Motif ID: bHLH_family.p2

Z-value: 1.374


Transcription factors associated with bHLH_family.p2:

Gene SymbolEntrez IDGene Name
ARNTL 406 aryl hydrocarbon receptor nuclear translocator-like
ARNTL2 56938 aryl hydrocarbon receptor nuclear translocator-like 2
CLOCK 9575 clock homolog (mouse)
HES6 55502 hairy and enhancer of split 6 (Drosophila)
HEY1 23462 hairy/enhancer-of-split related with YRPW motif 1
HEY2 23493 hairy/enhancer-of-split related with YRPW motif 2
HEYL 26508 hairy/enhancer-of-split related with YRPW motif-like
ID1 3397 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
MITF 4286 microphthalmia-associated transcription factor
MLXIPL 51085 MLX interacting protein-like
MNT 4335 MAX binding protein
MXD3 83463 MAX dimerization protein 3
MXD4 10608 MAX dimerization protein 4
MXI1 4601 MAX interactor 1
NPAS2 4862 neuronal PAS domain protein 2
OLIG1 116448 oligodendrocyte transcription factor 1
OLIG2 10215 oligodendrocyte lineage transcription factor 2
TFE3 7030 transcription factor binding to IGHM enhancer 3



Activity profile for motif bHLH_family.p2.

activity profile for motif bHLH_family.p2


Sorted Z-values histogram for motif bHLH_family.p2

Sorted Z-values for motif bHLH_family.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of bHLH_family.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr20_+_43952997 3.456 NM_000308
NM_001127695
NM_001167594
CTSA


cathepsin A


chr20_-_43953036 3.313 NM_080749
NEURL2
neuralized homolog 2 (Drosophila)
chr19_+_59077241 2.234 NM_002739
PRKCG
protein kinase C, gamma
chr17_+_9489578 2.003 NM_153210
USP43
ubiquitin specific peptidase 43
chr20_+_43953606 1.963 CTSA
cathepsin A
chr20_+_43953428 1.829 CTSA
cathepsin A
chr14_+_23855291 1.747 LTB4R
leukotriene B4 receptor
chr20_+_43028533 1.635 NM_006282
STK4
serine/threonine kinase 4
chr12_+_52653176 1.366 NM_014212
HOXC11
homeobox C11
chr14_-_23106372 1.326 AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr17_-_35510074 1.277 NR1D1
nuclear receptor subfamily 1, group D, member 1
chr7_-_1562272 1.233 NM_001097620
TMEM184A
transmembrane protein 184A
chr2_-_148494732 1.224 NM_001190882
NM_001190879
NM_002552
NM_001190881
NM_181741
ORC4




origin recognition complex, subunit 4




chr1_+_181259317 1.211


chr20_+_43028590 1.183 STK4
serine/threonine kinase 4
chr2_-_217267742 1.143 IGFBP5
insulin-like growth factor binding protein 5
chr17_+_75851984 1.111


chr4_-_158111995 1.099 NM_016205
PDGFC
platelet derived growth factor C
chr16_+_29373365 1.091 NM_001014999
NM_001015000
NM_024044
NM_178044
SLX1A-SULT1A3
SLX1A

SLX1B

SLX1A-SULT1A3 read-through transcript
SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae)

SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)

chr17_-_35510431 1.090 NM_021724
NR1D1
nuclear receptor subfamily 1, group D, member 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 17 of 17 entries
enrichment   p-value GO term description
1.90 2.29e-02 GO:0034330 cell junction organization
1.36 6.19e-03 GO:0042127 regulation of cell proliferation
1.24 7.46e-03 GO:0030154 cell differentiation
1.23 9.46e-03 GO:0048869 cellular developmental process
1.19 3.85e-03 GO:0048856 anatomical structure development
1.18 2.04e-03 GO:0007275 multicellular organismal development
1.18 4.06e-02 GO:0048731 system development
1.17 2.64e-04 GO:0044260 cellular macromolecule metabolic process
1.17 2.70e-03 GO:0032502 developmental process
1.17 9.78e-03 GO:0051179 localization
1.17 3.06e-02 GO:0006807 nitrogen compound metabolic process
1.17 4.81e-02 GO:0034641 cellular nitrogen compound metabolic process
1.15 6.89e-06 GO:0044237 cellular metabolic process
1.15 9.47e-04 GO:0043170 macromolecule metabolic process
1.13 2.92e-05 GO:0008152 metabolic process
1.13 9.30e-05 GO:0044238 primary metabolic process
1.11 7.57e-13 GO:0009987 cellular process

Gene overrepresentation in compartment category:

Showing 1 to 19 of 19 entries
enrichment   p-value GO term description
1.66 3.37e-02 GO:0005911 cell-cell junction
1.29 1.25e-03 GO:0005654 nucleoplasm
1.28 3.66e-07 GO:0031974 membrane-enclosed lumen
1.27 1.69e-06 GO:0043233 organelle lumen
1.27 3.38e-06 GO:0070013 intracellular organelle lumen
1.27 8.65e-05 GO:0031981 nuclear lumen
1.23 1.50e-03 GO:0005829 cytosol
1.22 1.26e-03 GO:0044428 nuclear part
1.17 7.45e-08 GO:0044422 organelle part
1.16 1.52e-07 GO:0044446 intracellular organelle part
1.14 2.26e-06 GO:0044444 cytoplasmic part
1.13 6.80e-09 GO:0005737 cytoplasm
1.10 1.70e-08 GO:0043226 organelle
1.10 1.84e-08 GO:0043229 intracellular organelle
1.10 1.98e-06 GO:0043227 membrane-bounded organelle
1.10 2.21e-06 GO:0043231 intracellular membrane-bounded organelle
1.10 3.71e-02 GO:0005634 nucleus
1.09 2.66e-09 GO:0044424 intracellular part
1.09 2.82e-09 GO:0005622 intracellular

Gene overrepresentation in function category:

Showing 1 to 2 of 2 entries
enrichment   p-value GO term description
1.17 1.19e-12 GO:0005515 protein binding
1.07 1.13e-06 GO:0005488 binding