Motif ID: HIF1A.p2

Z-value: 1.776


Transcription factors associated with HIF1A.p2:

Gene SymbolEntrez IDGene Name
HIF1A 3091 hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)



Activity profile for motif HIF1A.p2.

activity profile for motif HIF1A.p2


Sorted Z-values histogram for motif HIF1A.p2

Sorted Z-values for motif HIF1A.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HIF1A.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_174803768 1.881 NM_000794
 DRD1
dopamine receptor D1
chr3_-_185025989 1.552 NM_024871
 MAP6D1
MAP6 domain containing 1
chr2_-_97016027 1.297 NM_001122646
 FAM178B
family with sequence similarity 178, member B
chr21_+_25856311 1.278 MIR155HG
MIR155 host gene (non-protein coding)
chr1_-_77921681 1.270 ZZZ3
zinc finger, ZZ-type containing 3
chr13_-_110365282 1.222


chr10_-_64248932 0.953 NM_001136178
 EGR2
early growth response 2
chr12_+_105873803 0.914 C12orf23
chromosome 12 open reading frame 23
chr1_+_191357788 0.851 CDC73
cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr13_-_43259032 0.849 NM_017993
 ENOX1
ecto-NOX disulfide-thiol exchanger 1
chr17_+_32924110 0.849 DUSP14
dual specificity phosphatase 14
chr11_+_122936145 0.848 GRAMD1B
GRAM domain containing 1B
chr1_+_191357843 0.848 CDC73
cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr12_+_120635021 0.844 NM_001080825
 TMEM120B
transmembrane protein 120B
chr1_+_243384868 0.821 NM_018012
 KIF26B
kinesin family member 26B
chr2_-_227371698 0.813 NM_005544
 IRS1
insulin receptor substrate 1
chr1_+_191357680 0.804 NM_024529
 CDC73
cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr10_+_35456393 0.803 NM_181571
NM_183060
 CREM

cAMP responsive element modulator

chr9_+_99785405 0.799 ANP32B
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr3_-_47492421 0.775 NM_012235
 SCAP
SREBF chaperone

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 15 of 15 entries
enrichment   p-value GO term description
2.98 9.16e-03 GO:0050770 regulation of axonogenesis
2.41 1.18e-02 GO:0010769 regulation of cell morphogenesis involved in differentiation
2.39 1.41e-02 GO:0022604 regulation of cell morphogenesis
2.37 2.45e-02 GO:0010975 regulation of neuron projection development
2.13 2.10e-02 GO:0006913 nucleocytoplasmic transport
2.11 2.78e-02 GO:0051169 nuclear transport
1.47 1.12e-02 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.44 2.32e-02 GO:0006793 phosphorus metabolic process
1.44 2.32e-02 GO:0006796 phosphate metabolic process
1.31 2.56e-02 GO:0043412 macromolecule modification
1.30 4.73e-02 GO:0006464 protein modification process
1.21 7.85e-04 GO:0044260 cellular macromolecule metabolic process
1.16 1.56e-03 GO:0044237 cellular metabolic process
1.14 4.73e-03 GO:0008152 metabolic process
1.08 2.90e-02 GO:0009987 cellular process

Gene overrepresentation in compartment category:

Showing 1 to 19 of 19 entries
enrichment   p-value GO term description
1.79 4.50e-02 GO:0005635 nuclear envelope
1.52 1.85e-03 GO:0044432 endoplasmic reticulum part
1.45 4.09e-02 GO:0031967 organelle envelope
1.42 2.36e-05 GO:0012505 endomembrane system
1.36 1.32e-05 GO:0031090 organelle membrane
1.31 7.71e-04 GO:0005829 cytosol
1.23 7.56e-10 GO:0044444 cytoplasmic part
1.21 2.70e-14 GO:0005737 cytoplasm
1.19 4.76e-14 GO:0043231 intracellular membrane-bounded organelle
1.19 7.02e-14 GO:0043227 membrane-bounded organelle
1.18 5.28e-05 GO:0005634 nucleus
1.18 9.14e-05 GO:0044446 intracellular organelle part
1.17 1.49e-22 GO:0044424 intracellular part
1.17 2.02e-14 GO:0043226 organelle
1.17 2.42e-14 GO:0043229 intracellular organelle
1.17 2.76e-04 GO:0044422 organelle part
1.16 1.46e-19 GO:0005622 intracellular
1.05 1.11e-06 GO:0044464 cell part
1.05 1.15e-06 GO:0005623 cell

Gene overrepresentation in function category:

Showing 1 to 6 of 6 entries
enrichment   p-value GO term description
2.10 1.87e-02 GO:0004721 phosphoprotein phosphatase activity
1.39 3.80e-02 GO:0030528 transcription regulator activity
1.28 3.27e-03 GO:0000166 nucleotide binding
1.21 7.78e-03 GO:0003676 nucleic acid binding
1.18 9.20e-08 GO:0005515 protein binding
1.08 6.25e-05 GO:0005488 binding