Motif ID: TFAP2B.p2

Z-value: 1.021


Transcription factors associated with TFAP2B.p2:

Gene SymbolEntrez IDGene Name
TFAP2B 7021 transcription factor AP-2 beta (activating enhancer binding protein 2 beta)



Activity profile for motif TFAP2B.p2.

activity profile for motif TFAP2B.p2


Sorted Z-values histogram for motif TFAP2B.p2

Sorted Z-values for motif TFAP2B.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP2B.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr21_-_43671355 6.326 NM_173354
 SIK1
salt-inducible kinase 1
chr16_-_87535106 5.319 NM_175931
 CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr14_-_104705753 4.489 JAG2
jagged 2
chr12_-_122322117 4.395 NM_004642
 CDK2AP1
cyclin-dependent kinase 2 associated protein 1
chr17_+_17525571 4.123


chr19_+_3175700 4.056 NM_021938
NM_001172673
 CELF5

CUGBP, Elav-like family member 5

chr19_+_3175734 4.033 CELF5
CUGBP, Elav-like family member 5
chr10_+_134060681 3.897 NM_001098637
NM_138499
 PWWP2B

PWWP domain containing 2B

chr1_-_1274618 3.888 DVL1
dishevelled, dsh homolog 1 (Drosophila)
chr14_-_104706159 3.834 NM_002226
NM_145159
 JAG2

jagged 2

chr22_+_36286350 3.804 NM_152243
 CDC42EP1
CDC42 effector protein (Rho GTPase binding) 1
chr4_+_7245218 3.760 NM_020777
 SORCS2
sortilin-related VPS10 domain containing receptor 2
chr9_+_137119339 3.645 OLFM1
olfactomedin 1
chrX_+_9943793 3.624 NM_015691
 WWC3
WWC family member 3
chr10_+_99176028 3.600 PGAM1
phosphoglycerate mutase 1 (brain)
chr11_-_63292688 3.582 NM_001144936
 C11orf95
chromosome 11 open reading frame 95
chr2_+_96845704 3.531 NM_017623
NM_199078
 CNNM3

cyclin M3

chr5_+_1061900 3.481 NM_033120
 NKD2
naked cuticle homolog 2 (Drosophila)
chr9_+_137119334 3.443 OLFM1
olfactomedin 1
chr10_-_99175685 3.430



Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 105 entries
enrichment   p-value GO term description
1.59 1.03e-05 GO:0048011 nerve growth factor receptor signaling pathway
1.46 4.05e-03 GO:0046578 regulation of Ras protein signal transduction
1.44 3.40e-02 GO:0045786 negative regulation of cell cycle
1.42 1.04e-03 GO:0007411 axon guidance
1.41 2.91e-03 GO:0060284 regulation of cell development
1.40 3.85e-04 GO:0007264 small GTPase mediated signal transduction
1.40 8.39e-04 GO:0051056 regulation of small GTPase mediated signal transduction
1.39 8.78e-06 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.39 2.61e-04 GO:0007409 axonogenesis
1.37 1.03e-04 GO:0000904 cell morphogenesis involved in differentiation
1.37 5.86e-04 GO:0048812 neuron projection morphogenesis
1.37 6.52e-04 GO:0048667 cell morphogenesis involved in neuron differentiation
1.36 1.22e-02 GO:0016568 chromatin modification
1.34 1.65e-07 GO:0051128 regulation of cellular component organization
1.34 2.42e-05 GO:0007167 enzyme linked receptor protein signaling pathway
1.33 2.37e-03 GO:0031175 neuron projection development
1.31 1.56e-06 GO:0048699 generation of neurons
1.31 2.79e-06 GO:0006351 transcription, DNA-dependent
1.31 1.24e-03 GO:0010629 negative regulation of gene expression
1.31 6.56e-03 GO:0032990 cell part morphogenesis

Gene overrepresentation in compartment category:

Showing 1 to 20 of 31 entries
enrichment   p-value GO term description
1.94 5.97e-03 GO:0031228 intrinsic to Golgi membrane
1.94 1.19e-02 GO:0030173 integral to Golgi membrane
1.51 5.21e-03 GO:0031300 intrinsic to organelle membrane
1.51 1.81e-02 GO:0031301 integral to organelle membrane
1.48 2.28e-02 GO:0005912 adherens junction
1.30 2.85e-03 GO:0000139 Golgi membrane
1.28 7.61e-10 GO:0005654 nucleoplasm
1.27 3.65e-04 GO:0044451 nucleoplasm part
1.27 2.46e-03 GO:0044431 Golgi apparatus part
1.25 4.82e-13 GO:0005829 cytosol
1.24 8.46e-05 GO:0005794 Golgi apparatus
1.22 6.40e-09 GO:0031981 nuclear lumen
1.21 5.58e-10 GO:0044428 nuclear part
1.20 4.62e-09 GO:0070013 intracellular organelle lumen
1.19 7.35e-09 GO:0031974 membrane-enclosed lumen
1.19 1.05e-08 GO:0043233 organelle lumen
1.17 4.29e-22 GO:0005634 nucleus
1.16 3.44e-03 GO:0012505 endomembrane system
1.15 9.45e-34 GO:0005737 cytoplasm
1.14 4.66e-16 GO:0044444 cytoplasmic part

Gene overrepresentation in function category:

Showing 1 to 20 of 28 entries
enrichment   p-value GO term description
1.53 2.86e-03 GO:0005085 guanyl-nucleotide exchange factor activity
1.52 6.11e-03 GO:0004721 phosphoprotein phosphatase activity
1.43 2.33e-04 GO:0008134 transcription factor binding
1.39 1.11e-03 GO:0016563 transcription activator activity
1.39 2.11e-02 GO:0016791 phosphatase activity
1.35 1.74e-02 GO:0016564 transcription repressor activity
1.29 8.91e-08 GO:0030528 transcription regulator activity
1.28 8.22e-07 GO:0001071 nucleic acid binding transcription factor activity
1.28 8.22e-07 GO:0003700 sequence-specific DNA binding transcription factor activity
1.28 2.63e-04 GO:0043565 sequence-specific DNA binding
1.26 3.31e-05 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.26 3.55e-04 GO:0016301 kinase activity
1.25 1.83e-03 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.24 3.08e-02 GO:0004672 protein kinase activity
1.23 1.40e-02 GO:0042802 identical protein binding
1.20 1.53e-06 GO:0016740 transferase activity
1.17 7.71e-06 GO:0003677 DNA binding
1.16 1.04e-28 GO:0005515 protein binding
1.16 1.11e-03 GO:0017076 purine nucleotide binding
1.16 8.08e-03 GO:0030554 adenyl nucleotide binding