Motif ID: HES1.p2

Z-value: 1.957


Transcription factors associated with HES1.p2:

Gene SymbolEntrez IDGene Name
HES1 3280 hairy and enhancer of split 1, (Drosophila)



Activity profile for motif HES1.p2.

activity profile for motif HES1.p2


Sorted Z-values histogram for motif HES1.p2

Sorted Z-values for motif HES1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HES1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_225615556 2.599 NM_014689
 DOCK10
dedicator of cytokinesis 10
chr12_+_120840829 2.116 NM_001178003
NM_144668
 WDR66

WD repeat domain 66

chr7_+_129918408 1.700 NM_177525
 MEST
mesoderm specific transcript homolog (mouse)
chr17_-_53920699 1.668 NM_001080439
 HSF5
heat shock transcription factor family member 5
chr22_-_45037882 1.555 NM_006071
 PKDREJ
polycystic kidney disease (polycystin) and REJ homolog (sperm receptor for egg jelly homolog, sea urchin)
chr7_+_154720547 1.361 INSIG1
insulin induced gene 1
chr13_-_76358433 1.315 NM_138444
 KCTD12
potassium channel tetramerisation domain containing 12
chr13_+_20175481 1.231 NM_138284
 IL17D
interleukin 17D
chr7_+_154720416 1.202 NM_005542
NM_198336
NM_198337
 INSIG1


insulin induced gene 1


chr13_-_76358370 1.188 KCTD12
potassium channel tetramerisation domain containing 12
chr8_-_93184629 1.133 NM_001198633
NM_175634
 RUNX1T1

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

chr9_-_139316523 1.099 NM_001004354
 NRARP
NOTCH-regulated ankyrin repeat protein
chr11_+_43920385 1.097 NM_001145033
 C11orf96
chromosome 11 open reading frame 96
chr1_+_199108705 0.982 NM_005298
 GPR25
G protein-coupled receptor 25
chr16_+_66153810 0.970 NM_001191022
NM_006565
 CTCF

CCCTC-binding factor (zinc finger protein)

chr20_-_4752067 0.962 NM_014737
 RASSF2
Ras association (RalGDS/AF-6) domain family member 2
chr17_-_10042579 0.956 NM_201433
 GAS7
growth arrest-specific 7
chr17_+_75689985 0.951 GAA
glucosidase, alpha; acid
chr11_+_46325457 0.922 NM_003646
 DGKZ
diacylglycerol kinase, zeta
chr18_+_2836979 0.915 NM_032048
 EMILIN2
elastin microfibril interfacer 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 66 entries
enrichment   p-value GO term description
2.39 9.88e-03 GO:0030336 negative regulation of cell migration
2.39 9.88e-03 GO:2000146 negative regulation of cell motility
2.29 1.79e-02 GO:0051271 negative regulation of cellular component movement
2.08 1.53e-03 GO:0016311 dephosphorylation
2.00 2.75e-02 GO:0006470 protein dephosphorylation
1.80 1.17e-02 GO:0048514 blood vessel morphogenesis
1.78 2.75e-03 GO:0030334 regulation of cell migration
1.76 4.47e-03 GO:2000145 regulation of cell motility
1.72 4.65e-03 GO:0051270 regulation of cellular component movement
1.66 3.25e-02 GO:0040012 regulation of locomotion
1.59 1.02e-05 GO:0007167 enzyme linked receptor protein signaling pathway
1.55 2.52e-03 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.54 3.71e-02 GO:0040008 regulation of growth
1.49 1.84e-06 GO:0006793 phosphorus metabolic process
1.49 1.84e-06 GO:0006796 phosphate metabolic process
1.47 3.28e-03 GO:0045595 regulation of cell differentiation
1.45 2.84e-03 GO:0006468 protein phosphorylation
1.43 5.55e-04 GO:0050793 regulation of developmental process
1.41 3.62e-03 GO:0048699 generation of neurons
1.40 3.25e-03 GO:0022008 neurogenesis

Gene overrepresentation in compartment category:

Showing 1 to 20 of 23 entries
enrichment   p-value GO term description
1.44 1.86e-02 GO:0005730 nucleolus
1.29 3.49e-05 GO:0031981 nuclear lumen
1.28 3.39e-06 GO:0031974 membrane-enclosed lumen
1.27 3.55e-05 GO:0005829 cytosol
1.27 1.72e-02 GO:0005654 nucleoplasm
1.26 2.53e-05 GO:0043233 organelle lumen
1.26 4.41e-05 GO:0070013 intracellular organelle lumen
1.26 5.62e-05 GO:0044428 nuclear part
1.20 3.31e-11 GO:0005634 nucleus
1.18 1.54e-17 GO:0005737 cytoplasm
1.17 4.12e-18 GO:0043231 intracellular membrane-bounded organelle
1.17 7.22e-18 GO:0043227 membrane-bounded organelle
1.17 4.74e-09 GO:0044444 cytoplasmic part
1.17 3.79e-02 GO:0043228 non-membrane-bounded organelle
1.17 3.79e-02 GO:0043232 intracellular non-membrane-bounded organelle
1.15 1.06e-26 GO:0044424 intracellular part
1.15 4.16e-17 GO:0043226 organelle
1.15 5.13e-17 GO:0043229 intracellular organelle
1.14 1.36e-25 GO:0005622 intracellular
1.13 4.29e-04 GO:0044446 intracellular organelle part

Gene overrepresentation in function category:

Showing 1 to 20 of 25 entries
enrichment   p-value GO term description
2.23 4.39e-03 GO:0017016 Ras GTPase binding
2.07 1.86e-02 GO:0031267 small GTPase binding
1.99 2.29e-02 GO:0051020 GTPase binding
1.96 1.42e-03 GO:0004721 phosphoprotein phosphatase activity
1.76 1.28e-03 GO:0016791 phosphatase activity
1.63 2.00e-03 GO:0042578 phosphoric ester hydrolase activity
1.47 2.85e-02 GO:0016874 ligase activity
1.42 1.36e-03 GO:0019899 enzyme binding
1.41 2.48e-02 GO:0004672 protein kinase activity
1.39 9.51e-03 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.38 1.31e-03 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.35 2.83e-02 GO:0016301 kinase activity
1.32 1.56e-02 GO:0030528 transcription regulator activity
1.30 4.23e-05 GO:0016740 transferase activity
1.24 1.93e-04 GO:0000166 nucleotide binding
1.21 3.33e-02 GO:0008270 zinc ion binding
1.20 1.19e-02 GO:0003677 DNA binding
1.19 5.87e-04 GO:0003676 nucleic acid binding
1.19 2.31e-02 GO:0046914 transition metal ion binding
1.16 1.60e-10 GO:0005515 protein binding