Motif ID: GTF2I.p2

Z-value: 1.676


Transcription factors associated with GTF2I.p2:

Gene SymbolEntrez IDGene Name
GTF2I 2969 general transcription factor II, i



Activity profile for motif GTF2I.p2.

activity profile for motif GTF2I.p2


Sorted Z-values histogram for motif GTF2I.p2

Sorted Z-values for motif GTF2I.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GTF2I.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_113606322 3.495 NM_005996
NM_016569
 TBX3

T-box 3

chrX_+_152413540 3.281 NM_001711
 BGN
biglycan
chrX_+_152413646 2.987 BGN
biglycan
chr9_+_108665168 2.826 NM_021224
 ZNF462
zinc finger protein 462
chr1_-_29322993 2.360 NM_001003682
 TMEM200B
transmembrane protein 200B
chr17_+_19255083 2.192 NM_007148
 RNF112
ring finger protein 112
chr11_+_12355600 2.167 NM_018222
 PARVA
parvin, alpha
chr11_+_124539768 2.072 NM_022062
 PKNOX2
PBX/knotted 1 homeobox 2
chr8_-_93184629 2.033 NM_001198633
NM_175634
 RUNX1T1

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

chr2_-_148494732 2.029 NM_001190882
NM_001190879
NM_002552
NM_001190881
NM_181741
 ORC4




origin recognition complex, subunit 4




chr11_+_124539814 1.977 PKNOX2
PBX/knotted 1 homeobox 2
chr6_+_33495824 1.926 NM_006772
 SYNGAP1
synaptic Ras GTPase activating protein 1
chr2_-_19421852 1.915 NM_145260
 OSR1
odd-skipped related 1 (Drosophila)
chr2_-_61551403 1.882 USP34
ubiquitin specific peptidase 34
chr21_-_27139563 1.853 NM_006988
 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr1_-_68470585 1.814 NM_001002292
NM_001193334
NM_024911
 WLS


wntless homolog (Drosophila)


chr1_+_202308814 1.810 NM_005686
 SOX13
SRY (sex determining region Y)-box 13
chr1_+_2975590 1.727 NM_022114
NM_199454
 PRDM16

PR domain containing 16

chr18_-_21184824 1.719


chr16_+_56219802 1.718 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
 GPR56




G protein-coupled receptor 56





Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 197 entries
enrichment   p-value GO term description
2.90 6.21e-03 GO:0048008 platelet-derived growth factor receptor signaling pathway
2.38 1.98e-02 GO:0061035 regulation of cartilage development
2.32 8.39e-03 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
2.16 3.74e-02 GO:0060349 bone morphogenesis
2.13 4.19e-04 GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
2.06 9.54e-03 GO:0060348 bone development
2.01 3.64e-04 GO:0022612 gland morphogenesis
1.93 4.06e-02 GO:0048634 regulation of muscle organ development
1.90 8.42e-03 GO:2000027 regulation of organ morphogenesis
1.77 6.79e-04 GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
1.69 2.11e-09 GO:0001944 vasculature development
1.68 4.24e-08 GO:0001568 blood vessel development
1.63 4.35e-05 GO:0048514 blood vessel morphogenesis
1.61 4.19e-06 GO:0045596 negative regulation of cell differentiation
1.60 2.62e-04 GO:0043193 positive regulation of gene-specific transcription
1.59 2.02e-11 GO:0072358 cardiovascular system development
1.59 2.02e-11 GO:0072359 circulatory system development
1.59 4.34e-07 GO:0060284 regulation of cell development
1.59 1.04e-02 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter
1.59 1.04e-02 GO:0051272 positive regulation of cellular component movement

Gene overrepresentation in compartment category:

Showing 1 to 20 of 33 entries
enrichment   p-value GO term description
1.79 3.70e-04 GO:0005925 focal adhesion
1.74 7.67e-04 GO:0030055 cell-substrate junction
1.71 2.79e-03 GO:0005924 cell-substrate adherens junction
1.66 2.10e-04 GO:0005912 adherens junction
1.59 6.21e-04 GO:0070161 anchoring junction
1.54 1.81e-03 GO:0031252 cell leading edge
1.54 3.59e-03 GO:0043025 neuronal cell body
1.53 1.59e-03 GO:0030425 dendrite
1.51 6.80e-03 GO:0044297 cell body
1.45 5.97e-03 GO:0016323 basolateral plasma membrane
1.43 2.64e-05 GO:0043005 neuron projection
1.40 1.82e-07 GO:0030054 cell junction
1.37 1.31e-03 GO:0045202 synapse
1.36 5.23e-03 GO:0031012 extracellular matrix
1.36 4.53e-02 GO:0015629 actin cytoskeleton
1.31 3.90e-06 GO:0042995 cell projection
1.26 4.80e-03 GO:0044451 nucleoplasm part
1.25 4.54e-02 GO:0044431 Golgi apparatus part
1.23 3.97e-09 GO:0005829 cytosol
1.21 6.20e-04 GO:0005654 nucleoplasm

Gene overrepresentation in function category:

Showing 1 to 20 of 26 entries
enrichment   p-value GO term description
1.64 7.92e-04 GO:0003714 transcription corepressor activity
1.61 3.15e-05 GO:0000975 regulatory region DNA binding
1.61 3.15e-05 GO:0001067 regulatory region nucleic acid binding
1.61 3.15e-05 GO:0044212 transcription regulatory region DNA binding
1.61 6.32e-05 GO:0010843 promoter binding
1.50 2.03e-05 GO:0016563 transcription activator activity
1.47 6.27e-12 GO:0043565 sequence-specific DNA binding
1.47 3.05e-04 GO:0008134 transcription factor binding
1.42 1.80e-05 GO:0019904 protein domain specific binding
1.42 2.53e-04 GO:0000988 protein binding transcription factor activity
1.42 2.53e-04 GO:0000989 transcription factor binding transcription factor activity
1.41 3.63e-04 GO:0003712 transcription cofactor activity
1.39 3.50e-12 GO:0030528 transcription regulator activity
1.37 7.01e-11 GO:0001071 nucleic acid binding transcription factor activity
1.37 7.01e-11 GO:0003700 sequence-specific DNA binding transcription factor activity
1.36 2.67e-02 GO:0003779 actin binding
1.29 2.47e-04 GO:0019899 enzyme binding
1.29 2.04e-02 GO:0008092 cytoskeletal protein binding
1.28 1.19e-02 GO:0004672 protein kinase activity
1.27 9.51e-03 GO:0046983 protein dimerization activity