Motif ID: GTF2I.p2

Z-value: 1.676


Transcription factors associated with GTF2I.p2:

Gene SymbolEntrez IDGene Name
GTF2I 2969 general transcription factor II, i



Activity profile for motif GTF2I.p2.

activity profile for motif GTF2I.p2


Sorted Z-values histogram for motif GTF2I.p2

Sorted Z-values for motif GTF2I.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GTF2I.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_113606322 3.495 NM_005996
NM_016569
TBX3

T-box 3

chrX_+_152413540 3.281 NM_001711
BGN
biglycan
chrX_+_152413646 2.987 BGN
biglycan
chr9_+_108665168 2.826 NM_021224
ZNF462
zinc finger protein 462
chr1_-_29322993 2.360 NM_001003682
TMEM200B
transmembrane protein 200B
chr17_+_19255083 2.192 NM_007148
RNF112
ring finger protein 112
chr11_+_12355600 2.167 NM_018222
PARVA
parvin, alpha
chr11_+_124539768 2.072 NM_022062
PKNOX2
PBX/knotted 1 homeobox 2
chr8_-_93184629 2.033 NM_001198633
NM_175634
RUNX1T1

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

chr2_-_148494732 2.029 NM_001190882
NM_001190879
NM_002552
NM_001190881
NM_181741
ORC4




origin recognition complex, subunit 4




chr11_+_124539814 1.977 PKNOX2
PBX/knotted 1 homeobox 2
chr6_+_33495824 1.926 NM_006772
SYNGAP1
synaptic Ras GTPase activating protein 1
chr2_-_19421852 1.915 NM_145260
OSR1
odd-skipped related 1 (Drosophila)
chr2_-_61551403 1.882 USP34
ubiquitin specific peptidase 34
chr21_-_27139563 1.853 NM_006988
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr1_-_68470585 1.814 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr1_+_202308814 1.810 NM_005686
SOX13
SRY (sex determining region Y)-box 13
chr1_+_2975590 1.727 NM_022114
NM_199454
PRDM16

PR domain containing 16

chr18_-_21184824 1.719


chr16_+_56219802 1.718 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr7_-_100262971 1.667 NM_004444
EPHB4
EPH receptor B4
chr9_+_33807213 1.645 UBE2R2
ubiquitin-conjugating enzyme E2R 2
chr9_+_33807168 1.642 NM_017811
UBE2R2
ubiquitin-conjugating enzyme E2R 2
chr16_-_30841938 1.576 NCRNA00095
non-protein coding RNA 95
chr2_-_144994038 1.571 ZEB2
zinc finger E-box binding homeobox 2
chr1_-_20685314 1.570 NM_018584
CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr1_-_202595666 1.564 NM_014935
PLEKHA6
pleckstrin homology domain containing, family A member 6
chr17_-_34603577 1.547 CACNB1
calcium channel, voltage-dependent, beta 1 subunit
chr1_+_168898898 1.529 PRRX1
paired related homeobox 1
chr5_+_148766632 1.526 LOC728264
hypothetical LOC728264
chr16_-_63713485 1.474 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr21_-_27139143 1.445 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr5_-_10360873 1.431 CMBL
carboxymethylenebutenolidase homolog (Pseudomonas)
chr11_-_27697768 1.398 NM_001143807
BDNF
brain-derived neurotrophic factor
chr4_-_158111995 1.396 NM_016205
PDGFC
platelet derived growth factor C
chr22_-_34754343 1.394 NM_001082578
NM_001082579
RBFOX2

RNA binding protein, fox-1 homolog (C. elegans) 2

chr4_-_158111916 1.363 PDGFC
platelet derived growth factor C
chr2_+_148495043 1.338 NM_018328
MBD5
methyl-CpG binding domain protein 5
chr1_+_201711505 1.334 NM_002725
NM_201348
PRELP

proline/arginine-rich end leucine-rich repeat protein

chr2_-_144994349 1.328 NM_001171653
NM_014795
ZEB2

zinc finger E-box binding homeobox 2

chr2_+_188864975 1.328 GULP1
GULP, engulfment adaptor PTB domain containing 1
chr11_+_47236072 1.296 NM_001130101
NM_005693
NR1H3

nuclear receptor subfamily 1, group H, member 3

chr19_+_59077241 1.267 NM_002739
PRKCG
protein kinase C, gamma
chr16_-_71650034 1.255 NM_001164766
ZFHX3
zinc finger homeobox 3
chr16_-_63713466 1.237 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr10_-_105410840 1.225


chr22_+_44277354 1.204 NM_001996
NM_006485
NM_006486
NM_006487
FBLN1



fibulin 1



chr2_+_85213884 1.188 NM_031283
TCF7L1
transcription factor 7-like 1 (T-cell specific, HMG-box)
chr20_+_42807901 1.188 NM_022358
KCNK15
potassium channel, subfamily K, member 15
chr18_+_44319365 1.184 NM_001142397
NM_014772
CTIF

CBP80/20-dependent translation initiation factor

chr4_-_16509126 1.177 LDB2
LIM domain binding 2
chr2_+_27154938 1.170 NM_007046
EMILIN1
elastin microfibril interfacer 1
chr16_-_29817841 1.170 NM_001114099
NM_001114100
NM_012410
NM_201575
SEZ6L2



seizure related 6 homolog (mouse)-like 2



chr20_-_61755145 1.169 NM_015894
STMN3
stathmin-like 3
chr3_+_37878647 1.161 NM_001008392
NM_005808
CTDSPL

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like

chr1_-_212791597 1.136 NM_005401
PTPN14
protein tyrosine phosphatase, non-receptor type 14
chr12_-_56418295 1.131 NM_001122772
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr16_-_63713382 1.131 NM_001797
CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr19_+_59061422 1.119 NM_001020820
MYADM
myeloid-associated differentiation marker
chr21_-_44583505 1.117 C21orf2
chromosome 21 open reading frame 2
chr12_+_46133 1.114 NM_001170738
IQSEC3
IQ motif and Sec7 domain 3
chr2_+_176665694 1.110 NM_000523
HOXD13
homeobox D13
chr10_+_88506320 1.096 NM_004329
BMPR1A
bone morphogenetic protein receptor, type IA
chr9_-_16860719 1.090 NM_017637
BNC2
basonuclin 2
chr1_-_20684858 1.090 CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr19_-_44032449 1.086 NM_001533
HNRNPL
heterogeneous nuclear ribonucleoprotein L
chr3_+_152287365 1.084 NM_053002
MED12L
mediator complex subunit 12-like
chr5_-_32480174 1.083


chr4_-_177950658 1.083 NM_005429
VEGFC
vascular endothelial growth factor C
chr4_-_16509446 1.076 NM_001130834
NM_001290
LDB2

LIM domain binding 2

chr14_-_53491019 1.075 NM_130851
BMP4
bone morphogenetic protein 4
chr22_-_34566367 1.071 NM_001031695
NM_001082576
NM_001082577
NM_014309
RBFOX2



RNA binding protein, fox-1 homolog (C. elegans) 2



chr6_+_34590624 1.065 PACSIN1
protein kinase C and casein kinase substrate in neurons 1
chr16_-_10581944 1.064 NM_001424
EMP2
epithelial membrane protein 2
chr16_-_31390926 1.055


chr11_-_129803515 1.051 ADAMTS8
ADAM metallopeptidase with thrombospondin type 1 motif, 8
chr12_-_46499834 1.048 NM_001098416
NM_015401
HDAC7

histone deacetylase 7

chr4_-_16509354 1.040 LDB2
LIM domain binding 2
chr16_+_29726962 1.038 MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
chr20_+_60906605 1.026 NM_007346
OGFR
opioid growth factor receptor
chr1_+_201711578 1.025 PRELP
proline/arginine-rich end leucine-rich repeat protein
chr9_+_117955890 1.020 NM_002581
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr15_-_77085056 1.016 NM_153815
RASGRF1
Ras protein-specific guanine nucleotide-releasing factor 1
chr19_+_60691733 1.016 SSC5D
scavenger receptor cysteine rich domain containing (5 domains)
chr6_+_45498354 1.015 RUNX2
runt-related transcription factor 2
chr10_-_33663777 1.015 NM_001024628
NM_001024629
NM_003873
NRP1


neuropilin 1


chr7_+_73080362 1.015 NM_000501
NM_001081752
NM_001081753
NM_001081754
NM_001081755
ELN




elastin




chr17_+_58058774 1.014 MRC2
mannose receptor, C type 2
chr2_+_188864898 1.013 GULP1
GULP, engulfment adaptor PTB domain containing 1
chr1_-_212791467 1.010 PTPN14
protein tyrosine phosphatase, non-receptor type 14
chr12_+_54361596 1.004 NM_152637
METTL7B
methyltransferase like 7B
chr11_+_17714070 1.004 NM_001112741
NM_004976
KCNC1

potassium voltage-gated channel, Shaw-related subfamily, member 1

chr7_+_30917939 0.995 NM_198098
AQP1
aquaporin 1 (Colton blood group)
chr19_+_50446345 0.995 MARK4
MAP/microtubule affinity-regulating kinase 4
chr3_-_193609531 0.981 NM_021032
FGF12
fibroblast growth factor 12
chr11_-_65082705 0.980 LTBP3
latent transforming growth factor beta binding protein 3
chr14_+_22375656 0.974 MMP14
matrix metallopeptidase 14 (membrane-inserted)
chr2_-_207738858 0.973 NM_003709
KLF7
Kruppel-like factor 7 (ubiquitous)
chr12_+_6363482 0.971 NM_002342
LTBR
lymphotoxin beta receptor (TNFR superfamily, member 3)
chr4_+_184257337 0.970 NM_024949
WWC2
WW and C2 domain containing 2
chr4_-_102487649 0.969 NM_000944
NM_001130691
NM_001130692
PPP3CA


protein phosphatase 3, catalytic subunit, alpha isozyme


chr14_+_22375747 0.962 MMP14
matrix metallopeptidase 14 (membrane-inserted)
chr14_+_22375753 0.957 MMP14
matrix metallopeptidase 14 (membrane-inserted)
chr17_+_4560529 0.952 NM_004313
NM_199004
ARRB2

arrestin, beta 2

chr2_+_100802923 0.946 NM_002518
NPAS2
neuronal PAS domain protein 2
chr2_-_192767494 0.940 TMEFF2
transmembrane protein with EGF-like and two follistatin-like domains 2
chr1_+_156229686 0.940 NM_018240
KIRREL
kin of IRRE like (Drosophila)
chr2_+_188864640 0.938 GULP1
GULP, engulfment adaptor PTB domain containing 1
chr14_+_23907065 0.935 NM_001198965
NM_004554
NFATC4

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4

chr14_+_22375632 0.933 NM_004995
MMP14
matrix metallopeptidase 14 (membrane-inserted)
chr1_+_156229934 0.921 KIRREL
kin of IRRE like (Drosophila)
chr15_+_41597097 0.916 NM_002373
MAP1A
microtubule-associated protein 1A
chr10_+_20145350 0.915 NM_032812
PLXDC2
plexin domain containing 2
chr1_-_72521079 0.915


chr16_+_66244314 0.908 RLTPR
RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
chr6_-_30763057 0.899 NM_001134870
KIAA1949
KIAA1949
chr10_-_105604942 0.898 NM_014631
SH3PXD2A
SH3 and PX domains 2A
chr3_+_113061330 0.893 PHLDB2
pleckstrin homology-like domain, family B, member 2
chr2_-_158440587 0.889 NM_001111067
ACVR1
activin A receptor, type I
chr19_-_60740246 0.889 NM_001101401
SBK2
SH3-binding domain kinase family, member 2
chr9_-_34579679 0.888 NM_001842
NM_147164
CNTFR

ciliary neurotrophic factor receptor

chr2_-_218551786 0.873 TNS1
tensin 1
chr2_+_188864848 0.865 GULP1
GULP, engulfment adaptor PTB domain containing 1
chr13_+_92677012 0.864 NM_005708
GPC6
glypican 6
chr6_-_46566969 0.864 RCAN2
regulator of calcineurin 2
chr2_+_232281470 0.862 NM_001099285
NM_002823
PTMA

prothymosin, alpha

chr5_+_172193826 0.859 NM_001031711
ERGIC1
endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1
chr6_-_75972473 0.854 COL12A1
collagen, type XII, alpha 1
chr17_-_34811377 0.853 NM_001184906
NM_032875
FBXL20

F-box and leucine-rich repeat protein 20

chr7_+_105304445 0.851 LOC100506768
CDHR3
hypothetical LOC100506768
cadherin-related family member 3
chr12_+_52060689 0.851 NM_003109
SP1
Sp1 transcription factor
chr4_-_158111504 0.850 PDGFC
platelet derived growth factor C
chr5_+_135392482 0.850 NM_000358
TGFBI
transforming growth factor, beta-induced, 68kDa
chr4_-_83513648 0.846 HNRNPD
heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
chr2_-_165406564 0.846 COBLL1
COBL-like 1
chr14_+_32478209 0.845 NM_001164749
NM_001165893
NM_022123
NM_173159
NPAS3



neuronal PAS domain protein 3



chr1_-_72520735 0.842 NM_173808
NEGR1
neuronal growth regulator 1
chr12_+_56406296 0.841 LOC100130776
hypothetical LOC100130776
chr15_+_42506870 0.839 NM_016396
CTDSPL2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr10_-_126839546 0.834 NM_001083914
CTBP2
C-terminal binding protein 2
chr1_+_162795538 0.831 PBX1
pre-B-cell leukemia homeobox 1
chr8_+_97575317 0.830 SDC2
syndecan 2
chr5_-_178704934 0.826 ADAMTS2
ADAM metallopeptidase with thrombospondin type 1 motif, 2
chr12_+_6800950 0.825 NM_014449
NM_019858
GPR162

G protein-coupled receptor 162

chr8_+_37672427 0.824 NM_025069
ZNF703
zinc finger protein 703
chr17_+_4560680 0.824 ARRB2
arrestin, beta 2
chr3_+_113061296 0.824 PHLDB2
pleckstrin homology-like domain, family B, member 2
chr4_+_145786622 0.823 NM_022475
HHIP
hedgehog interacting protein
chr22_-_34566276 0.818 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr22_+_40093245 0.818 NM_001145398
TEF
thyrotrophic embryonic factor
chr20_+_31613800 0.815 NM_001039709
NM_005093
CBFA2T2

core-binding factor, runt domain, alpha subunit 2; translocated to, 2

chr17_+_58058479 0.812 NM_006039
MRC2
mannose receptor, C type 2
chr14_-_37134191 0.809 NM_004496
FOXA1
forkhead box A1
chr8_+_97575244 0.804 SDC2
syndecan 2
chrX_+_69559605 0.804 NM_001171191
NM_001171192
NM_001171193
NM_017711
GDPD2



glycerophosphodiester phosphodiesterase domain containing 2



chr9_+_129414287 0.799 NM_001032221
NM_003165
STXBP1

syntaxin binding protein 1

chr11_-_6451561 0.799 NM_006458
NM_033278
TRIM3

tripartite motif containing 3

chr12_-_24606616 0.796 NM_152989
SOX5
SRY (sex determining region Y)-box 5
chr19_+_60691671 0.794 NM_001144950
NM_001195267
SSC5D

scavenger receptor cysteine rich domain containing (5 domains)

chr12_+_92295738 0.794 NM_019094
NM_199040
NUDT4

NUDT4P1
nudix (nucleoside diphosphate linked moiety X)-type motif 4

nudix (nucleoside diphosphate linked moiety X)-type motif 4 pseudogene 1
chr19_-_44032415 0.793 HNRNPL
heterogeneous nuclear ribonucleoprotein L
chr22_-_34566210 0.789 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr19_-_44032388 0.782 HNRNPL
heterogeneous nuclear ribonucleoprotein L
chr5_+_175231170 0.774


chr3_+_185580554 0.771 NM_003741
CHRD
chordin
chr2_-_152663454 0.771 NM_001005746
CACNB4
calcium channel, voltage-dependent, beta 4 subunit
chr17_+_56032385 0.769 PPM1D
protein phosphatase, Mg2+/Mn2+ dependent, 1D
chr22_+_47350781 0.767 NM_015381
FAM19A5
family with sequence similarity 19 (chemokine (C-C motif)-like), member A5
chr6_+_45497796 0.764 NM_004348
RUNX2
runt-related transcription factor 2
chr8_+_97575196 0.758 SDC2
syndecan 2
chr8_-_42028634 0.755 NM_001099412
NM_001099413
NM_006766
MYST3


MYST histone acetyltransferase (monocytic leukemia) 3


chr14_-_22891865 0.754 NM_016609
SLC22A17
solute carrier family 22, member 17
chr1_-_212791188 0.754 PTPN14
protein tyrosine phosphatase, non-receptor type 14
chr16_-_29818334 0.754 SEZ6L2
seizure related 6 homolog (mouse)-like 2
chr15_+_45796802 0.754 SEMA6D
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr20_+_13924014 0.753 NM_080676
MACROD2
MACRO domain containing 2
chr22_-_44751671 0.752 NM_058238
WNT7B
wingless-type MMTV integration site family, member 7B
chr10_-_35143900 0.747 NM_001184785
NM_001184786
NM_001184787
NM_001184788
NM_001184789
NM_001184790
NM_001184791
NM_001184792
NM_001184793
NM_001184794
NM_019619
PARD3










par-3 partitioning defective 3 homolog (C. elegans)










chr7_+_33911636 0.747 NM_133468
BMPER
BMP binding endothelial regulator
chr19_-_14447163 0.743 NM_000955
PTGER1
prostaglandin E receptor 1 (subtype EP1), 42kDa
chr11_-_72698050 0.743 LOC100287837
hypothetical protein LOC100287837
chr12_+_54612055 0.741 NM_201444
NM_201445
NM_201554
DGKA


diacylglycerol kinase, alpha 80kDa


chr20_+_29870836 0.741 NM_033118
MYLK2
myosin light chain kinase 2
chr14_-_22891263 0.741 NM_020372
SLC22A17
solute carrier family 22, member 17
chr20_+_13924263 0.741 MACROD2
MACRO domain containing 2
chr4_-_122213018 0.739 NM_024574
C4orf31
chromosome 4 open reading frame 31
chr8_-_97242119 0.738 NM_001001557
GDF6
growth differentiation factor 6
chr3_+_77171938 0.737 NM_002942
ROBO2
roundabout, axon guidance receptor, homolog 2 (Drosophila)
chr3_-_170864111 0.735 NM_004991
MECOM
MDS1 and EVI1 complex locus
chr1_+_208472817 0.734 NM_019605
SERTAD4
SERTA domain containing 4
chr3_+_113061218 0.734 NM_001134439
PHLDB2
pleckstrin homology-like domain, family B, member 2
chr14_+_85069217 0.733


chr12_-_105057940 0.728 NM_014840
NUAK1
NUAK family, SNF1-like kinase, 1
chr9_+_35152092 0.727 UNC13B
unc-13 homolog B (C. elegans)
chr12_-_55316350 0.727 NM_013449
BAZ2A
bromodomain adjacent to zinc finger domain, 2A
chr2_-_75641535 0.726 FAM176A
family with sequence similarity 176, member A
chr4_+_30331289 0.726 PCDH7
protocadherin 7
chr6_+_17390273 0.725 NM_001143941
RBM24
RNA binding motif protein 24
chr20_+_43468617 0.722 NM_001048223
NM_001048224
DBNDD2

dysbindin (dystrobrevin binding protein 1) domain containing 2

chr1_-_225572419 0.722 NM_003607
NM_014826
CDC42BPA

CDC42 binding protein kinase alpha (DMPK-like)


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.18 1.29e-28 GO:0050794 regulation of cellular process
1.17 5.64e-27 GO:0050789 regulation of biological process
1.16 1.40e-26 GO:0065007 biological regulation
1.29 2.30e-21 GO:0048731 system development
1.24 1.28e-19 GO:0032502 developmental process
1.25 1.38e-19 GO:0007275 multicellular organismal development
1.26 3.97e-19 GO:0048856 anatomical structure development
1.40 2.68e-18 GO:0007399 nervous system development
1.09 3.19e-18 GO:0009987 cellular process
1.22 8.30e-17 GO:0023052 signaling
1.28 1.49e-16 GO:0048522 positive regulation of cellular process
1.27 2.57e-16 GO:0048518 positive regulation of biological process
1.30 9.77e-16 GO:0048523 negative regulation of cellular process
1.36 2.39e-15 GO:0009653 anatomical structure morphogenesis
1.28 2.59e-15 GO:0048519 negative regulation of biological process
1.37 3.23e-15 GO:0009966 regulation of signal transduction
1.35 3.24e-15 GO:0023051 regulation of signaling
1.22 2.20e-14 GO:0007165 signal transduction
1.29 6.84e-14 GO:0030154 cell differentiation
1.29 9.63e-14 GO:0048869 cellular developmental process
1.44 8.39e-13 GO:0022008 neurogenesis
1.29 2.33e-12 GO:0048583 regulation of response to stimulus
1.39 1.65e-11 GO:0010646 regulation of cell communication
1.18 1.68e-11 GO:0051716 cellular response to stimulus
1.59 2.02e-11 GO:0072358 cardiovascular system development
1.59 2.02e-11 GO:0072359 circulatory system development
1.40 2.46e-11 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.36 7.59e-11 GO:0010604 positive regulation of macromolecule metabolic process
1.42 9.24e-11 GO:0048699 generation of neurons
1.40 1.15e-10 GO:0050793 regulation of developmental process
1.45 1.38e-09 GO:0045595 regulation of cell differentiation
1.43 1.81e-09 GO:2000026 regulation of multicellular organismal development
1.32 1.99e-09 GO:0051239 regulation of multicellular organismal process
1.69 2.11e-09 GO:0001944 vasculature development
1.33 2.32e-09 GO:0031325 positive regulation of cellular metabolic process
1.45 3.54e-09 GO:0010628 positive regulation of gene expression
1.41 3.59e-09 GO:0051173 positive regulation of nitrogen compound metabolic process
1.32 3.70e-09 GO:0009893 positive regulation of metabolic process
1.41 7.94e-09 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.17 8.86e-09 GO:0080090 regulation of primary metabolic process
1.51 9.93e-09 GO:0000904 cell morphogenesis involved in differentiation
1.18 1.34e-08 GO:0060255 regulation of macromolecule metabolic process
1.46 2.58e-08 GO:0000902 cell morphogenesis
1.17 3.07e-08 GO:0031323 regulation of cellular metabolic process
1.68 4.24e-08 GO:0001568 blood vessel development
1.35 4.78e-08 GO:0032879 regulation of localization
1.44 4.86e-08 GO:0032989 cellular component morphogenesis
1.38 5.53e-08 GO:0051128 regulation of cellular component organization
1.42 6.23e-08 GO:0051254 positive regulation of RNA metabolic process
1.44 6.31e-08 GO:0045893 positive regulation of transcription, DNA-dependent
1.15 1.05e-07 GO:0019222 regulation of metabolic process
1.35 1.07e-07 GO:0048468 cell development
1.23 2.13e-07 GO:0048513 organ development
1.34 2.90e-07 GO:0042127 regulation of cell proliferation
1.16 3.78e-07 GO:0016043 cellular component organization
1.59 4.34e-07 GO:0060284 regulation of cell development
1.36 5.19e-07 GO:0031328 positive regulation of cellular biosynthetic process
1.38 5.43e-07 GO:0010557 positive regulation of macromolecule biosynthetic process
1.47 1.14e-06 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.16 1.23e-06 GO:0071840 cellular component organization or biogenesis
1.40 1.69e-06 GO:0007167 enzyme linked receptor protein signaling pathway
1.12 1.91e-06 GO:0032501 multicellular organismal process
1.34 2.33e-06 GO:0009888 tissue development
1.34 3.01e-06 GO:0009891 positive regulation of biosynthetic process
1.37 3.51e-06 GO:0009790 embryo development
1.61 4.19e-06 GO:0045596 negative regulation of cell differentiation
1.37 4.22e-06 GO:0030182 neuron differentiation
1.12 4.84e-06 GO:0043170 macromolecule metabolic process
1.44 6.90e-06 GO:0031175 neuron projection development
1.46 9.48e-06 GO:0048812 neuron projection morphogenesis
1.43 1.08e-05 GO:0032990 cell part morphogenesis
1.38 1.28e-05 GO:0030030 cell projection organization
1.43 1.49e-05 GO:0048858 cell projection morphogenesis
1.42 1.84e-05 GO:0009967 positive regulation of signal transduction
1.45 1.88e-05 GO:0051094 positive regulation of developmental process
1.41 1.94e-05 GO:0023056 positive regulation of signaling
1.45 2.28e-05 GO:0048667 cell morphogenesis involved in neuron differentiation
1.46 2.45e-05 GO:0009968 negative regulation of signal transduction
1.55 2.51e-05 GO:0051270 regulation of cellular component movement
1.12 2.57e-05 GO:0044260 cellular macromolecule metabolic process
1.40 3.24e-05 GO:0010647 positive regulation of cell communication
1.45 3.80e-05 GO:0007409 axonogenesis
1.44 3.80e-05 GO:0023057 negative regulation of signaling
1.58 3.90e-05 GO:0030334 regulation of cell migration
1.63 4.35e-05 GO:0048514 blood vessel morphogenesis
1.57 4.41e-05 GO:2000145 regulation of cell motility
1.16 4.50e-05 GO:0051171 regulation of nitrogen compound metabolic process
1.31 4.70e-05 GO:0006351 transcription, DNA-dependent
1.44 4.74e-05 GO:0010648 negative regulation of cell communication
1.17 4.86e-05 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.09 5.55e-05 GO:0044238 primary metabolic process
1.38 5.77e-05 GO:0048666 neuron development
1.17 6.62e-05 GO:0010468 regulation of gene expression
1.40 6.66e-05 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.43 7.63e-05 GO:0032583 regulation of gene-specific transcription
1.53 8.14e-05 GO:0040012 regulation of locomotion
1.51 9.60e-05 GO:0001501 skeletal system development
1.16 1.08e-04 GO:0031326 regulation of cellular biosynthetic process
1.17 1.12e-04 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.31 1.20e-04 GO:0048584 positive regulation of response to stimulus
1.27 1.26e-04 GO:0051246 regulation of protein metabolic process
1.27 1.35e-04 GO:0032268 regulation of cellular protein metabolic process
1.49 1.74e-04 GO:0051093 negative regulation of developmental process
1.29 2.53e-04 GO:0008219 cell death
1.60 2.62e-04 GO:0043193 positive regulation of gene-specific transcription
1.45 2.77e-04 GO:0009792 embryo development ending in birth or egg hatching
1.16 2.88e-04 GO:0009889 regulation of biosynthetic process
2.01 3.64e-04 GO:0022612 gland morphogenesis
1.45 3.82e-04 GO:0043009 chordate embryonic development
2.13 4.19e-04 GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
1.29 4.49e-04 GO:0016265 death
1.33 4.78e-04 GO:0042325 regulation of phosphorylation
1.32 5.49e-04 GO:0019220 regulation of phosphate metabolic process
1.32 5.49e-04 GO:0051174 regulation of phosphorus metabolic process
1.15 5.61e-04 GO:0071842 cellular component organization at cellular level
1.28 6.50e-04 GO:0040011 locomotion
1.77 6.79e-04 GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
1.16 6.97e-04 GO:0010556 regulation of macromolecule biosynthetic process
1.34 7.90e-04 GO:0009887 organ morphogenesis
1.19 9.62e-04 GO:0006464 protein modification process
1.35 1.23e-03 GO:0006928 cellular component movement
1.33 1.29e-03 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.40 1.33e-03 GO:0008285 negative regulation of cell proliferation
1.36 1.36e-03 GO:0045892 negative regulation of transcription, DNA-dependent
1.08 1.41e-03 GO:0008152 metabolic process
1.32 1.63e-03 GO:0001932 regulation of protein phosphorylation
1.42 1.73e-03 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.49 1.92e-03 GO:0035295 tube development
1.33 1.93e-03 GO:0042060 wound healing
1.20 2.07e-03 GO:0065009 regulation of molecular function
1.31 2.14e-03 GO:0010558 negative regulation of macromolecule biosynthetic process
1.30 2.37e-03 GO:0009890 negative regulation of biosynthetic process
1.16 2.37e-03 GO:0065008 regulation of biological quality
1.28 2.53e-03 GO:0031399 regulation of protein modification process
1.37 2.57e-03 GO:0048646 anatomical structure formation involved in morphogenesis
1.29 2.77e-03 GO:0051049 regulation of transport
1.32 2.81e-03 GO:0010629 negative regulation of gene expression
1.08 2.85e-03 GO:0044237 cellular metabolic process
1.34 2.88e-03 GO:0051253 negative regulation of RNA metabolic process
1.35 2.91e-03 GO:0007417 central nervous system development
1.30 2.92e-03 GO:0031327 negative regulation of cellular biosynthetic process
1.45 2.95e-03 GO:0022603 regulation of anatomical structure morphogenesis
1.25 3.25e-03 GO:0032774 RNA biosynthetic process
1.14 5.02e-03 GO:0071841 cellular component organization or biogenesis at cellular level
1.56 5.12e-03 GO:0048732 gland development
1.35 5.31e-03 GO:0048585 negative regulation of response to stimulus
1.13 5.48e-03 GO:0019538 protein metabolic process
2.90 6.21e-03 GO:0048008 platelet-derived growth factor receptor signaling pathway
1.53 6.71e-03 GO:0001701 in utero embryonic development
1.15 7.42e-03 GO:0051252 regulation of RNA metabolic process
1.51 7.77e-03 GO:0002009 morphogenesis of an epithelium
2.32 8.39e-03 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
1.90 8.42e-03 GO:2000027 regulation of organ morphogenesis
2.06 9.54e-03 GO:0060348 bone development
1.14 9.82e-03 GO:0044267 cellular protein metabolic process
1.59 1.04e-02 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter
1.59 1.04e-02 GO:0051272 positive regulation of cellular component movement
1.41 1.24e-02 GO:0045597 positive regulation of cell differentiation
1.43 1.28e-02 GO:0048729 tissue morphogenesis
1.15 1.32e-02 GO:0006355 regulation of transcription, DNA-dependent
1.17 1.45e-02 GO:0007166 cell surface receptor linked signaling pathway
1.16 1.50e-02 GO:0043412 macromolecule modification
1.47 1.51e-02 GO:0050767 regulation of neurogenesis
1.39 1.55e-02 GO:0007420 brain development
1.43 1.59e-02 GO:0051130 positive regulation of cellular component organization
1.30 1.74e-02 GO:0009725 response to hormone stimulus
1.16 1.76e-02 GO:0010467 gene expression
1.37 1.78e-02 GO:0007264 small GTPase mediated signal transduction
1.27 1.88e-02 GO:0012501 programmed cell death
1.24 1.97e-02 GO:0010605 negative regulation of macromolecule metabolic process
2.38 1.98e-02 GO:0061035 regulation of cartilage development
1.55 2.03e-02 GO:0030900 forebrain development
1.30 2.15e-02 GO:0050878 regulation of body fluid levels
1.43 2.36e-02 GO:0051960 regulation of nervous system development
1.29 2.36e-02 GO:0051172 negative regulation of nitrogen compound metabolic process
1.58 2.38e-02 GO:0040017 positive regulation of locomotion
1.59 2.49e-02 GO:0030335 positive regulation of cell migration
1.59 2.49e-02 GO:2000147 positive regulation of cell motility
1.34 2.79e-02 GO:0008283 cell proliferation
1.32 2.87e-02 GO:0007599 hemostasis
1.42 2.97e-02 GO:0030029 actin filament-based process
1.37 2.97e-02 GO:0051056 regulation of small GTPase mediated signal transduction
1.29 3.01e-02 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.26 3.03e-02 GO:0007267 cell-cell signaling
1.22 3.07e-02 GO:0006793 phosphorus metabolic process
1.22 3.07e-02 GO:0006796 phosphate metabolic process
1.27 3.38e-02 GO:0009719 response to endogenous stimulus
1.26 3.45e-02 GO:0006915 apoptosis
1.19 3.54e-02 GO:0035556 intracellular signal transduction
1.46 3.67e-02 GO:0007507 heart development
2.16 3.74e-02 GO:0060349 bone morphogenesis
1.36 3.81e-02 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.55 4.04e-02 GO:0001525 angiogenesis
1.93 4.06e-02 GO:0048634 regulation of muscle organ development
1.42 4.25e-02 GO:0061061 muscle structure development
1.22 4.67e-02 GO:0009892 negative regulation of metabolic process
1.58 4.76e-02 GO:0045165 cell fate commitment

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.06 1.09e-09 GO:0044424 intracellular part
1.23 3.97e-09 GO:0005829 cytosol
1.09 5.08e-09 GO:0005737 cytoplasm
1.06 2.70e-08 GO:0005622 intracellular
1.40 1.82e-07 GO:0030054 cell junction
1.31 3.90e-06 GO:0042995 cell projection
1.10 2.31e-05 GO:0005634 nucleus
1.43 2.64e-05 GO:0043005 neuron projection
1.06 1.67e-04 GO:0043226 organelle
1.66 2.10e-04 GO:0005912 adherens junction
1.05 3.43e-04 GO:0043229 intracellular organelle
1.79 3.70e-04 GO:0005925 focal adhesion
1.21 6.20e-04 GO:0005654 nucleoplasm
1.59 6.21e-04 GO:0070161 anchoring junction
1.74 7.67e-04 GO:0030055 cell-substrate junction
1.37 1.31e-03 GO:0045202 synapse
1.06 1.50e-03 GO:0043227 membrane-bounded organelle
1.53 1.59e-03 GO:0030425 dendrite
1.54 1.81e-03 GO:0031252 cell leading edge
1.06 1.83e-03 GO:0043231 intracellular membrane-bounded organelle
1.15 1.98e-03 GO:0044459 plasma membrane part
1.71 2.79e-03 GO:0005924 cell-substrate adherens junction
1.16 3.51e-03 GO:0031981 nuclear lumen
1.54 3.59e-03 GO:0043025 neuronal cell body
1.26 4.80e-03 GO:0044451 nucleoplasm part
1.36 5.23e-03 GO:0031012 extracellular matrix
1.45 5.97e-03 GO:0016323 basolateral plasma membrane
1.51 6.80e-03 GO:0044297 cell body
1.21 8.37e-03 GO:0005794 Golgi apparatus
1.14 9.24e-03 GO:0044428 nuclear part
1.11 1.85e-02 GO:0043234 protein complex
1.36 4.53e-02 GO:0015629 actin cytoskeleton
1.25 4.54e-02 GO:0044431 Golgi apparatus part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.18 4.71e-31 GO:0005515 protein binding
1.07 1.47e-14 GO:0005488 binding
1.39 3.50e-12 GO:0030528 transcription regulator activity
1.47 6.27e-12 GO:0043565 sequence-specific DNA binding
1.37 7.01e-11 GO:0001071 nucleic acid binding transcription factor activity
1.37 7.01e-11 GO:0003700 sequence-specific DNA binding transcription factor activity
1.42 1.80e-05 GO:0019904 protein domain specific binding
1.50 2.03e-05 GO:0016563 transcription activator activity
1.61 3.15e-05 GO:0000975 regulatory region DNA binding
1.61 3.15e-05 GO:0001067 regulatory region nucleic acid binding
1.61 3.15e-05 GO:0044212 transcription regulatory region DNA binding
1.61 6.32e-05 GO:0010843 promoter binding
1.29 2.47e-04 GO:0019899 enzyme binding
1.42 2.53e-04 GO:0000988 protein binding transcription factor activity
1.42 2.53e-04 GO:0000989 transcription factor binding transcription factor activity
1.47 3.05e-04 GO:0008134 transcription factor binding
1.41 3.63e-04 GO:0003712 transcription cofactor activity
1.64 7.92e-04 GO:0003714 transcription corepressor activity
1.27 9.51e-03 GO:0046983 protein dimerization activity
1.28 1.19e-02 GO:0004672 protein kinase activity
1.25 1.91e-02 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.29 2.04e-02 GO:0008092 cytoskeletal protein binding
1.36 2.67e-02 GO:0003779 actin binding
1.23 3.20e-02 GO:0042802 identical protein binding
1.20 3.58e-02 GO:0005102 receptor binding
1.23 4.64e-02 GO:0016301 kinase activity