Motif ID: ESR1.p2

Z-value: 0.991


Transcription factors associated with ESR1.p2:

Gene SymbolEntrez IDGene Name
ESR1 2099 estrogen receptor 1



Activity profile for motif ESR1.p2.

activity profile for motif ESR1.p2


Sorted Z-values histogram for motif ESR1.p2

Sorted Z-values for motif ESR1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ESR1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr21_-_45786709 3.560 NM_194255
SLC19A1
solute carrier family 19 (folate transporter), member 1
chr16_+_29734785 1.810 C16orf53
chromosome 16 open reading frame 53
chr1_-_29322993 1.674 NM_001003682
TMEM200B
transmembrane protein 200B
chr19_+_3536541 1.631 NM_133261
GIPC3
GIPC PDZ domain containing family, member 3
chr6_-_11152340 1.553 NM_017770
ELOVL2
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2
chr11_-_69228286 1.490 NM_005117
FGF19
fibroblast growth factor 19
chr19_-_14447122 1.428 PTGER1
prostaglandin E receptor 1 (subtype EP1), 42kDa
chr1_+_178466064 1.423 NM_033343
LHX4
LIM homeobox 4
chr19_-_14447163 1.410 NM_000955
PTGER1
prostaglandin E receptor 1 (subtype EP1), 42kDa
chr22_+_36632242 1.378 NM_033386
MICALL1
MICAL-like 1
chr16_+_88512769 1.356 MC1R
melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
chr2_-_200044233 1.355 NM_015265
SATB2
SATB homeobox 2
chr1_+_3360880 1.329 NM_014448
ARHGEF16
Rho guanine nucleotide exchange factor (GEF) 16
chr3_+_16901455 1.327 NM_001144382
PLCL2
phospholipase C-like 2
chr19_-_1463997 1.327 ADAMTSL5
ADAMTS-like 5
chr13_+_102249399 1.295 NM_001159596
NM_017693
BIVM

basic, immunoglobulin-like variable motif containing

chr5_+_1061900 1.285 NM_033120
NKD2
naked cuticle homolog 2 (Drosophila)
chr7_+_99919485 1.256 NM_173564
C7orf51
chromosome 7 open reading frame 51
chr9_+_139202874 1.174 NM_003731
SSNA1
Sjogren syndrome nuclear autoantigen 1
chr6_+_52334825 1.164 NM_133367
PAQR8
progestin and adipoQ receptor family member VIII
chr21_+_32167175 1.144 NM_014586
HUNK
hormonally up-regulated Neu-associated kinase
chr3_-_170970296 1.124 NM_032487
ARPM1
actin related protein M1
chr6_+_33530297 1.122 NM_152735
ZBTB9
zinc finger and BTB domain containing 9
chr11_-_118716244 1.120 MFRP
membrane frizzled-related protein
chr17_-_34635446 1.110 NM_198993
STAC2
SH3 and cysteine rich domain 2
chr4_-_122837579 1.096 ANXA5
annexin A5
chr12_+_50592379 1.070 NM_001077401
ACVRL1
activin A receptor type II-like 1
chr4_-_122837501 1.049 ANXA5
annexin A5
chr16_+_1974017 1.039 NM_005262
GFER
growth factor, augmenter of liver regeneration
chr9_-_139202804 1.036 ANAPC2
anaphase promoting complex subunit 2
chr14_+_105024301 1.027 NM_001311
CRIP1
cysteine-rich protein 1 (intestinal)
chr4_-_122837590 1.026 NM_001154
ANXA5
annexin A5
chr7_-_134505923 1.021 C7orf49
chromosome 7 open reading frame 49
chr10_-_43224312 1.011 NM_001098205
HNRNPF
heterogeneous nuclear ribonucleoprotein F
chr2_-_198358253 1.002 NM_033030
BOLL
bol, boule-like (Drosophila)
chr7_-_134506001 1.002 C7orf49
chromosome 7 open reading frame 49
chr7_-_134506012 1.002 C7orf49
chromosome 7 open reading frame 49
chr16_-_1600654 0.997 IFT140
intraflagellar transport 140 homolog (Chlamydomonas)
chr14_+_23855291 0.988 LTB4R
leukotriene B4 receptor
chr9_-_139202855 0.966 NM_013366
ANAPC2
anaphase promoting complex subunit 2
chr9_-_139202831 0.962 ANAPC2
anaphase promoting complex subunit 2
chr9_-_85342868 0.951 NM_174938
FRMD3
FERM domain containing 3
chrX_-_71442488 0.947 NM_001144885
NM_001144887
CITED1

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1

chr11_-_64368616 0.937 NM_017525
CDC42BPG
CDC42 binding protein kinase gamma (DMPK-like)
chr8_-_142586487 0.933 NM_207414
FLJ43860
FLJ43860 protein
chr19_+_10392128 0.933 NM_001111307
PDE4A
phosphodiesterase 4A, cAMP-specific
chr16_+_29734990 0.917 NM_024516
C16orf53
chromosome 16 open reading frame 53
chr10_+_129595289 0.917 NM_006504
PTPRE
protein tyrosine phosphatase, receptor type, E
chr2_-_42574587 0.912 NM_133329
NM_172344
KCNG3

potassium voltage-gated channel, subfamily G, member 3

chr19_-_11234117 0.908 NM_020812
DOCK6
dedicator of cytokinesis 6
chr7_+_100047877 0.899 NM_001040098
NM_001040099
NM_023948
MOSPD3


motile sperm domain containing 3


chr6_+_107917965 0.899 NM_018013
SOBP
sine oculis binding protein homolog (Drosophila)
chr13_+_75108450 0.893 LMO7
LIM domain 7
chr10_-_43224604 0.877 NM_004966
NM_001098204
HNRNPF

heterogeneous nuclear ribonucleoprotein F

chr7_+_2409731 0.845 NM_018641
CHST12
carbohydrate (chondroitin 4) sulfotransferase 12
chr7_-_100077072 0.840 NM_003227
TFR2
transferrin receptor 2
chr15_-_76890626 0.838 NM_014272
ADAMTS7
ADAM metallopeptidase with thrombospondin type 1 motif, 7
chr22_-_21193037 0.834 ZNF280B
zinc finger protein 280B
chr10_+_102748062 0.831 LZTS2
leucine zipper, putative tumor suppressor 2
chr16_+_67017 0.816 NM_001015054
MPG
N-methylpurine-DNA glycosylase
chr16_+_69950116 0.804 NM_001740
NM_007088
CALB2

calbindin 2

chr21_+_41461924 0.803 BACE2
beta-site APP-cleaving enzyme 2
chr9_-_133141726 0.795 NM_033387
FAM78A
family with sequence similarity 78, member A
chr2_-_232103352 0.790 NM_006056
NMUR1
neuromedin U receptor 1
chr22_+_42651018 0.790 PNPLA3
patatin-like phospholipase domain containing 3
chr13_+_50694364 0.784 NM_145019
FAM124A
family with sequence similarity 124A
chr19_-_4782711 0.783 NM_182919
TICAM1
toll-like receptor adaptor molecule 1
chr13_+_26742463 0.781 NM_206827
RASL11A
RAS-like, family 11, member A
chr8_+_21980315 0.774 EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr7_-_138316393 0.774 NM_001164665
NM_020910
KIAA1549

KIAA1549

chr11_-_70641267 0.772 SHANK2
SH3 and multiple ankyrin repeat domains 2
chr10_+_94823221 0.772 NM_057157
CYP26A1
cytochrome P450, family 26, subfamily A, polypeptide 1
chr19_+_13066956 0.766 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr16_+_69950138 0.764 CALB2
calbindin 2
chr20_+_61842880 0.759 SLC2A4RG
SLC2A4 regulator
chr16_+_21518313 0.749 NM_001077180
NM_016025
METTL9

methyltransferase like 9

chr2_-_20714303 0.738 NM_022460
HS1BP3
HCLS1 binding protein 3
chr8_+_28615062 0.733 NM_001440
EXTL3
exostoses (multiple)-like 3
chr19_+_43585606 0.728 NM_174905
FAM98C
family with sequence similarity 98, member C
chr22_-_49311439 0.727 NM_001169110
SCO2
SCO cytochrome oxidase deficient homolog 2 (yeast)
chr5_-_156935317 0.725 NM_033274
ADAM19
ADAM metallopeptidase domain 19
chr1_+_155157047 0.724 NM_144702
LRRC71
leucine rich repeat containing 71
chr3_+_69871252 0.722 NM_198159
MITF
microphthalmia-associated transcription factor
chr18_+_75825563 0.707 NM_001136180
HSBP1L1
heat shock factor binding protein 1-like 1
chr7_-_28964186 0.706


chr15_+_66658626 0.696 NM_006091
CORO2B
coronin, actin binding protein, 2B
chr5_-_156935283 0.691


chr7_-_130069399 0.689 NM_138693
KLF14
Kruppel-like factor 14
chr16_-_68657221 0.687 PDXDC2P
pyridoxal-dependent decarboxylase domain containing 2, pseudogene
chr22_+_42651007 0.675 PNPLA3
patatin-like phospholipase domain containing 3
chr7_-_148952591 0.673 ZNF767
zinc finger family member 767
chr11_+_57192034 0.668 NM_015457
ZDHHC5
zinc finger, DHHC-type containing 5
chr5_-_43593277 0.667 NM_183323
PAIP1
poly(A) binding protein interacting protein 1
chr12_+_120132319 0.665 P2RX4
purinergic receptor P2X, ligand-gated ion channel, 4
chr8_+_28614929 0.664 EXTL3
exostoses (multiple)-like 3
chr8_+_144428083 0.664 GLI4
GLI family zinc finger 4
chr20_+_773283 0.657 NM_031424
FAM110A
family with sequence similarity 110, member A
chr19_-_53914768 0.651 NM_001130915
MAMSTR
MEF2 activating motif and SAP domain containing transcriptional regulator
chr1_+_6537924 0.649 NM_138697
NM_177540
TAS1R1

taste receptor, type 1, member 1

chr6_-_136913649 0.645 NM_001198616
NM_001198617
NM_003980
MAP7


microtubule-associated protein 7


chr5_-_151118332 0.642 NM_004045
ATOX1
ATX1 antioxidant protein 1 homolog (yeast)
chr19_+_63611930 0.642 ZNF584
zinc finger protein 584
chr7_+_1543644 0.640 MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr16_+_1696162 0.638 NM_001040439
NM_015133
MAPK8IP3

mitogen-activated protein kinase 8 interacting protein 3

chr8_-_101187519 0.634 NM_015668
RGS22
regulator of G-protein signaling 22
chr22_+_42650951 0.633 NM_025225
PNPLA3
patatin-like phospholipase domain containing 3
chr2_+_238200922 0.631 NM_001137550
LRRFIP1
leucine rich repeat (in FLII) interacting protein 1
chr8_-_61356436 0.630 NM_004056
CA8
carbonic anhydrase VIII
chr8_-_27906287 0.629 NM_173833
SCARA5
scavenger receptor class A, member 5 (putative)
chr19_+_54309423 0.629 NM_022165
LIN7B
lin-7 homolog B (C. elegans)
chr11_-_900793 0.628 CHID1
chitinase domain containing 1
chr15_-_73035978 0.628 RPP25
ribonuclease P/MRP 25kDa subunit
chr7_+_100047660 0.623 NM_001040097
MOSPD3
motile sperm domain containing 3
chr11_-_289518 0.621 NM_001025295
IFITM5
interferon induced transmembrane protein 5
chr12_-_122584019 0.619 NM_178314
RILPL1
Rab interacting lysosomal protein-like 1
chr1_+_77520874 0.614 NM_012093
AK5
adenylate kinase 5
chr6_+_45498354 0.613 RUNX2
runt-related transcription factor 2
chr20_+_3749164 0.608 NM_018347
C20orf29
chromosome 20 open reading frame 29
chr19_-_17275083 0.608 NM_024527
ABHD8
abhydrolase domain containing 8
chr14_+_95575319 0.608 C14orf132
chromosome 14 open reading frame 132
chr19_-_13074669 0.608 LYL1
lymphoblastic leukemia derived sequence 1
chr9_+_137532294 0.604 NM_016034
MRPS2
mitochondrial ribosomal protein S2
chr16_+_66244314 0.602 RLTPR
RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
chr19_+_43585644 0.598 FAM98C
family with sequence similarity 98, member C
chr7_+_100792841 0.598 NM_133457
EMID2
EMI domain containing 2
chr3_-_135852514 0.595 NM_178554
KY
kyphoscoliosis peptidase
chr1_+_15352800 0.594 NM_001136218
NM_018022
TMEM51

transmembrane protein 51

chr10_+_24023680 0.592 NM_001098500
KIAA1217
KIAA1217
chr5_+_176446425 0.592 NM_002011
NM_213647
FGFR4

fibroblast growth factor receptor 4

chr16_+_84204424 0.591 NM_014615
KIAA0182
KIAA0182
chr7_-_134506070 0.591 NM_024033
C7orf49
chromosome 7 open reading frame 49
chr7_+_105304445 0.587 LOC100506768
CDHR3
hypothetical LOC100506768
cadherin-related family member 3
chr1_+_243200251 0.586 NM_001143943
EFCAB2
EF-hand calcium binding domain 2
chr21_+_41461962 0.585 BACE2
beta-site APP-cleaving enzyme 2
chr22_-_49311722 0.585 NM_001169109
SCO2
SCO cytochrome oxidase deficient homolog 2 (yeast)
chr17_+_41327808 0.584 MAPT
microtubule-associated protein tau
chr7_-_47588160 0.580 TNS3
tensin 3
chr19_+_54309443 0.578 LIN7B
lin-7 homolog B (C. elegans)
chr2_-_85494639 0.573 CAPG
capping protein (actin filament), gelsolin-like
chr15_-_76210611 0.572 NM_006383
CIB2
calcium and integrin binding family member 2
chr19_-_17349096 0.572 NM_031310
PLVAP
plasmalemma vesicle associated protein
chr16_-_45339605 0.571 NM_182493
MYLK3
myosin light chain kinase 3
chr1_-_51583281 0.568 NM_001144832
TTC39A
tetratricopeptide repeat domain 39A
chr2_-_85494664 0.564 CAPG
capping protein (actin filament), gelsolin-like
chr16_-_65984836 0.562 NM_015964
NM_016140
TPPP3

tubulin polymerization-promoting protein family member 3

chr17_-_59131210 0.560 NM_030576
LIMD2
LIM domain containing 2
chr19_+_63611819 0.560 NM_173548
ZNF584
zinc finger protein 584
chr7_+_149733309 0.560


chr16_+_14976509 0.559 PDXDC1
pyridoxal-dependent decarboxylase domain containing 1
chr20_+_47862656 0.559 NM_015266
SLC9A8
solute carrier family 9 (sodium/hydrogen exchanger), member 8
chr16_+_1974182 0.558 GFER
growth factor, augmenter of liver regeneration
chr12_+_120132233 0.558 P2RX4
purinergic receptor P2X, ligand-gated ion channel, 4
chr17_+_41327662 0.550 MAPT
microtubule-associated protein tau
chr14_+_104244998 0.549 INF2
inverted formin, FH2 and WH2 domain containing
chr1_-_27113018 0.546 NM_021969
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr13_-_27967215 0.544 NM_001159920
NM_001160030
NM_001160031
NM_002019
FLT1



fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)



chr16_+_57106883 0.542 NM_001160305
NM_024860
SETD6

SET domain containing 6

chr1_+_243199906 0.539 EFCAB2
EF-hand calcium binding domain 2
chr4_+_2013517 0.539 NM_001168243
NM_001141936
C4orf48

chromosome 4 open reading frame 48

chr16_+_65196153 0.538 CMTM3
CKLF-like MARVEL transmembrane domain containing 3
chr20_-_61600834 0.538 NM_001958
EEF1A2
eukaryotic translation elongation factor 1 alpha 2
chr11_+_57192132 0.537 ZDHHC5
zinc finger, DHHC-type containing 5
chr10_-_69836912 0.534 NM_017987
NM_001042417
RUFY2

RUN and FYVE domain containing 2

chr6_-_638010 0.531 NM_018303
EXOC2
exocyst complex component 2
chr9_+_89302574 0.530 NM_004938
DAPK1
death-associated protein kinase 1
chr20_+_47862782 0.529 SLC9A8
solute carrier family 9 (sodium/hydrogen exchanger), member 8
chr19_+_41177882 0.528 NM_001042631
SDHAF1
succinate dehydrogenase complex assembly factor 1
chr21_-_39739528 0.522 LCA5L
Leber congenital amaurosis 5-like
chr11_+_128067598 0.520 NM_001167681
FLI1
Friend leukemia virus integration 1
chr16_-_56393881 0.520 NM_001130100
NM_005550
KIFC3

kinesin family member C3

chr7_-_100262971 0.519 NM_004444
EPHB4
EPH receptor B4
chr17_-_77763945 0.506 NM_198082
CCDC57
coiled-coil domain containing 57
chr17_+_41327792 0.503 MAPT
microtubule-associated protein tau
chr9_-_13269562 0.498 MPDZ
multiple PDZ domain protein
chr1_+_243200275 0.496 EFCAB2
EF-hand calcium binding domain 2
chr16_-_67977334 0.494 NM_005652
TERF2
telomeric repeat binding factor 2
chr6_-_3102690 0.493 NM_001069
TUBB2A
tubulin, beta 2A
chr17_+_32924090 0.492 DUSP14
dual specificity phosphatase 14
chr16_-_55016872 0.492 NM_001144
AMFR
autocrine motility factor receptor
chr20_+_61963009 0.491 NM_080622
ABHD16B
abhydrolase domain containing 16B
chr1_-_25164061 0.491 NM_001031680
RUNX3
runt-related transcription factor 3
chr21_-_33774150 0.486 NM_006134
TMEM50B
transmembrane protein 50B
chr11_+_14621972 0.485 PDE3B
phosphodiesterase 3B, cGMP-inhibited
chr9_-_109290107 0.484 KLF4
Kruppel-like factor 4 (gut)
chr14_+_89492013 0.483 TDP1
tyrosyl-DNA phosphodiesterase 1
chr1_+_221966684 0.483 NM_001748
CAPN2
calpain 2, (m/II) large subunit
chr19_-_8581559 0.482 NM_030957
ADAMTS10
ADAM metallopeptidase with thrombospondin type 1 motif, 10
chr10_-_120345148 0.481 NM_004248
PRLHR
prolactin releasing hormone receptor
chr7_-_75206212 0.480 NM_005338
HIP1
huntingtin interacting protein 1
chr21_-_42247007 0.479 NM_015500
C2CD2
C2 calcium-dependent domain containing 2
chr19_+_43585668 0.479 FAM98C
family with sequence similarity 98, member C
chr6_+_157722467 0.475 NM_024630
NM_153746
ZDHHC14

zinc finger, DHHC-type containing 14

chr21_-_33774033 0.474 TMEM50B
transmembrane protein 50B
chr1_+_179148935 0.473 NM_020950
KIAA1614
KIAA1614
chr11_+_57191887 0.471 ZDHHC5
zinc finger, DHHC-type containing 5
chr10_-_133971136 0.470 NM_173575
STK32C
serine/threonine kinase 32C
chr16_-_68657256 0.469 PDXDC2P
pyridoxal-dependent decarboxylase domain containing 2, pseudogene
chr21_-_33774096 0.467 TMEM50B
transmembrane protein 50B
chr17_-_75808680 0.464 NM_000199
SGSH
N-sulfoglucosamine sulfohydrolase
chr2_+_100545827 0.462 NM_024065
PDCL3
phosducin-like 3

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.23 1.56e-03 GO:0023052 signaling
1.09 1.84e-03 GO:0009987 cellular process
1.23 5.70e-03 GO:0007165 signal transduction
1.39 5.73e-03 GO:0035556 intracellular signal transduction
1.20 8.26e-03 GO:0051716 cellular response to stimulus
1.13 1.25e-02 GO:0050794 regulation of cellular process
1.12 2.11e-02 GO:0065007 biological regulation
2.74 2.40e-02 GO:0009123 nucleoside monophosphate metabolic process
4.68 4.10e-02 GO:0009394 2'-deoxyribonucleotide metabolic process
2.64 4.80e-02 GO:0051146 striated muscle cell differentiation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.15 4.08e-07 GO:0005737 cytoplasm
1.08 4.15e-03 GO:0044424 intracellular part
1.07 6.81e-03 GO:0005622 intracellular
1.14 9.13e-03 GO:0044444 cytoplasmic part
1.26 1.56e-02 GO:0005829 cytosol
1.64 4.23e-02 GO:0048471 perinuclear region of cytoplasm

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.19 2.69e-09 GO:0005515 protein binding
1.09 4.57e-06 GO:0005488 binding
1.51 5.72e-03 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.46 1.37e-02 GO:0016301 kinase activity
1.52 1.83e-02 GO:0004672 protein kinase activity