Motif ID: ZNF423.p2

Z-value: 1.488


Transcription factors associated with ZNF423.p2:

Gene SymbolEntrez IDGene Name
ZNF423 23090 zinc finger protein 423



Activity profile for motif ZNF423.p2.

activity profile for motif ZNF423.p2


Sorted Z-values histogram for motif ZNF423.p2

Sorted Z-values for motif ZNF423.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ZNF423.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_46623325 2.263 NM_012249
RHOQ
ras homolog gene family, member Q
chr20_-_49592444 1.991 NFATC2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
chrX_+_30175191 1.887 NM_177404
MAGEB1
melanoma antigen family B, 1
chr17_-_33178987 1.744 HNF1B
HNF1 homeobox B
chr12_+_109956210 1.696 NM_015267
CUX2
cut-like homeobox 2
chr8_-_70908130 1.608 NM_001146008
SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr14_-_92651896 1.493 NM_001142593
NM_001142594
NM_014216
ITPK1


inositol 1,3,4-triphosphate 5/6 kinase


chr21_-_45786709 1.467 NM_194255
SLC19A1
solute carrier family 19 (folate transporter), member 1
chr16_-_87297525 1.415 NM_001171816
RNF166
ring finger protein 166
chr22_+_20067662 1.402 NM_001128633
RIMBP3C
RIMS binding protein 3C
chr16_+_2954217 1.351 NM_024507
NM_172229
KREMEN2

kringle containing transmembrane protein 2

chr16_+_66236512 1.326 NM_001013838
RLTPR
RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
chr7_+_99919485 1.307 NM_173564
C7orf51
chromosome 7 open reading frame 51
chr6_+_11202251 1.280 NM_001135575
LOC221710
hypothetical protein LOC221710
chr1_-_210939820 1.269 BATF3
basic leucine zipper transcription factor, ATF-like 3
chr19_-_55524445 1.253 NM_004977
KCNC3
potassium voltage-gated channel, Shaw-related subfamily, member 3
chr15_+_41450642 1.234 TUBGCP4
tubulin, gamma complex associated protein 4
chr19_+_14405100 1.229 NM_002741
PKN1
protein kinase N1
chr9_-_130526192 1.225 NM_032799
ZDHHC12
zinc finger, DHHC-type containing 12
chr19_+_11770360 1.222 NM_152356
ZNF491
zinc finger protein 491
chr7_-_150385867 1.219 CDK5
cyclin-dependent kinase 5
chr5_+_78443357 1.216 NM_001713
BHMT
betaine--homocysteine S-methyltransferase
chr6_+_11201977 1.210 LOC221710
hypothetical protein LOC221710
chr2_+_46623396 1.191 RHOQ
ras homolog gene family, member Q
chr19_+_14108974 1.166


chr11_-_47164514 1.164 NM_001184974
NM_016223
PACSIN3

protein kinase C and casein kinase substrate in neurons 3

chr19_+_18391423 1.131


chr16_+_2807164 1.107 NM_006799
NM_144956
NM_144957
PRSS21


protease, serine, 21 (testisin)


chr15_+_41450568 1.107 NM_014444
TUBGCP4
tubulin, gamma complex associated protein 4
chr6_-_109869066 1.103 NM_001111298
NM_173672
PPIL6

peptidylprolyl isomerase (cyclophilin)-like 6

chrX_-_18282698 1.065 NM_006089
SCML2
sex comb on midleg-like 2 (Drosophila)
chr11_+_61352348 1.063 FADS2
fatty acid desaturase 2
chr4_-_120768563 1.038 NM_033437
PDE5A
phosphodiesterase 5A, cGMP-specific
chr11_+_76561471 1.037 MYO7A
myosin VIIA
chr16_+_66236559 1.004 RLTPR
RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
chr19_-_46550788 0.997 TGFB1
transforming growth factor, beta 1
chr20_-_23350038 0.991 NM_022080
NAPB
N-ethylmaleimide-sensitive factor attachment protein, beta
chr16_+_69950116 0.986 NM_001740
NM_007088
CALB2

calbindin 2

chr16_+_170334 0.981 NM_005331
HBQ1
hemoglobin, theta 1
chr1_+_32438788 0.970 NM_024296
CCDC28B
coiled-coil domain containing 28B
chr2_-_120697441 0.967 TMEM185B
transmembrane protein 185B (pseudogene)
chr19_+_3536541 0.953 NM_133261
GIPC3
GIPC PDZ domain containing family, member 3
chr2_-_120697382 0.949 TMEM185B
transmembrane protein 185B (pseudogene)
chr6_+_151228577 0.932 MTHFD1L
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr6_+_33352886 0.929 NM_003782
B3GALT4
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
chr1_-_32574185 0.924 NM_023009
MARCKSL1
MARCKS-like 1
chr6_+_151228383 0.920 NM_015440
MTHFD1L
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr7_+_149733309 0.918


chr17_-_24918052 0.916 NM_198147
ABHD15
abhydrolase domain containing 15
chr9_-_99921336 0.914 TRIM14
tripartite motif containing 14
chr2_-_170389598 0.910 NM_014168
METTL5
methyltransferase like 5
chr19_-_6410735 0.910 NM_024103
SLC25A23
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
chr14_-_67051773 0.897 NM_182526
TMEM229B
transmembrane protein 229B
chr7_-_150385912 0.891 NM_001164410
NM_004935
CDK5

cyclin-dependent kinase 5

chr6_-_3172775 0.888 NM_178012
TUBB2B
tubulin, beta 2B
chr16_+_2807228 0.886 PRSS21
protease, serine, 21 (testisin)
chr12_+_52696908 0.885 NM_014620
NM_153693
HOXC4
HOXC6
homeobox C4
homeobox C6
chr1_-_33139425 0.876 NM_033504
TMEM54
transmembrane protein 54
chr2_-_170389669 0.875 METTL5
methyltransferase like 5
chr17_-_35017650 0.875 NEUROD2
neurogenic differentiation 2
chr16_-_45339605 0.874 NM_182493
MYLK3
myosin light chain kinase 3
chr16_+_69950138 0.868 CALB2
calbindin 2
chr17_-_35017691 0.863 NM_006160
NEUROD2
neurogenic differentiation 2
chr17_+_60563917 0.854 NM_001081955
NM_001165933
NM_003835
RGS9


regulator of G-protein signaling 9


chr3_+_157876051 0.845 TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
chr17_-_33179118 0.843 NM_000458
NM_001165923
HNF1B

HNF1 homeobox B

chr9_-_109290107 0.839 KLF4
Kruppel-like factor 4 (gut)
chr9_+_134275431 0.835 NM_207417
C9orf171
chromosome 9 open reading frame 171
chr15_+_62230962 0.823 NM_024798
SNX22
sorting nexin 22
chrX_+_152608159 0.822 NM_001142806
SLC6A8
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
chr8_+_22078589 0.809 NM_001199
NM_006129
BMP1

bone morphogenetic protein 1

chr4_-_44145266 0.808 KCTD8
potassium channel tetramerisation domain containing 8
chr19_-_18409971 0.806 NM_001170938
NM_016368
ISYNA1

inositol-3-phosphate synthase 1

chr6_-_36915195 0.806 NM_020939
CPNE5
copine V
chr11_-_118716244 0.805 MFRP
membrane frizzled-related protein
chr18_-_17538624 0.804 ABHD3
abhydrolase domain containing 3
chr22_+_21852551 0.798 NM_004327
NM_021574
BCR

breakpoint cluster region

chr11_+_61352209 0.791 NM_004265
FADS2
fatty acid desaturase 2
chr21_+_44256630 0.788 NM_003274
TRAPPC10
trafficking protein particle complex 10
chr7_-_97439590 0.781


chr17_-_69869552 0.780 NM_001080466
BTBD17
BTB (POZ) domain containing 17
chr9_-_132804243 0.777 NM_001145106
FIBCD1
fibrinogen C domain containing 1
chr6_+_109868580 0.776 NM_003080
SMPD2
sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
chr6_+_151228757 0.768 MTHFD1L
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr7_-_97439500 0.765 MGC72080
MGC72080 pseudogene
chr14_-_104706159 0.763 NM_002226
NM_145159
JAG2

jagged 2

chr19_-_18409788 0.761 NM_001170939
ISYNA1
inositol-3-phosphate synthase 1
chr19_+_2792432 0.760 NM_001172775
NM_152791
ZNF555

zinc finger protein 555

chr20_+_44083667 0.759 NM_001134771
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr1_+_10381671 0.757 NM_002631
PGD
phosphogluconate dehydrogenase
chr18_-_17538735 0.757 NM_138340
ABHD3
abhydrolase domain containing 3
chr12_+_52697160 0.754 HOXC5
HOXC6
homeobox C5
homeobox C6
chr15_-_81667169 0.752 NM_016073
HDGFRP3
hepatoma-derived growth factor, related protein 3
chr22_-_20235749 0.748 NM_001128633
RIMBP3C
RIMS binding protein 3C
chr21_+_44377974 0.747 C21orf33
chromosome 21 open reading frame 33
chr22_-_18841785 0.744 NM_015672
RIMBP3
RIMS binding protein 3
chr2_+_190753833 0.741 NM_001042519
NM_032321
C2orf88

chromosome 2 open reading frame 88

chr3_-_13436725 0.739 NUP210
nucleoporin 210kDa
chr1_-_210939727 0.735


chr11_+_65781322 0.730 NM_001134775
KLC2
kinesin light chain 2
chr19_+_1158129 0.730 EFNA2
ephrin-A2
chr3_+_157875408 0.725 NM_001184717
TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
chr1_+_110031940 0.723 NM_000561
NM_146421
GSTM1

glutathione S-transferase mu 1

chr20_+_762355 0.719 NM_001042353
FAM110A
family with sequence similarity 110, member A
chr19_+_52214885 0.718 NPAS1
neuronal PAS domain protein 1
chr2_-_120697148 0.718 TMEM185B
transmembrane protein 185B (pseudogene)
chr21_+_44256601 0.717 TRAPPC10
trafficking protein particle complex 10
chr7_-_97439573 0.715 MGC72080
MGC72080 pseudogene
chr1_+_945399 0.713


chr1_-_210939929 0.710 NM_018664
BATF3
basic leucine zipper transcription factor, ATF-like 3
chr14_-_105785639 0.709


chr2_-_42574587 0.708 NM_133329
NM_172344
KCNG3

potassium voltage-gated channel, subfamily G, member 3

chr7_+_75928907 0.707 NM_001102594
NM_001102595
NM_020892
DTX2


deltex homolog 2 (Drosophila)


chr4_-_141568210 0.700 NM_001130675
NM_004362
CLGN

calmegin

chr3_-_129694717 0.697 NM_032638
GATA2
GATA binding protein 2
chr7_+_5904858 0.692 NM_015622
C7orf28B
CCZ1
chromosome 7 open reading frame 28B
CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae)
chr16_-_10183616 0.692 NM_001134407
GRIN2A
glutamate receptor, ionotropic, N-methyl D-aspartate 2A
chr17_+_70244553 0.692 NM_001163989
RAB37
RAB37, member RAS oncogene family
chr19_+_4591028 0.683 NM_001167942
TNFAIP8L1
tumor necrosis factor, alpha-induced protein 8-like 1
chr16_+_65870641 0.682 PLEKHG4
pleckstrin homology domain containing, family G (with RhoGef domain) member 4
chr11_-_63292688 0.676 NM_001144936
C11orf95
chromosome 11 open reading frame 95
chr19_-_17420375 0.676 NM_001190844
TMEM221
transmembrane protein 221
chr22_+_21852699 0.673 BCR
breakpoint cluster region
chr9_-_139043035 0.673 NM_212533
ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr17_+_71065478 0.671 LLGL2
lethal giant larvae homolog 2 (Drosophila)
chr5_+_131774478 0.671 NM_001013717
C5orf56
chromosome 5 open reading frame 56
chrX_-_19815370 0.671 SH3KBP1
SH3-domain kinase binding protein 1
chr19_+_18391211 0.671 NM_001009998
NM_032627
SSBP4

single stranded DNA binding protein 4

chr20_-_61600834 0.670 NM_001958
EEF1A2
eukaryotic translation elongation factor 1 alpha 2
chr16_-_30453646 0.667 NM_023931
ZNF747
zinc finger protein 747
chr8_+_26569709 0.664 DPYSL2
dihydropyrimidinase-like 2
chr8_+_22078622 0.659 BMP1
bone morphogenetic protein 1
chr3_+_13496714 0.657 NM_024827
NM_001136041
HDAC11

histone deacetylase 11

chr9_-_99921258 0.655 NM_014788
NM_033219
NM_033220
TRIM14


tripartite motif containing 14


chr8_-_70907957 0.639 NM_001146009
SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr5_+_68824143 0.635 OCLN
occludin
chr19_+_3175700 0.631 NM_021938
NM_001172673
CELF5

CUGBP, Elav-like family member 5

chr5_+_153550463 0.629 NM_198321
GALNT10
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)
chr19_-_5573794 0.626 NM_014649
SAFB2
scaffold attachment factor B2
chr3_+_37468542 0.626 NM_002207
ITGA9
integrin, alpha 9
chr1_+_27591738 0.625 NM_005281
GPR3
G protein-coupled receptor 3
chr15_+_39310757 0.624 CHP
calcium binding protein P22
chr1_-_39910296 0.620 NM_032526
NT5C1A
5'-nucleotidase, cytosolic IA
chr19_+_9799587 0.620 UBL5
ubiquitin-like 5
chr17_+_77783432 0.620 NM_001042423
SLC16A3
solute carrier family 16, member 3 (monocarboxylic acid transporter 4)
chr17_-_24248834 0.613 NM_004475
FLOT2
flotillin 2
chr17_-_77488258 0.612 NM_006907
NM_153824
PYCR1

pyrroline-5-carboxylate reductase 1

chr7_+_100041143 0.611 PCOLCE
procollagen C-endopeptidase enhancer
chr7_-_6832350 0.608 C7orf28B
chromosome 7 open reading frame 28B
chr21_+_46568460 0.606 NM_006031
PCNT
pericentrin
chr1_+_31855873 0.605 NM_001525
HCRTR1
hypocretin (orexin) receptor 1
chr18_+_75967902 0.603 NM_014913
ADNP2
ADNP homeobox 2
chr16_+_76690664 0.599 NM_016373
NM_130791
NM_130844
WWOX


WW domain containing oxidoreductase


chr1_-_35431017 0.592 SFPQ
splicing factor proline/glutamine-rich
chr6_-_109868400 0.592 PPIL6
peptidylprolyl isomerase (cyclophilin)-like 6
chr16_+_65870481 0.591 NM_001129728
PLEKHG4
pleckstrin homology domain containing, family G (with RhoGef domain) member 4
chr16_-_31135895 0.584 NM_152901
PYDC1
PYD (pyrin domain) containing 1
chr12_-_116112495 0.582 NM_015002
NM_033624
FBXO21

F-box protein 21

chr6_+_151229003 0.579 MTHFD1L
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr1_+_27192719 0.578 NM_001013642
TRNP1
TMF1-regulated nuclear protein 1
chr9_+_4975243 0.577 NM_004972
JAK2
Janus kinase 2
chr22_+_36286350 0.577 NM_152243
CDC42EP1
CDC42 effector protein (Rho GTPase binding) 1
chr3_+_9933763 0.575 NM_032732
NM_153460
NM_153461
IL17RC


interleukin 17 receptor C


chr19_+_3175734 0.570 CELF5
CUGBP, Elav-like family member 5
chr1_+_9217384 0.569 H6PD
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
chr3_+_185430910 0.567 NM_138345
VWA5B2
von Willebrand factor A domain containing 5B2
chr19_-_5291700 0.566 NM_002850
NM_130853
NM_130854
NM_130855
PTPRS



protein tyrosine phosphatase, receptor type, S



chr16_+_88512769 0.566 MC1R
melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
chr11_-_61415429 0.563 NM_021727
FADS3
fatty acid desaturase 3
chr16_-_47201588 0.563 NM_153029
N4BP1
NEDD4 binding protein 1
chr1_-_201321711 0.561 MYOG
myogenin (myogenic factor 4)
chr20_-_35157744 0.560 RBL1
retinoblastoma-like 1 (p107)
chr9_-_100510657 0.555 NM_005458
GABBR2
gamma-aminobutyric acid (GABA) B receptor, 2
chrX_+_152562013 0.551 DUSP9
dual specificity phosphatase 9
chr8_-_143748391 0.551 NM_001077527
NM_003724
JRK

jerky homolog (mouse)

chr9_+_138805637 0.545 TMEM141
transmembrane protein 141
chr19_-_42901928 0.545 NM_001172677
ZNF607
zinc finger protein 607
chr1_+_1836125 0.543 NM_138705
CALML6
calmodulin-like 6
chr7_-_6832382 0.543 NM_198097
C7orf28B
CCZ1
chromosome 7 open reading frame 28B
CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae)
chr17_+_70244945 0.543 NM_001006638
NM_001163990
RAB37

RAB37, member RAS oncogene family

chr12_-_52827275 0.535


chr19_-_51909416 0.533 NM_001079882
PRKD2
protein kinase D2
chr11_-_832507 0.532 NM_021128
POLR2L
polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
chr11_+_14621914 0.532 PDE3B
phosphodiesterase 3B, cGMP-inhibited
chr19_+_47509274 0.531 NM_173633
TMEM145
transmembrane protein 145
chr6_+_43846372 0.529 VEGFA
vascular endothelial growth factor A
chr1_-_154737130 0.528 NM_005920
MEF2D
myocyte enhancer factor 2D
chr8_-_143748324 0.528 JRK
jerky homolog (mouse)
chr10_+_3099708 0.528 NM_002627
PFKP
phosphofructokinase, platelet
chr6_+_109868897 0.528 SMPD2
sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
chr16_-_15057328 0.525 NM_173474
NTAN1
N-terminal asparagine amidase
chr19_-_4054200 0.523 MAP2K2
mitogen-activated protein kinase kinase 2
chr11_+_1925075 0.521 NM_021134
MRPL23
mitochondrial ribosomal protein L23
chr17_+_74531873 0.521 C1QTNF1
C1q and tumor necrosis factor related protein 1
chr14_+_66044958 0.518 GPHN
gephyrin
chr7_+_26158257 0.516 NM_004289
NFE2L3
nuclear factor (erythroid-derived 2)-like 3
chr19_-_56303434 0.515 NM_145232
CTU1
cytosolic thiouridylase subunit 1 homolog (S. pombe)
chr11_+_14621884 0.513 PDE3B
phosphodiesterase 3B, cGMP-inhibited
chr5_+_68823874 0.510 NM_002538
OCLN
occludin
chr19_+_10392128 0.509 NM_001111307
PDE4A
phosphodiesterase 4A, cAMP-specific

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.18 1.51e-06 GO:0065007 biological regulation
1.19 2.35e-05 GO:0050794 regulation of cellular process
1.18 6.43e-05 GO:0050789 regulation of biological process
1.41 9.37e-03 GO:0007399 nervous system development
1.22 1.34e-02 GO:0051716 cellular response to stimulus
1.32 1.87e-02 GO:0048523 negative regulation of cellular process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.11 9.21e-06 GO:0044424 intracellular part
1.10 1.41e-05 GO:0005622 intracellular
1.15 2.36e-05 GO:0005737 cytoplasm
1.11 1.53e-02 GO:0043227 membrane-bounded organelle
1.04 1.71e-02 GO:0044464 cell part
1.04 1.76e-02 GO:0005623 cell
1.11 2.02e-02 GO:0043231 intracellular membrane-bounded organelle
1.80 3.74e-02 GO:0044456 synapse part
1.09 3.95e-02 GO:0043226 organelle
1.09 4.52e-02 GO:0043229 intracellular organelle

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.15 6.34e-04 GO:0005515 protein binding
1.43 4.35e-02 GO:0001071 nucleic acid binding transcription factor activity
1.43 4.35e-02 GO:0003700 sequence-specific DNA binding transcription factor activity