Motif ID: SPI1.p2

Z-value: 1.422


Transcription factors associated with SPI1.p2:

Gene SymbolEntrez IDGene Name
SPI1 6688 spleen focus forming virus (SFFV) proviral integration oncogene spi1



Activity profile for motif SPI1.p2.

activity profile for motif SPI1.p2


Sorted Z-values histogram for motif SPI1.p2

Sorted Z-values for motif SPI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SPI1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr22_+_35586950 1.416 NM_000631
NM_013416
 NCF4

neutrophil cytosolic factor 4, 40kDa

chr12_-_53071285 1.225 NM_001130967
NM_001130968
 ZNF385A

zinc finger protein 385A

chrX_-_47374187 1.111 NM_001145252
 CFP
complement factor properdin
chr5_-_88215034 0.915 NM_001193350
NM_002397
 MEF2C

myocyte enhancer factor 2C

chr1_+_159899528 0.872 NM_001002273
NM_001002274
NM_001002275
NM_001190828
NM_004001
 FCGR2B




FCGR2C
Fc fragment of IgG, low affinity IIb, receptor (CD32)




Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr19_+_54068373 0.828 PPP1R15A
protein phosphatase 1, regulatory (inhibitor) subunit 15A
chr22_-_18484428 0.803 TRMT2A
TRM2 tRNA methyltransferase 2 homolog A (S. cerevisiae)
chr12_-_55929189 0.753


chr11_-_46099531 0.753 NM_001101802
NM_016621
 PHF21A

PHD finger protein 21A

chr10_+_70553993 0.732 VPS26A
vacuolar protein sorting 26 homolog A (S. pombe)
chr1_-_32574185 0.724 NM_023009
 MARCKSL1
MARCKS-like 1
chrX_+_134482387 0.713 DDX26B
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B
chr8_+_126511739 0.695 NM_025195
 TRIB1
tribbles homolog 1 (Drosophila)
chr11_+_47386621 0.674 NM_001128225
NM_152264
 SLC39A13

solute carrier family 39 (zinc transporter), member 13

chr3_+_145173329 0.666 NM_173552
 C3orf58
chromosome 3 open reading frame 58
chr16_-_87570716 0.665 NM_005187
 CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr22_-_30018329 0.662 NM_001135911
NM_052880
 PIK3IP1

phosphoinositide-3-kinase interacting protein 1

chr11_+_47386707 0.660 SLC39A13
solute carrier family 39 (zinc transporter), member 13
chr17_-_44058612 0.647 NM_024017
 HOXB9
homeobox B9
chr1_+_233558375 0.645 NM_001037277
NM_004837
 GGPS1

geranylgeranyl diphosphate synthase 1


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 105 entries
enrichment   p-value GO term description
1.82 3.16e-02 GO:0007173 epidermal growth factor receptor signaling pathway
1.68 4.46e-04 GO:0050900 leukocyte migration
1.51 9.76e-04 GO:0016567 protein ubiquitination
1.48 1.73e-03 GO:0032446 protein modification by small protein conjugation
1.45 2.78e-02 GO:0045321 leukocyte activation
1.45 4.12e-02 GO:0030168 platelet activation
1.44 1.70e-02 GO:0010608 posttranscriptional regulation of gene expression
1.43 2.73e-03 GO:0070647 protein modification by small protein conjugation or removal
1.41 3.38e-05 GO:0007599 hemostasis
1.41 5.64e-05 GO:0007596 blood coagulation
1.41 5.64e-05 GO:0050817 coagulation
1.40 6.31e-05 GO:0001775 cell activation
1.40 1.37e-03 GO:0016477 cell migration
1.39 5.67e-03 GO:0010627 regulation of intracellular protein kinase cascade
1.38 7.19e-05 GO:0050878 regulation of body fluid levels
1.37 1.56e-02 GO:0032270 positive regulation of cellular protein metabolic process
1.36 2.86e-04 GO:0006928 cellular component movement
1.35 7.15e-03 GO:0048870 cell motility
1.35 7.15e-03 GO:0051674 localization of cell
1.34 4.75e-04 GO:0009057 macromolecule catabolic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 30 entries
enrichment   p-value GO term description
1.91 8.98e-03 GO:0016605 PML body
1.66 3.36e-02 GO:0016585 chromatin remodeling complex
1.39 4.43e-02 GO:0000785 chromatin
1.34 1.93e-06 GO:0044451 nucleoplasm part
1.29 4.61e-03 GO:0005694 chromosome
1.28 4.07e-02 GO:0044427 chromosomal part
1.26 1.86e-07 GO:0005654 nucleoplasm
1.24 2.48e-09 GO:0031981 nuclear lumen
1.23 3.80e-10 GO:0044428 nuclear part
1.22 1.45e-08 GO:0005829 cytosol
1.19 9.15e-07 GO:0043233 organelle lumen
1.19 1.68e-06 GO:0070013 intracellular organelle lumen
1.18 1.98e-06 GO:0031974 membrane-enclosed lumen
1.14 4.25e-13 GO:0005634 nucleus
1.14 6.73e-05 GO:0043234 protein complex
1.13 2.55e-05 GO:0032991 macromolecular complex
1.13 1.33e-03 GO:0043228 non-membrane-bounded organelle
1.13 1.33e-03 GO:0043232 intracellular non-membrane-bounded organelle
1.11 5.00e-07 GO:0044422 organelle part
1.11 8.12e-07 GO:0044446 intracellular organelle part

Gene overrepresentation in function category:

Showing 1 to 17 of 17 entries
enrichment   p-value GO term description
1.64 4.65e-02 GO:0051427 hormone receptor binding
1.52 7.28e-06 GO:0016564 transcription repressor activity
1.47 8.12e-03 GO:0004842 ubiquitin-protein ligase activity
1.45 3.63e-02 GO:0000975 regulatory region DNA binding
1.45 3.63e-02 GO:0001067 regulatory region nucleic acid binding
1.45 3.63e-02 GO:0044212 transcription regulatory region DNA binding
1.43 2.55e-02 GO:0019787 small conjugating protein ligase activity
1.36 7.00e-03 GO:0003712 transcription cofactor activity
1.35 8.38e-03 GO:0000988 protein binding transcription factor activity
1.35 8.38e-03 GO:0000989 transcription factor binding transcription factor activity
1.32 7.80e-08 GO:0030528 transcription regulator activity
1.32 5.09e-05 GO:0043565 sequence-specific DNA binding
1.28 5.44e-04 GO:0019899 enzyme binding
1.25 1.87e-04 GO:0001071 nucleic acid binding transcription factor activity
1.25 1.87e-04 GO:0003700 sequence-specific DNA binding transcription factor activity
1.19 8.99e-38 GO:0005515 protein binding
1.07 1.92e-13 GO:0005488 binding