Motif ID: NKX2-2,8.p2

Z-value: 1.151


Transcription factors associated with NKX2-2,8.p2:

Gene SymbolEntrez IDGene Name
NKX2-2 4821 NK2 homeobox 2
NKX2-8 26257 NK2 homeobox 8



Activity profile for motif NKX2-2,8.p2.

activity profile for motif NKX2-2,8.p2


Sorted Z-values histogram for motif NKX2-2,8.p2

Sorted Z-values for motif NKX2-2,8.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-2,8.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_+_37689903 4.124


chr7_+_111879348 2.977 NM_001197079
IFRD1
interferon-related developmental regulator 1
chr5_-_160044844 2.951 ATP10B
ATPase, class V, type 10B
chr9_+_122923864 2.827 CEP110
centrosomal protein 110kDa
chr1_+_239762179 2.462 NM_003679
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr10_-_93992982 2.027 NM_001178137
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr1_-_74971679 1.968 NM_001130042
NM_001130043
NM_001134759
NM_001889
CRYZ



crystallin, zeta (quinone reductase)



chr20_+_17622319 1.857 NM_001159495
BANF2
barrier to autointegration factor 2
chr11_+_117680504 1.774 NM_000733
CD3E
CD3e molecule, epsilon (CD3-TCR complex)
chr12_-_101115677 1.731 NM_002674
PMCH
pro-melanin-concentrating hormone
chr11_+_65027721 1.713


chr3_-_57301749 1.666 NM_001142733
ASB14
ankyrin repeat and SOCS box containing 14
chr2_-_61566477 1.624 XPO1
exportin 1 (CRM1 homolog, yeast)
chrX_+_11687655 1.550 NM_006800
MSL3
male-specific lethal 3 homolog (Drosophila)
chr3_+_153499883 1.522 NM_207293
NM_207294
NM_207295
NM_207296
NM_207297
MBNL1




muscleblind-like (Drosophila)




chr4_-_170770111 1.507 NM_012224
NEK1
NIMA (never in mitosis gene a)-related kinase 1
chr3_-_15814678 1.506 NM_001195098
ANKRD28
ankyrin repeat domain 28
chr16_+_24475129 1.486 RBBP6
retinoblastoma binding protein 6
chr1_-_143708467 1.480 NM_001195260
PDE4DIP
phosphodiesterase 4D interacting protein
chr1_-_103269356 1.461 COL11A1
collagen, type XI, alpha 1
chr9_-_113561613 1.437 NM_001080551
C9orf84
chromosome 9 open reading frame 84
chr6_-_155818728 1.392 NM_015718
NOX3
NADPH oxidase 3
chr5_-_137876416 1.374 ETF1
eukaryotic translation termination factor 1
chr17_+_3324096 1.369 NM_001128085
ASPA
aspartoacylase
chr1_+_200698493 1.343 NM_032103
NM_032104
PPP1R12B

protein phosphatase 1, regulatory (inhibitor) subunit 12B

chr1_+_74971423 1.324 NM_001162916
NM_138467
TYW3

tRNA-yW synthesizing protein 3 homolog (S. cerevisiae)

chr14_-_44046202 1.309 NM_032135
FSCB
fibrous sheath CABYR binding protein
chr7_-_76667045 1.308 NM_006682
FGL2
fibrinogen-like 2
chr3_+_133798770 1.304 NM_016557
CCRL1
chemokine (C-C motif) receptor-like 1
chr3_-_152449591 1.264 NM_001081455
P2RY14
purinergic receptor P2Y, G-protein coupled, 14
chr3_+_88270951 1.258 NM_018293
ZNF654
zinc finger protein 654
chr2_+_69974581 1.243 NM_006857
SNRNP27
small nuclear ribonucleoprotein 27kDa (U4/U6.U5)
chr6_+_55147029 1.241 NM_001526
HCRTR2
hypocretin (orexin) receptor 2
chr11_+_12917369 1.241 TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr1_-_111908085 1.233 NM_001081976
ADORA3
adenosine A3 receptor
chr3_-_121065112 1.227


chr4_-_170314382 1.226 SH3RF1
SH3 domain containing ring finger 1
chr9_-_3213007 1.216


chr1_-_197173159 1.204 LOC100131234
familial acute myelogenous leukemia related factor
chr5_+_128468785 1.194 ISOC1
isochorismatase domain containing 1
chr1_-_67039518 1.180 NM_005478
INSL5
insulin-like 5
chr2_-_162717159 1.152 NM_002054
GCG
glucagon
chr3_+_120982020 1.129 NM_003889
NM_033013
NR1I2

nuclear receptor subfamily 1, group I, member 2

chr12_-_10846435 1.124 NM_023919
TAS2R7
taste receptor, type 2, member 7
chr10_+_90336489 1.119 NM_001010939
LIPJ
lipase, family member J
chr5_+_147423727 1.115 NM_001127698
NM_001127699
NM_006846
SPINK5


serine peptidase inhibitor, Kazal type 5


chr15_-_75364387 1.093 NM_024776
PEAK1
NKF3 kinase family member
chr2_-_40593074 1.092 NM_001112802
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr15_+_22778233 1.024 SNRPN
small nuclear ribonucleoprotein polypeptide N
chr1_+_242281175 1.022 NM_205768
ZNF238
zinc finger protein 238
chr5_+_6799100 1.021 NM_001171806
PAPD7
PAP associated domain containing 7
chr2_+_102320148 1.016 NM_003856
IL1RL1
interleukin 1 receptor-like 1
chr6_+_73133152 1.006 NM_001168411
RIMS1
regulating synaptic membrane exocytosis 1
chr3_-_153541468 1.003 NM_001123228
TMEM14E
transmembrane protein 14E
chr1_+_15862887 0.993


chr8_+_118216517 0.982 NM_001172814
NM_173851
SLC30A8

solute carrier family 30 (zinc transporter), member 8

chr11_-_47467094 0.975 NM_001025596
NM_001172640
CELF1

CUGBP, Elav-like family member 1

chr10_-_37931864 0.966 NM_001190489
MTRNR2L7
MT-RNR2-like 7
chr5_+_54491702 0.962 NM_001008397
GPX8
glutathione peroxidase 8 (putative)
chr15_+_22832198 0.962 SNRPN
small nuclear ribonucleoprotein polypeptide N
chr17_-_1195096 0.949 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr2_-_217433018 0.948 NM_003284
TNP1
transition protein 1 (during histone to protamine replacement)
chr8_-_133841988 0.938 NM_001145153
NM_144649
TMEM71

transmembrane protein 71

chr16_+_55373241 0.938 NUP93
nucleoporin 93kDa
chr6_+_88021644 0.931 ZNF292
zinc finger protein 292
chr14_-_106184988 0.929 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr11_+_125163215 0.926 NM_001129883
PATE3
prostate and testis expressed 3
chr6_+_45404031 0.917 NM_001015051
NM_001024630
RUNX2

runt-related transcription factor 2

chr22_+_40372957 0.916 XRCC6
X-ray repair complementing defective repair in Chinese hamster cells 6
chr1_+_84402962 0.915 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr5_-_95044415 0.913 NM_031952
SPATA9
spermatogenesis associated 9
chr1_+_169747788 0.907 PRRC2C
proline-rich coiled-coil 2C
chr13_-_48873735 0.906 NM_030925
CAB39L
calcium binding protein 39-like
chr8_-_110689396 0.897 SYBU
syntabulin (syntaxin-interacting)
chr14_+_88130482 0.876 NM_207662
ZC3H14
zinc finger CCCH-type containing 14
chr14_-_31026901 0.873 NM_001197184
GPR33
G protein-coupled receptor 33 (gene/pseudogene)
chr7_-_143597313 0.859 NM_198495
CTAGE4
CTAGE8
CTAGE family, member 4
CTAGE family, member 8
chr14_-_74669864 0.857 TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chr8_-_18710575 0.856 NM_206909
PSD3
pleckstrin and Sec7 domain containing 3
chr12_+_63510481 0.849


chr18_-_62422195 0.835 NM_021153
CDH19
cadherin 19, type 2
chr3_-_187744808 0.833 NM_017541
CRYGS
crystallin, gamma S
chr1_+_144149794 0.828 NM_006472
TXNIP
thioredoxin interacting protein
chr22_-_39587944 0.821 NM_145174
DNAJB7
DnaJ (Hsp40) homolog, subfamily B, member 7
chr2_+_170074457 0.818 NM_006063
KBTBD10
kelch repeat and BTB (POZ) domain containing 10
chr1_-_74971276 0.815 CRYZ
crystallin, zeta (quinone reductase)
chr2_+_228064531 0.812 AGFG1
ArfGAP with FG repeats 1
chr17_-_36436979 0.812 NM_031957
KRTAP1-5
keratin associated protein 1-5
chr10_-_135290288 0.808 NM_001080998
FRG2B
FRG2
FSHD region gene 2 family, member B
FSHD region gene 2
chr7_-_93027057 0.801 NM_001164738
CALCR
calcitonin receptor
chr12_+_76749199 0.792 NM_014903
NAV3
neuron navigator 3
chr13_-_106018445 0.778 NM_018011
ARGLU1
arginine and glutamate rich 1
chr11_+_22646229 0.774 NM_177553
GAS2
growth arrest-specific 2
chr13_+_110653407 0.773 ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr9_+_101628829 0.771 NM_173200
NR4A3
nuclear receptor subfamily 4, group A, member 3
chr5_+_140532385 0.767 NM_018940
PCDHB7
protocadherin beta 7
chr1_-_242073094 0.767 NM_005465
NM_181690
AKT3

v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)

chr21_+_24722913 0.756 FLJ42200
FLJ42200 protein
chr14_-_24148658 0.750 NM_033423
GZMH
granzyme H (cathepsin G-like 2, protein h-CCPX)
chr5_-_58688428 0.747 NM_001197219
PDE4D
phosphodiesterase 4D, cAMP-specific
chr12_-_10850845 0.746 NM_023918
TAS2R8
taste receptor, type 2, member 8
chr12_+_32578513 0.737 FGD4
FYVE, RhoGEF and PH domain containing 4
chr3_+_75796170 0.730 NM_001124759
FRG2C
FLJ20518
FSHD region gene 2 family, member C
FSHD region gene 2 family, member C pseudogene
chr1_+_242281199 0.727 ZNF238
zinc finger protein 238
chr18_-_3835295 0.727 NM_001003809
DLGAP1
discs, large (Drosophila) homolog-associated protein 1
chr14_-_81069865 0.716 SEL1L
sel-1 suppressor of lin-12-like (C. elegans)
chr3_-_152541129 0.714 NM_176876
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr12_+_54106304 0.706 NM_001005183
OR6C76
olfactory receptor, family 6, subfamily C, member 76
chr3_-_102194938 0.705 NM_015429
ABI3BP
ABI family, member 3 (NESH) binding protein
chr7_+_113853790 0.697 NM_001172767
NM_148899
FOXP2

forkhead box P2

chr10_-_98326435 0.689 TM9SF3
transmembrane 9 superfamily member 3
chr9_+_102380156 0.689 NM_001018116
MURC
muscle-related coiled-coil protein
chr12_+_10054492 0.681 NM_001129998
NM_205852
CLEC12B

C-type lectin domain family 12, member B

chr9_-_21472311 0.681 NM_176891
IFNE
interferon, epsilon
chr18_-_65766068 0.679 CD226
CD226 molecule
chr3_-_69183926 0.675 NM_007114
TMF1
TATA element modulatory factor 1
chr1_+_144374513 0.671 RNF115
ring finger protein 115
chr12_+_63090008 0.670 XPOT
exportin, tRNA (nuclear export receptor for tRNAs)
chr5_-_169340321 0.667 NM_001129891
FAM196B
family with sequence similarity 196, member B
chr17_+_55098280 0.666 CLTC
clathrin, heavy chain (Hc)
chr3_+_122769467 0.664 NM_001012659
ARGFX
arginine-fifty homeobox
chr2_-_225086564 0.663 CUL3
cullin 3
chr8_+_7742811 0.657 NM_058203
NM_001081552
SPAG11B
SPAG11A
sperm associated antigen 11B
sperm associated antigen 11A
chr6_-_41362370 0.651 NM_018643
TREM1
triggering receptor expressed on myeloid cells 1
chr3_-_122862447 0.651 NM_005335
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr10_-_98315090 0.650 TM9SF3
transmembrane 9 superfamily member 3
chr1_-_20374273 0.648 NM_001105572
PLA2G2C
phospholipase A2, group IIC
chr4_+_88147107 0.642 NM_005935
AFF1
AF4/FMR2 family, member 1
chr1_+_154573728 0.639 NM_144627
C1orf182
chromosome 1 open reading frame 182
chr8_-_81155564 0.638 NM_001025252
TPD52
tumor protein D52
chr3_-_113701073 0.636 NM_001085357
NM_181780
BTLA

B and T lymphocyte associated

chr5_-_147996769 0.631 NM_001040169
NM_001040172
NM_001040173
NM_199453
HTR4



5-hydroxytryptamine (serotonin) receptor 4



chr14_-_19871267 0.628 NM_021178
NM_182849
CCNB1IP1

cyclin B1 interacting protein 1, E3 ubiquitin protein ligase

chr14_+_66901237 0.625 EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr1_-_41398126 0.614 NM_001172222
SCMH1
sex comb on midleg homolog 1 (Drosophila)
chr10_+_63478974 0.614 ARID5B
AT rich interactive domain 5B (MRF1-like)
chr9_-_74735669 0.613 ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr1_+_213245507 0.612 NM_001017424
KCNK2
potassium channel, subfamily K, member 2
chr3_-_56673113 0.610 NM_015224
C3orf63
chromosome 3 open reading frame 63
chr2_-_187422141 0.608 NM_182521
ZSWIM2
zinc finger, SWIM-type containing 2
chr3_-_122862391 0.605 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr12_-_110410730 0.603 ATXN2
ataxin 2
chr6_-_132073849 0.597 NM_001145659
CTAGE9
CTAGE family, member 9
chrX_-_44287032 0.597 NM_173794
FUNDC1
FUN14 domain containing 1
chr1_+_103840900 0.596 RNPC3
RNA-binding region (RNP1, RRM) containing 3
chr20_+_20296744 0.595 NM_002196
INSM1
insulinoma-associated 1
chr7_+_93373755 0.594 NM_021955
GNGT1
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
chr11_-_22838547 0.593 NM_001195637
LOC100500938
hypothetical LOC100500938
chr6_-_123999640 0.591 NM_006073
TRDN
triadin
chr3_-_33675484 0.591 CLASP2
cytoplasmic linker associated protein 2
chr4_+_69996780 0.584 NM_001074
UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr12_+_100394787 0.584 NM_152323
SPIC
Spi-C transcription factor (Spi-1/PU.1 related)
chr7_-_92693716 0.581 NM_001039372
HEPACAM2
HEPACAM family member 2
chr7_+_90177082 0.577 CDK14
cyclin-dependent kinase 14
chr10_+_90511142 0.576 NM_001102469
LIPN
lipase, family member N
chr13_-_98428244 0.576 NM_001130048
NM_001130050
DOCK9

dedicator of cytokinesis 9

chr4_-_157006827 0.572 NM_017419
ACCN5
amiloride-sensitive cation channel 5, intestinal
chr4_-_153493133 0.571 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr4_+_109763119 0.570 RPL34
ribosomal protein L34
chr11_+_123315459 0.570 NM_001001965
OR4D5
olfactory receptor, family 4, subfamily D, member 5
chr1_-_156816312 0.566 NM_001004477
OR10X1
olfactory receptor, family 10, subfamily X, member 1
chr1_-_21249974 0.565 EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr1_-_240679380 0.562 NM_001195811
NM_001195812
PLD5

phospholipase D family, member 5

chr3_+_51550635 0.561 NM_015106
RAD54L2
RAD54-like 2 (S. cerevisiae)
chr6_-_88095714 0.561 NM_198568
GJB7
gap junction protein, beta 7, 25kDa
chr4_-_177427252 0.559 NM_080874
ASB5
ankyrin repeat and SOCS box containing 5
chr8_+_17874128 0.553 PCM1
pericentriolar material 1
chr12_-_15706340 0.552 EPS8
epidermal growth factor receptor pathway substrate 8
chr6_-_33393696 0.548 NM_001145338
ZBTB22
zinc finger and BTB domain containing 22
chr11_-_102001259 0.547 NM_004771
MMP20
matrix metallopeptidase 20
chr17_-_26648375 0.544 NM_002544
OMG
oligodendrocyte myelin glycoprotein
chr1_-_115039614 0.543 NM_000036
NM_001172626
AMPD1

adenosine monophosphate deaminase 1

chr9_+_109131814 0.542 RAD23B
RAD23 homolog B (S. cerevisiae)
chr15_-_40537002 0.538 NM_022473
ZFP106
zinc finger protein 106 homolog (mouse)
chr2_-_216008689 0.535 FN1
fibronectin 1
chr3_+_153014550 0.532 NM_001086
AADAC
arylacetamide deacetylase (esterase)
chr10_+_57028755 0.532 NM_001190478
MTRNR2L5
MT-RNR2-like 5
chr3_+_1109619 0.530 NM_014461
CNTN6
contactin 6
chr6_-_11490487 0.529 NM_001142393
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr4_-_38534802 0.524 NM_006068
TLR6
toll-like receptor 6
chr2_+_151922350 0.519 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr10_+_98730977 0.517 NM_015652
C10orf12
chromosome 10 open reading frame 12
chr11_-_5657947 0.516 TRIM5
tripartite motif containing 5
chr17_-_19290745 0.516


chr21_-_26175068 0.515 APP
amyloid beta (A4) precursor protein
chr1_-_214963279 0.515 NM_001438
ESRRG
estrogen-related receptor gamma
chr10_-_27569269 0.510 NM_145698
ACBD5
acyl-CoA binding domain containing 5
chr4_-_152368492 0.508 SH3D19
SH3 domain containing 19
chr4_-_184478920 0.508 NM_001111319
CLDN22
claudin 22
chr1_-_161379606 0.506 RGS5
regulator of G-protein signaling 5
chr20_+_56659693 0.505 NM_001001433
NM_001134772
NM_001134773
NM_003763
STX16



syntaxin 16



chr21_-_30796278 0.505 NM_181611
KRTAP19-5
keratin associated protein 19-5
chr15_-_97366313 0.505 NM_001102612
PGPEP1L
pyroglutamyl-peptidase I-like
chr9_+_114671635 0.504 SNX30
sorting nexin family member 30
chr17_-_64462976 0.503 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr11_+_125258718 0.502 NM_145014
HYLS1
hydrolethalus syndrome 1
chr12_-_10215942 0.500 NM_001172632
NM_001172633
NM_002543
OLR1


oxidized low density lipoprotein (lectin-like) receptor 1


chr17_-_35327318 0.500 NM_018530
GSDMB
gasdermin B
chr2_-_20375497 0.496 PUM2
pumilio homolog 2 (Drosophila)
chr17_-_35975227 0.496 NM_001838
CCR7
chemokine (C-C motif) receptor 7

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
4.08 2.71e-03 GO:0009581 detection of external stimulus
4.30 6.23e-03 GO:0009582 detection of abiotic stimulus
5.94 7.01e-03 GO:0007602 phototransduction
1.20 1.85e-02 GO:0050896 response to stimulus
3.03 3.16e-02 GO:0051606 detection of stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.62 1.20e-02 GO:0005626 insoluble fraction
1.60 2.40e-02 GO:0005624 membrane fraction

Nothing significant found in function category.