Motif ID: LEF1_TCF7_TCF7L1,2.p2

Z-value: 1.225


Transcription factors associated with LEF1_TCF7_TCF7L1,2.p2:

Gene SymbolEntrez IDGene Name
LEF1 51176 lymphoid enhancer-binding factor 1
TCF7 6932 transcription factor 7 (T-cell specific, HMG-box)
TCF7L1 83439 transcription factor 7-like 1 (T-cell specific, HMG-box)
TCF7L2 6934 transcription factor 7-like 2 (T-cell specific, HMG-box)



Activity profile for motif LEF1_TCF7_TCF7L1,2.p2.

activity profile for motif LEF1_TCF7_TCF7L1,2.p2


Sorted Z-values histogram for motif LEF1_TCF7_TCF7L1,2.p2

Sorted Z-values for motif LEF1_TCF7_TCF7L1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of LEF1_TCF7_TCF7L1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_+_75232797 2.838 NM_015842
LMO7
LIM domain 7
chr10_+_53744043 2.592 NM_012242
DKK1
dickkopf homolog 1 (Xenopus laevis)
chr17_-_76985538 2.306


chr17_-_36760581 1.963 NM_004138
KRT33A
keratin 33A
chr20_+_18742369 1.871 NM_178483
C20orf79
chromosome 20 open reading frame 79
chr2_-_165768798 1.855 NM_001081676
NM_001081677
NM_006922
SCN3A


sodium channel, voltage-gated, type III, alpha subunit


chr4_-_158111995 1.827 NM_016205
PDGFC
platelet derived growth factor C
chr3_-_150422474 1.707 NM_000096
CP
ceruloplasmin (ferroxidase)
chr3_-_191650291 1.668 NM_207316
TMEM207
transmembrane protein 207
chr4_-_158111916 1.665 PDGFC
platelet derived growth factor C
chr14_-_22521544 1.651 NM_032876
JUB
jub, ajuba homolog (Xenopus laevis)
chr2_+_228386800 1.583 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr1_-_160260210 1.547 NM_015441
OLFML2B
olfactomedin-like 2B
chr4_+_38740246 1.538 NM_015990
NM_199039
KLHL5

kelch-like 5 (Drosophila)

chr8_-_6901661 1.467 NM_021010
DEFA5
defensin, alpha 5, Paneth cell-specific
chr10_-_123346148 1.461 NM_001144915
FGFR2
fibroblast growth factor receptor 2
chr6_-_128883125 1.452 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr9_-_21229975 1.427 NM_002172
IFNA14
interferon, alpha 14
chr2_+_101680594 1.412 NM_004834
NM_145686
NM_145687
MAP4K4


mitogen-activated protein kinase kinase kinase kinase 4


chr12_-_120781002 1.405 NM_002150
HPD
4-hydroxyphenylpyruvate dioxygenase
chr7_-_158304062 1.378 ESYT2
extended synaptotagmin-like protein 2
chr5_-_58370693 1.319 NM_001197221
NM_001197222
PDE4D

phosphodiesterase 4D, cAMP-specific

chr18_-_55136673 1.310 NM_181654
CPLX4
complexin 4
chr14_-_20642214 1.303


chr6_+_131190237 1.287 NM_001195597
LOC285733
hypothetical LOC285733
chr4_-_158111504 1.280 PDGFC
platelet derived growth factor C
chr12_+_19173669 1.266 NM_001143821
NM_001190860
NM_019012
PLEKHA5


pleckstrin homology domain containing, family A member 5


chr2_+_233443237 1.263 NM_206895
C2orf82
chromosome 2 open reading frame 82
chr2_+_165804157 1.244 NM_001040142
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr14_-_20642629 1.225 NM_001102454
ZNF219
zinc finger protein 219
chr16_-_18720192 1.216 NM_015161
ARL6IP1
ADP-ribosylation factor-like 6 interacting protein 1
chr7_+_90176647 1.204 NM_012395
CDK14
cyclin-dependent kinase 14
chr17_+_54997667 1.177 NM_001166301
NM_024612
DHX40

DEAH (Asp-Glu-Ala-His) box polypeptide 40

chr14_-_64479198 1.151 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr17_-_61253122 1.130 NM_001037325
CCDC46
coiled-coil domain containing 46
chr12_+_69046241 1.115 NM_014505
KCNMB4
potassium large conductance calcium-activated channel, subfamily M, beta member 4
chr2_+_11597530 1.112 NM_148903
GREB1
growth regulation by estrogen in breast cancer 1
chr4_+_109763119 1.105 RPL34
ribosomal protein L34
chr6_-_128263868 1.097 NM_001010923
NM_001164685
THEMIS

thymocyte selection associated

chr21_-_26294332 1.088 APP
amyloid beta (A4) precursor protein
chr2_-_37727472 1.080 CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr12_+_8958397 1.068 NM_004426
PHC1
polyhomeotic homolog 1 (Drosophila)
chr17_-_36779399 1.067 NM_002279
KRT33B
keratin 33B
chr12_+_67366989 1.038 NM_020401
NUP107
nucleoporin 107kDa
chr9_+_115265827 1.034 NM_017790
RGS3
regulator of G-protein signaling 3
chr20_+_42399039 1.013 NM_178491
R3HDML
R3H domain containing-like
chr14_-_22947320 1.000 NM_002471
MYH6
myosin, heavy chain 6, cardiac muscle, alpha
chr2_-_75641535 0.999 FAM176A
family with sequence similarity 176, member A
chr6_-_151754337 0.997 NM_020861
ZBTB2
zinc finger and BTB domain containing 2
chr2_-_75641587 0.997 NM_001135032
FAM176A
family with sequence similarity 176, member A
chr1_-_151045730 0.993 NM_178351
LCE1C
late cornified envelope 1C
chr5_+_140509803 0.982 NM_018939
PCDHB6
protocadherin beta 6
chr9_-_21295311 0.978 NM_002169
IFNA5
interferon, alpha 5
chr9_+_17568952 0.954 NM_003026
SH3GL2
SH3-domain GRB2-like 2
chr11_-_47502115 0.941 NM_001172639
CELF1
CUGBP, Elav-like family member 1
chr20_+_17622319 0.940 NM_001159495
BANF2
barrier to autointegration factor 2
chr17_-_45427565 0.938 NM_005220
DLX3
distal-less homeobox 3
chr13_-_32658215 0.930 NM_178007
STARD13
StAR-related lipid transfer (START) domain containing 13
chr1_-_110735158 0.929 NM_004696
SLC16A4
solute carrier family 16, member 4 (monocarboxylic acid transporter 5)
chr1_+_15957832 0.926 NM_017556
FBLIM1
filamin binding LIM protein 1
chr17_+_75766875 0.925 NM_024110
CARD14
caspase recruitment domain family, member 14
chr12_+_56406296 0.914 LOC100130776
hypothetical LOC100130776
chr16_-_71639670 0.907 NM_006885
ZFHX3
zinc finger homeobox 3
chr4_+_109761170 0.895 NM_000995
NM_033625
RPL34

ribosomal protein L34

chr5_+_140200995 0.893 NM_018911
NM_031856
PCDHA8

protocadherin alpha 8

chr11_+_125258718 0.875 NM_145014
HYLS1
hydrolethalus syndrome 1
chr2_+_104838177 0.873 NM_006236
POU3F3
POU class 3 homeobox 3
chr6_+_35812836 0.873 NM_145028
C6orf81
chromosome 6 open reading frame 81
chr6_+_64339869 0.861 NM_003463
PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr5_+_147775652 0.859 FBXO38
F-box protein 38
chr11_+_61794205 0.855 NM_002411
SCGB2A2
secretoglobin, family 2A, member 2
chr14_-_30746577 0.855


chr5_+_149526533 0.847 NM_001804
CDX1
caudal type homeobox 1
chr7_+_139750311 0.844 NM_001008749
RAB19
RAB19, member RAS oncogene family
chrX_-_117003310 0.843 NM_001168299
KLHL13
kelch-like 13 (Drosophila)
chr15_+_78483624 0.830 NM_014862
ARNT2
aryl-hydrocarbon receptor nuclear translocator 2
chr20_+_11846536 0.830 NM_014962
BTBD3
BTB (POZ) domain containing 3
chr2_-_74606819 0.826 NM_133637
DQX1
DEAQ box RNA-dependent ATPase 1
chr7_+_90177082 0.823 CDK14
cyclin-dependent kinase 14
chr11_+_100367929 0.810 NM_032021
TMEM133
transmembrane protein 133
chr8_+_121892719 0.810


chr1_-_240679380 0.807 NM_001195811
NM_001195812
PLD5

phospholipase D family, member 5

chr13_-_98708549 0.803 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chr11_-_121492010 0.796 NM_001001786
BLID
BH3-like motif containing, cell death inducer
chr19_-_50506883 0.768 CKM
creatine kinase, muscle
chr13_+_23042722 0.758 NM_148957
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr11_+_22646229 0.752 NM_177553
GAS2
growth arrest-specific 2
chr12_+_52713098 0.752 NM_018953
HOXC5
homeobox C5
chr14_-_20572783 0.748 NM_001012264
RNASE13
ribonuclease, RNase A family, 13 (non-active)
chr12_+_54611212 0.748 NM_001345
DGKA
diacylglycerol kinase, alpha 80kDa
chr14_+_20306425 0.736 NM_022360
EDDM3B
epididymal protein 3B
chr14_+_20283938 0.727 NM_006683
EDDM3A
epididymal protein 3A
chr18_-_63333487 0.727 DSEL
dermatan sulfate epimerase-like
chr2_+_169631777 0.726 NM_199204
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr19_-_2901583 0.723


chr8_-_139995417 0.721 NM_152888
COL22A1
collagen, type XXII, alpha 1
chr5_+_140460240 0.721 NM_018937
PCDHB3
protocadherin beta 3
chr11_-_89181390 0.720 NM_020358
TRIM49
tripartite motif containing 49
chr14_+_105012106 0.720 NM_001312
CRIP2
cysteine-rich protein 2
chr15_-_63457378 0.716 NM_004884
IGDCC3
immunoglobulin superfamily, DCC subclass, member 3
chr20_-_13919256 0.701 NM_025229
SEL1L2
sel-1 suppressor of lin-12-like 2 (C. elegans)
chr15_+_62175253 0.700 SNX1
sorting nexin 1
chr5_-_16791346 0.700 MYO10
myosin X
chr20_-_17459973 0.690 NM_001195
BFSP1
beaded filament structural protein 1, filensin
chr1_-_11674264 0.690 NM_001127325
MAD2L2
MAD2 mitotic arrest deficient-like 2 (yeast)
chr8_-_120033240 0.683 NM_002546
TNFRSF11B
tumor necrosis factor receptor superfamily, member 11b
chr1_+_62835759 0.683 NM_014495
ANGPTL3
angiopoietin-like 3
chr1_+_17719405 0.681 ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr6_-_138935359 0.678 NM_020464
NHSL1
NHS-like 1
chr4_-_52599181 0.672 NM_000232
SGCB
sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
chr7_+_72883128 0.669 NM_001305
CLDN4
claudin 4
chr19_-_18578577 0.669 CRLF1
cytokine receptor-like factor 1
chr6_-_52736231 0.668 NM_000846
GSTA2
glutathione S-transferase alpha 2
chr4_-_80079393 0.667 NM_001040202
PAQR3
progestin and adipoQ receptor family member III
chr1_+_48460943 0.662 NM_001011547
NM_001135181
SLC5A9

solute carrier family 5 (sodium/glucose cotransporter), member 9

chr1_+_156716290 0.661 NM_001004472
OR10R2
olfactory receptor, family 10, subfamily R, member 2
chr6_+_30212488 0.659 NM_138700
TRIM40
tripartite motif containing 40
chr18_-_44723116 0.658 NM_001190823
SMAD7
SMAD family member 7
chr12_+_54400417 0.657 NM_002905
RDH5
retinol dehydrogenase 5 (11-cis/9-cis)
chr3_+_152970904 0.654 LOC201651
arylacetamide deacetylase (esterase) pseudogene
chr1_+_227506751 0.649 NM_006542
SPHAR
S-phase response (cyclin related)
chrX_-_19598912 0.648 NM_001184960
SH3KBP1
SH3-domain kinase binding protein 1
chr14_+_74299748 0.642 NM_019589
YLPM1
YLP motif containing 1
chr4_-_5945596 0.641 NM_001014809
CRMP1
collapsin response mediator protein 1
chr6_-_52776558 0.638 NM_145740
GSTA1
glutathione S-transferase alpha 1
chr3_-_127258299 0.630 NM_001008487
SLC41A3
solute carrier family 41, member 3
chr16_-_18720375 0.622 ARL6IP1
ADP-ribosylation factor-like 6 interacting protein 1
chr2_-_37047113 0.619 NM_003162
STRN
striatin, calmodulin binding protein
chr2_+_11600287 0.618 NM_033090
GREB1
growth regulation by estrogen in breast cancer 1
chr6_+_31698447 0.610


chr4_-_40911212 0.608 NM_001166050
NM_004307
NM_173075
APBB2


amyloid beta (A4) precursor protein-binding, family B, member 2


chr5_-_148911194 0.606 NM_001025105
NM_001892
CSNK1A1

casein kinase 1, alpha 1

chr17_+_69939806 0.605 GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr9_-_21340885 0.603 NM_021002
IFNA6
interferon, alpha 6
chr9_-_74169445 0.601 ZFAND5
zinc finger, AN1-type domain 5
chr3_+_29297806 0.601 NM_001003792
NM_001003793
NM_001177711
NM_001177712
NM_014483
RBMS3




RNA binding motif, single stranded interacting protein 3




chr15_+_60146467 0.598 NM_207322
C2CD4A
C2 calcium-dependent domain containing 4A
chr8_-_16903911 0.597 NM_019851
FGF20
fibroblast growth factor 20
chr3_+_42825957 0.597 NM_001296
CCBP2
chemokine binding protein 2
chr2_-_128358903 0.597 NM_031445
AMMECR1L
AMME chromosomal region gene 1-like
chr2_+_54537842 0.595 SPTBN1
spectrin, beta, non-erythrocytic 1
chr14_+_19655405 0.595 NM_001004715
OR4K17
olfactory receptor, family 4, subfamily K, member 17
chr2_+_28572441 0.593 NM_001170585
NM_153021
PLB1

phospholipase B1

chr11_-_27637771 0.593 NM_001143816
NM_170735
BDNF

brain-derived neurotrophic factor

chr7_+_29486010 0.591 NM_001039936
CHN2
chimerin (chimaerin) 2
chr5_+_140714951 0.590 NM_018917
NM_032053
PCDHGA4

protocadherin gamma subfamily A, 4

chr12_+_15366712 0.588 NM_002848
NM_030667
PTPRO

protein tyrosine phosphatase, receptor type, O

chr20_-_43577677 0.588 NM_006652
SPINT3
serine peptidase inhibitor, Kunitz type, 3
chr2_+_10101081 0.584 NM_003597
NM_001177716
KLF11

Kruppel-like factor 11

chr7_-_27186400 0.583 NM_153715
HOXA10
homeobox A10
chr12_-_10497195 0.581 NM_002259
NM_007328
KLRC1

killer cell lectin-like receptor subfamily C, member 1

chr17_-_43390108 0.581 NM_024320
PRR15L
proline rich 15-like
chr4_-_10295412 0.576 NM_052964
CLNK
cytokine-dependent hematopoietic cell linker
chr22_-_43783449 0.569 PHF21B
PHD finger protein 21B
chr4_-_85638410 0.568 NM_006168
NKX6-1
NK6 homeobox 1
chr7_-_19778928 0.567 NM_152774
TMEM196
transmembrane protein 196
chr17_+_19377732 0.564 NM_018242
SLC47A1
solute carrier family 47, member 1
chr14_+_38720085 0.564 PNN
pinin, desmosome associated protein
chr9_+_71009746 0.563 NM_001170415
NM_001170416
TJP2

tight junction protein 2 (zona occludens 2)

chr11_-_87548199 0.561 NM_022337
RAB38
RAB38, member RAS oncogene family
chr16_+_70646008 0.558 NM_001126102
NM_005143
HP

haptoglobin

chr3_-_47798308 0.558 SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chr3_-_71860958 0.556 NM_001134650
EIF4E3
eukaryotic translation initiation factor 4E family member 3
chr1_+_183970093 0.555 NM_031935
HMCN1
hemicentin 1
chr10_+_104995633 0.553 NM_001143909
LOC729020
rcRPE
chr6_+_83130673 0.552 NM_001166392
TPBG
trophoblast glycoprotein
chr6_-_96131974 0.552


chr7_+_20653490 0.549 NM_001163942
NM_001163993
NM_178559
ABCB5


ATP-binding cassette, sub-family B (MDR/TAP), member 5


chr2_+_69093641 0.546 NM_018153
NM_032208
NM_053034
ANTXR1


anthrax toxin receptor 1


chr3_-_152541129 0.541 NM_176876
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr19_-_18578467 0.541 CRLF1
cytokine receptor-like factor 1
chr5_-_100266769 0.540 NM_175052
NM_005668
ST8SIA4

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4

chr6_+_83130220 0.533 TPBG
trophoblast glycoprotein
chr4_-_68304398 0.533 NM_000406
NM_001012763
GNRHR

gonadotropin-releasing hormone receptor

chr9_+_115246831 0.533 NM_144488
RGS3
regulator of G-protein signaling 3
chr20_+_20296744 0.532 NM_002196
INSM1
insulinoma-associated 1
chr4_-_68793928 0.532 NM_182502
TMPRSS11B
transmembrane protease, serine 11B
chr2_-_241484245 0.532 NM_001085437
C2orf54
chromosome 2 open reading frame 54
chr15_-_91433165 0.531 NM_020211
RGMA
RGM domain family, member A
chr14_-_34414277 0.531 BAZ1A
bromodomain adjacent to zinc finger domain, 1A
chr12_+_54316910 0.528 NM_206899
OR10P1
olfactory receptor, family 10, subfamily P, member 1
chr20_+_34937928 0.525 NM_080628
C20orf118
chromosome 20 open reading frame 118
chr2_-_172458970 0.521 NM_003705
SLC25A12
solute carrier family 25 (mitochondrial carrier, Aralar), member 12
chr12_+_21175394 0.520 NM_006446
SLCO1B1
solute carrier organic anion transporter family, member 1B1
chr2_+_166034402 0.512 NM_001172173
CSRNP3
cysteine-serine-rich nuclear protein 3
chr2_+_135312655 0.510 NM_138326
ACMSD
aminocarboxymuconate semialdehyde decarboxylase
chr5_-_148911105 0.509 CSNK1A1
casein kinase 1, alpha 1
chr10_-_51293220 0.508 NM_006327
TIMM23
TIMM23B
translocase of inner mitochondrial membrane 23 homolog (yeast)
translocase of inner mitochondrial membrane 23 homolog B (yeast)
chr3_-_79899748 0.508 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr6_-_119512035 0.508 NM_001100411
FAM184A
family with sequence similarity 184, member A
chr14_+_20048451 0.507 NM_001012975
RNASE10
ribonuclease, RNase A family, 10 (non-active)
chr17_+_24944605 0.505 NM_152345
ANKRD13B
ankyrin repeat domain 13B
chr18_-_24011349 0.505 NM_001792
CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr3_-_47798337 0.504 SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chr12_+_10222823 0.501 NM_153022
C12orf59
chromosome 12 open reading frame 59
chr6_+_123151669 0.500 NM_006714
SMPDL3A
sphingomyelin phosphodiesterase, acid-like 3A
chr11_+_58631190 0.500 NM_001142703
NM_001142704
NM_198947
FAM111B


family with sequence similarity 111, member B


chr17_+_72047709 0.496 NM_001077620
PRCD
progressive rod-cone degeneration
chr10_+_25345513 0.494 NM_024838
THNSL1
threonine synthase-like 1 (S. cerevisiae)
chr17_-_1359745 0.494 INPP5K
inositol polyphosphate-5-phosphatase K

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.21 2.32e-04 GO:0032501 multicellular organismal process
1.25 2.29e-02 GO:0048856 anatomical structure development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.19 8.10e-03 GO:0005886 plasma membrane
1.18 1.47e-02 GO:0071944 cell periphery
1.93 2.04e-02 GO:0016323 basolateral plasma membrane

Nothing significant found in function category.