Motif ID: HMX1.p2

Z-value: 1.465


Transcription factors associated with HMX1.p2:

Gene SymbolEntrez IDGene Name
HMX1 3166 H6 family homeobox 1



Activity profile for motif HMX1.p2.

activity profile for motif HMX1.p2


Sorted Z-values histogram for motif HMX1.p2

Sorted Z-values for motif HMX1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HMX1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_+_131286513 1.977 NTM
neurotrimin
chr12_-_47604930 1.678 NM_001143781
FKBP11
FK506 binding protein 11, 19 kDa
chr8_+_32525269 1.606 NM_001160002
NM_001160004
NM_001160005
NM_001160007
NM_001160008
NM_004495
NM_013956
NM_013957
NM_013958
NM_013960
NM_013964
NRG1










neuregulin 1










chr19_-_11352850 1.550 EPOR
erythropoietin receptor
chr4_-_11039600 1.496 NM_005114
HS3ST1
heparan sulfate (glucosamine) 3-O-sulfotransferase 1
chr8_+_120497732 1.464 NM_002514
NOV
nephroblastoma overexpressed gene
chr11_+_128751044 1.289 NM_003658
BARX2
BARX homeobox 2
chr19_+_58733144 1.158 NM_001079906
ZNF331
zinc finger protein 331
chr21_-_31853160 1.117 NM_003253
TIAM1
T-cell lymphoma invasion and metastasis 1
chr12_-_15265490 1.056 NM_001190726
NM_032918
RERG

RAS-like, estrogen-regulated, growth inhibitor

chr14_+_61653827 1.046 FLJ43390
hypothetical LOC646113
chr12_+_120840829 1.045 NM_001178003
NM_144668
WDR66

WD repeat domain 66

chr9_-_109290107 0.989 KLF4
Kruppel-like factor 4 (gut)
chr3_-_11736946 0.966 NM_014667
VGLL4
vestigial like 4 (Drosophila)
chr5_+_68746694 0.940 NM_001038603
MARVELD2
MARVEL domain containing 2
chr6_-_128883125 0.880 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr14_-_88328848 0.869 NM_183387
EML5
echinoderm microtubule associated protein like 5
chr18_-_45975163 0.855 NM_001080467
MYO5B
myosin VB
chr9_-_10602722 0.847 NM_002839
PTPRD
protein tyrosine phosphatase, receptor type, D
chr20_-_43370333 0.815 NM_003833
NM_030590
NM_030592
MATN4


matrilin 4


chr14_-_50631407 0.765 TRIM9
tripartite motif containing 9
chr6_-_40663089 0.760 NM_020737
LRFN2
leucine rich repeat and fibronectin type III domain containing 2
chr1_-_86394695 0.757 NM_152890
COL24A1
collagen, type XXIV, alpha 1
chr8_-_75396016 0.752 NM_020647
JPH1
junctophilin 1
chr2_-_101370355 0.747 NM_153836
CREG2
cellular repressor of E1A-stimulated genes 2
chr5_+_148186348 0.740 NM_000024
ADRB2
adrenergic, beta-2-, receptor, surface
chr20_+_43531806 0.713 NM_006103
WFDC2
WAP four-disulfide core domain 2
chr10_-_101935676 0.702 NM_006459
ERLIN1
ER lipid raft associated 1
chr4_+_81325447 0.701 NM_020226
PRDM8
PR domain containing 8
chr11_+_120828275 0.700 SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr4_-_54152385 0.696 LNX1
ligand of numb-protein X 1
chr3_-_112796855 0.668 NM_024508
ZBED2
zinc finger, BED-type containing 2
chr17_-_45427565 0.654 NM_005220
DLX3
distal-less homeobox 3
chr2_-_101370291 0.650 CREG2
cellular repressor of E1A-stimulated genes 2
chr1_-_53159991 0.637 NM_001198961
NM_001198962
NM_018281
ECHDC2


enoyl CoA hydratase domain containing 2


chr12_-_57599571 0.636 NM_001136051
LRIG3
leucine-rich repeats and immunoglobulin-like domains 3
chr2_-_73350103 0.635 NM_001080410
FBXO41
F-box protein 41
chr1_-_53159927 0.626 ECHDC2
enoyl CoA hydratase domain containing 2
chr8_+_24828359 0.626 NM_001105541
NEFM
neurofilament, medium polypeptide
chr1_-_58815415 0.625 TACSTD2
tumor-associated calcium signal transducer 2
chr9_-_21999270 0.623 NM_004936
NM_078487
CDKN2B

cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

chr4_-_54152480 0.621 NM_001126328
LNX1
ligand of numb-protein X 1
chr5_+_76150637 0.620 F2RL1
coagulation factor II (thrombin) receptor-like 1
chr18_+_48120539 0.613 NM_005215
DCC
deleted in colorectal carcinoma
chr8_+_31616809 0.609 NM_013962
NRG1
neuregulin 1
chr14_+_71468902 0.609 RGS6
regulator of G-protein signaling 6
chr13_+_24152548 0.591 NM_001185085
NM_001676
ATP12A

ATPase, H+/K+ transporting, nongastric, alpha polypeptide

chr20_-_34807882 0.585 NM_022477
NM_032013
NDRG3

NDRG family member 3

chr19_+_43447078 0.584 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr22_+_49128583 0.583 NM_014678
PPP6R2
protein phosphatase 6, regulatory subunit 2
chr14_-_24173205 0.578 NM_004131
GZMB
granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
chr1_-_43523825 0.577 NM_182517
NM_001164829
C1orf210

chromosome 1 open reading frame 210

chrX_+_48915127 0.576 NM_002668
PLP2
proteolipid protein 2 (colonic epithelium-enriched)
chr1_-_55039458 0.573 NM_001114108
NM_017904
TTC22

tetratricopeptide repeat domain 22

chr11_-_116474196 0.572 NM_025164
SIK3
SIK family kinase 3
chr11_+_69602055 0.569 NM_018043
ANO1
anoctamin 1, calcium activated chloride channel
chr13_-_44461554 0.567 NM_012345
NUFIP1
nuclear fragile X mental retardation protein interacting protein 1
chr7_+_96473225 0.561 NM_005222
DLX6
distal-less homeobox 6
chr2_-_20413838 0.559 PUM2
pumilio homolog 2 (Drosophila)
chr8_-_24828134 0.558 NEFM
neurofilament, medium polypeptide
chr12_-_26166485 0.555 BHLHE41
basic helix-loop-helix family, member e41
chr10_+_134972360 0.555 NM_145806
ZNF511
zinc finger protein 511
chr10_-_105604942 0.553 NM_014631
SH3PXD2A
SH3 and PX domains 2A
chr4_+_91267706 0.549 NM_001145065
FAM190A
family with sequence similarity 190, member A
chr20_-_41251878 0.547 NM_007050
NM_133170
PTPRT

protein tyrosine phosphatase, receptor type, T

chr5_+_76150588 0.546 NM_005242
F2RL1
coagulation factor II (thrombin) receptor-like 1
chr19_+_58750305 0.544 NM_001079907
ZNF331
zinc finger protein 331
chr8_-_26780665 0.542 ADRA1A
adrenergic, alpha-1A-, receptor
chr1_-_53159759 0.542 ECHDC2
enoyl CoA hydratase domain containing 2
chr16_+_23101538 0.539 NM_001039
SCNN1G
sodium channel, nonvoltage-gated 1, gamma
chr19_+_43447262 0.532 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr4_-_69570919 0.531 NM_001076
UGT2B15
UDP glucuronosyltransferase 2 family, polypeptide B15
chr1_+_226937732 0.519 RHOU
ras homolog gene family, member U
chr8_-_26780645 0.517


chr1_+_35020425 0.512 NM_001005752
GJB3
gap junction protein, beta 3, 31kDa
chr20_+_13150417 0.512 NM_080826
ISM1
isthmin 1 homolog (zebrafish)
chr8_+_145662510 0.509 NM_145754
KIFC2
kinesin family member C2
chr2_+_242289983 0.505 NM_032329
ING5
inhibitor of growth family, member 5
chr3_-_27739201 0.504 EOMES
eomesodermin
chr19_+_43446937 0.502 NM_001166103
NM_021102
SPINT2

serine peptidase inhibitor, Kunitz type, 2

chr8_+_95722448 0.492 ESRP1
epithelial splicing regulatory protein 1
chr22_+_45537181 0.491 NM_014346
TBC1D22A
TBC1 domain family, member 22A
chr19_+_62523636 0.489 NM_213598
ZNF543
zinc finger protein 543
chr4_+_102930856 0.484 BANK1
B-cell scaffold protein with ankyrin repeats 1
chr8_-_29263714 0.484 NM_001394
DUSP4
dual specificity phosphatase 4
chr8_-_67687980 0.481 NM_001080416
NM_001144755
MYBL1

LOC645895
v-myb myeloblastosis viral oncogene homolog (avian)-like 1

hypothetical LOC645895
chr11_+_63463009 0.471 NM_024771
NAA40
N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog (S. cerevisiae)
chr11_+_43658718 0.469 NM_016142
HSD17B12
hydroxysteroid (17-beta) dehydrogenase 12
chr5_+_5193442 0.468 NM_139056
ADAMTS16
ADAM metallopeptidase with thrombospondin type 1 motif, 16
chr9_+_139566129 0.466 NM_032477
MRPL41
mitochondrial ribosomal protein L41
chr12_-_51734434 0.461 LOC283335
hypothetical LOC283335
chr4_+_86615275 0.458 NM_001025616
ARHGAP24
Rho GTPase activating protein 24
chr14_+_62740878 0.452 NM_020663
RHOJ
ras homolog gene family, member J
chr17_-_3573822 0.451 ITGAE
integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
chr16_-_66827449 0.451 NM_024939
ESRP2
epithelial splicing regulatory protein 2
chr19_-_47413642 0.449 NM_133328
DEDD2
death effector domain containing 2
chr11_+_93394025 0.446 NM_001098672
HEPHL1
hephaestin-like 1
chr9_-_84867604 0.443 RASEF
RAS and EF-hand domain containing
chr22_+_49128639 0.442 PPP6R2
protein phosphatase 6, regulatory subunit 2
chr4_+_102930786 0.441 NM_001127507
NM_017935
BANK1

B-cell scaffold protein with ankyrin repeats 1

chr16_+_87232501 0.440 NM_013278
IL17C
interleukin 17C
chr3_+_57517013 0.436 NM_177966
PDE12
phosphodiesterase 12
chr12_-_29827952 0.435 NM_001193451
TMTC1
transmembrane and tetratricopeptide repeat containing 1
chr19_-_47413733 0.433 DEDD2
death effector domain containing 2
chr13_+_44461657 0.431 NM_018559
KIAA1704
KIAA1704
chr12_-_94708477 0.431 NTN4
netrin 4
chr11_-_67528103 0.431 NM_030930
UNC93B1
unc-93 homolog B1 (C. elegans)
chr4_-_90977149 0.430 NM_001146054
NM_007308
NM_000345
SNCA


synuclein, alpha (non A4 component of amyloid precursor)


chr17_-_40695216 0.429 NM_152343
C17orf46
chromosome 17 open reading frame 46
chr2_-_133144094 0.427 LYPD1
LY6/PLAUR domain containing 1
chr1_+_224477941 0.425 NM_031944
MIXL1
Mix1 homeobox-like 1 (Xenopus laevis)
chr2_+_171381317 0.418 NM_000817
NM_013445
GAD1

glutamate decarboxylase 1 (brain, 67kDa)

chr4_-_21559471 0.416 NM_147182
KCNIP4
Kv channel interacting protein 4
chr2_-_216586488 0.416 NM_018000
MREG
melanoregulin
chr9_-_26882713 0.410 NM_001167575
NM_024828
C9orf82

chromosome 9 open reading frame 82

chr3_-_57088332 0.410 NM_001128615
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr16_+_54247400 0.407 SLC6A2
solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
chr17_-_71386229 0.407 NM_033452
TRIM47
tripartite motif containing 47
chr1_-_9111674 0.406 NM_024980
GPR157
G protein-coupled receptor 157
chr19_-_10558906 0.405 NM_005498
AP1M2
adaptor-related protein complex 1, mu 2 subunit
chrX_-_7076146 0.404 NM_001135565
NM_001178135
NM_001178136
NM_012080
HDHD1



haloacid dehalogenase-like hydrolase domain containing 1



chr12_-_56422120 0.403 NM_014770
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr5_-_115938305 0.400 NM_020796
SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr21_-_26345294 0.400


chr17_+_9489578 0.399 NM_153210
USP43
ubiquitin specific peptidase 43
chr1_-_153213483 0.398 NM_001130041
NM_003029
SHC1

SHC (Src homology 2 domain containing) transforming protein 1

chr1_+_17719405 0.390 ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr22_-_45537081 0.388


chr17_+_71229191 0.387 ITGB4
integrin, beta 4
chr2_-_120697148 0.386 TMEM185B
transmembrane protein 185B (pseudogene)
chr20_+_13924263 0.385 MACROD2
MACRO domain containing 2
chr19_+_62554445 0.379 NM_020657
ZNF304
zinc finger protein 304
chr11_-_407324 0.379 NM_001135053
NM_021805
SIGIRR

single immunoglobulin and toll-interleukin 1 receptor (TIR) domain

chr1_-_153213454 0.377 SHC1
SHC (Src homology 2 domain containing) transforming protein 1
chr10_+_170423 0.375 NM_001161482
NM_006624
NM_212479
ZMYND11


zinc finger, MYND-type containing 11


chr19_-_61874934 0.375 ZNF835
zinc finger protein 835
chrX_+_130984912 0.374 NM_001042453
NM_016542
MST4

serine/threonine protein kinase MST4

chr8_+_102573837 0.373 NM_024915
GRHL2
grainyhead-like 2 (Drosophila)
chr3_-_52287297 0.372 WDR82
WD repeat domain 82
chr9_-_23811477 0.371 NM_001171197
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr18_+_54682261 0.370 ZNF532
zinc finger protein 532
chr8_+_145231386 0.370 MAF1
MAF1 homolog (S. cerevisiae)
chr11_-_117305277 0.368 NM_001077263
TMPRSS13
transmembrane protease, serine 13
chr14_-_49848538 0.368 NM_024884
L2HGDH
L-2-hydroxyglutarate dehydrogenase
chr8_+_82807218 0.367 NM_152284
CHMP4C
chromatin modifying protein 4C
chr1_-_153213425 0.366 SHC1
SHC (Src homology 2 domain containing) transforming protein 1
chr7_-_37454933 0.365 NM_014800
ELMO1
engulfment and cell motility 1
chr3_+_11171213 0.365 NM_001098212
HRH1
histamine receptor H1
chr7_-_156378382 0.364 LMBR1
limb region 1 homolog (mouse)
chr4_-_165523856 0.360 NM_001166373
MARCH1
membrane-associated ring finger (C3HC4) 1
chr18_+_48121067 0.360 DCC
deleted in colorectal carcinoma
chrX_-_78509662 0.356 NM_001171581
NM_004867
ITM2A

integral membrane protein 2A

chr5_-_172594691 0.351 NM_001166175
NM_001166176
NM_004387
NKX2-5


NK2 transcription factor related, locus 5 (Drosophila)


chr2_+_101235782 0.350 C2orf29
chromosome 2 open reading frame 29
chr13_-_40393804 0.347 SUGT1P3
suppressor of G2 allele of SKP1 (S. cerevisiae) pseudogene 3
chr10_-_33663777 0.347 NM_001024628
NM_001024629
NM_003873
NRP1


neuropilin 1


chr4_+_155884600 0.345 NM_004744
LRAT
lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
chr13_-_113651815 0.344 NM_182614
FAM70B
family with sequence similarity 70, member B
chr2_+_102345528 0.341 NM_003855
IL18R1
interleukin 18 receptor 1
chr10_+_99248605 0.339 NM_024954
UBTD1
ubiquitin domain containing 1
chr10_-_82039158 0.338 NM_000429
MAT1A
methionine adenosyltransferase I, alpha
chr1_+_27062215 0.333 NM_006142
SFN
stratifin
chr3_+_57969127 0.332 NM_001164317
NM_001164318
NM_001164319
NM_001457
FLNB



filamin B, beta



chr8_-_10550026 0.328 NM_178857
RP1L1
retinitis pigmentosa 1-like 1
chr15_+_82113813 0.325 NM_207517
ADAMTSL3
ADAMTS-like 3
chr14_-_104705753 0.324 JAG2
jagged 2
chr19_-_360138 0.323 NM_001136263
C2CD4C
C2 calcium-dependent domain containing 4C
chr1_+_154297588 0.322 NM_020387
RAB25
RAB25, member RAS oncogene family
chr14_-_35859545 0.321 NM_001144891
NM_016586
MBIP

MAP3K12 binding inhibitory protein 1

chr8_+_42247954 0.318 NM_001190722
NM_001556
IKBKB

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta

chr19_+_46992361 0.318 NM_001815
CEACAM3
carcinoembryonic antigen-related cell adhesion molecule 3
chr8_+_42247978 0.317 IKBKB
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
chr8_+_42248008 0.313 NM_001190721
IKBKB
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
chr8_+_42247991 0.313 NM_001190720
IKBKB
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
chr20_+_56701224 0.310 NM_024663
NPEPL1
aminopeptidase-like 1
chr8_-_28403652 0.309 NM_172366
FBXO16
ZNF395
F-box protein 16
zinc finger protein 395
chr12_+_56406296 0.307 LOC100130776
hypothetical LOC100130776
chr1_+_148788410 0.306 NM_019032
NM_025008
ADAMTSL4

ADAMTS-like 4

chr7_-_127833231 0.303 NM_001142573
NM_001142574
NM_001142575
IMPDH1


IMP (inosine 5'-monophosphate) dehydrogenase 1


chr7_+_29570024 0.303 PRR15
proline rich 15
chr8_-_49810270 0.303 NM_001142857
NM_024593
EFCAB1

EF-hand calcium binding domain 1

chr17_+_77289704 0.303 SLC25A10
solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
chr22_-_30071761 0.300 PATZ1
POZ (BTB) and AT hook containing zinc finger 1
chr12_+_4253143 0.299 NM_001759
CCND2
cyclin D2
chr1_-_152459506 0.298 C1orf43
chromosome 1 open reading frame 43
chr10_-_33663984 0.297 NRP1
neuropilin 1
chr1_-_150599105 0.297 NM_001014342
FLG2
filaggrin family member 2
chr9_+_22437353 0.297 DMRTA1
DMRT-like family A1
chr2_+_10009242 0.295 NM_198182
GRHL1
grainyhead-like 1 (Drosophila)
chr3_-_109423858 0.294 NM_018010
IFT57
intraflagellar transport 57 homolog (Chlamydomonas)
chr11_+_71176145 0.293 NM_001099653
NM_018172
NM_152563
FAM86C


family with sequence similarity 86, member C


chr21_+_25856311 0.292 MIR155HG
MIR155 host gene (non-protein coding)
chr19_-_62912347 0.291 NM_001085384
ZNF154
zinc finger protein 154
chr12_+_93066370 0.291 NM_005761
PLXNC1
plexin C1
chr5_-_168660293 0.291 NM_003062
SLIT3
slit homolog 3 (Drosophila)
chr3_-_15875932 0.291 NM_015199
ANKRD28
ankyrin repeat domain 28
chr1_+_28134090 0.289 NM_001009568
NM_014474
SMPDL3B

sphingomyelin phosphodiesterase, acid-like 3B

chr19_-_62680703 0.286 NM_001024596
NM_001144068
ZNF772

zinc finger protein 772

chrX_-_16640590 0.282 NM_175859
NM_019857
CTPS2

CTP synthase II

chr1_+_15941503 0.282 NM_001013641
TMEM82
transmembrane protein 82

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.46 8.80e-06 GO:0023051 regulation of signaling
1.48 3.87e-05 GO:0009966 regulation of signal transduction
1.40 5.25e-05 GO:0048583 regulation of response to stimulus
1.43 3.40e-04 GO:0007399 nervous system development
1.36 4.46e-04 GO:0030154 cell differentiation
1.55 6.73e-04 GO:0050793 regulation of developmental process
1.34 9.87e-04 GO:0048869 cellular developmental process
1.61 1.03e-03 GO:2000026 regulation of multicellular organismal development
1.98 1.14e-03 GO:0022603 regulation of anatomical structure morphogenesis
1.95 1.46e-03 GO:0060284 regulation of cell development
1.27 2.23e-03 GO:0048731 system development
1.25 4.94e-03 GO:0048856 anatomical structure development
1.60 5.35e-03 GO:0045595 regulation of cell differentiation
1.50 5.59e-03 GO:0048468 cell development
1.23 5.77e-03 GO:0007275 multicellular organismal development
1.82 6.27e-03 GO:0051056 regulation of small GTPase mediated signal transduction
1.95 7.46e-03 GO:0051960 regulation of nervous system development
1.30 1.01e-02 GO:0048523 negative regulation of cellular process
1.72 1.20e-02 GO:0051094 positive regulation of developmental process
1.21 1.60e-02 GO:0032502 developmental process
1.74 1.63e-02 GO:0009968 negative regulation of signal transduction
1.47 2.36e-02 GO:0022008 neurogenesis
1.65 2.79e-02 GO:0048585 negative regulation of response to stimulus
2.35 2.85e-02 GO:0010769 regulation of cell morphogenesis involved in differentiation
1.27 3.00e-02 GO:0048519 negative regulation of biological process
2.87 3.07e-02 GO:0050770 regulation of axonogenesis
2.33 3.37e-02 GO:0022604 regulation of cell morphogenesis
1.94 3.39e-02 GO:0050767 regulation of neurogenesis
1.56 3.71e-02 GO:0030030 cell projection organization
1.63 3.83e-02 GO:0032990 cell part morphogenesis
2.03 4.07e-02 GO:0045664 regulation of neuron differentiation
1.72 4.77e-02 GO:0007264 small GTPase mediated signal transduction

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.65 1.81e-02 GO:0043005 neuron projection

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.12 1.89e-02 GO:0005515 protein binding