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Motif ID: bHLH_family.p2

Z-value: 1.374

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr20_+_43952997	3.456	NM_000308 NM_001127695 NM_001167594	CTSA	cathepsin A
chr20_-_43953036	3.313	NM_080749	NEURL2	neuralized homolog 2 (Drosophila)
chr19_+_59077241	2.234	NM_002739	PRKCG	protein kinase C, gamma
chr17_+_9489578	2.003	NM_153210	USP43	ubiquitin specific peptidase 43
chr20_+_43953606	1.963		CTSA	cathepsin A
chr20_+_43953428	1.829		CTSA	cathepsin A
chr14_+_23855291	1.747		LTB4R	leukotriene B4 receptor
chr20_+_43028533	1.635	NM_006282	STK4	serine/threonine kinase 4
chr12_+_52653176	1.366	NM_014212	HOXC11	homeobox C11
chr14_-_23106372	1.326		AP1G2	adaptor-related protein complex 1, gamma 2 subunit
chr17_-_35510074	1.277		NR1D1	nuclear receptor subfamily 1, group D, member 1
chr7_-_1562272	1.233	NM_001097620	TMEM184A	transmembrane protein 184A
chr2_-_148494732	1.224	NM_001190882 NM_001190879 NM_002552 NM_001190881 NM_181741	ORC4	origin recognition complex, subunit 4
chr1_+_181259317	1.211
chr20_+_43028590	1.183		STK4	serine/threonine kinase 4
chr2_-_217267742	1.143		IGFBP5	insulin-like growth factor binding protein 5
chr17_+_75851984	1.111
chr4_-_158111995	1.099	NM_016205	PDGFC	platelet derived growth factor C
chr16_+_29373365	1.091	NM_001014999 NM_001015000 NM_024044 NM_178044	SLX1A-SULT1A3 SLX1A SLX1B	SLX1A-SULT1A3 read-through transcript SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)
chr17_-_35510431	1.090	NM_021724	NR1D1	nuclear receptor subfamily 1, group D, member 1
chr2_+_148495043	1.080	NM_018328	MBD5	methyl-CpG binding domain protein 5
chr4_-_158111916	1.079		PDGFC	platelet derived growth factor C
chr6_-_33493792	1.064		CUTA	cutA divalent cation tolerance homolog (E. coli)
chr16_-_66827449	1.044	NM_024939	ESRP2	epithelial splicing regulatory protein 2
chr21_-_38210531	1.044	NM_002240	KCNJ6	potassium inwardly-rectifying channel, subfamily J, member 6
chr11_-_116691574	1.036		BACE1	beta-site APP-cleaving enzyme 1
chr14_-_38971370	1.035	NM_203301	FBXO33	F-box protein 33
chr6_-_33493898	1.033		CUTA	cutA divalent cation tolerance homolog (E. coli)
chr20_+_43953372	1.030		CTSA	cathepsin A
chr2_-_120697148	1.026		TMEM185B	transmembrane protein 185B (pseudogene)
chr8_-_75396016	1.020	NM_020647	JPH1	junctophilin 1
chrX_+_95826507	1.003		DIAPH2	diaphanous homolog 2 (Drosophila)
chr2_-_85683268	0.993	NM_001031738	TMEM150A	transmembrane protein 150A
chr6_-_33494042	0.972	NM_001014433 NM_001014837 NM_001014838 NM_001014840 NM_015921	CUTA	cutA divalent cation tolerance homolog (E. coli)
chr22_-_36212160	0.955	NM_001166343 NM_002405	MFNG	MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr2_-_172675480	0.954	NM_004405	DLX2	distal-less homeobox 2
chr17_-_4405367	0.953	NM_001105538 NM_014520	MYBBP1A	MYB binding protein (P160) 1a
chr9_+_34636600	0.947		GALT	galactose-1-phosphate uridylyltransferase
chr9_+_34636608	0.938	NM_000155	GALT	galactose-1-phosphate uridylyltransferase
chr17_+_45488356	0.935		ITGA3	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
chr8_-_17702991	0.931
chr11_+_18300370	0.931	NM_001142307 NM_005316	GTF2H1	general transcription factor IIH, polypeptide 1, 62kDa
chr17_+_4560529	0.928	NM_004313 NM_199004	ARRB2	arrestin, beta 2
chr1_+_152459918	0.909	NM_014847	UBAP2L	ubiquitin associated protein 2-like
chr6_+_32229771	0.907		PPT2-EGFL8 PPT2	PPT2-EGFL8 read-through transcript palmitoyl-protein thioesterase 2
chr2_-_101134146	0.900	NM_001102426	TBC1D8	TBC1 domain family, member 8 (with GRAM domain)
chr20_-_13567529	0.896	NM_017714	TASP1	taspase, threonine aspartase, 1
chr14_-_91642703	0.894	NM_001127696 NM_001127697 NM_001164774 NM_001164776 NM_001164777 NM_001164778 NM_001164779 NM_001164780 NM_001164781 NM_001164782 NM_004993 NM_030660	ATXN3	ataxin 3
chr6_-_18230829	0.881	NM_198586	NHLRC1	NHL repeat containing 1
chr16_+_67236699	0.859		CDH3	cadherin 3, type 1, P-cadherin (placental)
chr20_-_3097070	0.851	NM_014731	ProSAPiP1	ProSAPiP1 protein
chr6_-_33493640	0.850		CUTA	cutA divalent cation tolerance homolog (E. coli)
chr6_-_80713589	0.836	NM_022726	ELOVL4	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4
chr14_-_91642641	0.832		ATXN3 ATXN8	ataxin 3 ataxin 8
chr4_+_1330957	0.825	NM_020894	KIAA1530	KIAA1530
chr16_-_52876390	0.823		IRX3	iroquois homeobox 3
chr2_-_120697382	0.817		TMEM185B	transmembrane protein 185B (pseudogene)
chr17_-_2561676	0.816	NM_015229	KIAA0664	KIAA0664
chr12_-_30740011	0.816		IPO8	importin 8
chr8_-_124622434	0.807	NM_058229	FBXO32	F-box protein 32
chr5_+_133735004	0.801		UBE2B	ubiquitin-conjugating enzyme E2B (RAD6 homolog)
chr2_+_241903395	0.798	NM_001008491 NM_006155	SEPT2	septin 2
chr17_+_4560680	0.798		ARRB2	arrestin, beta 2
chr20_-_391172	0.794	NM_144628	TBC1D20	TBC1 domain family, member 20
chr14_-_23752507	0.786		CHMP4A	chromatin modifying protein 4A
chr20_+_43953331	0.765		CTSA	cathepsin A
chr6_+_160310118	0.763	NM_000876	IGF2R	insulin-like growth factor 2 receptor
chr1_-_201162991	0.756	NM_021633	KLHL12	kelch-like 12 (Drosophila)
chr17_+_45488330	0.755	NM_002204 NM_005501	ITGA3	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
chr1_-_151775087	0.749		S100A6	S100 calcium binding protein A6
chr6_-_109810354	0.749		CD164	CD164 molecule, sialomucin
chr3_+_51992339	0.747	NM_000666 NM_001198895 NM_001198896 NM_001198897 NM_001198898	ACY1	aminoacylase 1
chr17_+_2627099	0.726		RAP1GAP2	RAP1 GTPase activating protein 2
chr19_+_54149843	0.725	NM_004324 NM_138761 NM_138763 NM_138764	BAX	BCL2-associated X protein
chr14_-_23752498	0.720		CHMP4A	chromatin modifying protein 4A
chr10_+_101079099	0.718		CNNM1	cyclin M1
chr16_+_23597691	0.715		PLK1	polo-like kinase 1
chr2_+_136005423	0.709	NM_015361	R3HDM1	R3H domain containing 1
chr19_+_54149941	0.706		BAX	BCL2-associated X protein
chr1_-_148936123	0.705	NM_018178	GOLPH3L	golgi phosphoprotein 3-like
chr2_-_210744158	0.705	NM_152519	C2orf67	chromosome 2 open reading frame 67
chr2_-_120697441	0.705		TMEM185B	transmembrane protein 185B (pseudogene)
chr11_+_126378507	0.699		NCRNA00288	non-protein coding RNA 288
chr16_+_29726195	0.699		MAZ	MYC-associated zinc finger protein (purine-binding transcription factor)
chrX_+_95826317	0.696	NM_006729 NM_007309	DIAPH2	diaphanous homolog 2 (Drosophila)
chr17_+_77478858	0.696		LOC92659	hypothetical LOC92659
chr11_+_9362775	0.689		IPO7	importin 7
chr16_+_23597692	0.677	NM_005030	PLK1	polo-like kinase 1
chr16_-_71549149	0.673		ZFHX3	zinc finger homeobox 3
chr17_-_54538898	0.673		TRIM37	tripartite motif containing 37
chr17_-_54538816	0.668		TRIM37	tripartite motif containing 37
chr10_+_101078784	0.665	NM_020348	CNNM1	cyclin M1
chr20_+_30410447	0.665		ASXL1	additional sex combs like 1 (Drosophila)
chr9_+_132874324	0.662	NM_006059	LAMC3	laminin, gamma 3
chr17_-_39556483	0.661		HDAC5	histone deacetylase 5
chr12_+_14409875	0.660	NM_018179	ATF7IP	activating transcription factor 7 interacting protein
chr3_+_106568334	0.650	NM_001627	ALCAM	activated leukocyte cell adhesion molecule
chr2_+_203811903	0.648		CYP20A1	cytochrome P450, family 20, subfamily A, polypeptide 1
chr14_-_23752476	0.648		CHMP4A	chromatin modifying protein 4A
chr1_-_151775119	0.647		S100A6	S100 calcium binding protein A6
chr17_-_36469869	0.646	NM_001165252	LOC730755	keratin associated protein 2-4-like
chr14_+_77336172	0.645	NM_001142545 NM_020421	ADCK1	aarF domain containing kinase 1
chr17_-_39556535	0.635	NM_001015053 NM_005474	HDAC5	histone deacetylase 5
chr2_-_172572993	0.634
chr3_-_69064364	0.633	NM_001005527 NM_182522	FAM19A4	family with sequence similarity 19 (chemokine (C-C motif)-like), member A4
chr6_+_32230172	0.633		PPT2	palmitoyl-protein thioesterase 2
chr9_+_70926009	0.632	NM_001170414	TJP2	tight junction protein 2 (zona occludens 2)
chr17_+_24944605	0.631	NM_152345	ANKRD13B	ankyrin repeat domain 13B
chr16_+_28893525	0.630	NM_001142448 NM_001142449 NM_001142450 NM_001142451 NM_032038	SPIN1 SPNS1	spindlin 1 spinster homolog 1 (Drosophila)
chr2_-_200424140	0.628		LOC348751	hypothetical LOC348751
chr15_-_71712605	0.625		NPTN	neuroplastin
chr16_-_15644465	0.623	NM_001184998 NM_001184999 NM_014647	KIAA0430	KIAA0430
chr11_+_6237541	0.623	NM_176875	CCKBR	cholecystokinin B receptor
chr14_-_34253473	0.613	NM_138638	CFL2	cofilin 2 (muscle)
chr16_-_28411123	0.612	NM_001042432	CLN3	ceroid-lipofuscinosis, neuronal 3
chr7_+_16652282	0.611	NM_001159767 NM_014038	BZW2	basic leucine zipper and W2 domains 2
chr11_+_111294810	0.609	NM_080659	C11orf52	chromosome 11 open reading frame 52
chr1_-_153195219	0.609		PBXIP1	pre-B-cell leukemia homeobox interacting protein 1
chr2_+_85683473	0.608		USP39	ubiquitin specific peptidase 39
chr6_+_122762449	0.608		HSF2	heat shock transcription factor 2
chr2_+_176665694	0.606	NM_000523	HOXD13	homeobox D13
chr19_+_54149963	0.603		BAX	BCL2-associated X protein
chr4_+_153676857	0.600		DKFZP434I0714	hypothetical protein DKFZP434I0714
chr20_+_46971618	0.595	NM_006420	ARFGEF2	ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
chr9_+_70926205	0.594		TJP2	tight junction protein 2 (zona occludens 2)
chr2_+_172573049	0.594	NM_199227	METAP1D	methionyl aminopeptidase type 1D (mitochondrial)
chr2_-_110230642	0.592		MALL	mal, T-cell differentiation protein-like
chr16_+_68542126	0.589	NM_001136214	CLEC18A	C-type lectin domain family 18, member A
chr16_+_29726962	0.588		MAZ	MYC-associated zinc finger protein (purine-binding transcription factor)
chr11_-_18300246	0.581	NM_007216 NM_181507 NM_181508	HPS5	Hermansky-Pudlak syndrome 5
chr4_-_84475328	0.577	NM_001166498 NM_006665	HPSE	heparanase
chr15_+_94676691	0.575	NM_001145156	NR2F2	nuclear receptor subfamily 2, group F, member 2
chr8_+_22281118	0.572		SLC39A14	solute carrier family 39 (zinc transporter), member 14
chr14_+_23700261	0.570	NM_006084	IRF9	interferon regulatory factor 9
chr12_-_12394402	0.569	NM_018050	MANSC1	MANSC domain containing 1
chr2_-_241903787	0.567		HDLBP	high density lipoprotein binding protein
chr17_+_4434582	0.561	NM_001114974	SMTNL2	smoothelin-like 2
chr15_+_60146467	0.561	NM_207322	C2CD4A	C2 calcium-dependent domain containing 4A
chr19_-_53914768	0.560	NM_001130915	MAMSTR	MEF2 activating motif and SAP domain containing transcriptional regulator
chr17_+_77110011	0.559	NM_001077182 NM_012418	FSCN2	fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)
chr13_+_27392136	0.559	NM_000209	PDX1	pancreatic and duodenal homeobox 1
chr16_+_23597661	0.557		PLK1	polo-like kinase 1
chr4_-_15694407	0.557		PROM1	prominin 1
chr2_-_133144094	0.556		LYPD1	LY6/PLAUR domain containing 1
chr12_-_40918417	0.554	NM_001190979 NM_001190980 NM_005748	YAF2	YY1 associated factor 2
chr17_-_54538896	0.549		TRIM37	tripartite motif containing 37
chr11_-_16992524	0.549	NM_175058	PLEKHA7	pleckstrin homology domain containing, family A member 7
chr12_+_51932252	0.548		MFSD5	major facilitator superfamily domain containing 5
chr2_-_241903657	0.548		HDLBP	high density lipoprotein binding protein
chr16_+_2510323	0.544	NM_001145815 NM_015944	AMDHD2	amidohydrolase domain containing 2
chr8_+_22280942	0.544	NM_001135153	SLC39A14	solute carrier family 39 (zinc transporter), member 14
chr16_-_8870343	0.543	NM_014316	CARHSP1	calcium regulated heat stable protein 1, 24kDa
chr5_+_173405343	0.543		HMP19	HMP19 protein
chr16_+_83618804	0.542	NM_014732	KIAA0513	KIAA0513
chr6_+_36670113	0.541		SRSF3	serine/arginine-rich splicing factor 3
chr12_-_40918249	0.540	NM_001190977	YAF2	YY1 associated factor 2
chr2_-_110230822	0.539		MALL	mal, T-cell differentiation protein-like
chr9_-_109290528	0.538		KLF4	Kruppel-like factor 4 (gut)
chr3_+_160002571	0.535		MFSD1	major facilitator superfamily domain containing 1
chr2_-_110230927	0.534		MALL	mal, T-cell differentiation protein-like
chr6_+_127629677	0.533	NM_030963	RNF146	ring finger protein 146
chr5_+_149320480	0.531	NM_000112	SLC26A2	solute carrier family 26 (sulfate transporter), member 2
chr17_+_7416780	0.530	NM_001416	EIF4A1	eukaryotic translation initiation factor 4A1
chr1_-_151775221	0.528	NM_014624	S100A6	S100 calcium binding protein A6
chr17_-_54538956	0.527	NM_001005207 NM_015294	TRIM37	tripartite motif containing 37
chr19_+_45799060	0.527	NM_001042545	LTBP4	latent transforming growth factor beta binding protein 4
chr6_-_46566969	0.527		RCAN2	regulator of calcineurin 2
chr16_+_23597713	0.525		PLK1	polo-like kinase 1
chr22_+_40093245	0.525	NM_001145398	TEF	thyrotrophic embryonic factor
chr21_-_36774257	0.525	NM_001146079 NM_144492	CLDN14	claudin 14
chr2_-_110231431	0.524	NM_005434	MALL	mal, T-cell differentiation protein-like
chr17_+_58915909	0.523	NM_001178057 NM_152830	ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
chr8_+_85258007	0.521	NM_001100392 NM_001100393	RALYL	RALY RNA binding protein-like
chr17_-_68769613	0.520	NM_001129885	CPSF4L	cleavage and polyadenylation specific factor 4-like
chr14_-_80757018	0.519	NM_015859	GTF2A1	general transcription factor IIA, 1, 19/37kDa
chr6_+_143423656	0.519	NM_016108	AIG1	androgen-induced 1
chr6_+_143423723	0.518		AIG1	androgen-induced 1
chr8_+_123863075	0.517	NM_014943	ZHX2	zinc fingers and homeoboxes 2
chr14_-_38971049	0.516		FBXO33	F-box protein 33
chr1_-_152797820	0.516		UBE2Q1	ubiquitin-conjugating enzyme E2Q family member 1
chr6_+_36670117	0.514		SRSF3	serine/arginine-rich splicing factor 3
chr19_-_15252261	0.512	NM_014299 NM_058243	BRD4	bromodomain containing 4
chr17_-_33043514	0.511	NM_001163544 NM_001163545 NM_001163546 NM_001163547 NM_007247 NM_080550 NM_198882	SYNRG	synergin, gamma
chr4_-_158111504	0.511		PDGFC	platelet derived growth factor C
chr10_-_82039158	0.507	NM_000429	MAT1A	methionine adenosyltransferase I, alpha
chr14_+_23575460	0.506	NM_001082488	DHRS4L1	dehydrogenase/reductase (SDR family) member 4 like 1
chr2_-_236741352	0.504	NM_001485	GBX2	gastrulation brain homeobox 2
chr12_-_47749996	0.500	NM_144593	RHEBL1	Ras homolog enriched in brain like 1
chr11_-_118477739	0.499		DPAGT1	dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
chr18_+_54958095	0.498	NM_033280	SEC11C	SEC11 homolog C (S. cerevisiae)
chr6_+_37333484	0.494	NM_017772	TBC1D22B	TBC1 domain family, member 22B
chr2_-_210743622	0.493		C2orf67	chromosome 2 open reading frame 67
chr19_-_3551576	0.491		TBXA2R	thromboxane A2 receptor
chr9_+_696744	0.491	NM_153186	KANK1	KN motif and ankyrin repeat domains 1
chr4_+_15089931	0.491		CC2D2A	coiled-coil and C2 domain containing 2A
chr19_-_1556464	0.489	NM_006830	UQCR11	ubiquinol-cytochrome c reductase, complex III subunit XI
chr3_-_102878301	0.487	NM_014415	ZBTB11	zinc finger and BTB domain containing 11
chr16_+_67236730	0.487		CDH3	cadherin 3, type 1, P-cadherin (placental)
chr8_+_32525269	0.486	NM_001160002 NM_001160004 NM_001160005 NM_001160007 NM_001160008 NM_004495 NM_013956 NM_013957 NM_013958 NM_013960 NM_013964	NRG1	neuregulin 1
chr16_+_2016807	0.486	NM_001130012 NM_004785	SLC9A3R2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.11	7.57e-13	GO:0009987	cellular process
1.15	6.89e-06	GO:0044237	cellular metabolic process
1.13	2.92e-05	GO:0008152	metabolic process
1.13	9.30e-05	GO:0044238	primary metabolic process
1.17	2.64e-04	GO:0044260	cellular macromolecule metabolic process
1.15	9.47e-04	GO:0043170	macromolecule metabolic process
1.18	2.04e-03	GO:0007275	multicellular organismal development
1.17	2.70e-03	GO:0032502	developmental process
1.19	3.85e-03	GO:0048856	anatomical structure development
1.36	6.19e-03	GO:0042127	regulation of cell proliferation
1.24	7.46e-03	GO:0030154	cell differentiation
1.23	9.46e-03	GO:0048869	cellular developmental process
1.17	9.78e-03	GO:0051179	localization
1.90	2.29e-02	GO:0034330	cell junction organization
1.17	3.06e-02	GO:0006807	nitrogen compound metabolic process
1.18	4.06e-02	GO:0048731	system development
1.17	4.81e-02	GO:0034641	cellular nitrogen compound metabolic process

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.09	2.66e-09	GO:0044424	intracellular part
1.09	2.82e-09	GO:0005622	intracellular
1.13	6.80e-09	GO:0005737	cytoplasm
1.10	1.70e-08	GO:0043226	organelle
1.10	1.84e-08	GO:0043229	intracellular organelle
1.17	7.45e-08	GO:0044422	organelle part
1.16	1.52e-07	GO:0044446	intracellular organelle part
1.28	3.66e-07	GO:0031974	membrane-enclosed lumen
1.27	1.69e-06	GO:0043233	organelle lumen
1.10	1.98e-06	GO:0043227	membrane-bounded organelle
1.10	2.21e-06	GO:0043231	intracellular membrane-bounded organelle
1.14	2.26e-06	GO:0044444	cytoplasmic part
1.27	3.38e-06	GO:0070013	intracellular organelle lumen
1.27	8.65e-05	GO:0031981	nuclear lumen
1.29	1.25e-03	GO:0005654	nucleoplasm
1.22	1.26e-03	GO:0044428	nuclear part
1.23	1.50e-03	GO:0005829	cytosol
1.66	3.37e-02	GO:0005911	cell-cell junction
1.10	3.71e-02	GO:0005634	nucleus

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.17	1.19e-12	GO:0005515	protein binding
1.07	1.13e-06	GO:0005488	binding