Motif ID: POU1F1.p2

Z-value: 1.363


Transcription factors associated with POU1F1.p2:

Gene SymbolEntrez IDGene Name
POU1F1 5449 POU class 1 homeobox 1



Activity profile for motif POU1F1.p2.

activity profile for motif POU1F1.p2


Sorted Z-values histogram for motif POU1F1.p2

Sorted Z-values for motif POU1F1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU1F1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_141484046 3.425 NM_001153446
NM_001153635
NM_001153585
NM_001153690
SCOC



short coiled-coil protein



chr4_+_73123712 3.103 NM_001144756
NM_053036
NPFFR2

neuropeptide FF receptor 2

chr11_+_59564323 2.434 NM_173801
PLAC1L
placenta-specific 1-like
chr4_-_70115037 2.189 NM_001073
UGT2B11
UDP glucuronosyltransferase 2 family, polypeptide B11
chrX_-_117003310 2.115 NM_001168299
KLHL13
kelch-like 13 (Drosophila)
chr6_-_52736231 1.906 NM_000846
GSTA2
glutathione S-transferase alpha 2
chr3_+_66094324 1.900 NM_173471
SLC25A26
solute carrier family 25, member 26
chr11_+_55319607 1.829 NM_001004735
OR5D14
olfactory receptor, family 5, subfamily D, member 14
chr2_-_178461710 1.754 NM_001077196
PDE11A
phosphodiesterase 11A
chr13_+_48582389 1.753 NM_014923
FNDC3A
fibronectin type III domain containing 3A
chr12_+_43972732 1.687 NM_001142678
ANO6
anoctamin 6
chr2_+_143351536 1.632 NM_001032998
NM_003937
KYNU

kynureninase

chr4_-_100461530 1.605 NM_000668
ADH1B
alcohol dehydrogenase 1B (class I), beta polypeptide
chr8_+_82807218 1.569 NM_152284
CHMP4C
chromatin modifying protein 4C
chr9_-_21177529 1.568 NM_021068
IFNA4
interferon, alpha 4
chr18_-_62422195 1.563 NM_021153
CDH19
cadherin 19, type 2
chr14_-_105845570 1.548 IGHA1
immunoglobulin heavy constant alpha 1
chr5_+_86712376 1.516


chr12_+_91341865 1.502 NM_001025233
CLLU1
chronic lymphocytic leukemia up-regulated 1
chr8_-_28403652 1.498 NM_172366
FBXO16
ZNF395
F-box protein 16
zinc finger protein 395
chr13_+_45174446 1.446 NM_152719
SPERT
spermatid associated
chr1_+_195123766 1.424 NM_006684
CFHR4
complement factor H-related 4
chr6_+_72979234 1.391 NM_001168407
NM_001168408
RIMS1

regulating synaptic membrane exocytosis 1

chr11_-_35235325 1.336 SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr4_+_70928718 1.334 NM_000200
HTN3
histatin 3
chr6_+_26359805 1.324 NM_003524
HIST1H2BH
histone cluster 1, H2bh
chr2_+_165804157 1.316 NM_001040142
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr20_-_44494961 1.283 ELMO2
engulfment and cell motility 2
chr10_+_90474280 1.277 NM_001080518
LIPK
lipase, family member K
chr12_-_43593977 1.274 NM_001145110
NELL2
NEL-like 2 (chicken)
chr1_+_169421011 1.241 NM_001460
FMO2
flavin containing monooxygenase 2 (non-functional)
chr12_+_53534565 1.218 NM_058173
MUCL1
mucin-like 1
chr6_+_47857733 1.205 NM_181744
OPN5
opsin 5
chrX_-_131089552 1.193 NM_194277
FRMD7
FERM domain containing 7
chr13_-_19244398 1.140 PSPC1
paraspeckle component 1
chr9_-_19368815 1.139 RPS6
ribosomal protein S6
chr4_+_9055357 1.135 NM_001040448
DEFB131
defensin, beta 131
chr14_-_94669547 1.132 NM_001195573
DICER1
dicer 1, ribonuclease type III
chr7_+_37746520 1.128 NM_181791
GPR141
G protein-coupled receptor 141
chr6_+_53043729 1.127 NM_012347
FBXO9
F-box protein 9
chr10_+_116687904 1.121 NM_139169
TRUB1
TruB pseudouridine (psi) synthase homolog 1 (E. coli)
chr21_-_26294332 1.104 APP
amyloid beta (A4) precursor protein
chr12_-_10953427 1.099 NM_023920
TAS2R13
taste receptor, type 2, member 13
chr7_+_37689903 1.099


chr13_+_110653407 1.096 ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr14_-_105785639 1.091


chr1_+_170656450 1.088 NM_139240
C1orf105
chromosome 1 open reading frame 105
chr3_+_133798770 1.031 NM_016557
CCRL1
chemokine (C-C motif) receptor-like 1
chr3_+_51870684 1.026 NM_203424
IQCF2
IQ motif containing F2
chr19_-_53444733 1.015 NM_001184901
NM_001184903
NM_014959
CARD8


caspase recruitment domain family, member 8


chr11_+_113155727 1.006 NM_001101389
CLDN25
claudin 25
chr2_+_62754489 0.996 NM_001142615
EHBP1
EH domain binding protein 1
chr6_-_48186868 0.983 C6orf138
chromosome 6 open reading frame 138
chrX_+_147608302 0.979 NM_001170628
AFF2
AF4/FMR2 family, member 2
chr12_-_54150188 0.945 NM_001005499
OR6C70
olfactory receptor, family 6, subfamily C, member 70
chr9_+_21430439 0.942 NM_024013
IFNA1
interferon, alpha 1
chr6_-_33149244 0.936 NM_033554
HLA-DPA1
major histocompatibility complex, class II, DP alpha 1
chr15_-_75259714 0.936 PEAK1
NKF3 kinase family member
chr21_+_41663853 0.924 MX2
myxovirus (influenza virus) resistance 2 (mouse)
chr12_+_21175394 0.912 NM_006446
SLCO1B1
solute carrier organic anion transporter family, member 1B1
chr3_+_123779122 0.911 NM_001113523
PARP15
poly (ADP-ribose) polymerase family, member 15
chr6_+_64344307 0.892 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr9_-_21207303 0.889 NM_002173
IFNA16
interferon, alpha 16
chr1_-_159191184 0.882 NM_080878
ITLN2
intelectin 2
chr3_+_99484421 0.878 NM_001005482
OR5H2
olfactory receptor, family 5, subfamily H, member 2
chr1_+_195010552 0.877 NM_001166624
NM_021023
CFHR3

complement factor H-related 3

chr5_-_41249270 0.872 NM_000065
C6
complement component 6
chr2_+_102456193 0.860 NM_001011552
SLC9A4
solute carrier family 9 (sodium/hydrogen exchanger), member 4
chr4_+_71298187 0.860 NM_021225
PROL1
proline rich, lacrimal 1
chr11_+_5862076 0.859 NM_001005165
OR52E4
olfactory receptor, family 52, subfamily E, member 4
chr14_-_19553191 0.859 NM_001004712
OR4K14
olfactory receptor, family 4, subfamily K, member 14
chr7_+_106897737 0.855 NM_005295
GPR22
G protein-coupled receptor 22
chr20_+_58146916 0.852 LOC284757
hypothetical protein LOC284757
chr2_+_234333653 0.844 NM_000463
UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A1
chr2_+_173794692 0.840 ZAK
sterile alpha motif and leucine zipper containing kinase AZK
chr4_-_152368492 0.836 SH3D19
SH3 domain containing 19
chr14_-_106170414 0.835 IGHG1
IGHG3
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
chr11_+_18150959 0.835 NM_054032
MRGPRX4
MAS-related GPR, member X4
chr11_-_16387001 0.834 NM_001145811
SOX6
SRY (sex determining region Y)-box 6
chr7_+_137411717 0.832 NM_001190906
NM_001190907
NM_005989
AKR1D1


aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)


chr12_+_100394787 0.813 NM_152323
SPIC
Spi-C transcription factor (Spi-1/PU.1 related)
chr12_-_11041740 0.805 NM_176889
TAS2R20
taste receptor, type 2, member 20
chr20_+_71230 0.805 NM_030931
DEFB126
defensin, beta 126
chr7_-_87180499 0.793 NM_000927
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr1_-_246554492 0.790 NM_001004691
OR2M7
olfactory receptor, family 2, subfamily M, member 7
chr2_+_211166323 0.789 NM_001122634
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr3_+_98641143 0.782 NM_173655
EPHA6
EPH receptor A6
chr6_-_128263868 0.733 NM_001010923
NM_001164685
THEMIS

thymocyte selection associated

chr15_-_48198697 0.730 NM_024837
ATP8B4
ATPase, class I, type 8B, member 4
chr1_-_89364273 0.729 NM_004120
GBP2
guanylate binding protein 2, interferon-inducible
chr4_-_5762175 0.705 NM_001166136
EVC2
Ellis van Creveld syndrome 2
chr4_+_74505710 0.701


chr2_+_135312655 0.696 NM_138326
ACMSD
aminocarboxymuconate semialdehyde decarboxylase
chr16_+_14938800 0.695 NM_006985
NPIP
nuclear pore complex interacting protein
chr3_+_12367993 0.691 NM_015869
PPARG
peroxisome proliferator-activated receptor gamma
chr6_+_27400518 0.688 NM_032030
FKSG83
FKSG83
chrX_-_30505804 0.668 NM_025159
CXorf21
chromosome X open reading frame 21
chr6_+_16251260 0.665 MYLIP
myosin regulatory light chain interacting protein
chr6_-_52060327 0.664 NM_138694
NM_170724
PKHD1

polycystic kidney and hepatic disease 1 (autosomal recessive)

chr4_+_123380569 0.662 KIAA1109
KIAA1109
chr9_-_21340885 0.661 NM_021002
IFNA6
interferon, alpha 6
chr6_+_20642665 0.659 NM_017774
CDKAL1
CDK5 regulatory subunit associated protein 1-like 1
chr1_+_246682699 0.649 NM_001004136
OR2T2
olfactory receptor, family 2, subfamily T, member 2
chr2_-_174475528 0.649


chr3_+_138132006 0.648 NM_001190796
NCK1
NCK adaptor protein 1
chr1_+_15862887 0.646


chr2_-_6924092 0.645 CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr4_+_68107039 0.638 NM_012108
STAP1
signal transducing adaptor family member 1
chr1_+_209586328 0.621 NM_145759
TRAF5
TNF receptor-associated factor 5
chr4_-_100431093 0.620 NM_000667
ADH1A
alcohol dehydrogenase 1A (class I), alpha polypeptide
chr12_-_18134319 0.618 NM_024730
RERGL
RERG/RAS-like
chr3_+_44667504 0.617 ZNF35
zinc finger protein 35
chr12_-_11106159 0.616 NM_176887
TAS2R46
taste receptor, type 2, member 46
chr8_+_24207524 0.616 NM_014265
NM_021777
ADAM28

ADAM metallopeptidase domain 28

chr12_-_60872814 0.613 NM_178539
FAM19A2
family with sequence similarity 19 (chemokine (C-C motif)-like), member A2
chr20_-_36191623 0.612 TGM2
transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)
chr6_-_32742265 0.603 NM_002123
HLA-DQB1
major histocompatibility complex, class II, DQ beta 1
chr11_+_36546138 0.602 NM_000448
RAG1
recombination activating gene 1
chr15_-_75364387 0.599 NM_024776
PEAK1
NKF3 kinase family member
chr4_-_77163609 0.598 NM_001565
CXCL10
chemokine (C-X-C motif) ligand 10
chr2_+_201464884 0.593 NM_001142356
NIF3L1
NIF3 NGG1 interacting factor 3-like 1 (S. pombe)
chr6_+_31059463 0.593 NM_001010909
MUC21
mucin 21, cell surface associated
chr13_+_107753764 0.592


chr17_+_3324096 0.589 NM_001128085
ASPA
aspartoacylase
chr6_-_29431950 0.587 NM_030876
OR5V1
olfactory receptor, family 5, subfamily V, member 1
chr9_-_36365965 0.580 RNF38
ring finger protein 38
chr1_-_181540631 0.578 NM_170706
NMNAT2
nicotinamide nucleotide adenylyltransferase 2
chr6_+_167456230 0.577 NM_031409
CCR6
chemokine (C-C motif) receptor 6
chr6_-_52776558 0.575 NM_145740
GSTA1
glutathione S-transferase alpha 1
chr14_+_88130482 0.574 NM_207662
ZC3H14
zinc finger CCCH-type containing 14
chr14_+_38772870 0.568 NM_054024
MIA2
melanoma inhibitory activity 2
chr12_-_10870134 0.564 NM_023921
TAS2R10
taste receptor, type 2, member 10
chr10_+_49279647 0.563 NM_002750
NM_139046
NM_139047
NM_139049
MAPK8



mitogen-activated protein kinase 8



chr15_+_64481270 0.561 MAP2K1
mitogen-activated protein kinase kinase 1
chr2_-_88208650 0.559 NM_001443
FABP1
fatty acid binding protein 1, liver
chr1_+_205344200 0.556 NM_000715
C4BPA
complement component 4 binding protein, alpha
chr1_-_246869181 0.556 NM_001001827
OR2T35
olfactory receptor, family 2, subfamily T, member 35
chr15_+_47502666 0.556 NM_002009
FGF7
fibroblast growth factor 7
chr14_-_105948734 0.555 LOC100126583
IGHV4-31
IGHA1
IGHA2
IGHG1
IGHG4
IGHM
hypothetical LOC100126583
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 4 (G4m marker)
immunoglobulin heavy constant mu
chr5_-_36027100 0.554 NM_152404
UGT3A1
UDP glycosyltransferase 3 family, polypeptide A1
chr18_+_50409387 0.553 NM_173629
C18orf26
chromosome 18 open reading frame 26
chr1_+_17404206 0.552 NM_013358
PADI1
peptidyl arginine deiminase, type I
chr11_+_5602782 0.552 NM_021616
TRIM34
tripartite motif containing 34
chr3_+_123817151 0.550 NM_152615
PARP15
poly (ADP-ribose) polymerase family, member 15
chr9_-_21358005 0.550 NM_006900
IFNA1
IFNA13
interferon, alpha 1
interferon, alpha 13
chr11_-_22838547 0.548 NM_001195637
LOC100500938
hypothetical LOC100500938
chr15_+_22652790 0.547 NM_022805
SNRPN
small nuclear ribonucleoprotein polypeptide N
chr12_-_10042956 0.546 NM_001099431
NM_016509
CLEC1B

C-type lectin domain family 1, member B

chr3_+_109504021 0.544 NM_007072
HHLA2
HERV-H LTR-associating 2
chr10_-_127559841 0.543 NM_018180
DHX32
DEAH (Asp-Glu-Ala-His) box polypeptide 32
chr12_-_107943227 0.542 NM_018711
SVOP
SV2 related protein homolog (rat)
chr16_+_68156497 0.537 NM_001113178
NM_006599
NM_138713
NM_138714
NM_173214
NFAT5




nuclear factor of activated T-cells 5, tonicity-responsive




chr17_+_3326045 0.535 NM_000049
ASPA
aspartoacylase
chr12_-_11066436 0.533 NM_176888
TAS2R19
taste receptor, type 2, member 19
chr8_-_7207899 0.533 NM_001164457
ZNF705G
zinc finger protein 705G
chr21_-_26345294 0.528


chr9_-_21132143 0.527 NM_002177
IFNW1
interferon, omega 1
chr12_-_101835183 0.522 PAH
phenylalanine hydroxylase
chr6_+_144227265 0.521 NM_001013623
C6orf94
chromosome 6 open reading frame 94
chr15_+_36014748 0.520 NM_152453
TMCO5A
transmembrane and coiled-coil domains 5A
chr2_+_37277131 0.520 LOC100505876
hypothetical LOC100505876
chr19_-_12028126 0.519 NM_001080404
ZNF878
zinc finger protein 878
chr4_-_77547481 0.518 NM_001042784
CCDC158
coiled-coil domain containing 158
chr2_+_102136833 0.512 NM_000877
IL1R1
interleukin 1 receptor, type I
chr16_-_66558197 0.512 NM_001145964
SLC12A4
solute carrier family 12 (potassium/chloride transporters), member 4
chr11_-_127962662 0.510 NM_001143820
ETS1
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
chr3_+_143858428 0.508 NM_001172312
PLS1
plastin 1
chr10_-_93992982 0.503 NM_001178137
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr4_-_75072683 0.499 NM_002704
PPBP
pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
chr12_-_9777126 0.499 NM_172004
CLECL1
C-type lectin-like 1
chr1_-_157003095 0.497 NM_001005185
OR6N1
olfactory receptor, family 6, subfamily N, member 1
chr17_+_58440629 0.496 NM_025185
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr10_-_50012058 0.495 NM_001164484
FAM170B
family with sequence similarity 170, member B
chr6_+_46869052 0.494 NM_005588
MEP1A
meprin A, alpha (PABA peptide hydrolase)
chr5_-_94250357 0.493 MCTP1
multiple C2 domains, transmembrane 1
chr13_-_98708549 0.493 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chr13_-_48008118 0.490 RCBTB2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chrX_+_105823723 0.488 NM_024539
RNF128
ring finger protein 128
chrX_-_19898302 0.487 NM_198279
CXorf23
chromosome X open reading frame 23
chr9_+_106496480 0.486 NM_001004484
OR13D1
olfactory receptor, family 13, subfamily D, member 1
chr15_-_54175954 0.485 RFX7
regulatory factor X, 7
chrX_+_101910713 0.480 LOC100287765
hypothetical LOC100287765
chr6_+_90660906 0.475 NM_032602
GJA10
gap junction protein, alpha 10, 62kDa
chr8_+_67201684 0.474 NM_033058
NM_184085
NM_184086
NM_184087
TRIM55



tripartite motif containing 55



chr4_+_166350620 0.471 NM_001161521
NM_001161522
KLHL2

kelch-like 2, Mayven (Drosophila)

chr11_+_56512922 0.471 NM_001005323
OR5AK2
olfactory receptor, family 5, subfamily AK, member 2
chr5_-_146441184 0.468 NM_181677
NM_181678
PPP2R2B

protein phosphatase 2, regulatory subunit B, beta

chr2_-_152299229 0.467 NM_001164507
NM_001164508
NM_004543
NEB


nebulin


chr1_+_151147646 0.465 NM_005547
IVL
involucrin
chr6_-_66473790 0.462 NM_001142800
NM_001142801
EYS

eyes shut homolog (Drosophila)

chr1_+_169747788 0.462 PRRC2C
proline-rich coiled-coil 2C
chr8_+_24297742 0.461 NM_001145271
NM_001145272
NM_014479
ADAMDEC1


ADAM-like, decysin 1


chr9_+_71134060 0.460 NM_004816
FAM189A2
family with sequence similarity 189, member A2
chr10_-_5436781 0.458 NM_001171864
NM_024803
TUBAL3

tubulin, alpha-like 3

chr11_-_57792206 0.456 NM_207374
OR10W1
olfactory receptor, family 10, subfamily W, member 1
chr2_-_21079145 0.453 APOB
apolipoprotein B (including Ag(x) antigen)
chrX_+_125781427 0.453 NM_001122716
CXorf64
chromosome X open reading frame 64
chr7_-_30032649 0.452 NM_017946
FKBP14
FK506 binding protein 14, 22 kDa
chr3_+_88114415 0.452 NM_000866
HTR1F
5-hydroxytryptamine (serotonin) receptor 1F
chr11_-_59390518 0.451 NM_001062
TCN1
transcobalamin I (vitamin B12 binding protein, R binder family)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.86 3.91e-23 GO:0007606 sensory perception of chemical stimulus
3.89 8.51e-21 GO:0007608 sensory perception of smell
2.63 2.65e-15 GO:0007600 sensory perception
1.37 1.59e-10 GO:0050896 response to stimulus
2.00 2.59e-10 GO:0050877 neurological system process
1.87 3.02e-10 GO:0003008 system process
2.19 9.31e-08 GO:0006952 defense response
2.12 3.93e-06 GO:0006955 immune response
1.30 1.15e-04 GO:0032501 multicellular organismal process
2.47 1.59e-04 GO:0045087 innate immune response
9.80 7.80e-04 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
1.68 1.05e-03 GO:0002376 immune system process
2.22 1.12e-03 GO:0050776 regulation of immune response
2.94 1.34e-03 GO:0019221 cytokine-mediated signaling pathway
2.76 3.04e-03 GO:0071345 cellular response to cytokine stimulus
4.37 1.06e-02 GO:0060333 interferon-gamma-mediated signaling pathway
2.28 2.89e-02 GO:0034097 response to cytokine stimulus
3.98 3.08e-02 GO:0071346 cellular response to interferon-gamma
3.64 4.24e-02 GO:0034341 response to interferon-gamma

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.48 2.51e-11 GO:0071944 cell periphery
1.47 2.44e-10 GO:0005886 plasma membrane
1.32 6.37e-07 GO:0016021 integral to membrane
1.32 6.58e-07 GO:0031224 intrinsic to membrane
1.26 1.37e-05 GO:0044425 membrane part
11.89 1.75e-05 GO:0042613 MHC class II protein complex
1.20 8.19e-05 GO:0016020 membrane
5.85 3.71e-03 GO:0042611 MHC protein complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
4.02 5.75e-22 GO:0004984 olfactory receptor activity
2.36 7.65e-19 GO:0004888 transmembrane receptor activity
2.67 2.77e-17 GO:0004930 G-protein coupled receptor activity
2.01 5.97e-15 GO:0004872 receptor activity
1.88 1.31e-14 GO:0004871 signal transducer activity
1.88 1.31e-14 GO:0060089 molecular transducer activity