Motif ID: EN1,2.p2

Z-value: 1.864


Transcription factors associated with EN1,2.p2:

Gene SymbolEntrez IDGene Name
EN1 2019 engrailed homeobox 1
EN2 2020 engrailed homeobox 2



Activity profile for motif EN1,2.p2.

activity profile for motif EN1,2.p2


Sorted Z-values histogram for motif EN1,2.p2

Sorted Z-values for motif EN1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EN1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_+_22845851 3.387 NM_004050
BCL2L2-PABPN1
BCL2L2
BCL2L2-PABPN1 read-through transcript
BCL2-like 2
chr1_+_69998445 3.380 NM_020794
LRRC7
leucine rich repeat containing 7
chr2_-_152299229 2.943 NM_001164507
NM_001164508
NM_004543
NEB


nebulin


chr1_+_169421011 2.836 NM_001460
FMO2
flavin containing monooxygenase 2 (non-functional)
chr9_+_33016482 2.501 DNAJA1
DnaJ (Hsp40) homolog, subfamily A, member 1
chr4_+_71126376 2.355 NM_152997
C4orf7
chromosome 4 open reading frame 7
chr3_-_38810504 2.183 NM_006514
SCN10A
sodium channel, voltage-gated, type X, alpha subunit
chr14_-_105845570 2.128 IGHA1
immunoglobulin heavy constant alpha 1
chr4_+_186587537 2.102 NM_001114357
C4orf47
chromosome 4 open reading frame 47
chr11_-_83706027 2.066 DLG2
discs, large homolog 2 (Drosophila)
chr5_-_135729062 2.037 NM_001167576
NM_001167577
NM_020389
TRPC7


transient receptor potential cation channel, subfamily C, member 7


chr15_-_32416336 1.957 NM_001042497
NM_133647
SLC12A6

solute carrier family 12 (potassium/chloride transporters), member 6

chr12_-_48285526 1.956 NM_032130
FAM186B
family with sequence similarity 186, member B
chr11_+_113155727 1.888 NM_001101389
CLDN25
claudin 25
chr1_-_240679380 1.882 NM_001195811
NM_001195812
PLD5

phospholipase D family, member 5

chr1_+_157526127 1.770 NM_002001
FCER1A
Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
chr4_-_40211324 1.731 RBM47
RNA binding motif protein 47
chr11_-_57947358 1.690 NM_001005566
OR5B2
olfactory receptor, family 5, subfamily B, member 2
chr7_+_106897737 1.684 NM_005295
GPR22
G protein-coupled receptor 22
chr17_+_29670171 1.652 NM_005623
CCL8
chemokine (C-C motif) ligand 8
chr1_-_150328153 1.618 NM_001008536
TCHHL1
trichohyalin-like 1
chr4_+_71235259 1.618 NM_033122
CABS1
calcium-binding protein, spermatid-specific 1
chr5_-_77880731 1.568 LHFPL2
lipoma HMGIC fusion partner-like 2
chr6_-_123999640 1.553 NM_006073
TRDN
triadin
chr7_+_50318801 1.548 IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr11_+_123625632 1.544 NM_001002905
OR8G1
olfactory receptor, family 8, subfamily G, member 1
chr6_-_132980901 1.543 NM_014626
TAAR2
trace amine associated receptor 2
chr17_-_60439764 1.527 GNA13
guanine nucleotide binding protein (G protein), alpha 13
chr2_-_162717159 1.484 NM_002054
GCG
glucagon
chr17_+_43165608 1.450 NM_013351
TBX21
T-box 21
chr14_-_64479198 1.369 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr4_+_110968594 1.367 NM_006583
RRH
retinal pigment epithelium-derived rhodopsin homolog
chr11_+_59979857 1.357 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr12_-_101115677 1.354 NM_002674
PMCH
pro-melanin-concentrating hormone
chr7_+_141054621 1.346 NM_001105558
WEE2
WEE1 homolog 2 (S. pombe)
chr3_-_188935363 1.338 NM_001134738
BCL6
B-cell CLL/lymphoma 6
chr3_-_150422474 1.311 NM_000096
CP
ceruloplasmin (ferroxidase)
chr11_+_55776251 1.302 NM_001004747
OR5T3
olfactory receptor, family 5, subfamily T, member 3
chr11_-_123130435 1.291 NM_001005188
OR6X1
olfactory receptor, family 6, subfamily X, member 1
chr1_+_159032551 1.290 NM_001033667
NM_002348
LY9

lymphocyte antigen 9

chr5_-_64813459 1.284 NM_197941
ADAMTS6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
chr4_-_80466177 1.278 NM_032693
NAA11
N(alpha)-acetyltransferase 11, NatA catalytic subunit
chr11_+_7463175 1.276 NM_198474
OLFML1
olfactomedin-like 1
chr17_-_36928604 1.268 NM_002275
KRT15
keratin 15
chr6_-_29503468 1.250 NM_013937
OR11A1
olfactory receptor, family 11, subfamily A, member 1
chr12_+_63510481 1.239


chr17_-_36594652 1.238 NM_033060
KRTAP4-1
keratin associated protein 4-1
chrX_+_130505630 1.224 NM_001004486
OR13H1
olfactory receptor, family 13, subfamily H, member 1
chr11_+_6762823 1.209 NM_001004489
OR2AG1
olfactory receptor, family 2, subfamily AG, member 1
chr6_+_41411505 1.208 NM_004828
NCR2
natural cytotoxicity triggering receptor 2
chr9_+_106496480 1.167 NM_001004484
OR13D1
olfactory receptor, family 13, subfamily D, member 1
chr6_+_160247962 1.161 NM_002377
MAS1
MAS1 oncogene
chr12_-_51585004 1.153 NM_002273
KRT8
keratin 8
chr11_+_54891935 1.144 NM_001005275
OR4A15
olfactory receptor, family 4, subfamily A, member 15
chrX_+_50670474 1.140 NM_005448
BMP15
bone morphogenetic protein 15
chr10_+_5228756 1.133 NM_001818
AKR1C4
aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
chr12_+_54316910 1.131 NM_206899
OR10P1
olfactory receptor, family 10, subfamily P, member 1
chr1_+_245720992 1.128 NM_001004698
OR2W5
olfactory receptor, family 2, subfamily W, member 5
chr1_+_246718487 1.123 NM_001004697
OR2T5
olfactory receptor, family 2, subfamily T, member 5
chr10_-_98021144 1.112 NM_001114094
NM_013314
BLNK

B-cell linker

chr2_+_102401580 1.107 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr10_+_95362334 1.089 NM_006204
PDE6C
phosphodiesterase 6C, cGMP-specific, cone, alpha prime
chr10_-_116241572 1.086


chr11_+_6085489 1.071 NM_001005181
OR56B4
olfactory receptor, family 56, subfamily B, member 4
chr13_+_112349358 1.066 NM_207440
C13orf35
chromosome 13 open reading frame 35
chr11_-_55518675 1.064 NM_003697
OR5F1
olfactory receptor, family 5, subfamily F, member 1
chr19_+_46286207 1.063 NM_000766
CYP2A13
cytochrome P450, family 2, subfamily A, polypeptide 13
chr6_-_52060327 1.047 NM_138694
NM_170724
PKHD1

polycystic kidney and hepatic disease 1 (autosomal recessive)

chr5_+_140454382 1.044 NM_018936
PCDHB2
protocadherin beta 2
chr20_+_54420574 1.033 NM_001164116
NM_001164114
NM_001164115
NM_020356
CASS4



Cas scaffolding protein family member 4



chr15_-_78050515 1.025 NM_001114735
NM_004049
BCL2A1

BCL2-related protein A1

chr1_+_159943385 1.012 NM_001184866
NM_001184867
NM_001184870
NM_001184871
NM_001184872
NM_001184873
NM_032738
FCRLA






Fc receptor-like A






chrX_-_7855400 1.007 NM_004650
PNPLA4
patatin-like phospholipase domain containing 4
chrX_+_139619589 1.002 RP1-177G6.2
hypothetical LOC286411
chrX_+_134803450 0.997 NM_018666
SAGE1
sarcoma antigen 1
chr14_-_106149623 0.977


chr2_+_68855436 0.967 NM_001166276
NM_014882
ARHGAP25

Rho GTPase activating protein 25

chr1_-_150353179 0.961 NM_007113
TCHH
trichohyalin
chr1_+_144124547 0.960 NM_145277
NM_202004
NM_213652
NM_213653
HFE2



hemochromatosis type 2 (juvenile)



chr7_+_129693938 0.959 NM_001869
CPA2
carboxypeptidase A2 (pancreatic)
chrX_+_49480643 0.944 NM_007003
PAGE4
P antigen family, member 4 (prostate associated)
chr1_+_227506751 0.942 NM_006542
SPHAR
S-phase response (cyclin related)
chr2_-_158008763 0.934 NM_004288
CYTIP
cytohesin 1 interacting protein
chr15_-_50375143 0.926 NM_018728
MYO5C
myosin VC
chr11_+_123639909 0.923 NM_001005198
OR8G5
olfactory receptor, family 8, subfamily G, member 5
chrX_-_117003310 0.905 NM_001168299
KLHL13
kelch-like 13 (Drosophila)
chr12_-_103846186 0.903 NM_032148
SLC41A2
solute carrier family 41, member 2
chr11_-_6870306 0.899 NM_003700
OR2D2
olfactory receptor, family 2, subfamily D, member 2
chr4_+_78651929 0.886 NM_006419
CXCL13
chemokine (C-X-C motif) ligand 13
chr14_-_23623657 0.874 NM_006177
NRL
neural retina leucine zipper
chr2_+_96355661 0.870 NM_178495
NM_001163524
ITPRIPL1

inositol 1,4,5-triphosphate receptor interacting protein-like 1

chr11_-_57792206 0.856 NM_207374
OR10W1
olfactory receptor, family 10, subfamily W, member 1
chr8_+_128497038 0.852 NM_001159542
POU5F1B
POU class 5 homeobox 1B
chr5_+_140509803 0.851 NM_018939
PCDHB6
protocadherin beta 6
chr11_+_5367182 0.840 NM_001004756
OR51M1
olfactory receptor, family 51, subfamily M, member 1
chr19_+_61624 0.838 NM_001005240
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr10_-_48036698 0.837 NM_016204
GDF2
growth differentiation factor 2
chr14_-_94669547 0.827 NM_001195573
DICER1
dicer 1, ribonuclease type III
chr15_-_40173949 0.824 NM_178034
PLA2G4D
phospholipase A2, group IVD (cytosolic)
chr6_+_30212488 0.823 NM_138700
TRIM40
tripartite motif containing 40
chr12_+_91620749 0.822 NM_001037671
NM_001178097
C12orf74

chromosome 12 open reading frame 74

chr11_-_5037432 0.815 NM_001005164
OR52E2
olfactory receptor, family 52, subfamily E, member 2
chr2_+_191009265 0.813 MFSD6
major facilitator superfamily domain containing 6
chr1_+_86707113 0.806 NM_001285
CLCA1
chloride channel accessory 1
chr16_-_88358946 0.805 FANCA
Fanconi anemia, complementation group A
chrX_+_36163971 0.800 NM_001098843
CXorf30
chromosome X open reading frame 30
chr3_+_46423682 0.778 NM_003965
NM_001130910
CCRL2

chemokine (C-C motif) receptor-like 2

chr14_-_93988838 0.774 NM_001080451
SERPINA11
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11
chr10_-_75127559 0.774 NM_001144000
AGAP5
ArfGAP with GTPase domain, ankyrin repeat and PH domain 5
chr16_+_56567839 0.774 NM_199046
NM_199456
TEPP

testis, prostate and placenta expressed

chr6_-_29431950 0.763 NM_030876
OR5V1
olfactory receptor, family 5, subfamily V, member 1
chr14_+_87541220 0.750 NM_003608
GPR65
G protein-coupled receptor 65
chr4_+_71096830 0.743 NM_017855
ODAM
odontogenic, ameloblast asssociated
chr3_-_46224791 0.733 NM_001295
CCR1
chemokine (C-C motif) receptor 1
chr14_+_22581215 0.733 NM_001099780
PSMB11
proteasome (prosome, macropain) subunit, beta type, 11
chr6_-_41114905 0.731 NM_173561
UNC5CL
unc-5 homolog C (C. elegans)-like
chr2_+_69055208 0.729 NM_019617
GKN1
gastrokine 1
chr1_+_173111306 0.729 NM_001035230
RABGAP1L
RAB GTPase activating protein 1-like
chr14_+_65205750 0.726 NM_178157
FUT8
fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
chr1_-_180822686 0.723 NM_021133
RNASEL
ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
chr11_-_5835507 0.721 NM_001005168
OR52E8
olfactory receptor, family 52, subfamily E, member 8
chrX_+_55666557 0.718 NM_198451
FOXR2
forkhead box R2
chr6_+_6533932 0.717 NM_004271
LY86
lymphocyte antigen 86
chr12_+_49922592 0.717 DAZAP2
DAZ associated protein 2
chr12_+_10054492 0.714 NM_001129998
NM_205852
CLEC12B

C-type lectin domain family 12, member B

chr11_-_125055884 0.714 NM_001612
NM_020069
NM_020107
NM_020108
NM_020109
NM_020110
NM_020111
NM_020113
NM_020115
ACRV1








acrosomal vesicle protein 1








chr1_+_157676135 0.709 NM_012351
OR10J1
olfactory receptor, family 10, subfamily J, member 1
chr21_+_24722913 0.709 FLJ42200
FLJ42200 protein
chr1_-_12830728 0.709 NM_001146181
HNRNPCL1
LOC649330
heterogeneous nuclear ribonucleoprotein C-like 1
heterogeneous nuclear ribonucleoprotein C-like
chr9_+_124072947 0.708 NM_199177
MRRF
mitochondrial ribosome recycling factor
chr9_+_104797413 0.704 NM_001340
CYLC2
cylicin, basic protein of sperm head cytoskeleton 2
chr7_+_139750311 0.696 NM_001008749
RAB19
RAB19, member RAS oncogene family
chr10_+_70152216 0.696 CCAR1
cell division cycle and apoptosis regulator 1
chr6_-_30236667 0.695 NM_006778
NM_052828
TRIM10

tripartite motif containing 10

chr2_-_179367925 0.692 TTN
titin
chr4_-_107508040 0.687 NM_001195138
LOC100507096
GTPase IMAP family member-like
chr17_-_2977594 0.684 NM_003555
OR1G1
olfactory receptor, family 1, subfamily G, member 1
chr6_+_97117144 0.680 NM_001170807
NM_020482
FHL5

four and a half LIM domains 5

chr7_+_116238309 0.678 CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr8_-_107023 0.678 NM_001005504
OR4F21
olfactory receptor, family 4, subfamily F, member 21
chr4_+_157044296 0.677 NM_005651
TDO2
tryptophan 2,3-dioxygenase
chr14_+_77939845 0.676 NM_004796
NRXN3
neurexin 3
chr2_+_33592445 0.675 NM_015376
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr4_-_146315341 0.668 NM_017493
OTUD4
OTU domain containing 4
chr19_-_60941551 0.667 NM_176820
NLRP9
NLR family, pyrin domain containing 9
chr2_+_108751033 0.667 RANBP2
RAN binding protein 2
chr18_-_29882555 0.665 NM_001198549
NOL4
nucleolar protein 4
chr8_-_28403652 0.665 NM_172366
FBXO16
ZNF395
F-box protein 16
zinc finger protein 395
chr4_+_159662349 0.664 NM_021634
RXFP1
relaxin/insulin-like family peptide receptor 1
chr16_-_20323533 0.661 NM_174924
PDILT
protein disulfide isomerase-like, testis expressed
chrX_-_74921704 0.659 NM_138703
MAGEE2
melanoma antigen family E, 2
chr16_-_20610078 0.656 NM_052956
ACSM1
acyl-CoA synthetase medium-chain family member 1
chr2_+_171316462 0.655 EIF2S2
eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
chr8_-_82769761 0.651 NM_001010893
SLC10A5
solute carrier family 10 (sodium/bile acid cotransporter family), member 5
chrX_+_150653873 0.651 NM_005140
CNGA2
cyclic nucleotide gated channel alpha 2
chr1_+_200698493 0.651 NM_032103
NM_032104
PPP1R12B

protein phosphatase 1, regulatory (inhibitor) subunit 12B

chr2_-_224974954 0.648 NM_001122779
NM_024785
FAM124B

family with sequence similarity 124B

chr1_-_9925412 0.643 NM_032368
LZIC
leucine zipper and CTNNBIP1 domain containing
chr20_+_58004811 0.638 NM_021810
CDH26
cadherin 26
chr4_-_17415918 0.638 DCAF16
DDB1 and CUL4 associated factor 16
chr12_-_7172641 0.636 NM_031491
RBP5
retinol binding protein 5, cellular
chr15_+_91244563 0.633 CHD2
chromodomain helicase DNA binding protein 2
chr3_-_194579207 0.630 NM_198505
ATP13A5
ATPase type 13A5
chr6_+_31782618 0.630 NM_001003693
LY6G6F
lymphocyte antigen 6 complex, locus G6F
chr10_+_17891348 0.626 NM_001009567
NM_002438
MRC1L1
MRC1
mannose receptor, C type 1-like 1
mannose receptor, C type 1
chr5_-_42211112 0.626


chr7_+_111879348 0.623 NM_001197079
IFRD1
interferon-related developmental regulator 1
chr15_-_48345453 0.621 NM_002112
HDC
histidine decarboxylase
chr9_-_34681135 0.619 NM_006274
CCL19
chemokine (C-C motif) ligand 19
chr12_-_18134319 0.618 NM_024730
RERGL
RERG/RAS-like
chr2_-_178681311 0.616 NM_001077197
PDE11A
phosphodiesterase 11A
chr6_-_30760413 0.612 KIAA1949
KIAA1949
chr3_-_57301749 0.608 NM_001142733
ASB14
ankyrin repeat and SOCS box containing 14
chr12_-_10215942 0.608 NM_001172632
NM_001172633
NM_002543
OLR1


oxidized low density lipoprotein (lectin-like) receptor 1


chr1_-_164402575 0.605 NM_001017961
FAM78B
family with sequence similarity 78, member B
chr1_+_148020869 0.604 NM_000566
FCGR1A
Fc fragment of IgG, high affinity Ia, receptor (CD64)
chr4_-_77147625 0.600 NM_002416
CXCL9
chemokine (C-X-C motif) ligand 9
chr2_-_43756964 0.596 NM_001101330
LOC728819
hCG1645220
chr1_-_148854503 0.596


chr12_-_54517241 0.592 MMP19
matrix metallopeptidase 19
chr3_+_188568861 0.590 NM_022147
RTP4
receptor (chemosensory) transporter protein 4
chr9_-_28709302 0.590 NM_152570
LINGO2
leucine rich repeat and Ig domain containing 2
chr3_+_120375053 0.589 NM_006952
UPK1B
uroplakin 1B
chr2_-_49235059 0.589 NM_000145
NM_181446
FSHR

follicle stimulating hormone receptor

chr7_+_30140868 0.589 NM_152793
C7orf41
chromosome 7 open reading frame 41
chr2_+_68445936 0.587 PLEK
pleckstrin
chrX_-_130792297 0.585 LOC286467
hypothetical LOC286467
chr7_+_141136485 0.584 NM_018980
TAS2R5
taste receptor, type 2, member 5
chr14_-_20340830 0.582 NM_002933
NM_198234
NM_198235
RNASE1


ribonuclease, RNase A family, 1 (pancreatic)


chr6_+_32515596 0.580 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr2_-_37269193 0.580 NM_001032377
SULT6B1
sulfotransferase family, cytosolic, 6B, member 1
chr19_-_7702977 0.578 NM_198492
CLEC4G
C-type lectin domain family 4, member G
chr9_-_124981125 0.577 STRBP
spermatid perinuclear RNA binding protein
chr16_+_2593351 0.577 LOC652276
hypothetical LOC652276
chr11_+_36546138 0.576 NM_000448
RAG1
recombination activating gene 1
chr19_+_46201665 0.575 CYP2B6
cytochrome P450, family 2, subfamily B, polypeptide 6
chr6_-_76838944 0.574 NM_001563
IMPG1
interphotoreceptor matrix proteoglycan 1
chr12_+_102859354 0.574 HSP90B1
heat shock protein 90kDa beta (Grp94), member 1
chr7_-_86433139 0.574 NM_152748
KIAA1324L
KIAA1324-like
chr17_-_26648375 0.572 NM_002544
OMG
oligodendrocyte myelin glycoprotein

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.70 7.28e-36 GO:0007606 sensory perception of chemical stimulus
3.80 6.84e-34 GO:0007608 sensory perception of smell
2.65 7.73e-27 GO:0007600 sensory perception
1.99 8.20e-18 GO:0050877 neurological system process
1.85 3.97e-17 GO:0003008 system process
1.30 5.37e-12 GO:0050896 response to stimulus
1.28 1.56e-07 GO:0032501 multicellular organismal process
1.79 3.64e-05 GO:0006955 immune response
1.68 6.94e-04 GO:0006952 defense response
1.48 7.32e-03 GO:0002376 immune system process
1.90 1.84e-02 GO:0045087 innate immune response
2.48 2.07e-02 GO:0002252 immune effector process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.42 2.86e-14 GO:0071944 cell periphery
1.41 9.31e-14 GO:0005886 plasma membrane
1.27 9.01e-09 GO:0031224 intrinsic to membrane
1.27 2.08e-08 GO:0016021 integral to membrane
1.45 1.73e-06 GO:0005576 extracellular region
1.21 1.83e-06 GO:0044425 membrane part
1.15 2.14e-04 GO:0016020 membrane
1.61 1.10e-03 GO:0005615 extracellular space
1.45 1.33e-02 GO:0044421 extracellular region part

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.91 3.54e-35 GO:0004984 olfactory receptor activity
2.70 2.21e-30 GO:0004930 G-protein coupled receptor activity
2.22 6.52e-26 GO:0004888 transmembrane receptor activity
1.92 2.30e-21 GO:0004872 receptor activity
1.78 8.91e-20 GO:0004871 signal transducer activity
1.78 8.91e-20 GO:0060089 molecular transducer activity
4.00 2.67e-03 GO:0008009 chemokine activity
2.18 9.43e-03 GO:0005125 cytokine activity
3.61 1.01e-02 GO:0042379 chemokine receptor binding
6.13 3.05e-02 GO:0008527 taste receptor activity