082
NM_001145093
NM_001145083
ZNF619


zinc finger protein 619


chrX_-_15782792 0.494 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr3_+_190372456 0.494 NM_198485
TPRG1
tumor protein p63 regulated 1
chr4_+_15080586 0.493 NM_001080522
NM_001164720
NM_020785
CC2D2A


coiled-coil and C2 domain containing 2A


chr7_+_154351087 0.493 LOC100132707
hypothetical LOC100132707
chr1_-_16812274 0.492 NM_017940
NBPF1
neuroblastoma breakpoint family, member 1
chr19_+_61624 0.492 NM_001005240
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr6_+_31651319 0.488 NM_000594
TNF
tumor necrosis factor
chr12_-_23995220 0.486 SOX5
SRY (sex determining region Y)-box 5
chrX_-_15782826 0.485


chr13_+_112789669 0.484 MCF2L
MCF.2 cell line derived transforming sequence-like
chrX_-_15782803 0.484 AP1S2
adaptor-related protein complex 1, sigma 2 subunit

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.23 1.76e-09 GO:0007608 sensory perception of smell
2.09 2.48e-08 GO:0007606 sensory perception of chemical stimulus
1.21 9.29e-07 GO:0050896 response to stimulus
1.57 2.08e-06 GO:0002376 immune system process
1.87 3.53e-05 GO:0001775 cell activation
1.58 9.86e-04 GO:0007600 sensory perception
1.19 2.65e-03 GO:0032501 multicellular organismal process
1.58 3.72e-03 GO:0006955 immune response
1.35 8.66e-03 GO:0003008 system process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.26 1.06e-06 GO:0071944 cell periphery
1.26 1.51e-06 GO:0005886 plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.23 1.56e-09 GO:0004984 olfactory receptor activity
1.51 1.46e-08 GO:0004872 receptor activity
1.42 5.49e-07 GO:0004871 signal transducer activity
1.42 5.49e-07 GO:0060089 molecular transducer activity
1.67 2.73e-06 GO:0004930 G-protein coupled receptor activity
1.48 3.60e-05 GO:0004888 transmembrane receptor activity
3.81 2.08e-03 GO:0003823 antigen binding
3.39 1.11e-02 GO:0019825 oxygen binding
8.47 3.74e-02 GO:0003840 gamma-glutamyltransferase activity