Motif ID: LEF1_TCF7_TCF7L1,2.p2

Z-value: 1.225


Transcription factors associated with LEF1_TCF7_TCF7L1,2.p2:

Gene SymbolEntrez IDGene Name
LEF1 51176 lymphoid enhancer-binding factor 1
TCF7 6932 transcription factor 7 (T-cell specific, HMG-box)
TCF7L1 83439 transcription factor 7-like 1 (T-cell specific, HMG-box)
TCF7L2 6934 transcription factor 7-like 2 (T-cell specific, HMG-box)



Activity profile for motif LEF1_TCF7_TCF7L1,2.p2.

activity profile for motif LEF1_TCF7_TCF7L1,2.p2


Sorted Z-values histogram for motif LEF1_TCF7_TCF7L1,2.p2

Sorted Z-values for motif LEF1_TCF7_TCF7L1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of LEF1_TCF7_TCF7L1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_+_75232797 2.838 NM_015842
 LMO7
LIM domain 7
chr10_+_53744043 2.592 NM_012242
 DKK1
dickkopf homolog 1 (Xenopus laevis)
chr17_-_76985538 2.306


chr17_-_36760581 1.963 NM_004138
 KRT33A
keratin 33A
chr20_+_18742369 1.871 NM_178483
 C20orf79
chromosome 20 open reading frame 79
chr2_-_165768798 1.855 NM_001081676
NM_001081677
NM_006922
 SCN3A


sodium channel, voltage-gated, type III, alpha subunit


chr4_-_158111995 1.827 NM_016205
 PDGFC
platelet derived growth factor C
chr3_-_150422474 1.707 NM_000096
 CP
ceruloplasmin (ferroxidase)
chr3_-_191650291 1.668 NM_207316
 TMEM207
transmembrane protein 207
chr4_-_158111916 1.665 PDGFC
platelet derived growth factor C
chr14_-_22521544 1.651 NM_032876
 JUB
jub, ajuba homolog (Xenopus laevis)
chr2_+_228386800 1.583 NM_001130046
NM_004591
 CCL20

chemokine (C-C motif) ligand 20

chr1_-_160260210 1.547 NM_015441
 OLFML2B
olfactomedin-like 2B
chr4_+_38740246 1.538 NM_015990
NM_199039
 KLHL5

kelch-like 5 (Drosophila)

chr8_-_6901661 1.467 NM_021010
 DEFA5
defensin, alpha 5, Paneth cell-specific
chr10_-_123346148 1.461 NM_001144915
 FGFR2
fibroblast growth factor receptor 2
chr6_-_128883125 1.452 NM_002844
NM_001135648
 PTPRK

protein tyrosine phosphatase, receptor type, K

chr9_-_21229975 1.427 NM_002172
 IFNA14
interferon, alpha 14
chr2_+_101680594 1.412 NM_004834
NM_145686
NM_145687
 MAP4K4


mitogen-activated protein kinase kinase kinase kinase 4


chr12_-_120781002 1.405 NM_002150
 HPD
4-hydroxyphenylpyruvate dioxygenase

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 2 of 2 entries
enrichment   p-value GO term description
1.25 2.29e-02 GO:0048856 anatomical structure development
1.21 2.32e-04 GO:0032501 multicellular organismal process

Gene overrepresentation in compartment category:

Showing 1 to 3 of 3 entries
enrichment   p-value GO term description
1.93 2.04e-02 GO:0016323 basolateral plasma membrane
1.19 8.10e-03 GO:0005886 plasma membrane
1.18 1.47e-02 GO:0071944 cell periphery

Nothing significant found in function category.