Motif ID: HNF4A_NR2F1,2.p2

Z-value: 5.615


Transcription factors associated with HNF4A_NR2F1,2.p2:

Gene SymbolEntrez IDGene Name
HNF4A 3172 hepatocyte nuclear factor 4, alpha
NR2F1 7025 nuclear receptor subfamily 2, group F, member 1
NR2F2 7026 nuclear receptor subfamily 2, group F, member 2



Activity profile for motif HNF4A_NR2F1,2.p2.

activity profile for motif HNF4A_NR2F1,2.p2


Sorted Z-values histogram for motif HNF4A_NR2F1,2.p2

Sorted Z-values for motif HNF4A_NR2F1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HNF4A_NR2F1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_241193492 6.866 NM_001195381
NM_001195382
GPR35

G protein-coupled receptor 35

chr19_+_5774817 6.819 NM_004558
NRTN
neurturin
chr20_-_3097070 6.361 NM_014731
ProSAPiP1
ProSAPiP1 protein
chr16_-_86527608 6.087 NM_001739
CA5A
carbonic anhydrase VA, mitochondrial
chr7_+_134567270 5.754 NM_182489
STRA8
stimulated by retinoic acid gene 8 homolog (mouse)
chr19_-_51109875 5.680 NM_001029861
NANOS2
nanos homolog 2 (Drosophila)
chr6_+_131190237 5.340 NM_001195597
LOC285733
hypothetical LOC285733
chr19_-_15451203 5.167 NM_052890
PGLYRP2
peptidoglycan recognition protein 2
chr6_+_31731647 5.142 NM_019101
APOM
apolipoprotein M
chr6_+_31731667 5.103 APOM
apolipoprotein M
chr20_+_29492071 4.772 NM_153324
DEFB123
defensin, beta 123
chr13_+_112825113 4.546 NM_000504
F10
coagulation factor X
chr17_+_24394281 4.530 PIPOX
pipecolic acid oxidase
chr10_+_102722275 4.431 NM_017893
SEMA4G
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr6_+_32090516 4.308 NM_007293
NM_001002029
C4A
C4B
complement component 4A (Rodgers blood group)
complement component 4B (Chido blood group)
chr17_-_68769613 3.979 NM_001129885
CPSF4L
cleavage and polyadenylation specific factor 4-like
chr2_+_128009782 3.876 NM_001080527
MYO7B
myosin VIIB
chr22_-_22970850 3.805 NM_001099781
NM_001099782
NM_004121
GGT5


gamma-glutamyltransferase 5


chr1_+_15941503 3.492 NM_001013641
TMEM82
transmembrane protein 82
chr13_-_112392051 3.479 LOC440149
hypothetical LOC440149
chr6_+_33280396 3.460 NM_014234
HSD17B8
hydroxysteroid (17-beta) dehydrogenase 8
chr16_+_21152516 3.389 NM_145865
ANKS4B
ankyrin repeat and sterile alpha motif domain containing 4B
chr11_-_65860450 3.182 NM_004292
RIN1
Ras and Rab interactor 1
chr19_+_46640902 3.154 NM_001130514
C19orf69
chromosome 19 open reading frame 69
chr14_-_23847000 3.132 CIDEB
cell death-inducing DFFA-like effector b
chr15_+_83228895 3.102 NM_004213
NM_201651
SLC28A1

solute carrier family 28 (sodium-coupled nucleoside transporter), member 1

chr2_-_241480058 3.087 NM_024861
C2orf54
chromosome 2 open reading frame 54
chr17_-_33753218 3.082 NM_001004334
GPR179
G protein-coupled receptor 179
chr2_-_88208650 3.038 NM_001443
FABP1
fatty acid binding protein 1, liver
chr14_-_23846993 3.021 CIDEB
cell death-inducing DFFA-like effector b
chr17_-_31332568 3.006 NM_004590
CCL16
chemokine (C-C motif) ligand 16
chr11_-_16992524 2.955 NM_175058
PLEKHA7
pleckstrin homology domain containing, family A member 7
chr14_-_23847024 2.904 CIDEB
cell death-inducing DFFA-like effector b
chr11_+_74548472 2.904 NM_001145211
SLCO2B1
solute carrier organic anion transporter family, member 2B1
chr16_-_11277806 2.901 NM_002762
PRM2
protamine 2
chr6_+_32057779 2.888 NM_007293
NM_001002029
C4A
C4B
complement component 4A (Rodgers blood group)
complement component 4B (Chido blood group)
chr14_-_23846904 2.856 CIDEB
cell death-inducing DFFA-like effector b
chr11_-_64520964 2.794 NM_138456
BATF2
basic leucine zipper transcription factor, ATF-like 2
chr17_-_31369046 2.694 NM_005064
NM_145898
CCL23

chemokine (C-C motif) ligand 23

chr21_+_42946719 2.672 NM_001001567
NM_001001568
NM_001001569
NM_001001570
NM_001001571
NM_001001572
NM_001001573
NM_001001574
NM_001001575
NM_001001576
NM_001001577
NM_001001578
NM_001001579
NM_001001580
NM_001001581
NM_001001582
NM_001001583
NM_001001584
NM_001001585
NM_002606
PDE9A



















phosphodiesterase 9A



















chr17_+_24394043 2.666 NM_016518
PIPOX
pipecolic acid oxidase
chr1_-_167822248 2.603 F5
coagulation factor V (proaccelerin, labile factor)
chr12_+_51783554 2.582 SOAT2
sterol O-acyltransferase 2
chr17_+_71582486 2.544 NM_003857
GALR2
galanin receptor 2
chr5_+_140537554 2.535 NM_019120
PCDHB8
protocadherin beta 8
chr17_-_23721351 2.534 VTN
vitronectin
chr20_-_52120421 2.526 BCAS1
breast carcinoma amplified sequence 1
chr20_-_52120710 2.503 NM_003657
BCAS1
breast carcinoma amplified sequence 1
chr2_-_74606819 2.499 NM_133637
DQX1
DEAQ box RNA-dependent ATPase 1
chr14_+_22911857 2.481 NM_172314
NM_022789
IL25

interleukin 25

chr2_+_113648036 2.466 PSD4
pleckstrin and Sec7 domain containing 4
chr5_-_42847716 2.455 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr12_+_51783540 2.437 NM_003578
SOAT2
sterol O-acyltransferase 2
chr2_-_238164042 2.331 RAB17
RAB17, member RAS oncogene family
chr2_+_27573206 2.308 NM_001486
GCKR
glucokinase (hexokinase 4) regulator
chr16_-_30032330 2.297 NM_024307
GDPD3
glycerophosphodiester phosphodiesterase domain containing 3
chr17_+_75766875 2.279 NM_024110
CARD14
caspase recruitment domain family, member 14
chr1_+_202647097 2.259


chr19_-_63715135 2.236 NM_012254
SLC27A5
solute carrier family 27 (fatty acid transporter), member 5
chr17_+_21249040 2.216 NM_001194958
KCNJ18
potassium inwardly-rectifying channel, subfamily J, member 18
chr19_+_38314837 2.197 NM_173479
WDR88
WD repeat domain 88
chr17_-_33982580 2.185 SRCIN1
SRC kinase signaling inhibitor 1
chr12_-_55637648 2.169 NM_003708
RDH16
retinol dehydrogenase 16 (all-trans)
chr16_+_88280594 2.169 CDK10
cyclin-dependent kinase 10
chr20_+_30409649 2.157 NM_001164603
NM_015338
ASXL1

additional sex combs like 1 (Drosophila)

chr14_-_23752875 2.157 NM_014169
CHMP4A
chromatin modifying protein 4A
chr17_+_69950782 2.141 GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr11_-_5247948 2.125 NM_005330
HBE1
hemoglobin, epsilon 1
chr17_-_40344203 2.121 GFAP
glial fibrillary acidic protein
chr3_-_195553297 2.118 NM_001080513
CPN2
carboxypeptidase N, polypeptide 2
chr6_+_30238961 2.114 NM_033229
TRIM15
tripartite motif containing 15
chr9_-_126309510 2.106 NM_004959
NR5A1
nuclear receptor subfamily 5, group A, member 1
chr17_-_40344322 2.102


chr17_+_70244553 2.078 NM_001163989
RAB37
RAB37, member RAS oncogene family
chr16_-_51138306 2.049 NM_001080430
TOX3
TOX high mobility group box family member 3
chr17_-_33178987 2.035 HNF1B
HNF1 homeobox B
chr1_+_38033666 2.031 NM_152496
MANEAL
mannosidase, endo-alpha-like
chr11_-_116199145 2.028 NM_000482
APOA4
apolipoprotein A-IV
chr17_+_39603599 2.027 NM_080863
ASB16
ankyrin repeat and SOCS box containing 16
chr1_-_110108048 2.026 NM_024526
NM_133181
NM_139053
EPS8L3


EPS8-like 3


chr11_+_63810157 1.986 NM_001170880
NM_020155
GPR137

G protein-coupled receptor 137

chr20_+_57308876 1.969 NM_000114
NM_207032
NM_207033
NM_207034
EDN3



endothelin 3



chr16_-_18720192 1.950 NM_015161
ARL6IP1
ADP-ribosylation factor-like 6 interacting protein 1
chr20_-_47963682 1.944 NM_001135773
SPATA2
spermatogenesis associated 2
chr14_+_73073570 1.934 NM_001037161
ACOT1
acyl-CoA thioesterase 1
chr6_+_32034767 1.933 SKIV2L
superkiller viralicidic activity 2-like (S. cerevisiae)
chr16_+_24765052 1.926 NM_052944
SLC5A11
solute carrier family 5 (sodium/glucose cotransporter), member 11
chr1_-_202647526 1.911 NM_032833
PPP1R15B
protein phosphatase 1, regulatory (inhibitor) subunit 15B
chr8_+_21972804 1.904 EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr17_+_4638966 1.903 NM_001014985
GLTPD2
glycolipid transfer protein domain containing 2
chr11_+_63809877 1.893 GPR137
G protein-coupled receptor 137
chr20_-_1257782 1.889 SDCBP2
syndecan binding protein (syntenin) 2
chr17_+_4621924 1.887 NM_003963
TM4SF5
transmembrane 4 L six family member 5
chr19_+_59107802 1.886 NM_031896
CACNG7
calcium channel, voltage-dependent, gamma subunit 7
chr17_+_38259620 1.882 AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr14_-_23752507 1.877 CHMP4A
chromatin modifying protein 4A
chr8_+_22909305 1.876 NM_001160037
RHOBTB2
Rho-related BTB domain containing 2
chr1_+_200358594 1.870 NM_004767
GPR37L1
G protein-coupled receptor 37 like 1
chr22_+_20899155 1.868


chr21_+_44169706 1.864 NM_001037553
AGPAT3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr11_-_404975 1.863 NM_001135054
SIGIRR
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
chr3_-_50315983 1.858 NM_007312
NM_033159
NM_153282
NM_153283
NM_153285
HYAL1




hyaluronoglucosaminidase 1




chr19_-_40995564 1.857 PRODH2
proline dehydrogenase (oxidase) 2
chr16_-_87646856 1.848


chr3_-_52235218 1.826 NM_017442
TLR9
toll-like receptor 9
chr20_-_32363268 1.826 NM_001161766
AHCY
adenosylhomocysteinase
chr16_-_16224791 1.816 NM_001079528
NM_001171
ABCC6

ATP-binding cassette, sub-family C (CFTR/MRP), member 6

chr2_-_19421852 1.808 NM_145260
OSR1
odd-skipped related 1 (Drosophila)
chr8_-_142333339 1.808 SLC45A4
solute carrier family 45, member 4
chr7_-_94863558 1.804 NM_000940
PON3
paraoxonase 3
chr17_-_33179118 1.787 NM_000458
NM_001165923
HNF1B

HNF1 homeobox B

chr9_-_34366831 1.781 NM_020702
KIAA1161
KIAA1161
chr1_-_167822334 1.774 NM_000130
F5
coagulation factor V (proaccelerin, labile factor)
chr5_+_140573692 1.774 NM_018933
PCDHB13
protocadherin beta 13
chr6_-_30631912 1.769 GNL1
guanine nucleotide binding protein-like 1
chr8_+_21972631 1.767 NM_001114138
NM_001978
EPB49

erythrocyte membrane protein band 4.9 (dematin)

chr14_-_23752498 1.757 CHMP4A
chromatin modifying protein 4A
chr3_+_52787478 1.757 NM_001166434
ITIH1
inter-alpha (globulin) inhibitor H1
chr9_-_129752687 1.755 NM_203305
FAM102A
family with sequence similarity 102, member A
chr1_+_1351370 1.745 NM_001146685
TMEM88B
transmembrane protein 88B
chr1_-_228916559 1.739 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr16_-_20246309 1.725 NM_001007240
NM_001007241
NM_001007242
NM_001502
GP2



glycoprotein 2 (zymogen granule membrane)



chr6_-_31953425 1.722 NM_001178045
SLC44A4
solute carrier family 44, member 4
chr16_-_45339605 1.697 NM_182493
MYLK3
myosin light chain kinase 3
chr6_+_18263514 1.695 NM_153042
KDM1B
lysine (K)-specific demethylase 1B
chr20_+_17628592 1.693 NM_001014977
NM_178477
BANF2

barrier to autointegration factor 2

chr6_-_31658044 1.689 NM_002341
NM_009588
LTB

lymphotoxin beta (TNF superfamily, member 3)

chr6_+_32021793 1.685 CFB
complement factor B
chr7_-_50600536 1.682 NM_001082971
DDC
dopa decarboxylase (aromatic L-amino acid decarboxylase)
chr22_+_19651446 1.680 NM_001146288
AIFM3
apoptosis-inducing factor, mitochondrion-associated, 3
chr2_-_70901186 1.671 NM_173535
CLEC4F
C-type lectin domain family 4, member F
chr19_-_40995606 1.670 PRODH2
proline dehydrogenase (oxidase) 2
chr22_+_21079355 1.660


chr6_-_44341222 1.644 NFKBIE
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
chr20_+_31219543 1.635 NM_080574
C20orf70
chromosome 20 open reading frame 70
chr14_-_23752476 1.633 CHMP4A
chromatin modifying protein 4A
chr2_+_26257088 1.629 NM_001191033
FAM59B
family with sequence similarity 59, member B
chr20_+_35964962 1.626 VSTM2L
V-set and transmembrane domain containing 2 like
chr17_-_23721420 1.625 VTN
vitronectin
chr7_+_99809003 1.617 NM_013439
NM_178272
NM_178273
PILRA


paired immunoglobin-like type 2 receptor alpha


chr20_-_7869068 1.613 NM_017545
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr10_+_114123765 1.610 ACSL5
acyl-CoA synthetase long-chain family member 5
chr19_-_48700824 1.607 NM_198850
PHLDB3
pleckstrin homology-like domain, family B, member 3
chr6_-_44341296 1.606 NM_004556
NFKBIE
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
chr1_-_6343306 1.601 NM_181865
ACOT7
acyl-CoA thioesterase 7
chr20_+_32762976 1.594 TP53INP2
tumor protein p53 inducible nuclear protein 2
chr16_+_88280569 1.587 NM_001098533
NM_001160367
NM_052987
NM_052988
CDK10



cyclin-dependent kinase 10



chr2_+_11597530 1.586 NM_148903
GREB1
growth regulation by estrogen in breast cancer 1
chr14_-_22825148 1.578 NM_020834
HOMEZ
homeobox and leucine zipper encoding
chr6_-_32034607 1.568 NM_002904
RDBP
RD RNA binding protein
chr7_+_101704145 1.566 CUX1
cut-like homeobox 1
chr14_+_19681734 1.566 NM_001004724
OR4N5
olfactory receptor, family 4, subfamily N, member 5
chr2_+_11591692 1.561 NM_014668
GREB1
growth regulation by estrogen in breast cancer 1
chr22_-_21231421 1.552 NM_206955
NM_206956
NM_006115
NM_206953
NM_206954
PRAME




preferentially expressed antigen in melanoma




chr20_-_1257809 1.540 NM_080489
SDCBP2
syndecan binding protein (syntenin) 2
chr17_-_23721468 1.536 VTN
vitronectin
chr7_+_100047877 1.530 NM_001040098
NM_001040099
NM_023948
MOSPD3


motile sperm domain containing 3


chr14_-_38642029 1.530 SEC23A
Sec23 homolog A (S. cerevisiae)
chr22_-_34930705 1.527 NM_030643
NM_145660
APOL4

apolipoprotein L, 4

chr17_+_72958207 1.522 NM_001113496
SEPT9
septin 9
chr12_+_56114724 1.521 NM_005538
INHBC
inhibin, beta C
chrX_-_70045285 1.519 NM_001003811
NM_031276
TEX11

testis expressed 11

chr16_+_55963883 1.518 CX3CL1
chemokine (C-X3-C motif) ligand 1
chr11_+_60391590 1.511 NM_207341
ZP1
zona pellucida glycoprotein 1 (sperm receptor)
chr17_-_71352182 1.507 NM_199242
UNC13D
unc-13 homolog D (C. elegans)
chr20_+_35406497 1.505 NM_005417
SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr22_+_22703107 1.504 NM_001144931
LOC391322
D-dopachrome tautomerase-like
chr10_+_114123828 1.503 NM_203379
ACSL5
acyl-CoA synthetase long-chain family member 5
chr16_+_464844 1.501 NM_001142272
RAB11FIP3
RAB11 family interacting protein 3 (class II)
chr7_+_99809068 1.500 PILRA
paired immunoglobin-like type 2 receptor alpha
chr17_+_53625084 1.484 NM_000502
EPX
eosinophil peroxidase
chr3_-_10522340 1.473 ATP2B2
ATPase, Ca++ transporting, plasma membrane 2
chr22_+_20715340 1.471


chr14_+_22410795 1.471 NM_014045
LRP10
low density lipoprotein receptor-related protein 10
chr5_-_176671897 1.467 NM_001142935
NM_031300
MXD3

MAX dimerization protein 3

chr7_-_158304062 1.466 ESYT2
extended synaptotagmin-like protein 2
chr18_+_52469559 1.460 NM_015285
NM_052834
WDR7

WD repeat domain 7

chr22_+_43451600 1.452 PRR5
proline rich 5 (renal)
chr1_+_153560841 1.444 NM_014328
RUSC1
RUN and SH3 domain containing 1
chr13_+_112392355 1.442 NM_015205
NM_032189
ATP11A

ATPase, class VI, type 11A

chr17_-_23721430 1.433 VTN
vitronectin
chr19_-_12028126 1.431 NM_001080404
ZNF878
zinc finger protein 878
chr6_+_32021742 1.427 CFB
complement factor B
chr17_-_23721485 1.425 NM_000638
VTN
vitronectin
chr2_-_233586145 1.425 NGEF
neuronal guanine nucleotide exchange factor
chr1_-_23999744 1.421 NM_001008216
GALE
UDP-galactose-4-epimerase
chr16_+_29734785 1.417 C16orf53
chromosome 16 open reading frame 53
chr12_-_6355165 1.416 NM_001038
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr7_-_50596238 1.401 NM_000790
DDC
dopa decarboxylase (aromatic L-amino acid decarboxylase)
chr20_+_55569542 1.401 NM_002591
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr20_+_31713750 1.398 NM_080825
C20orf144
chromosome 20 open reading frame 144
chr17_-_71352090 1.393 UNC13D
unc-13 homolog D (C. elegans)
chr14_-_106193403 1.393 IGKV3-20
immunoglobulin kappa variable 3-20
chr16_+_68542126 1.388 NM_001136214
CLEC18A
C-type lectin domain family 18, member A
chr7_-_100630912 1.386 NM_178176
MOGAT3
monoacylglycerol O-acyltransferase 3
chr10_-_74384569 1.383 PLA2G12B
phospholipase A2, group XIIB
chr10_-_74384485 1.380 NM_032562
PLA2G12B
phospholipase A2, group XIIB
chr20_-_3592045 1.373 NM_022139
NM_145762
GFRA4

GDNF family receptor alpha 4

chr6_+_32021831 1.364 CFB
complement factor B
chr2_+_220071780 1.362 NM_013335
NM_205847
GMPPA

GDP-mannose pyrophosphorylase A


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.31 2.39e-04 GO:0044281 small molecule metabolic process
1.49 1.16e-03 GO:0042180 cellular ketone metabolic process
1.49 1.27e-03 GO:0006082 organic acid metabolic process
1.25 1.81e-03 GO:0042221 response to chemical stimulus
1.48 2.47e-03 GO:0019752 carboxylic acid metabolic process
1.48 2.47e-03 GO:0043436 oxoacid metabolic process
2.49 1.47e-02 GO:0002449 lymphocyte mediated immunity
2.28 2.12e-02 GO:0002443 leukocyte mediated immunity

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.40 2.17e-03 GO:0005624 membrane fraction
1.09 5.53e-03 GO:0005737 cytoplasm
1.37 6.05e-03 GO:0005626 insoluble fraction
1.31 7.85e-03 GO:0000267 cell fraction
1.11 1.78e-02 GO:0044444 cytoplasmic part
1.35 2.94e-02 GO:0044432 endoplasmic reticulum part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.09 2.52e-02 GO:0005515 protein binding